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Design and Manufacture of Bionic Porous Titanium Alloy Spinal Implant Based on Selective Laser Melting(SLM)

Computer Modeling in Engineering & Sciences 2020年第9期124卷 1099-1117页

作者： Xiaojun Chen Di wang Wenhao Dou Yimeng wang Yongqiang Yang Jianhua wang Jie Chen School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510641China Hospital of Orthopedics Guangzhou General Hospital of Guangzhou Military CommandGuangzhou510010China

In order to meet the clinical requirements of spine surgery,this paper proposed the exploratory research of computer-aided design and selective laser melting(SLM)fabrication of a bionic porous titanium spine *** structural design of the spinal implant is based on CT scanning data to ensure correct matching,and the mechanical properties of the implant are verified by simulation analysis and laser selective melting *** surface roughness of the spinal implant manufactured by SLM without post-processing is Ra 15μm,and the implant is precisely jointed with the photosensitive resin model of the upper and lower *** surface micro-hardness of the implant is HV 373,tensile strengthσ_(b)=1238.7 MPa,yield strengthσ_(0.2)=1043.9 MPa,the elongation is 6.43%,and the compressive strength of porous structure under 84.60%porosity is 184.09 MPa,which can meet the requirements of the reconstruction of stable *** with the traditional implant and intervertebral fusion cage,the bionic porous spinal implant has the advantages of accurate fit,porous bionic structure and recovery of patients,and the ion release experiment proved that implants manufactured by SLM are more suitable for clinical application after certain *** elastic modulus of the sample is improved after heat treatment,mainly because the microstructure of the sample changes fromα’phase toα+βdual-phase after heat *** addition,the design of high-quality bionic porous spinal implants still needs to be optimized for the actual needs of doctors.

关键词： Selective laser melting(SLM) titanium spinal implant bionic porous

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MOLTEN SALT PHASE DIAGRAMS CALCULATION USING ARTIFICIAL NEURAL NETWORK OR PATTERN RECOGNITION-BOND PARAMETERS PART *** OF LIQUIDUS TEMPERATURE AND EXPERT SYSTEM

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中国有色金属学会会刊：英文版 1998年第3期8卷 150-154页

作者： wang, Xueye Qiu, Guanzhou wang, Dianzuo Li, Chonghe Chen, Nianyi Central South Univ of Technology Changsha China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｅｘｐｅｒｉｍｅｎｔａｌｄａｔａｏｎｔｈｅｌｉｑｕｉｄｕｓｌｉｎｅｓｏｒｓｕｒｆａｃｅｓｉｎｂｉｎａｒｙｏｒｔｅｒｎａｒｙｓｙｓｔｅｍｓｆｒｏｍｒｅｆｅｒｅｎｃｅｓａｒｅａｌｗａｙｓ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｅｘｐｅｒｉｍｅｎｔａｌｄａｔａｏｎｔｈｅｌｉｑｕｉｄｕｓｌｉｎｅｓｏｒｓｕｒｆａｃｅｓｉｎｂｉｎａｒｙｏｒｔｅｒｎａｒｙｓｙｓｔｅｍｓｆｒｏｍｒｅｆｅｒｅｎｃｅｓａｒｅａｌｗａｙｓｆｉｎｉｔｅ．Ｓｏｍｅｔｉｍｅｓｔ...

关键词： phase diagram calculation artificial neural network bond parameter molten salt system expert system

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The combination of DNA methylation and positive regulation of anthocyanin biosynthesis by MYB and bHLH transcription factors contributes to the petal blotch formation in Xibei tree peony

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Horticulture Research 2023年第7期10卷 69-86页

作者： Jin Zhu Yizhou wang Qianyu wang Bing Li Xiaohan wang Xian Zhou Hechen Zhang Wenzhong Xu Shanshan Li Liangsheng wang Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093 China University of Chinese Academy of Sciences Beijing 100049China Horticulture Research Institute Henan Academy of Agricultural SciencesZhengzhou 450002China

Xibei tree peony is a distinctive cultivar group that features red–purple blotches in ***,the pigmentations of blotches and non-blotches are largely independent of one *** underlying molecular mechanism had attracted lots of attention from investigators,but was still *** present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major *** characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic ***1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’*** SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal *** comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene *** methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch *** suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.

关键词： belongs synergistic pigment

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Expression profiles of genes regulated by BplMYB46 in Betula platyphylla

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Journal of Forestry Research 2019年第6期30卷 2267-2276页

作者： Huiyan Guo Chunrui Zhang Yanmin wang Yiming Zhang Yu Zhang Yucheng wang Chao wang Department of Life Science and Technology Mudanjiang Normal UniversityMudanjiang 157012People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040People’s Republic of China Key Laboratory of Fast-Growing Tree Cultivating of Heilongjiang Province Forestry Science Research Institute of Heilongjiang ProvinceHarbin 150081People’s Republic of China

The transcription factor BplMYB46 has been identified as a regulator of abiotic stress responses and promoter of secondary wall deposition in Betula *** investigate the downstream targets of BplMYB46,the expression profiles of genes in stems from BplMYB46-overexpressing(OE)and BplMYB46-silencing(SE)plants were *** OE stems,952 genes were upregulated,and 1469 were downregulated in comparison to SE *** a KEGG pathway enrichment analysis of differentially expressed genes(DEGs),1387 differentially expressed genes were annotated for 117 metabolic *** were abundant for metabolic pathway,secondary metabolite biosynthesis,plant hormone signal transduction,phenylpropanoid and flavonoid *** were implicated lignin or cellulose biosynthesis,cell wall modification,xylem development,disease resistance,stress responses,and anthocyanin *** results suggested that BplMYB46 regulates cell wall development and stress resistance by affecting the expression of these *** study further elucidates the mechanism by which BplMYB46 mediates abiotic stress responses and secondary cell wall biosynthesis in birch.

关键词： Betula platyphylla BplMYB46 The gene expression profiles Differentially expressed genes

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Anti-breast cancer effects and mechanisms of Xihuang pill on human breast cancer cell lines

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Journal of Traditional Chinese Medicine 2013年第6期33卷 770-778页

作者： Guofeng Pan Wandan wang Lan wang Fangbo Zhang Xiaojie Yin Jianlu wang Rixin Liang Department of Traditional Chinese Medicine Beijing Shijitan Hospital Affiliated to Capital Medical University School of Traditional Chinese Medicine Capital Medical University Pharmacology and Pharmacokinetics Laboratory Institute of Chinese Material Medical China Academy of Chinese Medical Sciences

OBJECTIVE： To investigate the anti-breast cancer （BC） effects and mechanisms of action of Xihuang pill （XHP） by conducting in vitro experiments on hu- man BC cell lines. METHODS： Two human BC cell lines （MCF-7 and MDA- MB231） were cultured and treated with XHP. Cell viability was detected using the 3-（4, 5-Dimeth- ylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide （MTT） assay. Flow cytometry was used to measure the cell cycle and apoptosis. The cell cycle was ana- lyzed with propidium iodide staining. Apoptosis was evaluated using the Annexin V-fluorescein iso- thiocyanate/propidium iodide method. Western blotting was used to analyze the expression of es- trogen receptor （ER）-α and ***： XHP had growth-inhibitory effects on MCF-7 and MDA-MB231 cells with a half-maximal inhibitory concentration （IC50） of 10.14 mg/mL （MCF-7） and 8.98 mg/mL （MDA-MB231）. Apoptosis was induced to some extent. Certain changes in the ER were caused. Upregulation of ER-a protein was found in MCF-7 cells. ER-β expression in MDA-MB231 cells was increased. Cell-cycle arrest was not observed in the two BC cell lines. ER-β ex- pression in MCF-7 cells was unchanged. No ER-a ex- pression was shown in MDA-MB231 cells. CONCLUSION： These data suggest that XHP can af- fect cell viability and cause apoptosis, but that the cell cycle is not blocked. XHP has a certain impact on ER expression, but its mechanisms of action of anti-13C effects may not be due to regulation of ER expression.

关键词： Breast neoplasms Inhibitor of apopto-sis proteins Cell cycle Apoptosis Estrogen recep-tor alpha Xihuang pill

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Watts-level ultraviolet-CLED integrated light sources for efficient surface and air sterilization

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Journal of Semiconductors 2022年第7期43卷 61-67页

作者： Wei Luo Tai Li Yongde Li Houjin wang Ye Yuan Shangfeng Liu Weiyun wang Qi wang Junjie Kang Xinqiang wang Songshan Lake Materials Laboratory Dongguan 523808China State Key Laboratory of Artificial Microstructure and Mesoscopic Physics School of Physics Nano-Optoelectronics Frontier Center of Ministry of EducationPeking UniversityBeijing 100871China Dongguan Institute of Opto-Electronics Peking UniversityDongguan 523808China

With the epidemic of the coronavirus disease(COVID-19) infection, AlGaN-based ultraviolet-C light emitting diodes(UVC-LEDs) have attracted widespread attention for their sterilization application. However, the sterilization characters of high power integrated light sources(ILSs) haven’t been widely investigated before utilizing in public sanitary security. In this work,by integrating up to 195 UVC-LED chips, high power UVC-LED ILSs with a light output power(LOP) of 1.88 W were demonstrated. The UVC-LED ILSs were verified to have efficient and rapid sterilization capability, which have achieved more than99.9% inactivation rate of several common pathogenic microorganisms within 1 s. In addition, the corresponding air sterilization module based on them was also demonstrated to kill more than 97% of Staphylococcus albus in the air of 20 m3 confined room within 30 min. This work demonstrates excellent sterilization ability of UVC-LED ILSs with high LOP, revealing great potential of UVC-LEDs in sterilization applications in the future.

关键词： ultraviolet-C LED integrated light source surface sterilization air sterilization

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Homogeneous precipitation of α-phase Co-Ni hydroxides hexagonal platelets

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Particuology 2012年第1期10卷 24-28页

作者： Juanjuan Liu Xuyang wang Xiayin Yao Jun wang Zhaoping Liu Ningbo Institute of Material Technology ＆ Engineering Chinese Academy of Sciences Ningbo 315201 China

This paper describes the synthesis of （x-phase Co-Ni hydroxides hexagonal platelets through homo- geneous precipitation, using hexamethylenetetramine （HMT） or urea as a hydrolytic agent. In the CoC12-NiC12-HMT system, pure β-phase can be synthesized at the concentrations of both metal ions higher than 20 raM, while in the CoCl2-NiCl2-urea system, the formation of pure α-phase is independent of the concentrations of the metal ions. When using HMT, monodisperse hexagonal platelets of α-phase Co-Ni hydroxides can be produced in the presence of polyvinylpyrrolidone （PVP）. Cyclic voltammogram curve of the hexagonal platelets prepared with HMT demonstrates electrochemical performance superior to that of urea.

关键词： Homogeneous precipitation α-PhaseHydrolysisHexagonal plateletsCyclic voltammogram

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Crystal Structure of Norfloxacin Methanol Solvate: C_(16)H_(18)FN_3O_3·CH_3OH·H_2O

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1359-1362页

作者： wang Ying SUN Li-Wei wang Wei YAN Lian-He Water Treatment Institute Nanjing University of Science and Technology Nanjing 210094 China

Norfloxacin methanol solvate （ 1 -ethyl-6-fluoro- 1,4-dihydro-4-oxo-7-（ 1 -piperazinyl）-3- quinoline carboxylic acid methanol solvate） has been prepared. The crystal and molecular structures of the title compound, C16H18FN3O3·CH3OH·H2O, were determined by X-ray diffraction method. The compound crystallizes in monoclinic, space group P21/c with a = 7.8660（16）, b = 22.525 （5）, c = 10.253（2）A, β= 108.31°, Mr = 369.39, V = 1724.7（6）A^3, Z = 4, Dc= 1.423 g/cm^3, F（000） = 784, R = 0.0557 and wR = 0.1224. The TGA analysis indicates that it decomposes completely at 723.75℃.

关键词： crystal structure norfloxacin methanol solvate

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Design and experimental confirmation of a novel switched hyperchaotic system

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 122-128页

作者： ZHANG Ya-jun wang Cui-ping wang Guang-yi XU Ning wang Zhong-lin School of Electronics Information Hangzhou Dianzi University Hangzhou 310018 China Department of Physics and Electronics Binzhou University Binzhou 256600 China

To generate complex pseudo-noise （PN） sequences for chaos-based communications, this article presents a novel switched hyperchaotic model, which is constructed based on a modified Chen system by introducing a dynamical controller. The system consists of two different hyperchaotic subsystems and can change its behavior randomly via a switching function. Basic dynamical behaviors of the hyperchaotic system are further investigated. Furthermore, the switched system is confirmed by its positive Lyapunov exponents and laboratory measurements by an electronic circuit.

关键词： chaos-based communication hyperchaos circuit realization

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Si-doping bone composite based on protein template- mediated assembly for enhancing bone regeneration

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Frontiers of Materials Science 2017年第2期11卷 106-119页

作者： Qin YANG Yingying DU Yifan wang Zhiying wang Jun MA Jianglin wang Shengmin ZHANG Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Wuhan 430074 China Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Bio-inspired hybrid materials that contain organic and inorganic networks interpenetration at the molecular level have been a particular focus of interest on designing novel nanoscale composites. Here we firstly synthesized a series of hybrid bone composites, silicon-hydroxyapatites/silk fibroin/collagen, based on a specific molecular assembled strategy. Results of material characterization confirmed that silicate had been successfully doped into nano-hydroxyapatite lattice. In vitro evaluation at the cellular level clearly showed that these Si-doped composites were capable of promoting the adhesion and proliferation of rat mesenchymal stem cells （rMSCs）, extremely enhancing osteoblastic differentiation of rMSCs compared with silicon-free composite. More interestingly, we found there was a critical point of silicon content in the composition on regulating multiple cell behaviors. In vivo animal evaluation further demonstrated that Si-doped composites enabled to significantly improve the repair of cranial bone defect. Consequently, our current work not only suggests fabricating a potential bone repair materials by integrating element-doping and molecular assembled strategy in one system, but also paves a new way for constructing multi-functional composite materials in the future.

关键词： silicate-doped molecular assembly biomimetic bone bone regeneration osteoblastic differentiation

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