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Clinical outcome in patients with hepatocellular carcinoma after living-donor liver transplantation

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World Journal of Gastroenterology 2013年第29期19卷 4737-4744页

作者： Ho Joong Choi Dong Goo Kim gun hyung na Jae Hyun Han Tae Ho Hong Young Kyoung You Hepatobiliary-Pancreas Surgery and Liver Transplantation Division Department of Surgery Seoul St. Mary's Hospital The Catholic University of Korea Seoul 137-701 South Korea

AIM: To investigate risk factors for hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT) and efficacy of various criteria. METHODS: From October 2000 to November 2011, 233 adult patients underwent LDLT for HCC at our institution. After excluding nine postoperative mortality cases, we analyzed retrospectively 224 patients. To identify risk factors for recurrence, we evaluated recurrence, disease-free survival (DFS) rate, survival rate, and various other factors which are based on the characteristics of both the patient and tumor. Additionally, we developed our own criteria based on our data. Next, we compared our selection criteria with various tumor-grading scales, such as the Milan criteria, University of California, San Francisco (UCSF) criteria, TNM stage, Barcelona Clinic Liver Cancer (BCLC) stage and Cancer of the Liver Italian Program (CLIP) scoring system. The median follow up was 68 (6-139) ***: In 224 patients who received LDLT for HCC, 37 (16.5%) experienced tumor recurrence during the follow-up period. The 5-year DFS and overall survival rates after LDLT in all patients with HCC were 80.9% and 76.4%, respectively. On multivariate analysis, the tumor diameter {5 cm; P < 0.001; exponentiation of the B coefficient [Exp(B)], 11.89; 95%CI: 3.784-37.368} and alpha fetoprotein level [AFP, 100 ng/mL; P = 0.021; Exp(B), 2.892; 95%CI: 1.172-7.132] had significant influences on HCC recurrence after LDLT. Therefore, these two factors were included in our criteria. Based on these data, we set our selection criteria as a tumor diameter ≤ 5 cm and AFP ≤ 100 ng/mL. Within our new criteria (140/214, 65.4%), the 5-year DFS and overall survival rates were 88.6% and 81.8%, respectively. Our criteria (P = 0.001), Milan criteria (P = 0.009), and UCSF criteria (P = 0.001) showed a significant difference in DFS rate. And our criteria (P = 0.006) and UCSF criteria (P = 0.009) showed a significant difference in overall survival rate. Bu

关键词： Hepatocellular carcinoma Living donor liver transplantation Selection criteria Milan criteria University of California, San Francisco criteria Barcelona Clinic Liver Cancer Cancer of the Liver Italian Program

Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17132-17140页

作者： Jae Hyun Han Dong Goo Kim gun hyung na Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery The Catholic University of Korea Seoul St.Mary’s Hospital

AIM: To select appropriate patients before surgical resection for hepatocellular carcinoma (HCC), especially those with advanced tumors.

关键词： Carcinoma Hepatocellular Hepatectomy Prognostic factor Survival Recurrence

Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

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World Journal of Gastroenterology 2014年第21期20卷 6594-6601页

作者： gun hyung na Dong Goo Kim Jae hyun Han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea

AIM: To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).

关键词： C-reactive protein Hepatocellular carcinoma Liver transplantation Neutrophil-lymphocyte ratio Selection criteria

High na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo Hong Harpalsinh H.Rana Jeong Hee Park Jun Su Kim Sang Joon Lee gun Jang Tae Hoon Kang Kang Ho Shin Sang Ha Baek Wooseok Yang Kwang Ho Kim Ju-Hyuk Lee Ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in naClO_(4) solution(ex-DDA-Dex+naClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+naClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

添加不同比例全株玉米青贮对合作猪小肠组织结构和肠道屏障功能相关基因表达的影响

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黑龙江畜牧兽医 2024年第15期 84-92页

作者：刘祥年殷熙彤唐于然王鹏飞闫尊强滚双宝甘肃农业大学动物科学技术学院兰州730070 甘肃省现代养猪工程技术研究中心兰州730070

为了探究日粮中添加不同比例全株玉米青贮对合作猪小肠组织结构和肠道屏障功能相关基因的影响,试验将32头健康状况良好、体重相近的断奶合作猪仔猪随机分为4组,每组8头(公母各半),对照组饲喂基础日粮,5%组、10%组和15%组分别饲喂添加5%... 详细信息

为了探究日粮中添加不同比例全株玉米青贮对合作猪小肠组织结构和肠道屏障功能相关基因的影响,试验将32头健康状况良好、体重相近的断奶合作猪仔猪随机分为4组,每组8头(公母各半),对照组饲喂基础日粮,5%组、10%组和15%组分别饲喂添加5%、10%和15%全株玉米青贮日粮,120 d后,每组随机选取3头合作猪屠宰,取小肠各段组织样本,一部分用4%多聚甲醛溶液固定,苏木精-伊红(H.E.)染色后测定小肠绒毛高度和隐窝深度,计算绒毛高度/隐窝深度;另一部分采用实时荧光定量PCR检测小肠肠道屏障功能相关基因mRna相对表达量。结果表明:与对照组相比,10%和15%组小肠各段绒毛高度均增加,隐窝深度均变浅,绒毛高度/隐窝深度均增大,其中10%组小肠各段绒毛高度均显著升高(Pna相对表达量均增加,促炎因子基因[Toll样受体2(TLR2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]mRna相对表达量均降低;且10%组小肠各段的ZO-1、Claudin-1、MUC2、IL-10 mRna相对表达量均显著升高(Pna相对表达量均显著升高(Pna相对表达量显著降低(P<0.05)。说明添加10%全株玉米青贮的日粮可更好地改善合作猪肠组织结构,增强肠道屏障功能,促进肠道健康。

关键词：合作猪全株玉米青贮肠组织结构肠道屏障基因表达

Improving the electrochemical stability of AZ31 Mg alloy in a 3.5wt.%naCl solution via the surface functionalization of plasma electrolytic oxidation coating

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Journal of Magnesium and Alloys 2022年第5期10卷 1311-1325页

作者： Mosab Kaseem Tehseen Zehra Burak Dikici Ali Dafali Hae Woong Yang Young gun Ko Department of nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Metallurgical and Materials Engineering Ataturk UniversityErzurum 25240Turkey Faculty of Sciences Oujda Department of ChemistryMohamed the First UniversityOujdaMorocco Pohang Institute of Metal Industry Advancement Pohang 37666Republic of Korea Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea

The unique interactions between hexadecanoic acid(HA)and albumin(ALB)molecules on the surface of the porous layer of AZ31 Mg alloy were exploited to fabricate a novel hybrid composite film with excellent electrochemical stability in a 3.5 wt.%na Cl ***,the inorganic layer(IL)obtained by plasma electrolytic oxidation of AZ31 Mg alloy in an alkaline-phosphate-WO_(3)electrolyte was soaked in an organic solution composed of ALB and HA for 10 and 24 h at 60℃.Although albumin and HA may coexist on the same surface of IL,the higher reactivity of ALB molecules would prevent the formation of a thick layer of *** donor-acceptor complexes formed due to the unique interactions between ALB and/or HA and IL surface would reduce the area exposed to the corrosive species which in turn would efficiently protect the substrate from *** porous structure of the IL would provide preferable sites for the physical and chemical locking triggered by charge-transfer phenomena,leading to the inhomogeneous nucleation and crystal growth of a flowery flakes-like organic *** calculations were performed to reveal the primary bonding modes between the ALB,HA,and IL and to assess the mechanistic insights into the formation of such novel hybrid composites.

关键词： Hybrid composite Coordination bond Albumin Fatty acid Porous layer Corrosion Theoretical approach

“葵花壳+玉米秸秆”加工粉尘对合作猪养分消化率、小肠组织形态和消化酶活性的影响

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饲料工业 2024年第15期45卷 51-56页

作者：许兰刘祥年耿永琪王鹏飞闫尊强马艳萍滚双宝甘肃农业大学动物科学技术学院甘肃兰州730070 甘肃农业大学图书馆甘肃兰州730070 甘肃现代养猪工程技术研究中心甘肃兰州730070

试验旨在研究饲粮中添加“葵花壳+玉米秸秆”加工粉尘对合作猪养分消化率、小肠组织形态和消化酶活性的影响。选择平均体重为(9.88±0.82)kg的合作猪50头,进行7 d预试验,饲喂基础饲粮。预试验结束后选取40头平均体重为(11.94±1.43)kg... 详细信息

试验旨在研究饲粮中添加“葵花壳+玉米秸秆”加工粉尘对合作猪养分消化率、小肠组织形态和消化酶活性的影响。选择平均体重为(9.88±0.82)kg的合作猪50头,进行7 d预试验,饲喂基础饲粮。预试验结束后选取40头平均体重为(11.94±1.43)kg的合作猪,随机分为4组,每组10个重复,每个重复1头猪。对照组饲喂基础饲粮,试验Ⅰ、Ⅱ、Ⅲ组分别饲喂添加5%、10%和15%的“30%葵花壳+70%玉米秸秆”加工粉尘的基础饲粮,正式试验期90 d。结果表明:①试验Ⅱ组粗蛋白和酸性洗涤纤维消化率显著高于对照组(P0.05)。③试验Ⅱ、Ⅲ组十二指肠内蛋白酶活性极显著高于对照组(P<0.01),试验Ⅱ组空肠内蛋白酶活性显著高于对照组(P<0.05);试验Ⅱ组试验猪十二指肠内淀粉酶活性显著高于对照组(P<0.05),试验Ⅰ、Ⅱ、Ⅲ组空肠内淀粉酶活性极显著高于对照组(P<0.01)。综上可知,饲粮中添加“葵花壳+玉米秸秆”加工粉尘,可提高合作猪的养分消化率、十二指肠和空肠内蛋白酶和淀粉酶活性,能够改善小肠组织形态,添加水平以10%最佳。

关键词：合作猪 “葵花壳+玉米秸秆”加工粉尘养分消化率小肠组织形态消化酶活性

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无人机载无后坐力枪内弹道性能数值模拟

兵工自动化 2024年第10期43卷 11-13页

作者：刘朋展王国强苏精明王敏祥张娜中北大学机电工程学院太原030051 重庆嘉陵特种装备有限公司弹药技术中心重庆400032 重庆建设工业(集团)有限责任公司通用装备研究所重庆400054 淮海工业集团工艺技术部山西长治046012

为降低枪械武器的发射后坐力,建立基于全可燃药筒、尾喷气体式无后坐力发射系统内弹道数值计算模型。分析尾喷气体式无后坐力发射系统工作原理与发射过程,建立发射过程中的内弹道模型,进行弹道系统参数设计与内弹道数值仿真。设计无后... 详细信息

为降低枪械武器的发射后坐力,建立基于全可燃药筒、尾喷气体式无后坐力发射系统内弹道数值计算模型。分析尾喷气体式无后坐力发射系统工作原理与发射过程,建立发射过程中的内弹道模型,进行弹道系统参数设计与内弹道数值仿真。设计无后坐力发射弹道系统验证方案,进行内弹道试验,并将数值模拟结果与试验结果进行对比分析。结果表明,该模型能正确模拟发射过程中膛压变化。

关键词：无人机无后坐力可燃药筒内弹道数值计算

基于FLUENT仿真的火炮抽气装置效能计算研究

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火炮发射与控制学报 2024年第2期45卷 61-65,77页

作者：马秋生司志桧刘飞飞张瑞王珂徐娜内蒙古北方重工业集团有限公司南京研发中心江苏南京210049

抽气装置的可靠性直接影响到炮手的工作环境及人身安全。为了研究抽气装置排气的可靠性,以某型105 mm火炮为研究对象,提出一种利用CFD方法计算抽气装置抽气效率的方法,借助FLUENT仿真软件,采用标准k-ε湍流模型,对考虑开闩过程的三维抽... 详细信息

抽气装置的可靠性直接影响到炮手的工作环境及人身安全。为了研究抽气装置排气的可靠性,以某型105 mm火炮为研究对象,提出一种利用CFD方法计算抽气装置抽气效率的方法,借助FLUENT仿真软件,采用标准k-ε湍流模型,对考虑开闩过程的三维抽气装置排气过程进行仿真。仿真过程对抽气装置储气室压力、抽气速度及抽气质量流率进行实时监测。仿真云图能较好的显示出抽气装置排气过程的射流发展过程。监测结果表明:仿真监测的储气室压力曲线和实验获得的储气室压力曲线在储气室排气阶段曲线变化规律基本一致,仿真曲线符合实际物理规律,也说明了仿真模型的可行性。计算结果显示:抽气效率符合设计要求,抽气装置工作是可靠的。该计算方法对抽气装置的优化设计及火炮设计具有一定的理论指导意义。

关键词：抽气装置仿真分析抽气效率可靠性

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