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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li Fang-Yi huo Qian-Fang Meng Ganglin Tong Xuan Wu Lin-Lin Bu Lang Rao Shubin Wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOD)as low as 15.4 nmol/L,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Ocular decompression retinopathy after phacoemulsification in a patient with primary acute angleclosure glaucoma undergoing chemotherapy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 397-400页

作者： Yi-Lin Chen Xiao-Nan Yang Ying-Li Liu Wen-Tao Li Li-Jun huo Department of Ophthalmology the First Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

Dear Editor,Ocular decompression retinopathy(ODR),which manifests as diffuse retinal hemorrhage occurring abruptly in multiple locations,including the subretinal,intraretinal,and preretinal spaces,is a rare complication after glaucoma surgery and is caused by sudden,iatrogenic lowering of intraocular pressure(IOP).Implicated procedures include glaucoma drainage implantation,trabeculectomy,iridotomy,and even cataract surgery[1].One report described a case of ocular decompression management following uncomplicated cataract surgery with no posterior capsular rupture or other intraoperative complications[2].Here,we report a rare case of ODR triggered by phacoemulsification and the use of systemic chemotherapeutic drugs in a patient with primary acute angleclosure glaucoma(PACG).The case not only improves our understanding of potential side effects of chemotherapeutic drugs on ophthalmic surgery but may also serve as a reference for clinicians in the management of patients with glaucoma with similar medical histories.

关键词： glaucoma decompression drugs

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接驳地铁的共享自动驾驶汽车动态合乘匹配研究

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中国公路学报 2024年第6期37卷 288-301页

作者：霍月英张越李晓娟陈国庆内蒙古大学交通学院内蒙古呼和浩特010070 内蒙古大学数学科学学院内蒙古呼和浩特010021 北京联合大学城市轨道交通与物流学院北京100101

为了实现共享自动驾驶汽车(Shared Autonomous Vehicles,SAV)和地铁的整合,提出采用SAV作为地铁“第一公里”(First Mile,FM)和“最后一公里”(Last Mile,LM)的接驳方式。构建了动态合乘匹配系统以厘清接驳地铁的SAV合乘的框架及运行规... 详细信息

为了实现共享自动驾驶汽车(Shared Autonomous Vehicles,SAV)和地铁的整合,提出采用SAV作为地铁“第一公里”(First Mile,FM)和“最后一公里”(Last Mile,LM)的接驳方式。构建了动态合乘匹配系统以厘清接驳地铁的SAV合乘的框架及运行规则,系统输入为路网数据、SAV数据(位置、载客状态等)、出行者数据(起点、终点等),输出为出行匹配结果、合乘路径。建立了出行路径模型和出行匹配模型来实现系统的合乘匹配功能。出行路径模型考虑出行者绕行时间最小化进行建模,可得到任意2名出行者合乘时的最优出行路径,用于出行匹配模型的参数计算。出行匹配模型协同考虑出行者服务质量和运营商利益以及SAV与地铁时刻表的联合优化进行建模,可得到最优出行匹配方案,包括人与SAV匹配、人与人匹配。选取纽约曼哈顿地铁进行4种出行需求(2160、4320、6480、8640次·h-1)的算例分析。结果表明:在出行需求2160、4320次·h-1的FM和LM出行、出行需求6480次·h-1的LM出行中,出行者平均等待时间最大值为1.06 min,出行者平均绕行时间最大值为1.11 min,出行者平均匹配时长最长为46.09 s,每小时最多可为运营商节约877.24 km的车辆行驶里程,匹配率最高可达61.67%,系统平均求解时长最长为2.09 s;表明所建系统和模型具有高效性和稳定性。

关键词：交通工程共享自动驾驶汽车地铁接驳动态合乘匹配路径选择

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High-density triple-phase contact points for enhanced photocatalytic CO_(2) reduction to methanol

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Chinese Chemical Letters 2024年第2期35卷 252-256页

作者： Hanwen Jian Kaiming Deng Tongyu Wang Chengxi Huang Fang Wu Hailing huo Bo Ouyang Xuan Liu Jingjing Ma Erjun Kan Ang Li MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing School of ScienceNanjing University of Science and TechnologyNanjing 210094China College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China

The efficiency of photocatalytic CO_(2) reduction reaction(PCRR)is restricted by the low solubility and mobility of CO_(2) in water,poor CO_(2) adsorption capacity of catalyst,and competition with hydrogen evolution reaction(HER).Recently,hydrophobic modification of the catalyst surface has been proposed as a potential solution to induce the formation of triple-phase contact points(TPCPs)of CO_(2)(gas phase),H_(2) O(liquid phase),and catalysts(solid phase)near the surface of the catalyst,enabling direct delivery of highly concentrated CO_(2) molecules to the active reaction sites,resulting in higher CO_(2) and lower H+surface *** TPCPs thus act as the ideal reaction points with enhanced PCRR and suppressed ***,the initial synthesis of triple-phase photocatalysts tends to possess a lower bulk density of TPCPs due to the simple structure leading to limited active points and CO_(2) adsorption ***,based on constructing a hydrophobic hierarchical porous TiO_(2)(o-HPT)with interconnected macropores and mesopores structure,we have significantly increased the density of TPCPs in a unit volume of the *** with hydrophobic macroporous TiO_(2)(o-MacPT)or mesoporous TiO_(2)(o-MesPT),the o-HPT with increased TPCP density leads to enhanced photoactivity,enabling a high methanol production rate with 1111.5μmol g^(−1) h^(−1) from *** results emphasize the significance of high-density TPCPs design and propose a potential path for developing efficient PCRR systems.

关键词： Photocatalysis CO_(2)reduction reaction Photocatalyst Triple-phase contact points Methanol

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Coupling Au with BO_(x) matrix induced by Closo-boron cluster for electrochemical synthesis of ammonia

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Journal of Energy Chemistry 2024年第6期93卷 471-477,I0012页

作者： Wenjing Liu Nan Yang Yuao Wei Yingjie Yu Jie Chen Mo Wei Yuting Huang Xiaohan Li Linghai Zhang Faisal Saleem Weina Zhang Haibo Zhang Fengwei huo Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816JiangsuChina College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072HubeiChina

Au is considered as one of the most promising catalysts for nitrogen reduction reaction(NRR),however maximizing the activity utilization rate of Au and understanding the synergistic effects between Au and carriers pose ongoing ***,we systematically explore the synergistic catalytic effect of incorporating Au with boron clusters for accelerating NRR *** in-situ abinitio strategy is employed to construct B-doped Au nanoparticles(2-6 nm in diameter)loaded on BO_(x) substrates(AuBO_(x)),in which B not only modulates the surface electronic structure of Au but also forms strong coupling interactions to stabilize the *** electrochemical results show that Au-BO_(x) possesses excellent NRR activity(NH_(3) yield of 48.52μg h^(-1)mg_(cat)^(-1),Faraday efficiency of 56.18%),and exhibits high stability and reproducibility throughout the electrocatalytic NRR *** calculations reveal that the introduction of B induces the formation of both Au dangling bond and Au-B coupling *** considerably facilitates the hydrogenation of~*N_(2)^(-)~*NH_(3).The present work provides a new avenue for the preparation of metal-boron materials achieved by one-step reduction and doping process,utilizing boron clusters as reducing and stabilizing agents.

关键词： Boron clusters Nitrogen reduction reaction Au–B coupling

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Building stabilized Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode enables an outstanding room‐/low‐temperature aqueous Zn‐ion batteries

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Carbon Energy 2024年第8期6卷 25-35页

作者： Ao Wang Dai‐huo Liu Lin Yang Fang Xu Dan Luo Haozhen Dou Mengqin Song Chunyan Xu Beinuo Zhang Jialin Zheng Zhongwei Chen Zhengyu Bai Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenanChina The State Key Laboratory of Catalysis(SKLC) Power Battery and System Research CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina

Vanadium oxide cathode materials with stable crystal structure and fast Zn^(2+)storage capabilities are extremely important to achieving outstanding electrochemical performance in aqueous zinc‐ion *** this work,a one‐step hydrothermal method was used to manipulate the bimetallic ion intercalation into the interlayer of vanadium *** pre‐intercalated Cu ions act as pillars to pin the vanadium oxide(V‐O)layers,establishing stabilized two‐dimensional channels for fast Zn^(2+)*** occupation of Mn ions between V‐O interlayer further expands the layer spacing and increases the concentration of oxygen defects(Od),which boosts the Zn^(2+)diffusion *** a result,as‐prepared Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode shows outstanding Zn‐storage capabilities under room‐and lowtemperature environments(e.g.,440.3 mAh g^(−1)at room temperature and 294.3 mAh g^(−1)at−60°C).Importantly,it shows a long cycling life and high capacity retention of 93.4%over 2500 cycles at 2 A g^(−1)at−60°***,the reversible intercalation chemistry mechanisms during discharging/charging processes were revealed via operando X‐ray powder diffraction and ex situ Raman *** strategy of a couple of 3d transition metal doping provides a solution for the development of superior room‐/lowtemperature vanadium‐based cathode materials.

关键词： aqueous zinc‐ion batteries Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O oxygen defects room‐/lowtemperature performance stabilized nanostructure

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Flexible wide-range multidimensional force sensors inspired by bones embedded in muscle

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Microsystems & Nanoengineering 2024年第3期10卷 49-61页

作者： Jie Zhang Xiaojuan Hou Shuo Qian Jiabing huo Mengjiao Yuan Zhigang Duan Xiaoguang Song HuiWu Shuzheng Shi Wenping Geng Jiliang Mu Jian He Xiujian Chou Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051China School of Software North University of ChinaTaiyuan 030051China School of Mechanical Engineering Hebei University of ArchitectureZhangjiakou 075000China HBIS Group Co.Ltd. Shijiazhuang 050023China

Flexible sensors have been widely studied for use in motion monitoring,human‒machine interactions(HMIs),personalized medicine,and soft intelligent ***,their practical application is limited by their low output performance,narrow measuring range,and unidirectional force ***,to achieve flexibility and high performance simultaneously,we developed a flexible wide-range multidimensional force sensor(FWMFS)similar to bones embedded in muscle *** adjustable magnetic field endows the FWMFS with multidimensional perception for detecting forces in different *** multilayer stacked coils significantly improved the output from theμV to the mV level while ensuring FWMFS *** optimized FWMFS exhibited a high voltage sensitivity of 0.227 mV/N(0.5–8.4 N)and 0.047 mV/N(8.4–60 N)in response to normal forces ranging from 0.5 N to 60 N and could detect lateral forces ranging from 0.2–1.1 N and voltage sensitivities of 1.039 mV/N(0.2–0.5 N)and 0.194 mV/N(0.5–1.1 N).In terms of normal force measurements,the FWMFS can monitor finger pressure and sliding trajectories in response to finger taps,as well as measure plantar pressure for assessing human *** plantar pressure signals of five human movements collected by the FWMFS were analyzed using the k-nearest neighbors classification algorithm,which achieved a recognition accuracy of 92%.Additionally,an artificial intelligence biometric authentication system is being developed that classifies and recognizes user *** on the lateral force measurement ability of the FWMFS,the direction of ball movement can be distinguished,and communication systems such as Morse Code can be *** research has significant potential in intelligent sensing and personalized spatial recognition.

关键词： password Morse force

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PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity

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Science China(Life Sciences) 2024年第9期67卷 2033-2035页

作者： Meihan Gong Ye Yuan Zhongye Dai Xuejiao Lv Jiacheng Su Dawei huo Lin Niu Xu Chen Xudong Wu State Key Laboratory of Experimental Hematology The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsKey Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Bone Marrow Transplantation Center the First Affiliated HospitalZhejiang University School of MedicineLiangzhu LaboratoryInstitute of HematologyZhejiang UniversityHangzhou 311113China

Dear Editor,Polycomb group proteins,conserved epigenetic transcriptional repressors,are crucial for orchestrating diverse developmental gene expression programs(Schuettengruber et al.,2017).The polycomb repressive complex 2(PRC2)catalyzes H3 lysine-27 trimethylation(H3K27me3)to establish a delicate balance with H3K4me3,forming a bivalent chromatin state at target gene promoters and thereby poising them for subsequent transcription activation(Bernstein et al.,2006).

关键词： valent thereby subsequent

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成人学习者微学习意蕴、问题与促进策略研究

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成人教育 2024年第10期44卷 1-7页

作者：孙国亮霍玉文郑州旅游职业学院郑州451464 广西师范大学广西桂林541004

微学习是一种基于移动技术的新型数字化学习方式,具有课程模块化、对象开放化、时空泛在化、方式交互化和媒介便捷化等基本特征,在丰富学习者学习内容与手段、增强学习者学习效能、缓解学习者工学矛盾等方面具有积极作用。在成人学习者... 详细信息

微学习是一种基于移动技术的新型数字化学习方式,具有课程模块化、对象开放化、时空泛在化、方式交互化和媒介便捷化等基本特征,在丰富学习者学习内容与手段、增强学习者学习效能、缓解学习者工学矛盾等方面具有积极作用。在成人学习者微学习活动中,针对微学习意识不强、微课程供给不足、微学习深度不够、微学习素养较低等问题,应采取提升微学习自觉、加强微课程供给、做好微学习支持服务、提高微学习能力等策略,保障学习者微学习质量。

关键词：成人学习者微学习微课程微时间微指导

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NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： Yu-Jie Xu Ya-Chang huo Qi-Tai Zhao Jin-Yan Liu Yi-Jun Tian Lei-Lei Yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

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