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Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer:A pictorial review

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World Journal of Clinical Oncology 2017年第3期8卷 214-229页

作者： gulgun engin Rasul Sharifov Oncology Institute Istanbul University Department of Radiology Faculty of MedicineBezmialem Vakif University

High-resolution pelvic magnetic resonance imaging(MRI) is the primary method for staging rectal *** is highly accurate in the primary staging of rectal cancer;however,it has not proven to be effective in restaging,especially in complete response evaluation after neoadjuvant *** chemoradiotherapy produces many changes in rectal tumors and on adjacent area,as a result,local tumor extent may not be accurately ***,adding diffusion-weighted sequences to the standard approach can improve diagnostic *** this pictorial review,an overview of the situation of MRI in the staging and re-staging of rectal cancer is exhibited as a pictorial *** experience-and literature-based discussion of limitations and difficulties in interpretation are also presented.

关键词： Rectal cancer Locally advanced Magnetic resonance imaging Staging Neoadjuvant treatment

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Imatinib response of gastrointestinal stromal tumor patients with germline mutation on KIT exon 13:A family report

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World Journal of Radiology 2017年第9期9卷 365-370页

作者： gulgun engin Serpil Eraslan Hülya Kayserili Yersu Kapran Haluk Akman Ali Akyuz Nuri Faruk Aykan Oncology Institute Istanbul University Medical Genetics Department Koc UniversitySchool of Medicine(KUSoM) Pathology Department Koc UniversitySchool of Medicine(KUSoM) International Hospital Acibadem University Acibadem International Hospital Istinye University Liv Hospital

Familial gastrointestinal stromal tumor(GIST) is a rare autosomal dominant disorder associated with mutations in the KIT gene in the majority of cases. Although, exon 11 appears to be the hot spot region for approximately 95% of germline mutations, pathogenic variations have also been identified in exon 8, 13 and 17. Exon 13 germline mutations are extremely rare amongst familial GISTs and seven families with a germline mutation have been reported to date. Moreover, the role of imatinib mesylate in this rare familiar settings is not completely known so far. We describe here clinical, imaging, pathological and genetic findings of a family with four affected members; grandmother, his son and two grand-sons having a germline gain-of-function mutation of KIT in exon 13 and discuss the imatinib mesylate treatment surveillance outcomes towards disease management.

关键词： Gastrointestinal stromal tumor Familial Germline mutation Imatinib Response

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