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Parametric analysis of craniocerebral injury mechanism in pedestrian trafficaccidents based on finite element methods

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Chinese Journal of Traumatology 2024年第4期27卷 187-199页

作者： Jin-Ming Wang zheng-Dong Li Chang-Sheng Cai Ying Fan Xin-Biao Liao Fu Zhang Jian-Hua Zhang Dong-Hua Zou Academy of Forensic Science Shanghai Key Laboratory of Forensic MedicineKey Laboratory of Forensic ScienceMinistry of JusticeShanghai Forensic Service PlatformShanghai200063China School of Forensic Medicine Guizhou Medical UniversityGuiyang550004China Key Laboratory of Forensic Pathology Ministry of Public Security PR ChinaGuangzhou510050China

Purpose:The toughest challenge in pedestrian traffic accident identification lies in ascertaining *** study aimed to systematically simulate and parameterize 3 types of craniocerebral injuryincluding impact injury,fall injury,and run-over injury,to compare the injury response outcomes ofdifferent injury ***:Based on the total human model for safety(THUMS)and its enhanced human model THUMShollow structures,a total of 84 simulations with 3 injury manners,different loading directions,andloading velocities were *** Mises stress,intracranial pressure,maximum principal strain,cumulative strain damage measure,shear stress,and cranial strain were employed to analyze the injuryresponse of all areas of the *** examine the association between injury conditions and injuryconsequences,correlation analysis,principal component analysis,linear regression,and stepwise linearregression were ***:There is a significant correlation observed between each criterion of skull and brain injury(p40 km/h),the Von Mises stress on the skull waswith a high possibility exceed the threshold for skull fracture(100 MPa).When falling and makingtemporal and occipital contact with the ground,the opposite side of the impacted area experienceshigher frequency stress concentration than contact at other ***-over injuries tend to have amore comprehensive craniocerebral injury,with greater overall deformation due to more adequate kinetic energy *** mean value of maximum principal strain of brain and Von Mises stress ofcranium at run-over condition are 1.39 and 403.8 MPa,while they were 1.31,94.11 MPa and 0.64,120.5 MPa for the impact and fall conditions,*** impact velocity also plays a significant rolein craniocerebral injury in impact and fall loading conditions(the p

关键词： Craniocerebral injury Finite element Injury mechanism Traffic accident Biomechanism Forensic practice

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钢厂CCPP发电机组提升负荷的研究与应用

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鞍钢技术 2024年第1期 37-41页

作者：郑振海张元华张明扬薛贵洋鞍钢股份有限公司鲅鱼圈钢铁分公司辽宁营口115007

为了提高CCPP发电机组负荷,根据不同环境温度采取不同的煤气热值,夏季利用空气冷却器降低空压机入口空气温度,采用水喷射系统降低燃气轮机入口燃料温度,上述措施实施后,能够降低燃烧温度,提高CCPP发电机组负荷。

关键词： CCPP发电机组负荷煤气热值空气冷却器水喷射

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Convolution-Transformer for Image Feature Extraction

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 87-106页

作者： Lirong Yin Lei Wang Siyu Lu Ruiyang Wang Youshuai Yang Bo Yang Shan Liu Ahmed AlSanad Salman A.AlQahtani zhengtong Yin Xiaolu Li Xiaobing Chen Wenfeng zheng Department of Geography and Anthropology Louisiana State UniversityBaton RougeLA70803USA School of Automation University of Electronic Science and Technology of ChinaChengdu610054China College of Computer and Information Sciences King Saud UniversityRiyadh11574Saudi Arabia College of Resources and Environmental Engineering Key Laboratory of Karst Georesources and Environment(Guizhou University)Ministry of EducationGuiyang550025China School of Geographical Sciences Southwest UniversityChongqing400715China School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA70803USA

This study addresses the limitations of Transformer models in image feature extraction,particularly their lack of inductive bias for visual *** to Convolutional Neural Networks(CNNs),the Transformers are more sensitive to different hyperparameters of optimizers,which leads to a lack of stability and slow *** tackle these challenges,we propose the Convolution-based Efficient Transformer Image Feature Extraction Network(CEFormer)as an enhancement of the Transformer *** model incorporates E-Attention,depthwise separable convolution,and dilated convolution to introduce crucial inductive biases,such as translation invariance,locality,and scale invariance,into the Transformer ***,we implement a lightweight convolution module to process the input images,resulting in faster convergence and improved *** results in an efficient convolution combined Transformer image feature extraction *** results on the ImageNet1k Top-1 dataset demonstrate that the proposed network achieves better accuracy while maintaining high computational *** achieves up to 85.0%accuracy across various model sizes on image classification,outperforming various baseline *** integrated into the Mask Region-ConvolutionalNeuralNetwork(R-CNN)framework as a backbone network,CEFormer outperforms other models and achieves the highest mean Average Precision(mAP)*** research presents a significant advancement in Transformer-based image feature extraction,balancing performance and computational efficiency.

关键词： Transformer E-Attention depth convolution dilated convolution CEFormer

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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iTRAQ-based proteomics reveals the mechanism of action of Yinlai decoction in treating pneumonia in mice consuming a high-calorie diet

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 21-32页

作者： Qianqian Li Tiegang Liu Chen Bai Xueyan Ma Hui Liu Zi’an zheng Yuxiang Wan He Yu Yuling Ma Xiaohong Gu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Institute of Chinese Medicine Epidemic Disease Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025China Department of Acupuncture and Mini-invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China OCMRC Center University of OxfordOxford OX13PTUnited Kingdom

Objective:To uncover the underlying mechanisms of action of the Yinlai decoction on high-calorie dietinduced pneumonia through proteomics ***:Based on the Gene Expression Omnibus(GEO)database,lung tissue samples from normal and high-fat diet(HFD)fed mice in the GSE16377 dataset were selected as test cohorts to identify differentially expressed genes and conduct bioinformatics *** the animal experiments,mice were randomly divided into the control(N),high-calorie diet pneumonia(M),and Yinlai decoction treatment(Y)*** in the M group received high-calorie feed and a 0.5 mg/mL lipopolysaccharide solution spray for 30 min for 3 *** mice in the Y group were intragastrically administered 2 mL/10 g Yinlai decoction twice daily for 3 *** evaluation of the lung tissue was *** expressed proteins(DEPs)in the lung tissue were identified using quantitative proteomics and bioinformatics *** drug-target relationships between Yinlai decoction and core DEPs in the lung tissue were verified using AutoDock Vina and Molecular Graphics Laboratory(MGL)*** were verified by western ***:GEO data mining showed that an HFD altered oxidative phosphorylation in mouse lung *** Yinlai decoction alleviated pathological damage to lung tissue and pneumonia in mice that were fed a high-calorie diet.A total of 47 DEPs were identified between the Y and M *** analysis revealed their association with energy metabolism pathways such as the tricarboxylic acid cycle(TCA)and oxidative *** protein-protein interaction network revealed that Atp5a1,Pdha1,and Sdha were the target proteins mediating the therapeutic effects of Yinlai *** docking results suggested that the mechanism of the therapeutic effect of Yinlai decoction involves the binding of brassinolide,praeruptorin B,chrysoeriol,and other components in Yinlai decoction to ***:The Yinlai decoction allevia

关键词： Yinlai decoction High-calorie diet Pneumonia iTRAQ proteomics Energy metabolism

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Critical behavior and Joule-Thomson expansion of charged AdS black holes surrounded by exotic fluid with modified Chaplygin equation of state

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Chinese Physics C 2024年第6期48卷 179-190页

作者：张梦瑶陈浩 Hassan Hassanabad 隆正文杨辉 School of Mathematics and Statistics Guizhou UniversityGuiyang 550025China School of Physics and Electronic Science Zunyi Normal UniversityZunyi 563006China Faculty of Physics Shahrood University of TechnologyShahroodIran Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia College of Physics Guizhou UniversityGuiyang 550025China

By considering the concept of a unified single fluid model,referred to as modified Chaplygin gas(MCG),which amalgamates dark energy and dark matter,we explore the thermodynamic characteristics of charged anti-de Sitter(AdS)black holes existing in an unconventional fluid accompanied by *** accomplish this objective,we derive the equations of state by regarding the charge Q^(2) as a thermodynamic *** effects of MCG parameters on the critical thermodynamic quantities(ψ_(c),T_(c),Q_(c)^(2))are examined,followed by a detailed analysis of the Q^(2)-ψ *** provide a clearer explanation of the phase transition,we present an analysis of the Gibbs free *** is important to note that if the Hawking temperature exceeds the critical temperature,a distinct pattern is observed known as swallowtail *** indicates that the system undergoes a first-order phase transition from a smaller black hole to a larger *** critical exponent of the system is found to be in complete agreement with that of the van der Waals fluid ***,we investigate the impact of MCG parameters and black hole charge on Joule-Thomson(J-T)expansion in the extended phase *** J-T coefficient is examined to pinpoint the exact region experiencing cooling or heating,and the observation reveals that the presence of negative heat capacity results in the occurrence of a cooling *** impact of MCG on the inversion curve of charged black holes exhibits a striking resemblance to that observed in most multi-dimensional black hole *** addition,it is worth noting that certain parameters exert a significant influence on the ratio T_(min)/*** specific values of the MCG parameters,the ratio is consistent with the charged AdS black *** parametersγandβhave a non-negligible effect on the isenthalpic curve.

关键词： black hole dark matter dark energy phase transition Joule-Thomson expansion

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Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

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Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li Ruiqiang Ye Wenzhen Chen Yuqing Huang Yue Yuan Yi Zhang Huayi Hu Peng zheng Zhongming Fang Zeng Tao Shiyong Song Ronghui Pan Jian Zhang Jumim Tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang University Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-MAF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3 at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

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基于自监督与蒸馏约束的正则化类增量学习方法

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计算机辅助设计与图形学学报 2024年第5期36卷 775-785页

作者：徐岸吴永明郑洋贵州大学公共大数据国家重点实验室贵阳550025 贵州大学现代制造教育部重点实验室贵阳550025

针对神经网络模型在增量学习中存在灾难性遗忘问题,提出一种基于自监督与隐层蒸馏约束的正则化类增量学习方法,包括自监督伪标签预测、隐层蒸馏约束和参数正则化.首先基于贝叶斯和信息论提出一种对模型参数重要性评价的正则化策略;然后... 详细信息

针对神经网络模型在增量学习中存在灾难性遗忘问题,提出一种基于自监督与隐层蒸馏约束的正则化类增量学习方法,包括自监督伪标签预测、隐层蒸馏约束和参数正则化.首先基于贝叶斯和信息论提出一种对模型参数重要性评价的正则化策略;然后利用自监督伪标签预测增强模型的表征能力,并保留隐层特征,通过加入高斯噪声提高隐层特征的泛化能力;最后使用蒸馏约束方法与交叉熵分类损失对历史任务的隐层特征与输出层特征进行训练.在CIFAR-10和CIFAR-100数据集上的实验结果表明,所提方法取得较好的效果,其中,在CIFAR-100数据集上的平均准确率和遗忘率分别达到64.16%和15.95%;该方法能够有效地减少灾难性遗忘的影响.

关键词：增量学习正则化知识蒸馏自监督伪标签预测

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Efficient DIPA-CRISPR-mediated knockout of an eye pigment gene in the white-backed planthopper,Sogatella furcifera

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Insect Science 2024年第4期31卷 1015-1025页

作者： Meng-Qi Zhang Lang-Lang Gong Ya-Qin Zhao Yun-Feng Ma Gui-Jun Long Huan Guo Xuan-zheng Liu J.Joe Hull Youssef Dewer Chao Yang Ning-Ning Zhang Ming He Peng He National Key Laboratory of Green Pesticides Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyangChina Pest Management and Biocontrol Research Unit US Arid Land Agricultural Research CenterUSDA Agricultural Research ServicesMaricopaArizonaUSA Phytotoxicity Research Department Central Agricultural Pesticide LaboratoryAgricultural Research CenterDokkiGizaEgypt Guizhou Jifeng Seed Industry Limited Liability Company XingyiGuizhou ProvinceChina Shandong Facility Horticulture Bioengineering Research Center Weifang University of Science and TechnologyWeifangShandong ProvinceChina

Although CRISPR/Cas9 has been widely used in insect gene editing,the need for the microinjection of preblastoderm embryos can preclude the technique being used in insect species with eggs that are small,have hard shells,and/or are difficult to collect and maintain outside of their normal *** is the case with Sogatella furcifera,the white-backed planthopper(WBPH),a significant pest of Oryza sativa(rice)that oviposits inside rice *** extraction from the stem runs the risk of mechanical damage and hatching is heavily influenced by the micro-environment of the rice *** bypass these issues,we targeted embryos prior to oviposition via direct parental(DIPA)-CRISPR,in which Cas9 and single-guide RNAs(sgRNAs)for the WBPH eye pigment gene tryptophan 2,3-dioxygenase were injected into the hemocoel of adult *** at varying numbers of days posteclosion were evaluated to determine at what stage their oocyte might be most capable of taking up the gene-editing *** evaluation of the offspring indicated that the highest G0 gene-edited efficacy(56.7%)occurred in females injected 2 d posteclosion,and that those mutations were heritably transmitted to the G1 *** study demonstrates the potential utility of DIPA-CRISPR for future gene-editing studies in non-model insect species and can facilitate the development of novel pest management applications.

关键词： CRISPR/Cas9 DIPA-CRISPR gene editing tryptophan 2,3-dioxygenase WBPH

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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