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Citric acid cross-linked curcumin/chitosan/chickpea flour film: An active packaging for chicken breast storage

Food Bioscience 2022年第6期50卷 1074-1082页

作者： Eda Yildiz Ayca Aydogdu Emir gulum sumnu Leyla Nesrin Kahyaoglu Department of Food Engineering Middle East Technical UniversityAnkaraTurkey Department of Food Technology Canakkale 18 Mart UniversityCanakkaleTurkey

Since there has been an increasing interest in natural, non-toxic, and biodegradable food packages instead of plastic ones, scientists put great effort into eliminating the potential drawbacks of these biodegradable films. In this study, citric acid (CA) was utilized as a crosslinker for the films produced by chitosan (CS), chickpea flour (CF), and active agent curcumin (CUR) by a solvent casting technique. CA was introduced into the film formulations at different concentrations (0, 0.5%, 1%, 1.5% w/v), and the influence on the functional film characteristics were extensively *** CA concentration in formulation caused a reduction in water vapor permeability (WVP) of the films such that the film with the highest CA concentration (1.5-CUR/CF/CS) was 62.6% more resistant to water vapor than film without CA (0-CUR/CF/CS). When CA concentration in the film formulation was increased, elongation at break (EAB) value increased from 1.64% ± 0.13%, to 11.1%± 1.21% whereas tensile strength (TS) value decreased from 7.83± 0.08 MPa to 3.58± 0.20 MPa. Contrary to expectations, antioxidant activity of the films decreased with increasing CA concentration. X-Ray Diffraction (XRD) patterns of the films proved the amorphous nature and inhibitory characteristic of CA against retrogradation. In addition to all these, CA concentration significantly influenced Thermogravimetric analysis (TGA) pattern of the films with the increasing number of degradation stages. Besides the cross-linker characteristic of CA, it also extensively enhanced the antibacterial characteristic of the films. Films formulated with 1.5% (w/v) CA (1.5-CUR/CF/CS) showed antibacterial effect against both Escherichia coli (***) (ATCC 11229) and Staphylococcus aureus (***) (ATCC 43300). Finally, chicken breast packed with 1.5-CUR/CF/CS films remained below unacceptable microbial threshold limits even at the end of the 9th -day of storage compared to samples packaged with the film with no antibacte

关键词： Chitosan Chickpea flour Curcumin Citric acid Antimicrobial activity Chicken

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Migrated endoclip and stone formation after cholecystectomy:A new danger of acute pancreatitis

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World Journal of Gastroenterology 2007年第47期13卷 6446-6448页

作者： Kemal Dolay Halil Alis Aliye Soylu gulum Altaca Ersan Aygun Department of General Surgery1 and Gastroenterology 2 Endoscopy UnitBakirkoy Research and Training HospitalBakirkoyIstanbulTurkey

Endoclip migration into the common bile duct following laparoscopic cholecystectomy (LC) is an extremely rare complication. Migrated endoclip into the common bile duct can cause obstruction,serve as a nidus for stone formation,and cause cholangitis. We report a case of obstructive jaundice and acute biliary pancreatitis due to choledocholithiasis caused by a migrated endoclip 6 mo after LC. The patient underwent early endoscopic retrog-rade cholangiopancreatography (ERCP) with endoscopic sphincterotomy and stone extraction.

关键词： Laparoscopic cholecystectomy Endoclip migration Biliary pancreatitis Endoscopic retrograde cholangiopancreatography

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The Frequency of K-ras Mutation in Colorectal Adenocarcinomas with Absence of Distant Metastasis at Diagnosis

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Surgical Science 2012年第3期3卷 111-115页

作者： Ebru Demiralay Yaman Saglam gulum Altaca Banu Bilezikci Handan Ozdemir Department of General Surgery School of Medicine Baskent University Istanbul Turkey Department of Pathology School of Medicine Baskent University Istanbul Turkey Medical Genetics Laboratory Goztepe Park Medical Hospital Istanbul Turkey

Purpose: K-ras mutations were reported to be in 40% - 60% of patients with sporadic colorectal cancers (CRCs). HER-2/neu oncogene that is important in breast carcinoma was reported in CRCs in several studies. The aims of our study are to determine;the frequency of K-ras mutation in CRC and positivity of HER-2/neu, the relation between K-ras mutation and HER-2/neu positivity, and also the relation between clinicopathological findings with K-ras mutation and HER-2/neu expression. Methods: Total of 35 colon resection specimen from patients without distant metastasis who were operated due to colorectal adenocarcinoma were included in the study. The sections were examined with light microscopy. Vascular and perineural invasions and pericolonic tumor deposits (PCTD) were investigated. HER-2/neu was applied immunohistochemically. DNA sample obtained from tumor paraffin block was screened for presence of 20 mutations in K-ras gene-codon 12, 13, 61 by AutoGenomics and Infinity Analyzer. Results: K-ras gene mutation was detected in 14 of 35 patients (40%). HER-2/neu positivity was detected in 7 cases (28.57%). There was not any significant correlation between HER-2/neu positivity, K-ras gene mutation and clinicopathological findings. There was direct correlation between PCTD and vascular invasion. Conclusions: There was not correlation between K-ras mutation and clinicopathological findings similar to several other studies. The relation between HER-2/neu expression and clinicopathological findings was not found.

关键词： Colon Adenocarcinoma K-ras HER-2/Neu

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