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L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing

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Chinese Chemical Letters 2022年第4期33卷 1880-1884页

作者： Tong Liu guiting Liu Jianhua Zhang Zhangfan Ding Yike Li Krishna Sigdel Xiaoyi Wang Huixu Xie State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Head and Neck Oncology SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610041China The State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Nowadays, there are still many challenges to skin regeneration. As a new type of skin substitute, hydrogel has emerging gradually with its excellent properties. However, it is still a challenge to combine with biological active agents to facilitate skin regeneration. Under the circumstance, we synthesized argininebased poly(ester amide)(Arg-PEA) and hyaluronic acid(HA-MA), and combined them into new hybrid hydrogels via photo-crosslinking. We found that the internal structure and physicochemical properties of hybrid hydrogels were greatly improved with the increase of content of Arg-PEA. Therefore, we designed hybrid hydrogels with 5 wt% and 10 wt% of Arg-PEA content, respectively. Besides, we selected the corresponding anti-inflammatory(CRP, TNF-α) indicators to detect the anti-inflammatory properties of the hybrid hydrogels at the protein level, and the corresponding antioxidant indicators(SOD, GSH/GSSG, MDA)were selected to investigate the antioxidant properties of hybrid hydrogels at the cellular level in *** addition, we also selected relevant genes to test the effect of hybrid hydrogels on fibrosis and vascularization in the process of skin wound healing in vitro and verified them in vivo with a mouse dorsum wound model. The results confirmed that Arg-PEA/HA-MA(AH) hybrid hydrogel was a prospective scaffold material for skin regeneration.

关键词： Hydrogel Skin wound healing Antioxidant Anti-inflammation

Signal-on bimodal sensing glucose based on enzyme product-etching MnO_(2)nanosheets for detachment of MoS_(2)quantum dots

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Chinese Chemical Letters 2021年第6期32卷 1967-1971页

作者： Lingzhi Chen Xueqin Huang Xueyi Zeng guiting Fang Weijian Chen Haibo Zhou Xing Zhong Huaihong Cai Department of Chemistry College of Chemistry and Materials ScienceJinan UniversityGuangzhou 510632China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacao 000583China Department of Ultrasonography The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Institute of Pharmaceutical Analysis and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New Drug Research College of PharmacyJinan UniversityGuangzhou 510632China

The sensitive and rapid detection of blood glucose is very important for monitoring and managing ***,a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite(MoS_(2)QDs-MnO_(2)NS).MoS_(2)QDs act as fluorescent probes,and MnO_(2)nanosheets are used as both quenchers and recognizers in this sensing *** the presence of glucose-mediated enzyme product(H_(2)O_(2)),MnO_(2)nanosheet is etched,thus releasing MoS_(2)QDs and Mn^(2+)ions,which causes the significantly enhancement of fluorescent and magnetic ***,MoS_(2)QDs-MnO_(2)NS-based fluorescent test paper is constructed for H_(2)O_(2)sensing with the naked *** optimal conditions,the dual linear ranges of 20-300μmol/L and 40-250μmol/L toward glucose detection are obtained for the fluorescent and magnetic mode,***,this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples,demonstrating great versatility and flexibility of multifunctional probes in glucose detection.

关键词： MoS_(2)quantum dots MnO_(2)nanosheets Bimodal sensing Glucose detection Fluorescent/magnetic enhancement

Dyke Emplacement in the Narmada Rift Zone and Implications for the Evolution of Deccan Traps

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 157-158页

作者： JU Wei HOU guiting K.R.HARI School of Resources and Geoscience China University of Mining and Technology Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space Science Peking University School of Studies in Geology and Water Resource Management Pt. Ravishankar Shukla University

Dykes are primarily extensional fractures that form perpendicular to the minimum principal compressive stress,which have been extensively studied in the world during the past decades for various reasons including the

关键词： Dyke Emplacement in the Narmada Rift Zone and Implications for the Evolution of Deccan Traps

化瘀降浊方治疗痰湿型多囊卵巢综合征机制研究

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陕西中医 2024年第7期45卷 888-892页

作者：刘博张成奇董青魏萱王娟梁贵廷石家庄市中医院内分泌科河北石家庄050051

目的:探讨化瘀降浊方对痰湿型多囊卵巢综合征(PCOS)大鼠的治疗作用及机制。方法:采用高脂饮食联合来曲唑灌胃法构建痰湿型PCOS大鼠模型,将50只大鼠随机分为对照组、模型组、二甲双胍组、低剂量化瘀降浊方组、高剂量化瘀降浊方组。采用EL... 详细信息

目的:探讨化瘀降浊方对痰湿型多囊卵巢综合征(PCOS)大鼠的治疗作用及机制。方法:采用高脂饮食联合来曲唑灌胃法构建痰湿型PCOS大鼠模型,将50只大鼠随机分为对照组、模型组、二甲双胍组、低剂量化瘀降浊方组、高剂量化瘀降浊方组。采用ELISA法检测大鼠血清中激素水平;采用HE染色检测大鼠卵巢组织病理变化;利用Western blot法检测TLR4/NF-κB p56信号通路蛋白变化。结果:干预后,与模型组比较,二甲双胍组、低剂量化瘀降浊方组、高剂量化瘀降浊方组大鼠的体重及Lee’s指数均较低(P<0.05)。与对照组相比,模型组大鼠的睾酮(T)、促黄体生成素(LH)、LH/FSH水平显著升高,雌二醇(E2)、孕酮(P)、促卵泡激素(FSH)水平较低(P<0.05)。与模型组比较,干预后二甲双胍组、低剂量化瘀降浊方组、高剂量化瘀降浊方组大鼠的T、LH、LH/FSH水平降低(P<0.05),而E2、P、FSH水平升高(P<0.05)。与对照组比较,模型组大鼠卵巢组织中TLR4、MyD88、NF-κB p65蛋白相对表达量增高(P<0.05)。与模型组比较,二甲双胍组、低剂量化瘀降浊方组、高剂量化瘀降浊方组大鼠卵巢组织中TLR4、MyD88、NF-κB p65蛋白相对表达量降低(P<0.05)。结论:化瘀降浊方通过抑制TLR4/NF-κB p56信号通路活性调节PCOS大鼠性激素分泌水平,改善卵巢组织病理损伤。

关键词：多囊卵巢综合征调补脾胃法痰湿型炎症 Toll样受体4 核转录因子κB

辽河盆地东部凹陷新生代火山岩K-Ar地质年代学及其地质意义

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北京大学学报（自然科学版） 2006年第2期42卷 184-191页

作者：杨默函侯贵廷史謌北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871

辽河盆地是中、新生代发育起来的裂谷盆地，东部凹陷是辽河盆地新生代火山活动最为频繁的地区，发育大量火山岩。通过对东部凹陷测得的28个火山岩样品K-Ar年龄数据，结合区域火山岩石学、地球化学研究结果，对比前人曾发表的K-Ar年龄数... 详细信息

辽河盆地是中、新生代发育起来的裂谷盆地，东部凹陷是辽河盆地新生代火山活动最为频繁的地区，发育大量火山岩。通过对东部凹陷测得的28个火山岩样品K-Ar年龄数据，结合区域火山岩石学、地球化学研究结果，对比前人曾发表的K-Ar年龄数据，将本区新生代火山活动分为房身泡、沙三、沙一和东营4个时期，始于65Ma，并在42—38Ma和32—25Ma经历2个活动高峰期。这为渤海湾盆地新生代构造演化乃至中国东部新生代裂谷活动研究，增加了同位素年代学方面的有力证据。

关键词：火山岩 K—Ar定年新生代东部凹陷辽河盆地

NCCN指南情况说明书在肺结节初筛患者健康教育中的应用与评价

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中国医药指南 2024年第1期22卷 15-18页

作者：林英李玉凤修艳丽刘贵廷齐晓轩牡丹江医学院附属红旗医院牡丹江157011

目的探讨NCCN指南情况说明书在肺结节初筛患者健康教育中的应用效果。方法基于NCCN指南情况说明书,选择2021年1月至2023年12月在牡丹江医学院附属红旗医院胸外科门诊和体检科确诊为肺结节的患者62例,运用随机数字表法将试验对象分为试验... 详细信息

目的探讨NCCN指南情况说明书在肺结节初筛患者健康教育中的应用效果。方法基于NCCN指南情况说明书,选择2021年1月至2023年12月在牡丹江医学院附属红旗医院胸外科门诊和体检科确诊为肺结节的患者62例,运用随机数字表法将试验对象分为试验组31例,对照组31例。试验组采用NCCN指南情况说明书对肺结节初筛患者进行干预,对照组采用科室常规门诊管理。在入组当天填写一般资料、状态焦虑量表和疾病不确定感成人量表,第30天填写状态焦虑量表和疾病不确定感成人量表,进行干预效果的评价。结果干预前,两组患者的一般资料比较,差异无统计学意义(P>0.05)。干预后,试验组焦虑得分(41.52±4.35)分明显低于对照组(50.42±4.15)分(P<0.05)。重复测量方差分析显示,两组患者在干预前后焦虑得分的时间效应和交互效应显著(P<0.05)。干预后,试验组患者的疾病不确定感评分(59.48±7.80)分明显低于对照组(70.97±11.18)分(P<0.05)。重复测量方差分析显示,两组患者在干预前后的疾病不确定感评分的时间效应和交互效应显著(P<0.05)。结论NCCN指南情况说明书在肺结节初筛患者健康教育中的运用可以帮助门诊肺结节患者正确认识疾病,减轻焦虑情绪和疾病不确定感。

关键词： NCCN指南肺结节健康教育

岩石力学参数影响断背斜内张裂缝发育带的概念模型

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石油与天然气地质 2020年第3期41卷 455-462页

作者：孙帅侯贵廷北京大学地球与空间科学学院教育部造山带与地壳演化重点实验室北京100871 中国石油勘探开发研究院北京100083

在对库车坳陷克拉苏构造带内断背斜的构造裂缝研究中,发现断背斜内转折端发育张裂缝发育带,且张裂缝发育带的单井测试产量高,是断背斜内的油气高产区,深化研究张裂缝发育带及其影响因素对于油气勘探开发具有重要意义。前期工作发现张裂... 详细信息

在对库车坳陷克拉苏构造带内断背斜的构造裂缝研究中,发现断背斜内转折端发育张裂缝发育带,且张裂缝发育带的单井测试产量高,是断背斜内的油气高产区,深化研究张裂缝发育带及其影响因素对于油气勘探开发具有重要意义。前期工作发现张裂缝发育带受背斜"中和面"的控制,而岩石力学参数对断背斜内张裂缝发育带的影响还不清楚。因此,以库车坳陷克拉苏构造带内断背斜为背景,通过有限元数值模拟方法,建立了不同岩石力学参数的二维力学概念模型,分析了杨氏模量、泊松比和粘度比对张裂缝发育带的影响。结果表明:在杨氏模量大于70 GPa时,最大应变值随着杨氏模量增大而快速增大;随着杨氏模量的增加,张裂缝发育带的宽度和厚度总体上呈现线性增加的特征。在杨氏模量大于40 GPa条件下,随着泊松比增加,最大应变值和张裂缝发育带的宽度总体上缓慢增加。在粘度比小于25的情况下,最大应变值为0,不存在张裂缝发育带的宽度和张裂缝发育带的厚度;在粘度比大于25的情况下,最大应变值开始大于0且逐渐增大,张裂缝发育带的宽度和张裂缝发育带的厚度都随着粘度比的增加而增加。

关键词：杨氏模量泊松比粘度比张裂缝发育带二维力学数值模拟断背斜库车坳陷

Recent advances in andrology-related stem cell research

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Asian Journal of Andrology 2008年第2期10卷 171-175页

作者： Ching-Shwun Lin Zhong-Cheng Xin Chun-Hua Deng Hongxiu Ning guiting Lin Tom F. Lue Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA 94143 USA Andrology Center Peking University First Hospital Beijing 100009 China Urology Department The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 China

Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells （BSC） have greater differentiation potential than adult stem cells, the former is lagging in reaching clinical applications because of ethical concerns and governmental restrictions. Bone marrow stem cells （BMSC） are the best-studied adult stem cells （ASC） and have the potential to treat a wide variety of diseases, including erectile dysfunction （ED） and male infertility. More recently discovered adipose tissuederived stem cells （ADSC） are virtually identical to bone marrow stem cells in differentiation and therapeutic potential, but are easier and safer to obtain, can be harvested in larger quantities, and have the associated benefit of reducing obesity. Therefore, ADSC appear to be a better choice for future clinical applications. We have previously shown that ESC could restore the erectile function of neurogenic ED in rats, and we now have evidence that ADSC could do so as well. We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency. （Asian JAndrol 2008 Mar; 10： 171-175）

关键词： stem cells bone marrow stem cells adipose tissue-derived stem cells erectile dysfunction male infertility

低强度体外冲击波疗法激活精原干细胞在无精症中的应用展望

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第二军医大学学报 2020年第4期41卷 444-448页

作者：周铁 guiting LIN Tom FLUE 海军军医大学(第二军医大学)长海医院泌尿外科上海200433 美国加州大学旧金山分校泌尿外科旧金山94143-0738

低强度体外冲击波疗法(LI-ESWT)作为物理医学的一个代表具有多疾病、多方向的应用潜力,近年研究显示LI-ESWT可以招募、激活内源性干细胞。用LI-ESWT激活精原干细胞可给原发性非梗阻性无精症和医源性无精症患者的治疗带来新突破。本文拟... 详细信息

低强度体外冲击波疗法(LI-ESWT)作为物理医学的一个代表具有多疾病、多方向的应用潜力,近年研究显示LI-ESWT可以招募、激活内源性干细胞。用LI-ESWT激活精原干细胞可给原发性非梗阻性无精症和医源性无精症患者的治疗带来新突破。本文拟对LI-ESWT激活精原干细胞治疗无精症的应用进行展望。

关键词：低强度体外冲击波治疗干细胞男性不育生育力保存无精子症