检索结果-南通市图书馆

Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with Viscum album extracts: A case report

引用

World Journal of Gastroenterology 2019年第12期25卷 1524-1530页

作者： Paul G Werthmann Robert Kempenich Gerlinde Lang-Averous gunver s kienle Department of Methodology Institute for Applied Epistemology and Medical Methodology (IFAEMM) Center for Complementary Medicine Institute for Environmental Health Sciences and Hospital Infection Control Medical Center-University of Freiburg Private Praxis General Practitioner with Specialization in Oncology Department of Pathology Hopital de Hautepierre University Hospital of Strasbourg

BACKGROUND Advanced pancreatic cancer(aPC) has a poor prognosis with limited survival benefit from current standard treatment. Viscum album extracts(VAE) are used by many cancer patients, showing immune-stimulating effects, improved quality of life, and a survival benefit in patients with *** sUMMARY A 59-year-old architect developed epigastric pain. A cystic lesion of the pancreas of 45-mm diameter was detected. In a follow-up magnetic resonance imaging,about one year later, multiple lesions were seen in the corpus and the tail of the pancreas; CA-19-9 was elevated to 58.5 U/mL. A distal pancreatectomy with splenectomy was performed, and a tumor of 7 cm × 5 cm × 3.5 cm was *** investigation showed an intraductal papillary mucinous neoplasmassociated invasive adenocarcinoma with invasion of the lymph vessels,perineural invasion, and positive nodes(2/27); surgical margins showed tumor cells, and the tumor was classified as pT3 N1 M0 R1. The patient was treated with radiation of the tumor bed and capecitabine/oxaliplatin followed by gemcitabine and FOLFIRINOX. seven months after surgery, a liver metastasis was detected and treatment with FOLFIRINOX was started. Four months after detection of the metastasis, the patient opted for additional treatment with VAE. Another month later, the metastasis was treated with radiofrequency ablation(RFA). Eight months later, the hepatic lesion recurred and was again treated with RFA. Thecontinuous VAE treatment was increased in dose, and the patient stayed recurrence-free for the next 39 mo in good health and working full-time(as of the time this case report was written).CONCLUsION We present the case of a patient with aPC with R1-resection with development of liver metastasis during the course of treatment who showed an overall survival of 63 mo and a relapse-free survival of 39 mo under increasing VAE therapy. The possible synergistic effect on tumor control of RFA treatment and immunestimulatory effects of VAE

关键词： Pancreatic cancer Integrative medicine Viscum album extract Radiofrequency ablation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A dynamic two-zone model of continuous fluidized bed layering granulation with internal product classification

引用

Particuology 2017年第2期15卷 8-14页

作者： C. Neugebauer s. Palis A. Buck E. Tsotsas s. Heinrich A. kienle Otto yon Guericke University Universitatsplatz 2 D-39106 Magdeburg Germany Max Planck Institute for Dynamics of Complex Technical systems Sandtorstraβe 1 D-39106 Magdeburg Germany Hamburg University of Technology Denickestraβe 15 D-21073 Hamburg Germany

A dynamic two-zone model is proposed to address the formation of granulation and drying zones in fluidized bed layering granulation processes with internal product classification. The model assumes a constant volume for the granulation zone, but a variable overall volume for the fluidized bed to account for classified product removal. The model is used to study the effect of various process parameters on dynamics and process stability. stability is shown to depend on the separation diameter of product removal and the flow rate of the injected liquid. A lower and upper range of separation diameters with stable process behavior are found. In an intermediate range instability in the form of self-sustained oscillations is observed. The lower stability boundary is in qualitative agreement with recent experimental observations （schmidt, Bück, ＆ Tsotsas, 2015）; the upper boundary was reported in a theoretical paper by Vreman, Van Lare, and Hounslow （2009） based on a single zone model.

关键词： Layering granulation Zone formation Internal product classification Population balance modeling stability analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of zone formation on stability of continuous fluidized bed layering granulation with external product classification

引用

Particuology 2015年第6期13卷 1-7页

作者： C. Dreyschultze C. Neugebauer s. Palis A. Buck E. Tsotsas s. Heinrich A. kienle Otto yon Guericke University Universit~tsplatz 2 D-39106 Magdeburg Germany Max Planck Institute for Dynamics of Complex Technical systems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Hamburg University of Technology Denickestrae 15 D-21073 Hamburg Germany

Continuous fluidized bed layering granulation with external product classification and a sieve-mill cycle can show instability in the form of self-sustained nonlinear oscillations of the particle size distribution. In the present study, the stability and bifurcation analysis of this process is presented. The underlying process models explicitly account for compartmentalization of the fluidized bed into a granulation and a drying zone, which is an important feature of many technical processes. Implications for plant operations are discussed with the help of stability diagrams as a function of zone size, residence time within different zones, the addition of external seeds and particular properties of the sieve-mill cycle.

关键词： Fluidized bed Granulation Population balance stability Bifurcation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

引用

Nano Research 2022年第1期15卷 581-592页

作者： Jacob Johny Oleg Prymak Marius Kamp Florent Calvo se-Ho Kim Anna Tymoczko Ayman El-Zoka Christoph Rehbock Ulrich schurmann Baptiste Gault Lorenz kienle stephan Barcikowski Technical Chemistry I and Center for Nanointegration Duisburg-Essen(CENIDE) University of Duisburg-EssenEssen 45141Germany Inorganic Chemistry and Center for Nanointegration Duisburg-Essen(CENIDE) University of Duisburg-EssenEssen 45141Germany Institute for Materials science Synthesis and Real StructureKiel UniversityKiel 24143Germany University Grenoble Alpes CNRSLiPhyGrenoble 38000France Max-Planck-Institut fur Eisenforschurtg GmbH Diisseldorf40237Germany Department of Materials Royal School of MineImperial College LondonLondon SW72AZUK

Bimetallic nanoparticles are often superior candidates for a wide range of technological and biomedical applications owing to their enhanced catalytic,optical,and magnetic properties,which are often better than their monometallic *** of their properties strongly depend on their chemical composition,crystallographic structure,and phase ***,little is known of how their crystal structure,on the nanoscale,transforms over time at elevated temperatures,even though this knowledge is highly relevant in case nanoparticles are used in,e.g.,high-temperature ***-Fe is a promising bimetallic system where the low-cost and magnetic Fe is combined with catalytically active and plasmonic ***,we report on the in s/fi;temporal evolution of the crystalline ordering in Au-Fe nanoparticles,obtained from a modern laser ablation in liquids *** in-depth analysis,complemented by dedicated atomistic simulations,includes a detailed structural characterization by X-ray diffraction and transmission electron microscopy as well as atom probe tomography to reveal elemental distributions down to a single atom *** show that the Au-Fe nanoparticles initially exhibit highly complex internal nested nanostructures with a wide range of compositions,phase distributions,and size-depended *** elevated temperature induces a diffusion-controlled recrystallization and phase merging,resulting in the formation of a single face-centered-cubic ultrastructure in contact with a body-centered cubic phase,which demonstrates the metastability of these *** these unique nanostructures with nested features could be highly attractive from a fundamental viewpoint as they could give further insights into the nanoparticle formation mechanism under non-equilibrium ***,the in situ evaluation of the crystal structure changes upon heating is potentially relevant for high-temperature process utilization of bimetallic na

关键词： nanoparticles in situ atom probe tomography diffusion recrystallization atomistic simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling and Numerical solution of a Cancer Therapy Optimal Control Problem

引用

Applied Mathematics 2018年第8期9卷 985-1004页

作者： Melina-Lorén kienle Garrido Tim Breitenbach Kurt Chudej Alfio Borzì Institut für Mathematik Universit&auml t Würzburg Würzburg Germany Lehrstuhl für Wissenschaftliches Rechnen Fakult&uuml t für Mathematik Physik und Informatik Universit&auml t Bayreuth Bayreuth Germany

A mathematical optimal-control tumor therapy framework consisting of radio- and anti-angiogenesis control strategies that are included in a tumor growth model is investigated. The governing system, resulting from the combination of two well established models, represents the differential constraint of a non-smooth optimal control problem that aims at reducing the volume of the tumor while keeping the radio- and anti-angiogenesis chemical dosage to a minimum. Existence of optimal solutions is proved and necessary conditions are formulated in terms of the Pontryagin maximum principle. Based on this principle, a so-called sequential quadratic Hamiltonian (sQH) method is discussed and benchmarked with an “interior point optimizer—a mathematical programming language” (IPOPT-AMPL) algorithm. Results of numerical experiments are presented that successfully validate the sQH solution scheme. Further, it is shown how to choose the optimisation weights in order to obtain treatment functions that successfully reduce the tumor volume to zero.

关键词： Cancer Radiotherapy Anti-Angiogenesis sparse Controls Optimal Control Pontryagin’s Maximum Principle sQH Method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：