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Harnessing bacteria for tumor therapy:Current advances and challenges

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： lina guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

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Theoretical investigation on Raman induced Kerr effect spectroscopy in nonlinear confocal microscopy

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Science China(Physics,Mechanics & Astronomy) 2008年第7期51卷 788-796页

作者： guo lina TANG ZhiLie XING Da School of Physics and Telecommunication Engineering South China Normal UniversityGuangzhou 510006China Key Laboratory of Laser Life Science Ministry of Education of ChinaSouth China Normal UniversityGuangzhou 510631China

The imaging theory of Raman induced Kerr effect spectroscopy (RIKES) in nonlinear confocal microscopy is presented in this paper. Three-dimensional point spread function (3D-PSF) of RIKES nonlinear confocal microscopy in isotropic media is derived with Fourier imaging theory and RIKES theory. The impact of nonlinear property of RIKES on the spatial resolution and imaging properties of confocal microscopy have been analyzed in detail. It is proved that RIKES nonlinear confocal microscopy can simultaneously provide more information than two-photon confocal microscopy concerning molecular vibration mode, vibration orientation and optically induced molecular reorientation, etc. It is shown that RIKES nonlinear confocal microscopy significantly enhances the spatial resolution and imaging quality of confocal microscopy and achieves much higher resolution than that of two-photon confocal microscopy.

关键词： nonlinear confocal microscopy Raman induced Kerr effect spectroscopy three-dimensional point spread function

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Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5074-5090页

作者： lina guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Xiangya HospitalChangsha 410008China

Autologous cancer vaccine that stimulates tumor-specific immune responses for personalized immunotherapy holds great potential for tumor ***,its efficacy is still suboptimal due to the immunosuppressive tumor microenvironment(ITM).Here,we report a new type of bacteria-based autologous cancer vaccine by employing calcium carbonate(CaCO_(3))biomineralized Salmonella(Sal)as an in-situ cancer vaccine producer and systematical ITM ***_(3) can be facilely coated on the Sal surface with calcium ionophore A23187 co-loading,and such biomineralization did not affect the bioactivities of the *** intratumoral accumulation,the CaCO_(3) shell was decomposed at an acidic microenvironment to atenuate tumor acidity,accompanied by the release of Sal and Ca^(2+)/***,Sal served as a cancer vaccine producer by inducing cancer cells'immunogenic cell death(ICD)and promoting the gap junction formation between tumor cells and dendritic cells(DCs)to promote antigen ***^(2+),on the other hand,was intermalized into various types of immune cells with the aid of A23187 and synergized with Sal to systematically regulate the immune system,including DCs maturation,macrophages polarization,and T cells *** a result,such bio-vaccine achieved remarkable effcacy against both primary and metastatic tumors by eliciting potent anti-tumor immunity with full *** work demonstrated the potential of bioengineered bacteria as bio-active vaccines for enhanced tumor immunotherapy.

关键词： Bacteria-mediated cancer therapy Tumor microenvironment Calcium carbonate Mineralization Metalloimmunology Autologous tumor vaccine Immunotherapy Tumor metastasis

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FURTHER RESEARCH OF A NEW KIND OF SERIES REPAIRABLE SYSTEM

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Journal of Systems Science & Complexity 2012年第4期25卷 744-758页

作者： lina guo Houbao XU Chao GAO Guangtian ZHU Department of Mathematics Taiyuan University of Technology Department of Mathematics Beijing Institute of Technology Department of System Engineering Beijing Institute of Information and Control Academy of Mathematics and System Sciences Chinese Academy of Sciences

This paper is devoted to studying the uniqueness and existence of the system dynamic solution by using C0-semigroup theory and discussing its exponential stability by analyzing the spectrul distribution of system operator and its quasi-compactness. Some primary reliability indices are discussed with the eigenfunction of system operator and the optimal vacation time to get the maximum system profit is analyzed at the end of paper.

关键词： Co-semigroup theory dynamic solution exponential stability profit analysis reliability indices steady-state solution.

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Influence of mechanical alloying time on the properties of Fe_3Al intermetallics prepared by spark plasma sintering

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Journal of University of Science and Technology Beijing 2007年第4期14卷 331-334页

作者： Chengchang Jia Qing He Jie Meng lina guo Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

The Fe3Al-based intermetallics were prepared by mechanical alloying and spark plasma sintering （SPS）, and the influence of milling time on the properties of materials was investigated. The phase identification was investigated by X-ray, and the surface morphology and fractography were observed by scanning electron microscope （SEM）. The mechanical properties such as bending strength, strain, and microhardness were tested. The results show that Fe reacts with Al completely to form Fe3Al during short SPS processing time. The relative densities of the sintered samples were nearly 100%. The mechanical properties of the sintered samples can be improved along with the milling time. The representative values are the bend strength of 1327 MPa and the microhardness of 434.

关键词： Fe3A1 intermetallics mechanical properties mechanical alloying and milling powder metallurgy

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Karstification characteristics of the Cenomanian-Turonian Mishrif Formation in the Missan Oil Fields,southeastern Iraq,and their effects on reservoirs

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Frontiers of Earth Science 2022年第2期16卷 435-445页

作者： Peiyuan CHEN lina guo Chen LI Yi TONG CNOOC International Ltd. Beijing 100028China CNOOC Research Institute Co. Ltd.Beijing 100028China

The Middle Cretaceous Mishrif Formation of the Cenomanian-Turonian age is an important Middle Eastern *** studies have shown that carbonates in the Mishrif Formation are affected by karstification and are concentrated at the top of the ***,there is a lack of systematic research on the effects of karstification on the formation’s reservoir *** on core samples,scanning electron microscopy of thin sections,and geochemical analysis of C,O,and Sr isotopes from wells in the Missan Oil Fields,unconformity was identified at the top of the B21 subzone of the Mishrif *** and cast-thin-section observations indicate that there is a significant lithological difference above and below the unconformity,and dissolution pores and voids are well-developed beneath *** silt fills the intragranular pores and geopetal fabric is developed inside some mouldic pores beneath the unconformity *** isotopic values of ^(87)Sr/^(86)Sr(0.707270-0.707722)and δ^(18)O(−5.94‰—−2.32‰)suggest that the top of the B21 subzone of the Mishrif Formation has been severely affected by syngenetic *** is the key to high-quality reservoir formation and the reservoir’s oil-bearing *** study will inform oil and gas exploration in the Missan Oil Fields and in other areas with similar reservoir characteristics.

关键词： unconformity karstification carbonate reservoir Mishrif Formation Missan Oil Fields southeastern Iraq

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Nonextensivity and the q-distribution of a relativistic gas under an external electromagnetic field

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Chinese Science Bulletin 2011年第34期56卷 3689-3692页

作者： LIU ZhiPeng guo lina DU JiuLin Department of Physics School of Science Tianjin University Tianjin 300072 China Department of Fundamental Subject Tianjin Institute of Urban Construction Tianjin 300384 China

We investigate the nonextensivity and the q-distribution of a relativistic gas under an external electromagnetic field. We derive an expression for the nonextensive parameter q based on the relativistic generalized Boltzmann equation, the relativistic q-H theorem and the relativistic version of the q-power-law distribution function in the nonextensive q-kinetic theory. We thus provide the connection between the parameter q≠1 and the spatial-temporal derivatives of the temperature field of the gas as well as the four-potential, and thereby present a clearly physical meaning for the nonextensivity for the relativistic gas.

关键词：电磁场分布相对论气体 Boltzmann方程动力学理论分布函数物理意义 H定理

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Analysing the Subversive Writing Techniques in the Enigma of Arrival

Analysing the Subversive Writing Techniques in the Enigma of...

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作者： guo lina 西安外国语大学

学位级别：硕士

《抵达之谜》（The Enigma of Arrival）作为一部总结性作品，是2001年诺贝尔文学奖维·苏·奈保尔的杰作。在该作中，奈保尔通过空间的转换，地点的挪移，记录了一位与其有着相似混杂移民身份的第一人称叙事者“我”在一个混杂文化世... 详细信息

《抵达之谜》（The Enigma of Arrival）作为一部总结性作品，是2001年诺贝尔文学奖维·苏·奈保尔的杰作。在该作中，奈保尔通过空间的转换，地点的挪移，记录了一位与其有着相似混杂移民身份的第一人称叙事者“我”在一个混杂文化世界中的抵达之旅，展现了包容开放的写作手法，打破了非此即彼的绝对二元等级对立，建立了一个开放空间。然而，鲜有很明确地从写作手法角度入手的相关研究，而沿用解构原理的研究基本没有。因此，本论文将以德里达解构主义为理论依托，从写作手法的颠覆性视角入手对作品进行文本解读，以期更深入地理解大师的混杂身份，更好地进行文本阐释，体悟大师的高超语言能力与行文的运筹帷幄。本论文包括六部分。引言部分介绍作家作品、文献综述以及论文框架。第二至五章为论文核心部分，主要研究通过三对二元对立元素的颠覆体现出来的颠覆性写作手法。最后为结论部分，指出该论文研究不仅有助于更好地理解作家作品，而且也为生活在多元文化中的多重身份者提供一个开放的跨文化世界观。

关键词：《抵达之谜》颠覆性写作手法解构二元等级对立

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Effect of interaction between different CeO_(2)plane and platinum nanoparticles on catalytic activity of Pt/CeO_(2)in toluene oxidation

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Journal of Rare Earths 2022年第11期40卷 1743-1750,I0003页

作者： Shengsheng Chang Yong jia Yiqing Zeng Fuping Qian lina guo Shenghua Wu Jinli Lu Yunlong Han School of Energy and Environment Anhui University of TechnologyMa'anshan 243002China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Civil Engineering and Architecture Anhui University of TechnologyMa'anshan 243002China

The plane exposure of support vitally affects the catalytic performance of the *** this work,CeO_(2)nanorods((110)plane exposure),nano-octahedrons((111)plane exposure)and nano-cubes((100)plane exposure)were prepared as the supports of Pt/CeO_(2)samples to investigate the effect of CeO_(2)plane exposure on total toluene *** reveal that the(110)plane of CeO_(2)is more helpful to the dispersion of Pt species,followed by(111)*** improved dispersion of Pt species can enhance the metal-supports interaction,which promotes the electron transfer of CeO_(2)carrier to Pt nanoparticles and the adsorption-activation of O_(2),thereby facilitating the total oxidation of toluene via the Langmuir-Hinshelwood(L-H)***,Pt/CeO_(2)-r(nanorods)sample expresses excellent catalytic performance of toluene ***,the procedure of toluene total oxidation was studied by in-situ diffuse reflectance infrared Fourier transform(DRIFT)*** expect that this work can contribute to the development of an effective sample for the decomposition of volatile organic compounds(VOCs).

关键词： CeO_(2)plane Pt/CeO_(2) Toluene oxidation Metal-supports interaction Rare earths

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Permutation Code Encryption—New Achievement Based on Path Encryption

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Wuhan University Journal of Natural Sciences 2006年第6期11卷 1581-1584页

作者： WU Jinmu LIU Maohua FU Guiqin guo lina School of Computer Science and Engineering Hebei University of Technology Tianjin 300130 China

By researching into the attack to present block cipher, we find an essential reason leading to the assailable encryption strength, set up a new block cipher idea and put forward a block cipher encryption concept path encryption. We present permutation code encryption which is based on path encryption. Now permutation code encryption is a patent of Chinese invention. In Permutation Code Encryption, we use a pseudo-random sequence of the keys to control the paths. The simulation result shows that for n-bit block the encryption strength is novel higher than 2^n and the algorithm can finish the encryption of one block in 7.5 ns, which is unrelated with the block length.

关键词： attack encryption strength path encryption permutation code encryption block cipher

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