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COVID-19 and cardiac complications:Myocarditis and multisystem inflammatory syndrome in children

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World Journal of Cardiology 2024年第5期16卷 260-268页

作者： Muhammed gunes Oner Ozdemir Department of Pediatric Cardiology Research and Training Hospital of SakaryaAdapazarı54100SakaryaTürkiye Department of Pediatric Allergy and Immunology Research and Training Hospital of SakaryaSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Coronavirus is an important pathogen causing disease in humans and *** the end of 2019,an investigation into an increase in pneumonia cases in Wuhan,Hubei Province,China,found that the cause was a new *** disease,which spread rapidly across China and caused an outbreak worldwide,resulted in a *** this virus has previously been referred to as 2019-nCoV,which causes coronavirus disease 2019(COVID-19),later it was named severe acute respiratory syndrome coronavirus *** were usually asymptomatic and rarely severely *** April 2020,reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock *** clinical picture was later defined as multisystem inflammatory syndrome in *** then,similarly affected children as well as cases with other cardiac complications have been reported in other parts of the *** this review,we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.

关键词： COVID-19 Cardiac complication Myocarditis Multisystem inflammatory syndrome in children SARS-CoV-2

Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa

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Neural Regeneration Research 2024年第11期19卷 2543-2552页

作者： Sam Enayati Karen Chang Anton Lennikov Menglu Yang Cherin Lee Ajay Ashok Farris Elzaridi Christina Yen Kasim gunes Jia Xie Kin-Sang Cho Tor Paaske Utheim Dong Feng Chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Institute of clinical medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalUniversity of OsloOsloNorway Department of Ophthalmology Drammen HospitalVestre Viken Hospital TrustDrammenNorway Department of Histology and Embryology School of MedicineMarmara UniversityIstanbulTurkiye

Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor *** research supports the beneficial effect of electrical stimulation on photoreceptor *** study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal ***,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem *** this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in C57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp *** investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with *** retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in *** density was evaluated by rhodopsin *** vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp *** function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),*** was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse *** recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest *** of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human *** tem

关键词： bipolar cells electrical stimulation neuroprotection photoreceptor degeneration retina retinal explants retinitis pigmentosa transcorneal electrical stimulation waveform

Wear Behaviour of Plasma Paste Boronized of AISI 8620 Steel with Borax and B_2O_3 Paste Mixtures

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Journal of Materials Science & Technology 2013年第7期29卷 662-668页

作者： Ibrahim gunes Department of Metallurgical and Materials Engineering Faculty of TechnologyAfyon Kocatepe UniversityAfyonkarahisar 03200Turkey

In the present study, AlSl 8620 steel was plasma paste boronized （PPB） by using paste mixtures with different borax and B2O3 percentages. The PPB process was carried out in a DC plasma system at 973, 1023 and 1073 K for 5 h in a gas mixture with 70% H2-30% Ar under a constant pressure of 103 Pa （10 mbar）. The thickness of boride layers ranged from 15.9 to 53.6 tim depending on the temperature and process time. The hardness of the borides formed on the surface of the steel substrate and unborided steel substrate were 1648-1924 HV0.05 and 226 HV0.05, respectively. X-ray diffraction analysis of the boride layers on the surface of the samples were obtained for FeB and Fe2B phases. The wear tests on the steel were performed by using a ball-on-disc test device at room temperature with applied load of 10 N and with a shear velocity of 0.2 m/s. Wear test results showed that the highest value of wear rate was observed in the unborided sample while the lowest wear rate was observed in the PPB samples with 30% borax ＋ 70% B4C paste at 1073 K for 5 h.

关键词： Coating Borax B2O3 Wear Coefficient of friction

Wnt/β-catenin signaling in heart regeneration

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Cell Regeneration 2015年第1期4卷 20-31页

作者： gunes Ozhan Gilbert Weidinger Izmir Biomedicine and Genome Center(iBG-izmir) Dokuz Eylul UniversityInciralti-Balcova35340 IzmirTurkey Department of Medical Biology and Genetics Dokuz Eylul University Medical SchoolInciralti-Balcova35340 IzmirTurkey Institute for Biochemistry and Molecular Biology Ulm UniversityAlbert-Einstein-Allee 1189081 UlmGermany

The ability to repair damaged or lost tissues varies significantly among *** regenerative ability of the heart is clinically very relevant,because adult teleost fish and amphibians can regenerate heart tissue,but we mammals ***,heart regeneration is possible in neonatal mice,but this ability is lost within 7 days after *** zebrafish and neonatal mice,lost cardiomyocytes are regenerated via proliferation of spared,differentiated *** some cardiomyocyte turnover occurs in adult mammals,the cardiomyocyte production rate is too low in response to injury to regenerate the ***,mammalian hearts respond to injury by remodeling of spared tissue,which includes cardiomyocyte ***/β-catenin signaling plays important roles during vertebrate heart development,and it is re-activated in response to cardiac *** this review,we discuss the known functions of this signaling pathway in injured hearts,its involvement in cardiac fibrosis and hypertrophy,and potential therapeutic approaches that might promote cardiac repair after injury by modifying Wnt/β-catenin *** of cardiac remodeling by this signaling pathway appears to vary depending on the injury model and the exact stages that have been ***,conflicting data have been published regarding a potential role of Wnt/β-catenin pathway in promotion of fibrosis and cardiomyocyte *** addition,the Wnt inhibitory secreted Frizzled-related proteins(sFrps)appear to have Wnt-dependent and Wnt-independent roles in the injured ***,while the exact functions of Wnt/β-catenin pathway activity in response to injury still need to be elucidated in the non-regenerating mammalian heart,but also in regenerating lower vertebrates,manipulation of the pathway is essential for creation of therapeutically useful cardiomyocytes from stem cells in ***,a detailed understanding of the in vivo role of Wnt/β-catenin signaling in injure

关键词： Wnt Beta-catenin Cardiomyocyte sFrp Regeneration Heart Fibrosis Hypertrophy Zebrafish

Progress in surgical and nonsurgical approaches for hepatocellular carcinoma treatment

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Hepatobiliary & Pancreatic Diseases International 2016年第3期15卷 234-256页

作者： Ender gunes Yegin Erkan Oymac1 Emrah Karatay Ahmet Coker Department of Gastroenterology Bozyaka Trainingand Research HospitalIzmir Depatment of Gastroenterology Surgery Bozyaka Trainingand Research HospitalIzmir Department of Radiology Bulanlk State HospitalMus Department of General Surgery Ege University Faculty of MedicineIzmiTurk

BACKGROUND： Hepatocellular carcinoma （HCC） is a com- plex and heterogeneous malignancy, frequently occurs in the setting of a chronically diseased organ, with multiple con- founding factors making its management challenging. HCC represents one of the leading causes of cancer-related mortal- ity globally with a rising trend of incidence in some of the de- veloped countries, which indicates the need for better surgical and nonsurgical management strategies.

关键词： hepatocellular carcinoma surgical liver resection liver transplantation locoregional therapies molecular targeted systemic therapies immunotherapy gene therapy

Recent progress of electromagnetic wave absorbers: A systematic review and bibliometric approach

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ChemPhysMater 2023年第3期2卷 197-206页

作者： Yuksel Akinay Umit gunes BektaşÇolak Tayfun Cetin Mining Engineering Van Yuzuncu Yil UniversityVan 65080Turkey Naval Architecture and Marine Engineering Yildiz Technical UniversityBesiktasIstanbul 34349Turkey Natural Sciences Faculty Physics DepartmentGebze Technical UniversityGebz 41400Turkey Yuksekova Vocational High School Hakkari UniversityHakkari 30110Turkey

The electromagnetic wave absorption capabilities of an absorber depend on its dielectric and magnetic compo- nents, which determine its interfacial polarization, conductivity loss, magnetic loss, and other such mechanisms. In this study, a comprehensive review of the electromagnetic wave and material interaction was conducted. Moreover, for a better understanding of the trends and evolutionary developments in the study of the electro- magnetic wave absorber, 23300 documents dated between 1990 and 2020 were examined, which were obtained from Scopus using the keywords of “electromagnetic wave absorption ”and “microwave absorption ”. The data search in Scopus was conducted using the related keywords in the search bar for titles and abstracts. These results demonstrate that the majority of research regarding electromagnetic wave absorbers was conducted in China, which was followed by the United States. The number of published documents regarding the electromagnetic wave absorption field significantly increased between 1990 and 2020;these documents were mostly published as journal articles. With respect to the journal activity, the most productive journal was the “Journal of Alloys and Compounds ”, with a total of 592 articles. In addition, graphene and titanium dioxide were determined to be the materials that were most studied in the field of electromagnetic wave absorption.

关键词： Electromagnetic wave absorption Microwave absorption Bibliometric approach Reflection loss Composites

Comparison of the effect of intravitreal bevacizumab and intravitreal fasudil on retinal VEGF,TNFα,and caspase 3 levels in an experimental diabetes model

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 57-61页

作者： Fatih Celik Fatih Ulas Zeynep gunes Ozunal Tulin Firat Serdal Celebi Umit Dogan Department of Ophthalmology Faculty of MedicineAbant Izzet Baysal University Department of Medical Pharmacology Faculty of MedicineAbant Izzet Baysal University Department of Histology and Embryology Faculty of MedicineAbant Izzet Baysal University

AIM: To evaluate the influence of an intravitreal injection of bevacizumab and fasudil on the retinal vascular endothelial growth factor(VEGF),tumor necrosis factor alpha(TNFα),and caspase 3 levels in a diabetic rabbit model. · METHODS: The study included 6 healthy rabbits(Group 1),6 rabbits with experimentally induced diabetes mellitus(DM)(Group 2),7 rabbits with experimentally induced DM to which intravitreal bevacizumab was administered(Group 3),and 7 rabbits with experimentally induced DM to which intravitreal fasudil was administered(Group 4). An intravitreal injection of 1.25mg/50μL bevacizumab in the right eye of rabbits in Group 3 and an intravitreal injection of 0.0064mg/50μL fasudil in the right eye of rabbits in Group 4 were administered on day 21 after the induction of DM. The studied eyes of the rabbits were enucleated three days after the intravitreal injection. The TNFα,VEGF,and caspase 3 levels were determined using the ELISA method. · RESULTS: There was a statistically significant difference in the VEGF and caspase 3 levels between groups(P =0.005 and P =0.013,respectively),but the TNF α level did not differ significantly between groups(P = 0.792). It was found that VEGF levels were significantly lower in Group 1 and Group 3 than in Group 2 using the Mann-Whitney U test with the Bonferroni correction(P = 0.004 for both comparison). There was no statistically significant difference between other groups with regard to VEGF levels(the P value ranged between 0.015 and 0.886). Although the P values of the caspase 3 levels were 0.015 for Group 1 and Group 4,0.038 for Group 2and Group 3,and 0.018 for Group 3 and Group 4,these P values remained above the threshold P value of 0.0083,which was the statistically significant level for post hoc tests. ·CONCLUSION: An intravitreal injection of bevacizumab decreased both the VEGF level,which plays a role in angiogenesis,and the caspase 3 level,which plays a role in apoptosis. Although not as effective as bevacizum

关键词： bevacizumab caspase 3 experimental diabetes fasudil tumor necrosis factor alpha vascular endothelial growth factor

Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 938-944页

作者： Ozlem Yalcin Tok Levent Tok Inci Meltem Atay Tugba Cakmak Argun Nazire Demirci Alime gunes Department of Ophthalmology Süleyman Demirel University Research and Education Hospital Department of Psychiatry Süleyman Demirel University Research and Education Hospital

AIMTo evaluate the clinical findings of toxic keratopathy associated with abuse of topical anesthetics and the treatment efficacy of amniotic membrane transplantation (AMT).METHODSFifteen eyes of 10 patients with abuse of topical anesthetics were included in this study. The data collected included patients' demographic information, initial best corrected visual acuity (BCVA), clinical findings, time to AMT, duration of epithelization, additional treatments, posttreatment BCVA, and the results of psychiatric *** patients were male, with the mean age of 37.9±5.4y. The patients had received 0.5% proparacaine hydrochloride due to pain resulting from foreign bodies, such as welding flash burns and car battery explosions, for a mean of 18.2±12.4d. The mean initial BCVA of the patients was 0.069±0.100. All patients had persistent epithelial defects, stromal infiltration, ring ulcer, and corneal edema. Initially, medical treatment was attempted in all cases. Because of severe pain, persistent epithelial defects and progressing stromal thinning did not improve with medical treatment, thus, the patients underwent AMT. The mean posttreatment BCVA of the patients was 0.33±0.27. All of them, except for two patients, showed improved visual acuity. One patient underwent evisceration for corneal melting and endophthalmitis in another center, and one patient underwent evisceration for severe pain of unknown origin. All 5 patients who consented to a psychiatric examination had depression, had personality disorder, and used *** appears to be an effective method for pain relief, rapid epithelial and stromal healing; however, visual prognosis is still poor despite medical and surgical interventions.

关键词： amniotic membrane transplantation ring stromal infiltration topical anesthetic abuse toxic keratopathy

The Sumame of Turkish Women： A Question of Identity？

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Journalism and Mass Communication 2015年第12期5卷 658-665页

作者： Seldag gunes Peschke Yildirim Beyazit University Ankara Turkey

After the foundation of Turkish Republic in1923, Turkish Civil Code which was codificated from Switzerland in 1926 was a new code for modem Turkey that aimed gender equality. Even if, there were some articles, contrary to the equality of men and women, they were ignored when they were compared with the reforms performed in favor of women. The surname of woman was one of the issues where there was gender discrimination. In the Civil Code of 1926, it was stated that the married woman must have taken her husband＇s surname after the official marriage and she had to use it through her marriage life. In 1997, there was an amendment in TCC Article 153 that the married woman had the right to register her maiden name in front of her husband＇s surname which was also accepted in the new TCC in Article 187 in 2002. As the equality of the spouses is neglected under Article 187, many women are trying to change the current situation, by lawsuits. In this article, the regulations about the surname, will be discussed under personality rights and identity, within the current legislation with some court decisions from the last years in favor of women.

关键词： surname women Turkish Civil Code women rights personality rights identity gender equality