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Non-destructive testing and pre-warning analysis on the quality of bolt support in deep roadways of mining districts

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International Journal of Mining Science and Technology 2017年第6期27卷 989-998页

作者： zhang Houquan Miao Xiexing zhang guimin Wu Yu Chen Yanlong State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology Xuzhou 221116 China School of Mechanics and Civil Engineering China University of Mining and Technology Xuzhou 221116 China

The bolt support quality of coal roadways is one of the important factors for the efficiency and security of coal production. By means of a self-developed technique and equipment of random non-destructive testing, non-destructive detection and pre-warning analysis on the quality of bolt support in deep roadways of mining districts were performed in a number of mining areas. The measured data were obtained in the detection instances of abnormal in-situ stress and support invalidation etc. The corresponding relation between axial bolt load variation and roadway surrounding rock deformation and stability was summarized in different mining service stages. Pre-warning technology of roadway surrounding rock stability is proposed based on the detection of axial bolt load. Meanwhile, pre-warning indicators of axial bolt load in different mining service stages are offered and some successful pre-warning cases are also *** research results show that the change rules of axial bolt load in different mining service stages are quite similar in different mining areas. The change of axial bolt load is in accord with the adjustment of surrounding rock stress, which can consequently reflect the deformation and stability state of roadway surrounding rock. Through the detection of axial bolt load in different sections of roadways, the status of real-time bolt support quality can be reflected; meanwhile, the rationality of bolt support design can be evaluated which provides reference for bolting parameters optimization.

关键词： Deep roadways Bolt support quality Random nondestructive testing Surrounding rock stability Prediction and pre-warning

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Bolt-grouting combined support technology in deep soft rock roadway

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International Journal of Mining Science and Technology 2016年第5期26卷 777-785页

作者： Chen Yanlong Meng Qingbin Xu Guang Wu Haoshuai zhang guimin State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining & Technology Department of Mining Engineering & Metallurgical Engineering Western Australian School of Mines Curtin University School of Mechanics and Civil Engineering China University of Mining & Technology

Analyzing the mineral composition, mechanical properties and ground stress testing in surrounding rock,the study investigated the failure mechanism of deep soft rock roadway with high stress. The boltgrouting combined support system was proposed to prevent such failures. By means of FLAC3D numerical simulation and similar material simulation, the feasibility of the support design and the effectiveness of support parameters were discussed. According to the monitoring the surface and deep displacement in surrounding rock as well as bolt axial load, this paper analyzed the deformation of surrounding rock and the stress condition of the support structure. The monitor results were used to optimize the proposed support scheme. The results of field monitors demonstrate that the bolt-grouting combined support technology could improve the surround rock strength and bearing capacity of support structure, which controlled the great deformation failure and rheological property effectively in deep soft rock roadway with high stress. As a result, the long term stability and safety are guaranteed.

关键词： Deep soft rock roadway Bolt-grouting support Numerical simulation Similar material simulation High stress

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Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2188-2201页

作者： Lijuan Ma Jing zhang Ling Lin Tuanjie Wang Chaofu Ma Xiaomeng Wang Mingshuang Li Yanjiang Qiao Yongxiang Wang guimin zhang Zhisheng Wu Beijing University of Chinese Medicine Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug DevelopmentMinistry of EducationBeijing 100029China Jiangsu Kanion Pharmaceutical Co. Ltd.State Key Laboratory of New Technology in Pharmaceutical Process of Traditional Chinese MedicineLianyungang 222001China Yangtze River Pharmaceutical(Group)Co. Ltd.State Pharmaceutical Engineering Technology Research Center of Traditional Chinese MedicineTaizhou 225321China Lunan Pharmaceutical Group Co. Ltd.State Key Laboratory of Generic Technology of Traditional Chinese MedicineLinyi 276005China

Smart manufacturing still remains critical challenges for pharmaceutical ***,an original data-driven engineering framework was proposed to tackle the ***,from sporadic indicators to five kinds of systematic quality characteristics,nearly 2,000,000 real-world data points were successively characterized from Ginkgo Folium tablet ***,from simplex to the multivariate system,the digital process capability diagnosis strategy was proposed by multivariate C_(pk)integrated *** C_(pk)of Ginkgo Folium extracts,granules,and tablets were discovered,which was 0.59,0.42,and 0.78,respectively,indicating a relatively weak process capability,especially in ***,the quality traceability was discovered from unit to end-to-end analysis,which decreased from 2.17 to *** further proved that attention should be paid to granulating to improve the quality *** conclusion,this paper provided a data-driven engineering strategy empowering industrial innovation to face the challenge of smart pharmaceutical manufacturing.

关键词： Smart manufacturing Data-driven engineering Artificial intelligence Information fusion Process capability index End-to-end Quality traceability Real-world Ginkgo Folium products

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Developmental Exposure to Bisphenol A Degrades Auditory Cortical Processing in Rats

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Neuroscience Bulletin 2022年第11期38卷 1292-1302页

作者： Binliang Tang Kailin Li Yuan Cheng guimin zhang Pengying An Yutian Sun Yue Fang Hui Liu Yang Shen Yifan zhang Ye Shan E´tienne de Villers-Sidani Xiaoming Zhou Key Laboratory of Brain Functional Genomics of Ministry of Education Shanghai Key Laboratory of Brain Functional GenomicsSchool of Life SciencesEast China Normal UniversityShanghai 200062China New York University-East China Normal University Institute of Brain and Cognitive Science NYU-ShanghaiShanghai 200062China Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQC H3A 2B4Canada

Developmental exposure to bisphenol A(BPA),an endocrine-disrupting contaminant,impairs cognitive function in both animals and ***,whether BPA affects the development of primary sensory systems,which are the first to mature in the cortex,remains largely *** the rat as a model,we aimed to record the physiological and structural changes in the primary auditory cortex(A1)following lactational BPA exposure and their possible effects on behavioral *** found that BPA-exposed rats showed significant behavioral impairments when performing a sound temporal rate discrimination test.A significant alteration in spectral and temporal processing was also recorded in their A1,manifested as degraded frequency selectivity and diminished stimulus rate-following by *** post-exposure effects were accompanied by changes in the density and maturity of dendritic spines in *** findings demonstrated developmental impacts of BPA on auditory cortical processing and auditory-related discrimination,particularly in the temporal ***,the health implications for humans associated with early exposure to endocrine disruptors such as BPA merit more careful examination.

关键词： Auditory cortex Auditory behavior BPA exposure Cortical processing Plasticity

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Inhibitory Effect of Jingfang Mixture on Staphylococus aureus α-Hemolysin

Inhibitory Effect of Jingfang Mixture on Staphylococus aureu...

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2023年度全国临床药理学学术论坛

作者： Wenting NI Xiaoping zhang guimin zhang College of Pharmacy Shandong University of Traditional Chinese Medicine

Staphylococcus aureus(***) is a kind of gram-positive bacteria,and its virulence factors can cause many kinds of infections,such as pneumonia,sepsis,enteritis and *** main purpose of this study is to explore the inhibitory effect of JFM on alpha-hemolysin(Hla) of *** and to alleviate the damage caused by *** found that JFM could inhibit the hemolytic activity,transcription level and neutralizing activity of Hla in a dose-dependent manner,without affecting the growth of *** addition,JFM reduced the damage of Hla to A549 cells and the release of lactate dehydrogenase(LDH).We also observed that in the ***-induced pneumonia mouse model,JFM could significantly prolong the life of mice,reduce the bacterial load in the lungs,significantly improve the pathological state of the lungs and alleviate the damage caused by inflammatory factors,and the pathogenicity of gene deletion strain DU 1090 of *** to pneumonia mice was also significantly *** conclusion,this study proved that JFM is a potential drug against *** infection,and this study provided a preliminary study for better guidance of clinical drug use.

关键词： Jingfangmixt ure Staphylococcus aureus α-hemolysin Anti-virulence strategy

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Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development

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Chinese Herbal Medicines 2024年第2期16卷 239-247页

作者： Liping Gong Hang Du Xin Guo Jianchao Li Xiaomin Zhu Xianhui Shen Zhiyan Huang Kaiyi Wu guimin zhang Rong Sun The Second Hospital of Shandong University Jinan 250033China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276006China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Shandong University of Traditional Chinese Medicine Jinan 250355China Advanced Medical Research Institute Shandong UniversityJinan 250012China

Constipation is common in the diseases of the digestive system in *** the change in diet structure and the increase in life pressure,the prevalence rate increases year by *** traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other *** pathogenesis is conductive dysfunction of large *** on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the *** study has been carried out to review the latest advances of SHTB in the treatment of *** results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac ***,obvious adverse reactions were not *** could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。

关键词： constipation gastrointestinal hormones interstitial cells of cajal intestinal fluid secretion intestinal motility Shouhui Tongbian Capsule

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论体育消费环境

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体育与科学 2000年第6期21卷 21-23页

作者：张贵敏沈阳体育学院

体育消费环境是影响体育消费质量的因素之一 ,是推动体育产业发展不可忽视的重要环节。本文将体育消费过程中的有关环境概括为自然、社会、文化和服务环境 ,并论述各方面环境的相关内容、体育消费环境与体育消费的关系、以及营造体育消... 详细信息

体育消费环境是影响体育消费质量的因素之一 ,是推动体育产业发展不可忽视的重要环节。本文将体育消费过程中的有关环境概括为自然、社会、文化和服务环境 ,并论述各方面环境的相关内容、体育消费环境与体育消费的关系、以及营造体育消费环境应考虑的问题。

关键词：体育产业体育消费环境

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Systematic Evaluation of Biyuan Tongqiao Granule in the Treatment of Chronic Sinusitis in Children Based on Meta-analysis

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Medicinal Plant 2020年第1期11卷 1-6,16页

作者： Zhiyan HUANG Yongxia GUAN Qun FENG guimin zhang Shili YE Jingchun YAO Lunan Pharmaceutical Group Co. Ltd.Linyi 276006China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006China Center for New Drug Pharmacology of Lunan Pharmaceutical Group Co. Ltd.Linyi 273400China

[Objectives]To make an evaluation of the efficacy and safety of Biyuan Tongqiao Granule in the treatment of chronic sinusitis in children,and provide evidence-based medical reference for clinical use.[Methods]Databases such as Chinese Biomedical Literature Service System(SinoMed),China Knowledge Infrastructure(CNKI),Wanfang Digital Journal Full-text Database(WF),VIP Database(VIP),EmBase,PubMed,Science Direct,and Cochrane Library were used to collect the clinical randomized controlled trials of Biyuan Tongqiao Granule in children with chronic sinusitis published since the creation of *** quality of the included literature was evaluated and the data were *** data was analyzed using Review Manager 5.3 software for meta-analysis,and descriptive analysis was performed for studies that could not be *** GRADE method was applied to evaluate the quality of evidence.[Results]A total of 12 studies were included,including 1645 cases of *** analysis results show that compared with the control group,Biyuan Tongqiao Granule has an excellent curative effect on children with chronic sinusitis and has a lower incidence of adverse *** GRADE evidence level indicated that the sinus CT scan lesion score was intermediate evidence,and the visual analog score,endoscopic mucosal morphology score,and total effective rate were low-level evidence.[Conclusions]Biyuan Tongqiao Granule has a significant effect in treating chronic sinusitis in children and does not increase the incidence of adverse reactions,but its efficacy and safety need support of more high-quality studies.

关键词： Biyuan Tongqiao Granule Chronic sinusitis Randomized controlled trial Meta-analysis

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全运会无形资产开发的驱动力与文化理念创新

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沈阳体育学院学报 2012年第4期31卷 6-8,18页

作者：张贵敏沈阳体育学院辽宁沈阳110102

随着体育的功能扩展,作为我国最大的品牌赛事,全运会已经在推动经济社会的发展中发挥重要作用。市场经济体制建立以后,以市场为导向的文化理念影响着政府的制度安排和决策,也影响着企业和市民获取利益的基本方式。文化理念决定利益各方... 详细信息

随着体育的功能扩展,作为我国最大的品牌赛事,全运会已经在推动经济社会的发展中发挥重要作用。市场经济体制建立以后,以市场为导向的文化理念影响着政府的制度安排和决策,也影响着企业和市民获取利益的基本方式。文化理念决定利益各方对待全运会无形资产开发的基本动机和最终目标。全运会无形资产开发的基本动力,也是根本动力,来自利益主体如何获得最大化的利益。面对全运会的无形资产开发,各种文化理念主导着各利益主体的思想观念、思维方式和行为方式。代表一个时期的文化理念无时无刻不在影响、渗透、推动其开发驱动机制的转变。

关键词：全运会无形资产开发文化理念

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试析道家教学思想的方法论特征

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山东师范大学学报（人文社会科学版） 2007年第4期52卷 74-77页

作者：张桂敏济宁学院教育系山东济宁272000

道家从自然人本主义教育观出发尊道而尚"自然"。其教学方法论思想的基点就在于尊重学习主体的自然自我,顺应自然,无为而治。其基本特征表现为通一而毕,取法自然;无为之治,不言之教;逆向而求,"复"而反"约";智恬交养,心与物齐等等。探索... 详细信息

道家从自然人本主义教育观出发尊道而尚"自然"。其教学方法论思想的基点就在于尊重学习主体的自然自我,顺应自然,无为而治。其基本特征表现为通一而毕,取法自然;无为之治,不言之教;逆向而求,"复"而反"约";智恬交养,心与物齐等等。探索其教学方法论的思想底蕴,对于我们反观当代教育,超越局限性,具有重要意义。

关键词：道家教学方法论通一而毕智恬交养

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