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Numerical study of the influence of the atmospheric pressure on the thermal environment in the passenger cabin

Building Simulation 2024年第2期17卷 253-265页

作者： Xin Su Yu guo Zhengwei Long yi Cao Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure remains lower than the horizontal atmospheric pressure when the airplane is in *** pressure is one of the parameters that must be taken into consideration while studying the thermal environment of an airplane *** are still no reference values for aircraft cabins despite the fact that numerous studies on low pressure heat transfer have demonstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction method for CHTC under low pressure conditions was established by using the dummy heat dissipation in the low-pressure cabin *** this basis,a thermal environment simulation model was developed,then was applied to the simulation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dummy surface in the cabin were ***,the results of PMV calculated by using heat dissipation and air parameters at sampling points were *** results show that the modified CHTC can accurately reflect the cabin thermal environment under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl number,which is nonlinear correlated with the *** simulation results of the thermal environment in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from 5.09 W/(m^(2)·K)to 4.56 W/(m^(2)·K),but the air temperature rises by about 0.2°C as a *** deviation of PMV results calculated by using simulated heat loss data and using air parameters of measuring points in space is up to 0.5,but the latter is representative for calculating the thermal comfort level of the whole cabin.

关键词： low pressure aircraft cabin simulation heat dissipation convective heat transfer coefficient

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Predicting torsional capacity of reinforced concrete members by data-driven machine learning models

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 444-460页

作者： Shenggang chen Congcong chen Shengyuan LI Junying guo Quanquan guo Chaolai LI School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 211116China Jiangsu Key Laboratory Environmental Impact and Structural Safety in Engineering China University of Mining and TechnologyXuzhou 211116China China Nuclear Power Design Co.Ltd. Shenzhen 518031China School of transportation and science engineering Beihang UniversityBeijing 100191China China Construction First Group Corporation Limited Beijing 100161China

Due to the complicated three-dimensional behaviors and testing limitations of reinforced concrete(RC)members in torsion,torsional mechanism exploration and torsional performance prediction have always been *** the present paper,several machine learning models were applied to predict the torsional capacity of RC *** results of a total of 287 torsional specimens were collected through an overall literature *** of extreme gradient boosting machine(XGBM),random forest regression,back propagation artificial neural network and support vector machine,were trained and tested by 10-fold cross-validation *** performances of proposed machine learning models were evaluated and compared,both with each other and with the calculated results of existing design codes,i.e.,GB 50010,ACI 318-19,and Eurocode *** results demonstrated that better predictive performance was achieved by machine learning models,whereas GB 50010 slightly overestimated the torsional capacity,and ACI 318-19 and Eurocode 2 underestimated it,especially in the case of ACI *** XGBM model gave the most favorable predictions with R^(2)=0.999,RMSE=1.386,MAE=0.86,andλ=***,strength of concrete was the most sensitive input parameters affecting the reliability of the predictive model,followed by transverse-to-longitudinal reinforcement ratio and total reinforcement ratio.

关键词： RC members torsional capacity machine learning models design codes

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Azocalixarenes: a scaffold of universal excipients with high efficiency

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Science China Chemistry 2024年第5期67卷 1697-1706页

作者： Yu-Xin Yue yi-Lin Lin Meng-Meng chen Han-Wen Tian Rong Ma Ze-Han Wang Fang-Yuan chen Yu-chen Pan Dong-Sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China

Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, including molecular-level protection, small sizes,fast kinetics of host-guest recognition, and modular construction. With the continuous advances in the medical field, personalized and precision medicine requires the development of excipients with low dosages, integrated modifying effects, universality,and controlled release. To meet these requirements, we have developed a new family of macrocyclic excipients based on calixarenes by integrating their covalent(broad chemical design space) and noncovalent(wide range of substrates) ***, azocalixarenes(Azo CAs) were designed, showing high binding affinities to a broad spectrum of active pharmaceutical ingredients(APIs), selectivity to interferents, and responsiveness to hypoxic microenvironments. Due to their highly efficient and controllable recognition, Azo CAs serve as low-dose excipients for 30 APIs. Molecular encapsulation by Azo CAs results in the integrated modification of the physicochemical properties of APIs, including solubility, stability, bioavailability,and biocompatibility. Moreover, Azo CAs can be reduced by azoreductases overexpressed in hypoxic microenvironments,leading to the controlled release of APIs. Collectively, Azo CA excipients have broad application prospects for a series of diseases such as enteritis, arthritis, stroke, cancer, bacterial infection and kidney injury, with diverse therapeutic modalities,including chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, boron neutron capture therapy, radiotherapy, fluorescence imaging, and their combinations.

关键词： supramolecular chemistry host-guest systems excipient calixarene molecular recognition

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Investigation of high-quality-factor aluminum nitride MEMS cantilever resonators

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Nanotechnology and Precision Engineering 2024年第1期7卷 32-43页

作者： Shuai Shi Qingrui Yang yi Yuan Haolin Li Pengfei Niu Wenlan guo chen Sun Wei Pang State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

This paper presents the design,fabrication,and characterization of cantilever-type resonators with a novel stacked *** nitride is adopted as the material for both the structural layer and the piezoelectric layer;this simpliﬁes the fabrication process and improves the quality factor of the *** in-plane and out-of-planeﬂexural modes were *** effect of the structural dimensions and electrode patterns on the resonator’s performance were also ***-element simulations and experiments examining anchor loss and thermoelastic damping,which are the main loss mechanisms affecting the quality factor of these resonators,were carried *** optimal structural dimensions and electrode patterns of the cantilever-type resonators are presented.A quality factor of 7922 with a motional impedance of 88.52 kΩand a quality factor of 8851 with a motional impedance of 67.03 kΩwere achieved for the in-plane and out-of-planeﬂexural-mode resonators,*** proposed resonator design will contribute to the development of high-performance devices such as accelerometers,gyroscopes,and pressure sensors.

关键词： MEMS Cantilever-type micro-resonator AlN Finite-element simulation

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Simultaneous enhanced ammonia and nitrate removal from secondary effluent in constructed wetlands using a new manganese-containing substrate

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 91-102页

作者： Zhihao Xian Jun Yan Jingyi Dai Hao Wu Xin Zhang Wenbo Nie Fucheng guo yi chen Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment(Ministry of Education) Chongqing UniversityChongqing 400044China College of Environment and Ecology Chongqing UniversityChongqing 400044China

Constructed wetlands(CWs)are widely used to treat secondary ***,simultaneously removing ammonia(NH_(4)^(+)-N)and nitrate(NO_(3)^(–)–N)is challenging because of insufficient oxygen and carbon *** this study,a novel composite material(MPCM)comprising MnO_(2) and polycaprolactone was developed as a substrate for CWs to enhance the synchronous removal of NH_(4)^(+)–N and NO_(3)^(–)–*** CWs with a higher MPCM content(H-CW),lower MPCM content(LCW),and controlled CW(C-CW)exhibited average NH_(4)^(+)–N removal efficiencies of 75.69%,70.49%,and 52.40%,*** 15N isotope tracking technique showed that NH_(4)^(+)–N removal was attributed to anaerobic ammonia oxidation mediated by MnO2 reduction(Mnammox),which accounted for 17.16%–27.24%of the NH_(4)^(+)–N removal in the composite material layers(0–20 cm)of the H-CW and *** richness of ammonia oxidizers in the upper layers(40–50 cm)of the HCW and L-CW further facilitated NH_(4)^(+)–N ***,the average total nitrogen(TN)removal efficiencies of the H-CW and L-CW were 1.99 and 1.59 times that of C-CW,respectively,owing to enhanced denitrification by ***,N_(2)O emissions were reduced by 81.31%and 70.83%in the H-CW and L-CW,*** study provides an effective approach for improving nitrogen removal and reducing N2O emissions during the treatment of secondary effluent by CWs.

关键词： Constructed wetland Nitrogen removal Manganese redox Polycaprolactone Nitrous oxide

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Effectiveness of Acupoint Application in Patients with Pharyngeal Pain: Evidence from CHUNBO, A Prospective Real-World Study

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Chinese Journal of Integrative Medicine 2024年第1期30卷 18-24页

作者： MA Hang-kun WANG yi-ming guo Man-ping LI chen-fei LI Rui GAO Rui Emergency Department Xiyuan Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing(100091)China National Medical Products Administration for Laboratory of Clinical Research and Evaluation of Traditional Chinese Medicine Beijing(100091)China National Clinical Research Center for Chinese Medicine Cardiology Beijing(100091)China Postdoctoral Workstation of Yabao Pharmaceutical Group Co. Ltd.YunchengShanxi Province(044602)China

Objective: To assess the outcomes after acupoint application in patients with pharyngeal pain in a real-world settings, and analyze the characteristics of effective population and prescription characteristics of acupoint application. Methods: Based on CHUNBO platform, patients with pharyngeal pain who were candidates for acupoint application on the basis of physician-evaluation, were enrolled in a nationwide, prospective, 69-week multicenter observational study from August 2020 to February 2022. Propensity score matching(PSM) was used to match the confounding factors and the association rules were used to analyze the characteristics of effective population and prescription characteristics of acupoint application. Outcome assessments included the disappearance rate of pharyngeal pain(within 3, 7, and 14 days), disappearance time of pharyngeal pain, as well as adverse events. Results: Of 7,699 enrolled participants, 6,693(86.9%) received acupoint application and 1,450(21.7%) with non-acupoint application. After PSM, there were 1,004 patients each in the application group(AG) and non-application group(NAG). The disappearance rate of pharyngeal pain in the AG at 3, 7, and 14 days were all higher than those in the NAG(P<0.05). The disappearance time of pharyngeal pain in the AG were shorter than that in the NAG(logrank P<0.001, hazard ratio=1.51, 95% confidence interval: 1.41–1.63). The median age of effective cases was 4 years, mainly 3–6 years old(40.21%). The disappearance rate of pharyngeal pain in the application group with tonsil diseases was 2.19 times higher than that in the NAG(P<0.05). The commonly used acupoints for the effective cases were Tiantu(RN 22), Shenque(RN 8) and Dazhui(DU 14). The commonly used herbs for the effective cases were Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae. Among them, Natrii sulfas was applied to RN 8 most frequently(support 84.39%). A total of 1,324(17.2%) patients experienced AEs, and mainly occurred in the AG, with s

关键词： acupoint application Chinese medicine pharyngeal pain multicentre effectiveness characters real-world study

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Let-7i-5p maintains the stemness via R-spondin2/Wnt pathway in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 20-23页

作者： Qinghua Wei Xueshan Dai Jiahui Wei Wenwei Sun Xiaoqian Yang Yuxin Zhang Xin guo yi chen College of Pharmaceutical Sciences&Chinese Medicine Southwest UniversityChongqing 400716China Center for Basic Medical Research TEDA International Cardiovascular HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300457China Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine Chongqing 400716China pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine Chongqing 400716China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China National Demonstration Center for Experimental Pharmacy Education(Southwest University) Chongqing 400716China Engineering Research Center of Coptis Development and Utilization(Ministry of Education) College of Pharmaceutical Sciences and Chinese MedicineSouthwest UniversityChongqing 400716China

Cancer stem cells(CSCs)are related to tumorigenesis,recurrence,metastasis,and drug resistance in hepatocellular carcinoma(HCC).1 Let-7i is a noncoding small RNA,belonging to the famous miRNA let-7 ***,let-7i has been ... 详细信息

关键词： hepatocellular Cancer metastasis

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Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS

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Nuclear Science and Techniques 2024年第4期35卷 82-95页

作者： Jing Tian Zhi-Peng Sun Song-Bo Chang yi Qian Hong-Yun Zhao Zheng-guo Hu Xi-Meng chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of LanzhouLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

The High-energy Fragment Separator(HFRS),which is currently under construction,is a leading international radioactive beam *** sets of position-sensitive twin time projection chamber(TPC)detectors are distributed on HFRS for particle identification and beam *** twin TPCs'readout electronics system operates in a trigger-less mode due to its high counting rate,leading to a challenge of handling large amounts of *** address this problem,we introduced an event-building *** algorithm employs a hierarchical processing strategy to compress data during transmission and *** addition,it reconstructs twin TPCs'events online and stores only the reconstructed particle information,which significantly reduces the burden on data transmission and storage *** studies demonstrated that the algorithm accurately matches twin TPCs'events and reduces more than 98%of the data volume at a counting rate of 500 kHz/channel.

关键词： High counting rate Twin TPCs Trigger-less Readout electronics Event building Hierarchical data processing

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Hematite-facilitated microbial ammoxidation for enhanced nitrogen removal in constructed wetlands

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 35-45页

作者： Hao Qin Wenbo Nie Duo yi Dongxu Yang Mengli chen Tao Liu yi chen Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment(Ministry of Education) Chongqing UniversityChongqing 400045China College of Environment and Ecology Chongqing UniversityChongqing 400045China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 610031China

Constructed wetlands(CWs)are widely applied for decentralized wastewater ***,achieving efficient removal of ammonia(NH+-N)has proven challenging due to insufficient *** this study,natural hematite(Fe,O3)was employed as a CW substrate(H-CWs)for the first time to drive anaerobic ammonia oxidation coupled with iron(I)reduction(Feammox).Compared to gravel constructed wetlands(G-CWs),ammonia removal was enhanced by 38.14%to 54.03%and nitrous oxide(N_(2)0)emissions were reduced by 34.60%in *** synergistic removal of ammonia and nitrate by H-CWs also resulted in the absence of ammoxidation *** and 15N isotope tracer incubations showed that Feammox accounting for approximately 40%of all ammonia removal in the *** enrichment of iron phosphate(Fe_(3)Fe_(4)(PO_(4))_(6))promoted the accumulation of the Feammox intermediate compound *** nanowires were observed on the surface of H-CW substrates as well,suggesting that the observed biological ammoxidation was most likely related to extracellular electron transfer(EET).Microbial and metagenomics analysis revealed that H-CWs elevated the integrity and enhanced the abundance of functional microorganisms and genes associated with nitrogen ***,the efficient ammonia removal in the absence of O2 together with a reduction in N_(2)O emissions as described in this study may provide useful guidance for hematite-mediated anaerobic ammonia removal in CWs.

关键词： Constructed wetlands Nitrogen removal Feammox Hematite Iron cycle

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A deformation criterion of pressurized non-circular cross-section cabin and its effects on cruise performance of BWB civil aircraft

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Chinese Journal of Aeronautics 2024年第6期37卷 78-88页

作者： Siyi guo Zhenli chen Xuanyu YAO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aero Engine Academy of China Beijing 101304China

Blended-Wing-Body(BWB)aircraft is promoted as one of the most possible layouts to achieve more sustainable civil *** to the non-circular cross-section of the center-body,a bulge deformation forms over the upper surface of the body under the coupled loads of the internal pressurization of the cabin and the aerodynamic bending moments of the wing,which reduces the lift-to-drag ratio of BWB *** a limited deformation,the relationship between the aerodynamic performance and the structural weight needs to be *** this work,the effects of stiffness constraints on the center-body deformation,structural weight of the airframe and aerodynamic performance were investigated by using an analytical model of the Pultruded Rod Stitched Efficient Unitized Structure(PRSEUS)for the airframe and the computational fluid dynamics method,*** results show that as the stiffness constraint increases,the spacings between the rod stringers and the frame stiffeners decrease,and the structural weight increases inversely.A 5.2% reduction of the lift-to-drag ratio is encountered at cruise for a medium deformation design of 42.8 mm/m.A higher aerodynamic penalty is suffered when the stiffness constraint is further *** final deformation criterion is different when the weight vector of the aerodynamic performance and structural weight is different.

关键词： Blended-Wing-Body(BWB) Deformation PultrudedRod Stitched Effi-cient Unitized Structure(PRSEUS) Cabin structure Stiffness constraint

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