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Effect of growth hormone,hyperbaric oxygen and combined therapy on the gastric serosa

World Journal of Gastroenterology 2013年第19期19卷 2904-2912页

作者： Gokhan Adas Mine Adas Soykan Arikan Ahu Kemik Sarvan Akin Savas TokluDepartment of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine 34091 Istanbul Turkey Selva Mert gul barut Sedat Kamali Bora Koc Firat Tutal Department of Surgery Bakirkoy Dr.Sadi Konuk Training and Research Hospital34147 IstanbulTurkey Department of Endocrinology Okmeydani Training and Research Hospital34384 IstanbulTurkey Department of Surgery Istanbul Training and Research Hospital34098 IstanbulTurkey Department of Biochemistry Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Pathology Haseki Training and Research Hospital34096 IstanbulTurkey Department of Surgery Okmeydani training and Research Hospital34384 IstanbulTurkey

AIM:To investigate the role of growth hormone(GH),hyperbaric oxygen therapy(HBOT) and combined therapy on the intestinal neomucosa formation of the gastric ***:Forty-eight male Wistar-albino rats,weighing 250-280 g,were used in this *** rats were divided into four groups(n = 12):Group 1,control,gastric serosal patch;Group 2,gastric serosal patch + GH;Group 3,gastric serosal patch + HBOT;and Group 4,gastric serosal patch + GH + *** access was achieved through a midline incision,and after the 1-cm-long defect was created in the jejunum,a 1 cm × 1 cm patch of the gastric corpus was anastomosed to the jejunal *** blood samples were taken to determine the insulin-like growth factor 1(IGF-1) and insulin-like growth factor binding protein 3(IGFBP-3) basal *** was performed in Groups 3 and *** Groups 2 and 4,human GH was given subcutaneously at a dose of 2 mg per kg/d for 28 d,beginning on the operation *** animals were sacrificed 60 d after *** jejunal segment and the gastric anastomotic area were excised for histological *** inflammatory process,granulation,collagen deposition and fibroblast activity at the neomucosa formation were studied and ***,the villus density,villus height,and crypt depth were counted and *** measurements of villus height and crypt depth were calculated with an ocular *** vessel growth was determined by calculatingeach new vessel in a 1 mm 2 ***:In the histological comparison of groups,no significant differences were observed between the control group and Groups 2 and 3 with respect to epithelialization,granulation,fibroblastic activity and the inflammatory process,but significant differences were present between the control group and all others groups(Groups 2-4) with respect to angiogenesis(P < 0.01) and collagen deposition(P < 0.05,P < 0.01).Significant differences between the control group and Group 4 were also observed with respe

关键词： Growth hormone Hyperbaric oxygen Neomucosa Short bowel syndrome Hypoxia

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