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Investigation of the Active Ingredients and Mechanism of Hudi Enteric-coated Capsules in DSS-induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification

Investigation of the Active Ingredients and Mechanism of Hud...

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第十四届全国免疫学学术大会

作者： guiying peng Jiajing Liu Qiuyi Li Peiguang Ma School of life sciences Beijing University of Chinese Medicine

Background:Hudi enteric-coated capsule(HDC) is a Chinese medicine prescribed to treat ulcerative colitis(UC) but its anti-inflammatory active ingredients and mechanism remain *** study aimed to investigate the active ingredients and pathways of HDC and to further explore its potential mechanism in UC by integrating network pharmacology and molecular ***:Dextran sulphate sodium(DSS)-induced colitis murine model was established to validate the efficacy of HDC by detecting disease activity index(DAI) and histopathological *** pharmacological analysis was performed to identify the active compounds and core action targets of HDC in the treatment of *** main chemical compounds in HDC were identified by high-performance liquid chromatography(HPLC).HDC’s core targets of mRNA and protein expression levels in vivo were further approved by using Real-time PCR and Western ***,molecular docking was applied to model the interaction between HDC and target ***:In an in vivo experiment,HDC effectively reduced clinical symptoms of UC,including weight loss,bloody stool,and colon *** severity of colitis was considerably suppressed as evidenced by a reduced DAI.A total of 118 active compounds were screened out from HDC and 69 candidate targets of HDC were identified that were closely related to UC progression via network *** analysis revealed that key targets of HDC were associated with PTGS2,TNF-α,IL-6,and IL-1(3 expression,and they were also enriched in various biological process through JAK2/STAT3 and IL-17 signaling ***’s more,treatment with HDC ameliorated colon inflammation through the JAK2/STAT3 and IL-17 signaling pathways in UC *** docking experiments showed that 9 ingredients of HDC were capable of binding with JAK2,STAT3,IL-17 and IL-6,confirming the inhibitory effect of HDC on JAK2/STAT3 and IL-17 signaling ***:HDC exerted anti-UC effect in a mult

关键词： Hudi enteric-coated capsule Ulcerative colitis Network pharmacology IL-17/JAK2/STAT3 pathway

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Prophylactic treatment of Lacticaseibacillus paracasei K56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation

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Food Science and Human Wellness 2024年

作者： Jiaqi Cui Yanfei Hong Wei-Hsien Liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li Haotian Feng Qiuyue Jiang Weilian Hung guiying peng Department of Immunology and Microbiology， School of Life Sciences， Beijing University of Chinese Medicine Inner Mongolia Yili Industrial Group Co.， Ltd.

Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis. Based on the gut-lung axis theory， probiotic intervention may be a potential strategy for respiratory diseases. Lacticaseibacillus paracasei K56 was reported to regulate gut microbiota in mice. However， its effect on allergic asthma has not been reported. In this study， we investigated the effect of the K56 on ovalbumin-induced asthma and its possible mechanisms. Our results showed that K56 reduced asthma symptoms and inflammatory cell infiltration in the lung of asthmatic mice. And K56 regulated the differentiation of helper T cells in the lung and intestine. Results from 16S rRNA gene sequencing showed that K56 prophylaxis significantly elevated the richness of Akkermansia and Burkholderia. Meanwhile， K56 abrogated the decrease in the levels of short-chain fatty acids (SCFAs) in the feces. In addition， a rebound in the mRNA expression of the SCFA receptors was observed after K56 prophylaxis. Notably， the regulatory T cell (Treg) frequencies and the FFAR3 levels were positively correlated. These results suggest that K56 could attenuate asthma， possibly by modulating the intestinal microbiota and regulating Treg differentiation through SCFA metabolized. Our study showed that K56 may be used as a probiotic to prevent pulmonary inflammation and dysbiosis of the intestinal microbiota in allergic asthma.

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Da Cheng Qi Decoction ameliorates OVA-induced allergic lung inflammation in mice via regulating gut microbial homeostasis

Da Cheng Qi Decoction ameliorates OVA-induced allergic lung ...

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第十二届全国免疫学学术大会

作者： peng guiying Wu Jiajia Liu Zirui Qin Jinbo Wang Yongan Beijing University of Chinese Medicine

This study is to find the biological evidences of "Treating the gut for pulmonary diseases".Twenty C57 BL/6 mice were randomly divided into control group,model group,Da Cheng Qi Decoction group(DCQ) and dexamethasone positive *** asthmatic model was established by *** of OVA plus Al(OH) and *** of *** lung histopathological assessment and differential cell counts of inflammatory cells from BALF was detected by HE and Diff-quick staining *** ratios of Th17/Treg cells from lungs and colons were measured by flow *** composition of intestinal microbiota was analyzed by 16 SrDNA *** was clearly shown that there was plenty of mucus secretion inside the airway and a large number of inflammatory cells infiltrating around the airway in asthma *** Cheng Qi Decoction obviously alleviated the cellular infiltration of the *** asthmatic mice had increasing numbers of Th17 and decreasing Treg both from lungs and colons compared with normal mice(p< 0.01).In DCQ group,this ratios of Th17/Treg has been reversed(p<0.05).16 SrDNA sequencing indicated that total number of bacteria from colons in model group had an obvious decreased(p<0.01).What’s more,the number of Enterobacteriaceae and Enterococcaceae increased(p<0.05),the number of LactobaciUaceae decreased significantly(p<0.05).No significant changes were detected in Bacteroidaceae,Bifidobacteriaceae and *** treatment,the number of Enterobacteriaceae was restored(p<0.05).What’s more,NMDS analysis from 16 S data clearly revealed differentiation in the bacterial communities among different *** data indicated that Da Cheng Qi Decoction has a remarkable therapeutic effect on allergic pulmonary inflammation in mice,which might be caused by regulating gut microbial homeostasis.

关键词： microbiota allergic asthma Th17 Treg

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Tuo Min Ding Chuan Decoction ameliorates OVA-induced allergic lung inflammation in mice via regulating the differentiation of ILC2s in gut and lung

Tuo Min Ding Chuan Decoction ameliorates OVA-induced allergi...

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第十三届全国免疫学学术大会

作者： Yongan Wang Jingbo Qin Zirui Liu Ji Wang Dongyu Ge guiying peng School of Life Sciences Beijing University of Chinese Medicine School of Traditional Chinese Medicine Beijing University of Chinese Medicine

Objective: To find the effect and mechanism of Tuo Min Ding Chuan(TMDC) Decoction on mice with allergic asthma Methods: Twenty Balb/c mice were randomly divided into control group, model group, TMDC Decoction and dexamethasone positive group. Murine asthmatic model was established by i.p. injection of OVA plus Al(OH)3 and i.n. nebulization of OVA. The histopathological assessment and differential cell counts of inflammatory cells from BALF were detected by HE and Diff-quick staining respectively. The amount of ILC2 s from lung and gut was measured by flow ***: It clearly showed that there were plenty of mucus secretion inside the bronchia and a large number of inflammatory cells infiltrating around the bronchia in asthmatic mice. After the treatment of TMDC decoction, inflammatory exudation and mucus secretion was obviously alleviated in the lung from asthmatic mice(p<0.05). It’s worth noting that inflammatory cells were simultaneously infiltrated in intestinal lamina propria in model mice. What’s more, both of the amounts of ILC2 from pulmonary and intestinal tissues were increased significantly in asthmatic mice, compared to control(p<0.01). TMDC decoction not only inhibited the inflammation of lung and intestine tissues, but also decreased the numbers of ILC2 from lung and gut of asthmatic mice(p<0.05).Conclusion: Our data indicated that murine allergic asthma model induced by OVA shows immune damage in both lung and intestine while Tuo Min Ding Chuan decoction has a remarkable effect probably through regulating the differentiation of ILC2 s from gut in asthmatic mice.

关键词： ILC2s Allergic asthma Tuo Min Ding Chuan Decoction

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儿童支气管哮喘发病的危险因素分析

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中国医药科学 2014年第8期4卷 191-193页

作者：彭桂英深圳罗湖区妇幼保健院广东深圳518000

目的探讨儿童支气管哮喘发病的危险因素。方法选取就诊于我院的儿童支气管患儿176例纳入哮喘组,同时选取同期正常儿童176例纳入正常组。首先采用SPSS17.0作单因素分析可能引起儿童支气管哮喘的发病因素17项,筛选出P<0.05的单因素作Logis... 详细信息

目的探讨儿童支气管哮喘发病的危险因素。方法选取就诊于我院的儿童支气管患儿176例纳入哮喘组,同时选取同期正常儿童176例纳入正常组。首先采用SPSS17.0作单因素分析可能引起儿童支气管哮喘的发病因素17项,筛选出P<0.05的单因素作Logistic回归模型的自变量,作多因素分析,得出影响儿童支气管哮喘的高危因素。结果经单因素分析结果显示,影响儿童支气管哮喘的单因素共有10项,且P<0.05,与正常组对比具有统计学意义。Logistic多因素回归分析结果显示,影响儿童支气管哮喘的高危因素为呼吸道感染、家族哮喘史、未补充鱼肝油、家人吸烟,且母乳喂养是哮喘的保护因素。结论积极预防儿童哮喘的高危因素,提高保护意识,对于预防和控制儿童哮喘具有重要意义。

关键词：儿童支气管哮喘危险因素多因素分析

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综合护理干预对肾病综合征患者服用激素治疗依从性的作用

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中国继续医学教育 2018年第22期10卷 176-178页

作者：彭桂英江苏省徐州市第六人民医院血液净化科江苏徐州221006

目的探讨综合护理干预对肾病综合征患者服用激素治疗依从性的影响作用。方法选取2016年1月—2017年12月在我院治疗的肾病综合征患者100例作为研究对象,将其随机将其分为观察组和对照组,每组均50例。对照组实施常规护理,观察组给予综合... 详细信息

目的探讨综合护理干预对肾病综合征患者服用激素治疗依从性的影响作用。方法选取2016年1月—2017年12月在我院治疗的肾病综合征患者100例作为研究对象,将其随机将其分为观察组和对照组,每组均50例。对照组实施常规护理,观察组给予综合护理干预。结果观察组患者的临床治疗依从性为96.00%,高于对照组患者的68.00%,组间比较,差异具有统计学意义(P<0.05)。观察组患者的疾病总缓解率为94.00%,高于对照组患者的76.00%,组间比较,差异具有统计学意义(P<0.05)。结论综合护理干预能够显著提高肾病综合征患者激素治疗依从性,从而促使其临床疗效得到提升。

关键词：综合护理干预肾病综合征激素治疗依从性疗效影响作用

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植物源正辛酸的抑藻效应及其机制

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卫生研究 2016年第2期45卷 189-193,199页

作者：陈永玲彭桂莹韩玉珍张庭廷安徽师范大学生命科学学院生物环境与生态安全安徽省高校重点实验室安徽省皖江城市带退化生态系统的恢复与重建协同创新中心芜湖241000

目的研究从椰子油中提取的植物源正辛酸对铜绿微囊藻(Microcystis aeruginosa)的抑制效应及其机制。方法分别采用0、12.5、25、50和100μL/L的椰油正辛酸对铜绿微囊藻进行胁迫处理,测定其藻密度变化、细胞通透性改变以及藻细胞抗氧化能... 详细信息

目的研究从椰子油中提取的植物源正辛酸对铜绿微囊藻(Microcystis aeruginosa)的抑制效应及其机制。方法分别采用0、12.5、25、50和100μL/L的椰油正辛酸对铜绿微囊藻进行胁迫处理,测定其藻密度变化、细胞通透性改变以及藻细胞抗氧化能力的变化。结果随着椰油正辛酸浓度的增加,铜绿微囊藻生长受抑现象越明显。当椰油正辛酸浓度为100μL/L,处理时间为96 h时,其对铜绿微囊藻的抑制率达到99%。与对照组相比,实验组藻液的电导率、核酸含量、蛋白质含量明显升高;椰油浓度低于25μL/L时,SOD活性随椰油正辛酸浓度的增加而增强,但超过25μL/L时,其活性明显减弱。MDA含量始终随着椰油正辛酸浓度的增加而增加。结论椰油正辛酸对铜绿微囊藻具有明显的抑制作用,主要与其改变了细胞膜通透性、降低了抗氧化能力有关。

关键词：椰油正辛酸铜绿微囊藻抑制效应

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妊娠期合并沙眼衣原体感染对新生儿肺炎发病率的影响及睡眠质量分析

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世界睡眠医学杂志 2021年第6期8卷 1022-1023页

作者：彭桂英李月凤广东省深圳市罗湖区妇幼保健院儿科深圳518000

目的:探讨妊娠期合并沙眼衣原体感染对新生儿肺炎发病率的影响,及患儿睡眠质量分析。方法:选取2018年4月至2020年12月广东省深圳市罗湖区妇幼保健院儿科收治的孕妇7000例、新生儿及儿科采集标本3000例作为研究对象,利用聚合酶链反应检... 详细信息

目的:探讨妊娠期合并沙眼衣原体感染对新生儿肺炎发病率的影响,及患儿睡眠质量分析。方法:选取2018年4月至2020年12月广东省深圳市罗湖区妇幼保健院儿科收治的孕妇7000例、新生儿及儿科采集标本3000例作为研究对象,利用聚合酶链反应检测结果分析孕妇是否沙眼衣原体感染,新生儿是否因母体沙眼衣原体感染,发生肺炎,以及发生肺炎的新生儿睡眠质量状况。结果:孕妇衣原体感染例数为75例,新生儿肺炎例数为16例,其中因母体沙眼衣原体感染导致新生儿肺炎例数为3例。结论:妊娠期合并沙眼衣原体感染会导致新生儿发生肺炎,并降低患儿的睡眠质量。

关键词：妊娠期沙眼衣原体感染新生儿肺炎睡眠质量

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医学院校非医学专业医学免疫学与微生物学课程的教学实践

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卫生职业教育 2022年第8期40卷 65-66页

作者：王晴彭桂英曾郁敏北京中医药大学生命科学学院北京100029

分析医学免疫学与微生物学课程当前教学中存在的问题,并结合教研室教学提出教学改革措施,旨在优化课程体系和评价方法,提高课程教学质量,增强非医专业学生对免疫学与微生物学的学习兴趣,为学生更好地从事与医学相关工作积淀丰富的知识... 详细信息

分析医学免疫学与微生物学课程当前教学中存在的问题,并结合教研室教学提出教学改革措施,旨在优化课程体系和评价方法,提高课程教学质量,增强非医专业学生对免疫学与微生物学的学习兴趣,为学生更好地从事与医学相关工作积淀丰富的知识储备。

关键词：非医学专业医学免疫学与微生物学教学实践

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3种乳制品对低免疫力模型斑马鱼免疫功能的影响

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食品科学 2022年第11期43卷 113-120页

作者：史珅李昊虬王龙李楠谭圣杰刘华彭桂英李亚兰张冲 FENG HAOTIAN 内蒙古乳业技术研究院有限责任公司内蒙古呼和浩特010110 内蒙古伊利实业集团股份有限公司内蒙古呼和浩特010110 北京中医药大学生命科学学院北京100029

目的:研究3种乳制品对长春瑞滨(一种半合成的长春花生物碱)诱导的低免疫力斑马鱼免疫功能的调节作用。方法:分别给斑马鱼静脉注射0.2 mg/mL酒石酸长春瑞滨注射液诱导低免疫力模型,按照随机法将斑马鱼随机分为正常对照组、模型对照组、... 详细信息

目的:研究3种乳制品对长春瑞滨(一种半合成的长春花生物碱)诱导的低免疫力斑马鱼免疫功能的调节作用。方法:分别给斑马鱼静脉注射0.2 mg/mL酒石酸长春瑞滨注射液诱导低免疫力模型,按照随机法将斑马鱼随机分为正常对照组、模型对照组、低温酸奶组(8333μg/mL)、常温纯牛奶组(70.4μL/mL)、冷冻酸奶冰淇淋组(33333μg/mL),每组30尾。利用荧光显微镜观察并分析3种乳制品对低免疫力斑马鱼的巨噬细胞数量、巨噬细胞吞噬功能,以及T淋巴细胞数量的影响。结果:与正常对照组比较,模型对照组巨噬细胞数量显著降低、巨噬细胞吞噬功能减弱、T细胞数量高度显著降低(P0.05);冷冻酸奶冰淇淋组巨噬细胞数量、T淋巴细胞数量、巨噬细胞吞噬功能均无显著性差异(P>0.05)。结论:低温酸奶、常温纯牛奶和冷冻酸奶冰淇淋可以通过增加巨噬细胞、T淋巴细胞的数量,改善巨噬细胞的吞噬能力,从而提高长春瑞滨诱发的低免疫力斑马鱼的免疫功能。

关键词：乳制品免疫功能巨噬细胞 T细胞

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