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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： guixin li Danli Yang Xin liu Ting Zhang Hui liu Jun Zou Zimeng Xu Xiangmei Chen lizhong Dai Hongsong Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg Institute DoylestownPA18901USA Shenzhen Sanyuansheng Biotechnology Co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure Biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative status.However,the replicative capacity of HBV with PC/BCP mutations remains ambiguous.Herein,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the mutation.Both PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse models.In human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic core protein accumulation.Mechanistically,preC RNA harboring PC mutation could serve as mRNA to express core and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative status.Additionally,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric mice.This study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepatitis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress

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Structural Engineering of Anode Materials for Low-Temperature lithium-Ion Batteries:Mechanisms,Strategies,and Prospects

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Nano-Micro Letters 2024年第8期16卷 169-195页

作者： Guan Wang guixin Wang linfeng Fei lina Zhao Haitao Zhang Beijing Key Laboratory of Ionic liquids Clean Process Institute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Chemical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Energy Materials and Chemical Engineering Hefei UniversityHefei 230601People’s Republic of China School of Materials Science and Engineering Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Polymer and Catalyst Synthesis Technology of liaoning Province School of Environmental and Chemical EngineeringShenyang University of TechnologyShenyang 110870People’s Republic of China

The severe degradation of electrochemical performance for lithium-ion batteries(liBs)at low temperatures poses a significant challenge to their practical applications.Consequently,extensive efforts have been contributed to explore novel anode materials with high electronic conductivity and rapid li^(+)diffusion kinetics for achieving favorable low-temperature performance of liBs.Herein,we try to review the recent reports on the synthesis and characterizations of low-temperature anode materials.First,we summarize the underlying mechanisms responsible for the performance degradation of anode materials at subzero temperatures.Second,detailed discussions concerning the key pathways(boosting electronic conductivity,enhancing li^(+)diffusion kinetics,and inhibiting lithium dendrite)for improving the low-temperature performance of anode materials are presented.Third,several commonly used low-temperature anode materials are briefly introduced.Fourth,recent progress in the engineering of these low-temperature anode materials is summarized in terms of structural design,morphology control,surface&interface modifications,and multiphase materials.Finally,the challenges that remain to be solved in the field of low-temperature anode materials are discussed.This review was organized to offer valuable insights and guidance for next-generation liBs with excellent low-temperature electrochemical performance.

关键词： Low-temperature performance Anode materials Microstructural regulations Surface modifications

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Optical metasurfaces:fundamentals and applications

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Photonics Research 2023年第5期11卷 I0004-I0006页

作者： THOMAS PERTSCH SHUMIN XIAO ARKA MAJUMDAR guixin li Friedrich-Schiller-Universität Jena 07737 JenaGermany Harbin Institute of Technology(Shenzhen) Shenzhen 518055China University of Washington SeattleWashington 98195USA Southern University of Science and Technology Shenzhen 518055China

Optical metasurfaces are currently an important research area all around the world because of their wide application opportunities in imaging,wavefront engineering,nonlinear optics,quantum information processing,just to name a few.The feature issue“Optical Metasurfaces:Fundamentals and Applications”in Photonics Research allows for archival publication of the most recent works in optical metasurface and provides for broad dissemination in the photonics community.

关键词： surfaces optics quantum

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Influence of Mass Ratio of Resin and Stabilizer on Mechanical Properties of Mo Fiber-reinforced Granite Polymer Composite

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 912-920页

作者：张超任秀华 BA Dongzhe ZHANG Jianhua li Jianyong GUO Mengnan GAO Yinghao WANG guixin li Jiayang School of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan 250101China Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of Education of ChinaSchool of Mechanical EngineeringShandong UniversityJinan 250061China

Because inferior mechanical strength of granite polymer composite(GPC)has become the main drawback limiting its application and popularization,Mo fibers were added into(GPC)to improve its mechanical strength.Mechanical properties of matrix materials with different mass ratio of resin and stabilizer(MRRS)were investigated systematically.The influences of MRRS on interface bonding strength of Mo fiber-matrix,wettability and mechanical strength of GPC were discussed,respectively,and the theoretical calculation result of MRRS k was obtained,with the optimal value of k=4.When k=4,tensile strength,tensile strain and fracture stress of the cured resin achieve the maximum values.But for k=7,the corresponding values reach the minimum.With the increase of MRRS k,surface free energy of the cured resin first increases and then decreases,while contact angles between Mo sample and matrix have displayed the opposite trend.Wettability of resin to Mo fiber is the best at k=4.Pulling load of Mo fiber and interface bonding strength appear the maximum at k=4,followed by k=5,k=3 the third,and k=7 the minimum.When k=4,mechanical properties of Mo fiber-reinforced GPC are optimal,which is consistent with the result of theoretical calculation.This study is of great significance to get better component formulas of Mo fiber reinforced GPC and to improve its application in machine tools.

关键词： polymer composite fiber mechanical strength interface bonding

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Thermal energy dependent transient permittivity of epsilon-near-zero material

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 96-101页

作者： Heng Wang lixun Sun Kang Du Wending Zhang SooJin Chua guixin li Ting Mei MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an710129China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China Department of Electrical and Computer Engineering National University of SingaporeSingapore117583Singapore LEES Program Singapore-MIT Alliance for Research&Technology(SMART)Singapore138602Singapore

Transparent conductive oxides exhibit attractive optical nonlinearity with ultrafast response and giant refractive index change near the epsilon-near-zero(ENZ) wavelength, originating from the intraband dynamics of conduction electrons. The optical nonlinearity of ENZ materials has been explained by using the overall-effective-mass and the overall-scattering-time of electrons in the extended Drude model. However, their response to optical excitation is yet the last building block to complete the theory. In this paper, the concept of thermal energy is theoretically proposed to account for the total energy of conduction electrons exceeding their thermal equilibrium value. The time-varying thermal energy is adopted to describe the transient optical response of indium-tin-oxide(ITO), a typical ENZ material. A spectrally-resolved femtosecond pump-probe experiment was conducted to verify our theory. By correlating the thermal energy with the pumping density, both the giant change and the transient response of the permittivity of ITO can be predicted. The results in this work provide a new methodology to describe the transient permittivities of ENZ materials, which will benefit the design of ENZ-based nonlinear photonic devices.

关键词： epsilon-near-zero optical nonlinearity transient response thermal energy hot electron indium tin oxide

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Achromatic metasurface lens at visible wavelengths

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Science Bulletin 2018年第6期63卷 333-335页

作者： guixin li Department of Materials Science and Engineering Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology

Lenses,such as optical lens,electron lens,acoustic lens and so on,are devices that can focus waves to form an image.Since the invention of telescopes and objectives,optical lenses play important roles in observing objects from molecular to astronomical levels,and high-resolution lithography using optical,electron or X-ray beams.To improve the imaging quality,usually,the

关键词：电子透镜无色波长平版印刷术高分辨率成像质量望远镜

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Optical Orbital Angular Momentum: Thirty Years and Counting

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Advanced Photonics 2023年第3期5卷 22-22页

作者： guixin li Junsuk Rho Xiao-Cong Yuan Southern University of Science and Technology Shenzhen China Pohang University of Science and Technology(POSTECH)POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang Republic of Korea Shenzhen University College of Optoelectronics Nanophotonics Research Center ShenzhenChina

In 1992,Professor Allen’s paper published in Physical Review A indi-cated that laser light with a Laguerre-Gaussian amplitude distribution has an orbital angular momentum(OAM).Since then,conceptual stud-ies on OAM of photons have been attracting continual attention in physics and optics communities.In recent years,we have witnessed the birth and fast development of many break-through technologies driven by the concept of OAM,from advanced light-field manipulation to super-resolution imaging,classical and quantum optical communi-cations,and many others.

关键词： OAM Orbital attracting

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Gigantic electric-field-induced second harmonic generation from an organic conjugated polymer enhanced by a band-edge effect

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light(Science & Applications) 2019年第1期8卷 1006-1011页

作者： Shumei Chen King Fai li guixin li Kok Wai Cheah Shuang Zhang School of Physics and Astronomy University of BirminghamBirmingham B152TTUK Department of Materials Science and Engineering Shenzhen Institute for Quantum Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Department of Physics Hong Kong Baptist UniversityKowloon TongHong KongChina

Electric-field-induced second harmonic generation(EFISH),a third-order nonlinear process,arises from the interaction between the electric field of an external bias and that of two incident photons.EFISH can be used to dynamically control the nonlinear optical response of materials and is therefore promising for active nonlinear devices.However,it has been challenging to achieve a strong modulation with EFISH in conventional nonlinear materials.Here,we report a large tunability of an EFISH signal from a subwavelength-thick polymer film sandwiched between a transparent electrode and a metallic mirror.By exploiting the band-edge-enhanced third-order nonlinear susceptibility of the organic conjugated polymer,we successfully demonstrate a gigantic EFISH effect with a modulation ratio up to 422%V^(−1) at a pumping wavelength of 840 nm.The band-edge-enhanced EFISH opens new avenues for modulating the intensity of SHG signals and for controlling nonlinear electro-optic interactions in nanophotonic devices.

关键词： nonlinear harmonic conjugated

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Large-scale achromatic flat lens by light frequency-domain coherence optimization

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light(Science & Applications) 2022年第12期11卷 2900-2908页

作者： Xingjian Xiao Yunwei Zhao Xin Ye Chen Chen Xinmou Lu Yansen Rong Junhong Deng guixin li Shining Zhu Tao li National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationsJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Flat lenses,including metalens and diffractive lens,have attracted increasing attention due to their ability to miniaturize the imaging devices.However,realizing a large scale achromatic flat lens with high performance still remains a big challenge.Here,we developed a new framework in designing achromatic multi-level diffractive lenses by light coherence optimization,which enables the implementation of large-scale flat lenses under non-ideal conditions.As results,a series achromatic polymer lenses with diameter from 1 to 10mm are successfully designed and fabricated.The subsequent optical characterizations substantially validate our theoretical framework and show relatively good performance of the centimeter-scale achromatic multi-level diffractive lenses with a super broad bandwidth in optical wavelengths(400-1100 nm).After comparing with conventional refractive lens,this achromatic lens shows significant advantages in white-light imaging performance,implying a new strategy in developing practical planar optical devices.

关键词： conditions chromatic optimization

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Reversible switching of electromagnetically induced transparency in phase change metasurfaces

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Advanced Photonics 2020年第5期2卷 74-83页

作者： libang Mao Yang li guixin li Shuang Zhang Tun Cao Dalian University of Technology School of Optoelectronic Engineering and Instrumentation ScienceDalianChina Southern University of Science and Technology Department of Materials Science and EngineeringShenzhenChina University of Birmingham School of Physics and AstronomyBirminghamUnited Kingdom

Metasurface analogue of the phenomenon of electromagnetically induced transparency(EIT)that is originally observed in atomic gases offers diverse applications for new photonic components such as nonlinear optical units,slow-light devices,and biosensors.The development of functional integrated photonic devices requires an active control of EIT in metasurfaces.We demonstrate a reversible switching of the metasurface-induced transparency in the near-infrared region by incorporating a nonvolatile phase change material,Ge2Sb2Te5,into the metasurface design.This leads to an ultrafast reconfigurable transparency window under an excitation of a nanosecond pulsed laser.The measurement agrees well with both theoretical calculation and finite-difference time-domain numerical simulation.Our work paves the way for dynamic metasurface devices such as reconfigurable slow light and biosensing.

关键词： metasurfaces electromagnetically induced transparency surface plasmon resonance reconfigurable phase change material

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