检索结果-南通市图书馆

Microencapsulated Lactobacillus plantarum promotes intestinal development through gut colonization of layer chicks

ANIMAL NUTRITION 2024年第3期18卷 1-16页

作者： Cui, Yaoming Liu, Yanxia Yang, Jing Duan, Haitao Wang, Peng guo, linna guo, Yanjiao Li, Suying Zhao, Yating Wang, Jinrong Qi, Guanghai Guan, Junjun Henan Univ Technol Sch Biol Engn Zhengzhou 450001 Henan Peoples R China Henan Univ Anim Husb & Econ Coll Anim Sci & Technol Zhengzhou 450046 Henan Peoples R China Chinese Acad Agr Sci Feed Res Inst Beijing 100081 Peoples R China

The effects of Lactobacillus plantarum in microencapsulation (LPM) on intestinal development in layer chicks were investigated in this study, as well as the colonization of L. plantarum in the gut. A total of 480 healthy Hy-Line Brown layer chicks at 0 d old were randomly divided into 4 groups (8 replicates each treatment), and the diets of these birds were supplemented with nothing (control), L. plantarum (0.02 g/kg feed; 10(9) CFU/kg feed), LPM (1.0 g/kg feed; 10(9) CFU/kg feed) and wall material of LPM (WM; 0.98 g/kg feed), respectively. Compared to control, LPM improved growth performance and intestinal development of layer chicks, evidenced by significantly increased body weight, average daily gain, average daily feed intake, villus height, villus height/crypt depth, as well as weight and length of the duodenum, jejunum and ileum (P < 0.05). These results could be attributed to the increased colonization of L. plantarum in the gut, which was verified by significant increases in lactic acid content, viable counts in chyme and mucosa (P < 0.05), as well as a visible rise in number of strains labeled with fluorescein isothiocyanate. Meanwhile, the relative abundances of Lactobacillus and Bifidobacterium significantly increased in response to microencapsulated L. plantarum supplementation (P < 0.05), accompanied by the significant up-regulation of colonization related genes (P < 0.05), encoding solute carrier family, monocarboxylate transporter, activin A receptor, succinate receptor and secretogranin II. To sum up, microencapsulated L. plantarum supplementation promoted intestinal development, which could be attributed to the enhancement of L. plantarum colonization in the intestine through the mutual assistance of Bifidobacterium and interactions with colonization related transmembrane proteins. (c) 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://

关键词： Intestinal development Colonization Microbiota Layer chick Lactobacillus plantarum ACID PRODUCTION MUCUS LAYERS RESISTANCE MORPHOLOGY MICROBIOTA PROBIOTICS ADHESION DISEASE PERFORMANCE INFECTIONS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

颠覆性技术创新项目评估模型构建——基于合成生物学的分析

引用

科技管理研究 2024年第11期44卷 155-163页

作者：郭琳娜闫冬霍竹石峰席红梅张如锦科技部科技评估中心北京100081

针对缺乏颠覆性技术创新项目特点的评估指标的问题,围绕颠覆性技术创新项目的质量、贡献和绩效价值,建立基于战略生态位理论的颠覆性技术创新科技项目分析模型。基于该模型,以合成生物学为例,从保护空间构建、创新成果和创新贡献三方面... 详细信息

针对缺乏颠覆性技术创新项目特点的评估指标的问题,围绕颠覆性技术创新项目的质量、贡献和绩效价值,建立基于战略生态位理论的颠覆性技术创新科技项目分析模型。基于该模型,以合成生物学为例,从保护空间构建、创新成果和创新贡献三方面开展分析,提炼实施和管理特色措施,提出评估框架。在此基础上,分析提出适于颠覆性技术创新项目的评估模型和12个方面具体评估内容。最后提出相关政策建议。所提出评估模型和内容对指导相关评估具积极意义。

关键词：颠覆性技术创新合成生物学科技项目评估

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

蘼芜水热合成碳量子点的透射电子显微镜结构表征

引用

分析测试技术与仪器 2024年第3期30卷 161-165页

作者：孙晶莹郭琳娜董鑫黄烘梁超伦中山大学分析测试中心广东广州510275

运用透射电子显微镜技术(transmission electron microscopy,TEM)观察分析了以植物蘼芜为碳源,通过水热法合成的CQDs(carbon quantum dots,CQDs)的结构.针对TEM明场像中CQDs衬度弱而难以观察的问题,利用高角环形暗场扫描透射技术(high a... 详细信息

运用透射电子显微镜技术(transmission electron microscopy,TEM)观察分析了以植物蘼芜为碳源,通过水热法合成的CQDs(carbon quantum dots,CQDs)的结构.针对TEM明场像中CQDs衬度弱而难以观察的问题,利用高角环形暗场扫描透射技术(high angle annular dark field-scanning transmission electron microscopy,HAADF-STEM)在铜网中快速定位CQDs.相应区域的明场像显示CQDs形貌为不规则多边形,尺寸约3 nm.通过高分辨透射电子显微镜技术(HRTEM)及相应的快速傅里叶变换(fast Fourier transform,FFT),观察到具有六次对称性的晶格条纹(0.21 nm)和衍射斑点,以及石墨π键的层间距(0.34 nm),讨论了CQDs特征晶面指数的指标化方法.晶格结构分析结果表明,CQDs为晶态六方相类石墨烯结构.

关键词：植物碳源碳量子点高分辨透射电子显微镜

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

引用

Nano Research 2020年第8期13卷 2197-2202页

作者： Hongxia Liang Zhenhua Li Zhigang Ren Qiaodi Jia linna guo Shasha Li Hongyu Zhang Shiqi Hu Dashuai Zhu Deliang Shen Zujiang Yu Ke Cheng Department of Infectious Disease and Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State UniversityRaleighNC27607USA Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State UniversityRaleighNC27695USA Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China The Key Lab of Chemical Biology and Organic Chemistry of Henan Province Zhengzhou UniversityZhengzhou450001China

Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.

关键词： liver fibrosis nitric oxide(NO) hepatic stellate cells(HSC) nanoparticles near infrared light(NIR)-controlled release

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

探讨SPOC教学在系统解剖学实验教学中的应用效果

引用

中国高等医学教育 2024年第2期 77-79页

作者：姜杨郭林娜李莉李永涛金海峰姚立杰齐齐哈尔医学院基础医学院黑龙江齐齐哈尔161006

目的:探讨SPOC教学在系统解剖学实验教学中的应用效果。方法:对照组采用传统式教学,试验组采用SPOC教学,对比两组应用效果。结果:试验组学生实验考试成绩明显高于对照组(P<0.05),调查问卷结果显示SPOC教学满意度较高。结论:系统解剖学... 详细信息

目的:探讨SPOC教学在系统解剖学实验教学中的应用效果。方法:对照组采用传统式教学,试验组采用SPOC教学,对比两组应用效果。结果:试验组学生实验考试成绩明显高于对照组(P<0.05),调查问卷结果显示SPOC教学满意度较高。结论:系统解剖学实验课采用SPOC教学能够提高系统解剖学实验课教学质量。

关键词： SPOC教学系统解剖学实验教学应用效果

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Adaptive Optimal Output Regulation of Interconnected Singularly Perturbed Systems With Application to Power Systems

引用

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 595-607页

作者： Jianguo Zhao Chunyu Yang Weinan Gao linna Zhou Xiaomin Liu the Engineering Research Center of Intelligent Control for Underground Space Ministry of EducationChina University of Mining and TechnologyXuzhou 221116 the School of Information and Control Engineering China University of Mining and TechnologyXuzhou 221116 IEEE the State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China

This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the slow and fast characteristics among system states,the interconnected SPS is decomposed into the slow time-scale dynamics and the fast timescale dynamics through singular perturbation *** the fast time-scale dynamics with interconnections,we devise a decentralized optimal control strategy by selecting appropriate weight matrices in the cost *** the slow time-scale dynamics with unknown system parameters,an off-policy RL algorithm with convergence guarantee is given to learn the optimal control strategy in terms of measurement *** combining the slow and fast controllers,we establish the composite decentralized adaptive optimal output regulator,and rigorously analyze the stability and optimality of the closed-loop *** proposed decomposition design not only bypasses the numerical stiffness but also alleviates the *** efficacy of the proposed methodology is validated by a load-frequency control application of a two-area power system.

关键词： Adaptive optimal control decentralized control output regulation reinforcement learning(RL) singularly perturbed systems(SPSs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatio-temporal evolution and topographic gradient effect of land use and ecosystem service value in the Lhasa River Basin

引用

Journal of Mountain Science 2024年第6期21卷 2059-2074页

作者： ZHOU Jianwei FENG Bin WU Hua XU Tong CHEN linna ZHAO Xinyong guo Qiyun LI Jiatong ZHANG Chenguang ZHU Kangcheng KONG Yuzhong School of Ecology and Environment Tibet UniversityLhasa 850000China School of Engineering Tibet UniversityLhasa 850000China Joint Laboratory of Plateau Surface Remote Sensing Tibet UniversityLhasa 850000China

The Lhasa River Basin forms an essential human settlement area in the southern part of the Qinghai-Tibet *** study employed ecosystem service value(ESV)evaluation model,terrain gradient grading,and Geodetector to analyze land use and ESV in the Lhasa River Basin from 1985 to *** findings reveal that:(1)From 1985 to 2020,grassland was the dominant land *** was a trend of grassland reduction and the expansion of other land types.(2)ESV has increased over the research period(with a total increase of 0.84%),with higher values in the southeast and lower values in the *** contributed the most to ESV,and climate regulation and hydrological regulation were the ecosystem services that contribute the most to ESV.(3)Natural factors like NDVI and altitude,as well as economic factors like population density and distance from roads,influenced the spatial differentiation of ESV,the explanatory power of NDVI reached up to *** interaction between factors had a greater impact than individual *** research results can provide theoretical support for national spatial planning and ecological environment protection in the Lhasa River Basin and other similar areas.

关键词： Ecosystem services value Land use Terrain gradient effect Lhasa River Basin Driving factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear relationship between urban form and transport CO_(2)emissions:Evidence from Chinese cities based on machine learning

引用

Journal of Geographical Sciences 2024年第8期34卷 1558-1588页

作者： LI linna DENG Zilin HUANG Xiaoyan Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Northwest Land and Resources Research Center Global Regional and Urban Research InstituteShaanxi Normal UniversityXi'an 710119China

Reducing carbon emissions from the transport sector is essential for realizing the carbon neutrality goal in *** substantial studies on the influence of urban form on transport cO_(2)emissions,most of them have treated the effects as a linear process,and few have studied their nonlinear *** research focused on 274 Chinese cities in 2019 and applied the gradient-boosting decision tree(GBDT)model to investigate the nonlinear effects of four aspects of urban form,including compactness,complexity,scale,and fragmentation,on urban transport CO_(2)*** was found that urban form contributed 20.48%to per capita transport CO_(2)emissions(PTCEs),which is less than the contribution of socioeconomic development but more than that of transport *** contribution of urban form to total transport CO_(2)emissions(TCEs)was the lowest,at 14.3%.In particular,the effect of compactness on TCEs was negative within a threshold,while its effect on PTCEs showed an inverted U-shaped *** effect of complexity on PTCEs was positive,and its effect on TCEs was *** effect of scale on TCEs and PTCEs was positive within a threshold and negative beyond that *** effect of fragmentation on TCEs was also nonlinear,while its effect on PTCEs was positively *** results show the complex effects of the urban form on transport CO_(2)***,strategies for optimizing urban form and reducing urban transport carbon emissions are recommended for the future.

关键词： urban form transport CO,emissions nonlinear effect sustainable transport gradient-boosting decision treemodel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hole-Transporting Materials with Rational Combination of Pyridine and Dibenzo[a,c]phenazine as Electron Acceptor for Dopant-Free Perovskite Solar Cells

引用

Chinese Journal of Chemistry 2024年第10期42卷 1100-1106页

作者： Weidong Ling Fei Wu Wentao Yuan linna Zhu Qianqian Li Zhen Li Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials Department of ChemistryWuhan UniversityWuhanHubei 430072China Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energy Faculty of Materials&EnergySouthwest UniversityChongqing400715China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhanHubei 430072China

Perovskite solar cells(PSCs)have been proven to be a promising option for photovoltaic *** the aim to achieve efficient and stable PSCs,it is essential to explore dopant-free hole-transporting materials(HTMs)with high hole ***,HTMs bearing electron donor(D)-electron acceptor(A)-electron donor(D)structures have been constructed with strong intramolecular charge transfer(ICT)effect,based on rational combination of dibenzo[a,c]phenazine and pyridine as electronic acceptors and anchoring groups to perovskite ***,high hole mobility(7.31×10^(-5) cm^(2)·V^(-1)·s^(-1))and photoelectric conversion efficiency(20.45%)have been achieved by dopant-free DPyP-based *** afforded an efficient way to design HTMs with high hole mobility by adjustment of molecular configurations and electronic property of conjugated systems.

关键词： Perovskite solar cell Charge transfer Donor-acceptor systems Energy conversion Hole mobility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isoliquiritigenin inhibits Ishikawa endometrial carcinoma cells proliferation and promotes apoptosis

Isoliquiritigenin inhibits Ishikawa endometrial carcinoma ce...

引用

中国解剖学会2021年年会

作者： Yao Lijie Jiang Yang Ma Yong guo linna Jin Haifeng Department of Anatomy Qiqihar Medical University

Endometrial cancer is the fourth most frequent neoplasia in women worldwide,and the molecular mechanisms involved in the etiology and pathogenesis continue to be *** (ISL),an important flavonoid isolated from Glycyrrhizae radix,possesses a wide range of pharmacological properties such as antioxidant,antiinflammatory,antitumor and immunoregulatory activities.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：