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Robust, breathable, and chemical-resistant polytetrafluoroethylene (PTFE) films achieved by novel in-situ fibrillation strategy for highperformance triboelectric nanogenerators

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Nano Research 2024年第3期17卷 1942-1951页

作者： Jialong Chai Guilong Wang Jinchuan zhao guizhen Wang Chao Wei Aimin Zhang Guoqun zhao Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Key Laboratory of Chinese Education Ministry for Tropical Biological Resources Hainan UniversityHaikou 570228China

In the era of advanced wearable electronic devices,the triboelectric nanogenerators(TENGs)as energy harvesting and self-powered sensing units hold great *** appropriate triboelectric material is the crucial factor to optimize the performance of TENG,while polytetrafluoroethylene(PTFE)stands out as a highly versatile option among the various *** this study,we present an ultrafine nanofibrous PTFE(NF-PTFE)films prepared by novel in-situ fibrillation strategy as the triboelectric material in TENG *** innovative processing methodology facilely addresses the dilemma between high porosity and fine pore size of traditional porous PTFE films,meanwhile achieves exceptional mechanical strength,hydrophobicity,air permeability,and chemical resistance of the *** the integration of nanofibrous PTFE films into contact-separation mode TENG and droplet-based TENG,these devices realize the peak electrical output of 131 V/10.8μA and 54 V/14μA with great durability,which surpass the performance of TENGs using traditional expanded PTFE ***,a smart glove capable of recognizing hand gestures is proposed,which demonstrates the versatility,flexibility,and practicality of this material for potential use in smart *** reported NF-PTFE film provides insights for the design of high-performance TENG device for advanced wearable electrical applications.

关键词： polytetrafluoroethylene(PTFE) nanofibrous film hydrophobic triboelectric nanogenerator self-powered sensor

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All-dielectric terahertz metasurface governed by bound states in the continuum with high-Q factor

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 44-54页

作者： Li Kun zhao Xu Wang Meng Jia Xingning zhao Ruiqi Lu guizhen School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China School of Electronic and Electrical Engineering Ningxia UniversityYinchuan 750021China QILU Aerospace Information Research Institute Chinese Academy of Sciences(CAS)Jinan 250101China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing 100024China

The method of terahertz(THz)resonance with a high-quality(high-Q)factor offers a vital physical mechanism for metasurface sensors and other high-Q factor ***,it is challenging to excite the resonance with a high-Q factor in metasurfaces with proper sensitivity as well as figure of merit(FOM)***,an all-dielectric metasurface composed of two asymmetrical rectangular blocks is *** and silicon are the materials applied for the substrate and cuboids *** distinct resonance governed by bound states in the continuum(BIC)is excited by forming an asymmetric cluster by a novel hybrid method of cutting and moving the *** investigation focuses on analyzing the transmission spectra of the metasurface under different variations in structural parameters and the loss of silicon refractive *** the proposed defective metasurface serves as a transmittance sensor,it shows a Q factor of 1.08×10^(4)and achieves an FOM up to 4.8×10^(6),which is obtained under the asymmetric parameter equalling 1μ***,the proposed defective metasurface is sensitive to small changes in refractive *** the thickness of the analyte is 180μm,the sensitivity reaches a maximum value of 578 GHz/***,the proposed defective metasurface exhibits an extensive number of possible applications in the filters,biomedical diagnosis,security screening,and so on.

关键词： terahertz(THz)metasurface high-quality(high-Q)factor bound states in the continuum figure of merit(FOM)

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Single-cell mass spectrometry studies of drug metabolism heterogeneity and primary resistance to gefitinib in non-small cell lung cancer cells

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Chinese Chemical Letters 2024年第2期35卷 436-440页

作者： guizhen Zhu Yaoyao zhao Wenmei Zhang Yuanyuan Wu Yuanxing Liu Guangsheng Guo Xiayan Wang Zhihong Liu Center of Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Minzu University of China Beijing 100081China Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Health Science and EngineeringHubei UniversityWuhan 430062China

Patients with epidermal growth factor receptor(EGFR)wild-type non-small cell lung cancer(NSCLC)often show primary resistance to gefitinib *** is thus necessary to study the metabolism of gefitinib in NSCLC cells to comprehensively reveal the reasons for the primary resistance of ***,we develop a platform for studying drug metabolism heterogeneity based on single-cell mass spectrometry(sDMH-scMS)by integrating living-cell electrolaunching ionization MS(ILCEI-MS)and high-performance liquid chromatography-MS(HPLC-MS)analysis,and the primary resistance of NSCLC cells to gefitinib was studied using this *** ILCEI-MS analysis showed that approximately 11.9%of NSCLC single cells contained the gefitinib metabolite M11;HPLC-MS detection diluted the intensity of M11 in subpopulations and concealed the heterogeneity of drug metabolism in tumor single *** intensity of gefitinib in EGFR wild-type A549 cells was markedly lower than in mutant PC9 cells,and the intensity of gefitinib metabolites was significantly higher than in PC9 cells,suggesting that the primary resistance of NSCLC cells is related to gefitinib ***,the combination of gefitinib and the drug-metabolizing enzyme inhibitorα-naphthoflavone was shown to overcome the primary resistance of the NSCLC ***,the results of this study are expected to be applicable for clinical drug resistance diagnosis and treatment at the single-cell level.

关键词： Single-cell mass spectrometry Drug metabolism Non-small cell lung cancer Gefitinib Primary resistance

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Predictive factors for sustained response to interferon treatment in patients with chronic hepatitis C: a randomized, open, and multi-center controlled trial

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 213-219页

作者： Yao Xie DaoZhen Xu ZhiMeng Lu KangXian Luo JiDong Jia YuMing Wang guizhen zhao ShuLin Zhang DaZhi Zhang Ninth Clinical Department Beijing Ditan Hospital Beijing 100011 China. xieyao@***

BACKGROUND:This study was undertaken to investigate the predictive factors of sustained viral response in roferon-A or pegasys treated chronic hepatitis C patients after logistic regression analysis of the factors that might be associated with the therapeutic effects of interferon (IFN).;METHODS:All patients enrolled into this randomized, open and multi-center controlled trial were divided into two groups randomly and treated with pegasys and roferon-A for 24 weeks, then followed up for another 24 weeks. Before treatment, hepatitis C virus (HCV) genotype was determined, and HCV-RNA in serum was detected before and at the end of treatment and follow-up. HCV-RNA turning negative was considered the major index for evaluating the therapeutic effect. The clinical characteristics including gender, age, infection route of HCV, treatment with IFN, platelet count, AST/ALT ratio and treatment drugs were analyzed by logistic regression.;RESULTS:Intention to treat (ITT) and per-protocol (PP) population groups have 208 and 197 patients respectively. In the PP group, after treatment for 24 weeks, the response rates of female patients aged less than 50 years, infected through non-transfusion, relapsed after IFN treatment, and presented with a AST/ALT ratio/=1, virus load equal or more than 8 x 10(5) IU/ml, and genotype 1 infection, and treated finally with roferon-A. But, at the end of follow-up, the patients with a AST/ALT ratio>/=1 and virus load more than 8 x 10(5) IU/ml had a higher rate of sustained response than did those with a AST/ALT ratio

关键词： hepatitis C virus chronic hepatitis C interferon peg-IFN genotype

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Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction

Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic ...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： zhao guizhen Xu Qingbo Kong Wei Peking University Health Science Center King's College London BHF Centre

Rationale:Although not fully understood,the phenotypic transition of vascular smooth muscle cells(VSMCs) exhibits at the early onset of the pathology of aortic *** the key regulators that are responsible for maintaining the contractile phenotype of VSMCs may confer vascular homeostasis and prevent aneurysmal disease.X-box binding protein 1(XBP1),which exists in a transcriptionally inactive unspliced form(XBP1 u) and a spliced active form(XBP1 s),is a key

关键词： Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction

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挥洒艺术潇洒人生——记中国的“合唱妈妈”吴灵芬

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人民音乐 2011年第4期 12-14,95-96页

作者：赵桂珍忻州师范学院音乐系

回顾那些站在历史关头奏响黄钟大吕、领唱时代大风的大师们,因他们将毕生精力与时代命运紧密地联系在一起,已经或终将把自己的名字嵌入历史。吴灵芬教授对中国合唱事业所做的贡献足以跻身其中。就如同把周广仁先生称为中国的＂钢琴妈妈... 详细信息

回顾那些站在历史关头奏响黄钟大吕、领唱时代大风的大师们,因他们将毕生精力与时代命运紧密地联系在一起,已经或终将把自己的名字嵌入历史。吴灵芬教授对中国合唱事业所做的贡献足以跻身其中。就如同把周广仁先生称为中国的＂钢琴妈妈＂一样,把吴灵芬教授称为中国的＂合唱妈妈＂,名至实归。

关键词：中国妈妈合唱艺术人生潇洒周广仁历史

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以历史昭示未来用艺术震撼心灵——漫谈大型音乐舞蹈史诗《复兴之路》

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解放军艺术学院学报 2010年第3期 69-70页

作者：赵桂珍山西省忻州师范学院音乐系

大型音乐舞蹈史诗《复兴之路》以"不重复过去,不重复别人,也包括不重复自己,一定要呈现一部属于这个伟大时代的崭新的艺术作品"(总导演张继钢语)为创作原则,用全新的创作理念、深度解读的文学剧本、站在时代高度上突破的音乐舞蹈编排、... 详细信息

大型音乐舞蹈史诗《复兴之路》以"不重复过去,不重复别人,也包括不重复自己,一定要呈现一部属于这个伟大时代的崭新的艺术作品"(总导演张继钢语)为创作原则,用全新的创作理念、深度解读的文学剧本、站在时代高度上突破的音乐舞蹈编排、朴素凝练的串联词与摄人魂魄的诵赋、新颖别致的舞台设计、板块拼接的大写意等表现手段,生动再现了中国人民为争取民族独立和民族解放、实现国家富强和人民富裕前赴后继的奋斗历程,清晰勾勒出中华民族从屈辱、抗争、胜利、振兴到走向复兴的历史画卷。

关键词：《复兴之路》音乐舞蹈史诗创新艺术经典

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简述中国音乐舞蹈史诗的发展历程

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音乐探索 2011年第2期 82-84,100页

作者：赵桂珍忻州师范学院音乐系山西忻州034000

中国宫廷乐舞艺术源远流长,在中国文化史上留下了璀璨的一页。新中国成立以后,中国音乐舞蹈史诗在继承传统的基础上不断探索、不断创新,逐步完善了有效运用音乐、舞蹈、诗歌和声光技术表现重大历史题材的艺术形式。《东方红》、《中国... 详细信息

中国宫廷乐舞艺术源远流长,在中国文化史上留下了璀璨的一页。新中国成立以后,中国音乐舞蹈史诗在继承传统的基础上不断探索、不断创新,逐步完善了有效运用音乐、舞蹈、诗歌和声光技术表现重大历史题材的艺术形式。《东方红》、《中国革命之歌》、《复兴之路》就像三座灯塔,在中国音乐舞蹈史诗的发展历程中闪烁着永不熄灭的光芒。

关键词：宫廷乐舞音乐舞蹈史诗《东方红》《中国革命之歌》《复兴之路》

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XBP1 Deficiency in VSMC Contributes to Abdominal Aortic Aneurysm via Regulating VSMC Phenotypic Switching

XBP1 Deficiency in VSMC Contributes to Abdominal Aortic Aneu...

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中国生理学会基质生物学专业委员会成立大会暨第一次全国基质生物学学术会议

作者： guizhen zhao Yi Fu Qingbo Xu Xian Wang Wei Kong Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University

Abdominal aortic aneurysm(AAA) is a life-threatening cardiovascular disease,characterized by chronic vascular wall inflammation,extracellular matrix degradation and apoptosis of vascular smooth muscle *** studies showed that VSMC phenotypic switching may also play an important role in the pathogenesis of AAA.X-box binding protein 1(XBP1),a basic-region leucine zipper(bZIP) transcription factor,involves spliced(XBP1s) and unspliced(XBP1u) isoforms translated from XBP1 pre-mRNA with or without inositol requiring enzyme 1 alpha(BRE1)-mediated splicing *** functions of XBP1s in cardiovascular diseases has been recently ***,little is known about the role of XBP1u,especially in vascular smooth muscle cells(VSMCs).Firstly,SMC contractile proteins and XBP1u were decreased in aneurysmal aorta compared with normal aortic ***,SMC-specific XBP 1 knockout mice were more susceptible to CaP04 and angiotensin Ⅱ(Ang Ⅱ)-induced AAA than littermate wildtype *** vitro experiments revealed that XBP1u silencing reduced VSMC contractile proteins expression,but enhanced Ang Ⅱ-induced MCP-1 and IL-6 expression,indicating that VSMCs displayed a proinflammatory phenotype following XBP1u *** XBP1u deficiency in VSMCs has no significant effect on the expression of SRF,myocardin,MRTF(myocardin-related protein factor),KLF4 and FOXOs,the transcriptional factors related to VSMC phenotypic *** XBP1u overexpression inhibited the interaction between FOXO4 and myocardin,thus promoting the transcriptional activity of *** study indicated that XBP1 deficiency in VSMCs promotes the formation of abdominal aortic aneurysm through regulating the phenotypic switching of VSMCs.

关键词： aortic aneurysm XBP1u FOXO4 VSMC phenotypic modulation

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丙烯腈接枝SBS共聚胶粘剂的研究

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现代化工 1999年第1期19卷 24-25页

作者：孙秋菊赵桂贞段纪东沈阳师范学院化学系

以丙烯腈单体在溶剂中对ＳＢＳ进行接枝共聚，并添加增粘树脂等助剂，研制成的接枝改性ＳＢＳ胶粘剂，具有较高的粘结强度，同时还探讨了单体的含量、引发剂的用量、反应温度和时间以及增粘树脂的用量对胶液性能的影响。

关键词：接枝共聚 SBS 胶粘剂丙烯腈热塑性弹性体

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