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The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome

International Journal of Ophthalmology(English edition) 2013年第1期6卷 50-53页

作者： Zuhal Yildirim Filiz Yildirim Nil Irem Ugun Aylin Sepici-Dinel Etimesgut Public Health Laboratory Duatepe Government Hospital Clinic of Internal Medicine Ankara Numune Education and Research Hospital Second Ophthalmology Clinic Gazi University Faculty of MedicineDepartment of Medical Biochemistry

AIM:To examine the mechanism of the development of pseudoexfoliation (PSX) syndrome via both cytokine formation and endothelial vasorelaxing and growth factors that will provide us new therapeutic insights for the treatment. METHODS:This is a cross sectional study included two groups; Group 1:control patients with nuclear cataract(n =20, aged 51-80 years). Group 2:PSX patients with nuclear cataract (n=18, aged 50-90 years). Patients with other ophthalmic problems and systemic diseases were excluded. Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and interleukin-1β (IL-1β) and nitrotyrosine levels were determined through serum samples by Enzyme-linked immunosorbent assay (ELISA) method. Nitrite-nitrate levels were measured with photometric endpoint determination. RESULTS:There were no significant differences between the groups in terms of age, VEGF, IL-1β, nitrite-nitrate and nitrotyrosine. The significant results were the mean IL-6 levels that were higher in PSX group 2 (37.68± 29.52 pg/mL) compared to that in control group 1 (15.32± 10.08 pg/mL) (P <0.001). CONCLUSION:Several interacting and extending biochemical pathways may lead to the promotion of VEGF and IL-6 expressions. IL-6 which is the only altered marker in our study may indirectly cause an increase of vascular permeability and neovascularization. We suggest inflammation as a factor that can be involved in etiopathogenesis of PSX.

关键词： pseudoexfoliation syndrome inflammation vascular endothelial growth factor interleukin-6 interleukin-1β

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Influence of Acid Treatment on Pore Structure and Fractal Characterization of a Tight Sandstone:A Case Study from Wudun Sag,Dunhuang Basin

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 562-572页

作者： GENG Weile WANG Jiandong ZHANG Xuecai WANG Jun DONG Chenqiang ZHOU Guangqing HUANG gun LI Lin State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing 400030China School of Safety and Management Engineering Hunan Institute of TechnologyHengyangHunan 421002China Oil and Gas Exploration Management Centre Shengli Oilfield CompanySINOPECDongyingShandong 257000China Xinjiang Xinchun Petroleum Development Company Limited SINOPECDongyingShandong 257000China

In this study,X-ray diffraction,N_(2)adsorption(N_(2)A),and mercury intrusion(MI)experiments were used to investigate the influence of acid treatment on pore structure and fractal characterization of tight *** results showed that acid treatment generated a certain number of ink-bottle pores in fine sandstone,aggravated the ink-bottle effect in the sandy mudstone,and transformed some smaller pores into larger *** the acid treatment,both the pore volume in the range of 2–11 nm and 0.271–8μm for the fine sandstone and the entire pore size range for the sandy mudstone significantly *** dissolution of sandstone cement causes the fine sandstone particles to fall off and fill the pores;the porosity increased at first but then decreased with acid treatment *** fractal dimension obtained using the Frenkel-Halsey-Hill model was positively correlated with acid treatment ***,the total fractal dimensions obtained by MI tests showed different changes with acid treatment time in fine sandstone and sandy *** results provide good guiding significance for reservoir acidification stimulation.

关键词： pore structure acid treatment full pore size distribution fractal dimension tight sandstone

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Psychological and Physiological Health Benefits of a Structured Forest Therapy Program for Children and Adolescents with Mental Health Disorders

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International Journal of Mental Health Promotion 2023年第10期25卷 1117-1125页

作者： Namyun Kil Jin gun Kim Emily Thornton Amy Jeranek Department of Recreation Management and Recreational Therapy University of Wisconsin-La CrosseLa Crosse54601USA Korea Forest Therapy Forum Incorporated Association Cheongju28644Korea Hiawatha Valley Education District-SAIL Program Kellogg55945USA

Mental health conditions in children and adolescents can be improved by slow mindful nature connection known as forest therapyor *** therapy has recently received growing attention as an enabler of relaxation and preventive health care withdemonstrated clinical ***,it is not well-known that forest therapy also decreases mental health issues amongindividuals with mental health *** study explored the psychological and physiological health benefits of structuredforest therapy programs for children and adolescents with mental health disorders.A one-group pre-test-posttest design wasemployed for our study *** participants(aged 9–14 years)engaged in two one-hour guided standard sequenceforest therapy experiences.A Mindful Attention Awareness Scale(MAAS),Connectedness to Nature Scale(CNS),Profile ofMood States(POMS),place meanings(e.g.,functional,emotional,and cognitive attachment to the forest)questionnaire,andphysiological health assessment were administered to the *** results showed that negative mood states weresignificantly reduced and that a positive mood state was significantly improved after the structured forest therapy ***,mindfulness,nature connection,place meanings,and physiological health were significantly boosted after *** results demonstrate substantial psychological and physiological health and well-being outcomes ofstructured forest therapy for similar individuals.

关键词： Forest therapy mental health disorders mindfulness mood states place meanings physiological health

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Recent Advances in Multifunctional Reticular Framework Nanoparticles:A Paradigm Shift in Materials Science Road to a Structured Future

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纳微快报:英文版 2023年第11期15卷 435-502页

作者： Maryam Chafiq Abdelkarim Chaouiki Young gun Ko Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea

Porous organic frameworks(POFs)have become a highly sought-after research domain that offers a promising avenue for developing cutting-edge nanostructured materials,both in their pristine state and when subjected to various chemical and structural ***–organic frameworks,covalent organic frameworks,and hydrogen-bonded organic frameworks are examples of these emerging materials that have gained significant attention due to their unique properties,such as high crystallinity,intrinsic porosity,unique structural regularity,diverse functionality,design flexibility,and outstanding *** review provides an overview of the state-of-the-art research on base-stable POFs,emphasizing the distinct pros and cons of reticular framework nanoparticles compared to other types of nanocluster ***,the review highlights the unique opportunity to produce multifunctional tailoring nanoparticles to meet specific application *** is recommended that this potential for creating customized nanoparticles should be the driving force behind future synthesis efforts to tap the full potential of this multifaceted material category.

关键词： Porous organic framework Reticular chemistry Reticular framework nanoparticle Environmental remediation Multifunctional material

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畜牧兽医学报 2024年第8期55卷 3418-3426页

作者：李瑶贾蕊李杰滚双宝杨巧丽王龙龙张鹏霞高小莉黄晓宇甘肃农业大学动物科学技术学院兰州730070 甘肃省现代养猪工程技术研究中心兰州730070 甘肃迭部蕨麻猪科技小院甘南740070

旨在探究低温对合作猪脂肪组织形态、脂代谢相关基因表达和酶活性及AMPK/PGC-1α通路的影响。本研究选择75日龄体重相近、健康状况良好的合作猪10头,常温饲养7 d后随机分为对照组((23±2)℃)和低温组((-15±2)℃),每组5头,试验期15 d。... 详细信息

旨在探究低温对合作猪脂肪组织形态、脂代谢相关基因表达和酶活性及AMPK/PGC-1α通路的影响。本研究选择75日龄体重相近、健康状况良好的合作猪10头,常温饲养7 d后随机分为对照组((23±2)℃)和低温组((-15±2)℃),每组5头,试验期15 d。试验结束后采集合作猪腋下和腹股沟脂肪组织,采用HE染色观察脂肪组织形态;ELISA法检测脂代谢相关酶活性;荧光定量PCR法检测脂肪棕色化产热基因和脂代谢相关基因的表达;Western blot检测AMPK/PGC-1α通路蛋白的表达。结果发现:与对照组相比,低温处理后合作猪腋下脂肪和腹股沟脂肪呈现褐色化改变,脂肪细胞数量变多且横截面积减小;腋下和腹股沟脂肪中LPL活性,IL-6 mRNA表达量及AMPK、P-AMPK和PGC-1α蛋白表达量极显著增加(P0.05)。综上,低温下合作猪腋下脂肪和腹股沟脂肪发生褐色化改变,且脂肪细胞数量增多,面积减小,机体产热增加,脂代谢关键基因LEP、ADPN、PPARγ、FAT及AMPK/PGC-1α通路可能参与机体脂质代谢。

关键词：低温脂肪组织脂代谢 AMPK/PGC-1α

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毕节市秋绵雨时空特征分析

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山地气象学报 2024年第4期48卷 96-101页

作者：衮毅施倩雯王志红胡妍妍聂祥贵州省大方县气象局贵州大方551600 贵州省织金县气象局贵州织金552100 贵州省七星关区气象局贵州七星关551799 贵州省毕节市气象局贵州毕节551700

【目的】研究毕节市秋绵雨特征,对该地区秋收秋种农事安排具有指导意义。【方法】利用毕节市8个国家气象观测站1960—2022年9—11月逐日降水、日照资料,采用线性趋势和小波分析法,统计分析毕节市无日照条件下秋绵雨时空变化特征。【结果... 详细信息

【目的】研究毕节市秋绵雨特征,对该地区秋收秋种农事安排具有指导意义。【方法】利用毕节市8个国家气象观测站1960—2022年9—11月逐日降水、日照资料,采用线性趋势和小波分析法,统计分析毕节市无日照条件下秋绵雨时空变化特征。【结果】1960—2022年,毕节市秋季降水量与日照时数均呈现下降趋势,无日照条件下降水量在时间上存在5 a、9 a、17 a、30 a的周期变化特征,主周期为17 a;毕节市东部受秋绵雨的影响较大,西部相对较小,总体上秋绵雨出现的频次在时间序列上呈波动下降趋势,有利于农业生产,且该地区秋绵雨集中出现在10月,9月中旬前完成秋收晾晒工作能有效避免秋绵雨的影响。【结论】近63 a,轻、中、重、特重等级秋绵雨发生的频次占比分别为44.1%、34.2%、18.5%、3.2%,且轻级秋绵雨存在6 a、20 a和32 a的变化周期,中级秋绵雨存在5 a、8 a、17 a和28 a的变化周期,重级秋绵雨存在7 a、18 a、35 a的变化周期,特重级秋绵雨存在13 a、21 a、41 a的变化周期,不同等级秋绵雨空间分布上整体呈东多西少分布。

关键词：秋绵雨时空特征线性趋势小波分析法

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Experimental investigation of friction coefficient in tube hydroforming

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 194-198页

作者： Hyae Kyung YI Hong Sup YIM gun Yeop LEE Sung Mun LEE Gi Suk CHUNG Young-Hoon MOON Engineering Research Center for Net Shape and Die Manufacturing School of Mechanical Engineering Pusan National University Technical Research laboratories POSCO Jeonnam 545-090 Korea

The friction coefficient between tube and die in guide zone of tube hydroforming was obtained. In hydroforming, the tube is expanded by an internal pressure against the tool wall. By pushing the tube through tool, a friction force at the contact surface between the tube and the tool occurs. In guiding zone, the friction coefficients between tube and die can be estimated from the measured axial feeding forces. In expansion zone, the friction coefficients between tube and die can be evaluated from the measured geometries of expanded tubes and FE analysis.

关键词： tube hydroforming friction coefficient lubricant axial force internM pressure

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The Future Prospect for the Evolution of Islamic Banking in Turkey

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Chinese Business Review 2012年第6期11卷 511-521页

作者： gun Lamiha Turgut ozal University Ankara Turkey

In Turkey, banks having ＂Islamic＂ features that are long neglected have experienced strong business growth since 2003 that is just after the date of a moderate Islamic party which emerged victorious in parliamentary elections. While Turkey has only four ＂Islamic＂ banks, they capture more than 4% market share. The purpose of this research is to analyze the mechanisms that have allowed such a growth between 2002 （just after the financial crisis in 2001） and 2009, by comparing the results of activities of these four Islamic banks and find out possible opportunities that might exist in this sector. The results indicate that these institutions have a respectively higher risk-taking and internationally more fair open policy than the banks known as ＂conventional＂. While Bank Asya （the market leader of the participatory banks in Turkey） and Albaraka Turk capture the individual customers, the other two institutions that are TurkiyeFinans and Kuveyt Turk capture the commercial customers. In addition, the development of these institutions seems to be very difficult because of the lack of Turkish Sukuk in Turkish banking context having no adequate liquidity. Moreover, in its political context, leading actors in Turkish political and economic structure reject utterly the existence of Sharia Board. In fact, it is clear that the Turkish banking sector is an untapped potential market that could be easily converted into an opportunity by improving the regulatory framework and communication strategy for these institutions. Indeed, since the controversy still exists around the concept of secularism, which is an impediment to the development of these banks called ＂Islamic＂ in Turkey, there is a necessity for a communication strategy to break down prejudices and to become popular for Islamic finance sector, which is still known very poorly and superficially by general public in Turkey.

关键词： Islamic banking participation banks Turkish Sukuk Sharia Board risk-taking

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Keystone design perforator island flap in facial defect reconstruction

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World Journal of Clinical Cases 2020年第10期8卷 1832-1847页

作者： Soo Yeon Lim Chi Sun Yoon Hyun gun Lee Kyu Nam Kim Department of Plastic and Reconstructive Surgery Konyang University HospitalUniversity of Konyang College of MedicineMyunggok Medical Research CenterDaejeon 35365South Korea Department of Plastic and Reconstructive Surgery Wonkwang University HospitalWonkwang University School of MedicineIksan 54538South Korea

Facial defect coverage is a common subject in the field of reconstructive *** are many methods for facial defect reconstruction,and reconstructive surgeons should choose the most appropriate method on a case-by-case basis to achieve both functional and aesthetic *** various options for facial reconstruction,the local flap technique is considered the best reconstructive modality to provide good tissue matches of color and texture,which is consistent with the ideal goal of reconstruction(replacement of like-with-like).Keystone design perforator island flap(KDPIF),devised by Behan in 2003,has been applied to various fields of reconstructive surgery in the past decade due to its design simplicity,robust vascular supply,and *** studies have reported KDPIF reconstruction of facial defects,such as large parotid defects,small-to-moderate nasal defects,and eyelid ***,KDPIF has been used relatively less in facial defects than in other body regions,such as the trunk and *** purpose of this review is to provide an organized overview of facial KDPIF reconstruction including the classification of KDPIF,modifications,physiology,mechanism of flap movement,consideration of facial relaxed skin tension lines and aesthetics,surgical techniques,clinical applications,and precautions for successful execution of KDPIF reconstruction.

关键词： Keystone design perforator island flap Reconstructive surgery Facial defects Aesthetics Plastic surgery Flap surgery

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Wrinkle-free graphene with spatially uniform electrical properties grown on hot-pressed copper

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Nano Research 2015年第4期8卷 1075-1080页

作者： Jeong Hun Mun Joong gun Oh Jae Hoon Bong Hai Xu Kian Ping Loh Byung Jin Cho Departmen t of Electrical Engineering KAIST Daejeon 305-701 Republic of Korea Department of Chemistry National University of Singapore Singapore 117543 Singapore

The chemical vapor deposition （CVD） of graphene on Cu substrates enables the fabrication of large-area monolayer graphene on desired substrates. However, during the transfer of the synthesized graphene, topographic defects are unavoidably formed along the Cu grain boundaries, degrading the electrical properties of graphene and increasing the device-to-device variability. Here, we introduce a method of hot-pressing as a surface pre-treatment to improve the thermal stability of Cu thin film for the suppression of grain boundary grooving. The flattened Cu thin film maintains its smooth surface even after the subsequent high temperature CVD process necessary for graphene growth, and the formation of graphene without wrinkles is realized. Graphene field effect transistors （FETs） fabricated using the graphene synthesized on hot-pressed Cu thin film exhibit superior field effect mobility and significantly reduced device-to-device variation.

关键词： CVD graphene graphene synthesis graphene wrinkle graphene field effecttransistor

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