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Graphic correlation of Argentine Precordillera and North American Lower/Middle Ordovician sections

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Episodes 2006年第1期29卷 16-19页

作者： Walter C. Sweet guillermo L. Albanesi Department of Geological Sciences The Ohio State University Columbus Ohio 43210 USA CONICET - Museo de Paleontologia Universidad Nacional de Cordoba C. C. 1598 5000 Cordoba Argentina.

Present work demonstrates that a level equivalent to the proposed Whiterockian basal GSSP can be located graphically in a composite section anchored by the Niquivil section of the Argentine Precordillera. The FAD ofCooperignathus aranda in the Niquivil composite section, a candidate for GSSP of the Lower/Middle Ordovician boundary, projects to a level very close to the FAD of Tripodus laevis in the Whiterockian reference section. The conodont-based framework reported here includes the potential for recognition of the proposed Whiterock Canyon-based GSSP, the Cooperignathus aranda-based GSSP, and, possibly, the Baltoniodus triangularisbased GSSP, recently proposed.

关键词：奥陶纪美国相关性阿根廷生物地层学

Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： guillermo Valenzuela Mauricio Burotto Katherine Marcelain Jaime Gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine Liquid biopsy Cetuximab Panitumumab

Seed loss before seed predation: experimental evidence of the negative effects of leaf feeding insects on acorn production

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Integrative Zoology 2018年第3期13卷 238-250页

作者： Tara CANELO Álvaro GAYTÁN guillermo GONZÁLEZ-BORNAY Raul BONAL Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain CREAF Cerdanyola del VallèsCataloniaSpain

Insect herbivory decreases plant fitness by constraining plant growth,survival and reproductive *** studies on the effects of herbivory in trees rely on correlational inter-individual comparisons and could,thus,be affected by confounding factors linked to both herbivory and plant *** the Mediterranean Holm oak(Quercus ilex)as a study model,we followed an experimental approach in which leaf-feeding insects(mainly Lepidoptera caterpillars)were excluded from some shoots in all study *** subjected to herbivore exclusion exhibited lower defoliation rates and produced more acorns than control *** constrained shoot growth throughout the study period,but had no effect on the number of female flowers produced per *** production was,however,lower in control shoots due to their higher abortion rates,and also to their greater mortality risk during summer drought,as shoots with fewer leaves were less likely to *** reaction to herbivory inhibits certain physiological pathways involved in plant growth,which,together with the effects of physical damage,reduces the amount and efficiency of the photosynthetic *** increases their vulnerability to environmental stresses,such as water deficit,which limit resource *** is likely a key factor affecting oak regeneration,as it may be a significant source of seed loss prior to pre-dispersal acorn *** experimental studies could help to elucidate its effects in contrasting *** Mediterranean regions,the harsher droughts predicted by climate change models could worsen the effects of insect herbivory on oak reproductive output.

关键词： drought stress insect defoliation oak seed abortion shoot mortality

Influence of steel jacket thickness on the RC bridges' seismic vulnerability

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 15-34页

作者： Bertha Olmos José Manuel Jara Gerardo Gómez guillermo Martínez Department of Civil Engineering Universidad Michoacana de San Nicolas de Hidalgo

The seismic demands of bridges subjected to strong earthquakes are mostly concentrated on piers. The main objective of this study is to assess the seismic vulnerability of retrofitted bridges with steel jackets. It analyzes the influence of the steel jacket thickness on the seismic capacity and demand of bridges. The bridges in study have two simple supported spans with superstructure composed by AASHTO type girders and a substructure formed with one circular pier over a stiff foundation. They are located on the Pacific coast of Mexico that is a zone of high seismicity. The bridges seismic capacity are evaluated through nonlinear static analyses and the shear force and displacement demands were determined using capacity spectra with a group of 10 real accelerograms from a subduction source. The response spectra were scaled to several peak ground accelerations(PGA) with the aim to estimate four damage scenarios linked each one to a probability of exceedance in a specific period, for return periods in the range of 72-3500 years that represent service level and maximum considered earthquake. Results show that the confining effect provided by the steel jackets substantially improves the seismic performance of the bridges piers. The increase of jacket thickness guides to important increments on columns base shear capacity, and the influence of the steel jacket thickness depends on the limit state and bridge slenderness ratio.

关键词： Steel jacket Piers’retrofit Subduction earthquakes RC piers’vulnerability

Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass

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World Journal of Gastroenterology 2014年第21期20卷 6534-6540页

作者： Andrés Marambio guillermo Watkins Fabiola Castro Andrea Riffo Roberta Zú?iga Jaime Jans María E Villanueva guillermo Díaz Department of Surgery University of Chile Clinical HospitalSantiago 8380456Chile Department of Gastroenterology Chilean Air Force Clinical HospitalSantiago 7560171Chile Department of Pharmacological and Toxicological Chemistry University of Chile Chemistry and Pharmacy FacultySantiago 8380492Chile Pathology Service University of Chile Clinical HospitalSantiago 8380456Chile

AIM: To describe the variation that divalent metal transporter 1 (DMT1) shows in patients after Roux-en-Y gastric bypass (RYGB) surgery.

关键词： Roux-en-Y gastric bypass Bariatric surgery Divalent metal transporter 1 Anaemia Iron

Photoelectrochemical CO_(2) electrolyzers: From photoelectrode fabrication to reactor configuration

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Journal of Energy Chemistry 2023年第10期85卷 455-480,I0012页

作者： Jose Antonio Abarca guillermo Díaz-Sainz Ivan Merino-garcia Angel Irabien Jonathan Albo Departamento de Ingenierías Química y Biomolecular Universidad de CantabriaETSIITAvenida de los Castros s/n39005 SantanderSpain

The photoelectrochemical conversion of CO_(2) into value-added products emerges as an attractive approach to alleviate climate change. One of the main challenges in deploying this technology is, however, the development and optimization of(photo)electrodes and photoelectrolyzers. This review focuses on the fabrication processes, structure, and characterization of(photo)electrodes, covering a wide range of fabrication techniques, from rudimentary to automated fabrication processes. The work also highlights the most relevant features of(photo)electrodes, with special emphasis on how to measure and optimize them. Finally, the review analyses the integration of(photo)electrodes in different photoelectrolyzer architectures, analyzing the most recent research work that comprises photocathode, photoanode,photocathode-photoanode, and tandem photoelectrolyzer configurations to ideally achieve self-sustained CO_(2) conversion systems. Overall, comprehensive guidelines are provided for future advancements in developing effective devices for CO_(2) conversion, bridging the gap towards the use of sunlight as the unique energy input and practical applications.

关键词： Decarbonization CO_(2)photoelectroreduction (Photo)Electrodes Fabrication techniques Photoelectrolyzer configuration

Nesting innovations allow population growth in an invasive population of rose-ringed parakeets

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Current Zoology 2022年第6期68卷 617-626页

作者： Dailos HERNANDEZ-BRITO Jose L.TELLA guillermo BLANCO Martina CARRETE Department of Conservation Biology Donana Biological Station(CSIC)Calle Americo Vespucio26Sevilla 41092Spain Department of Evolutionary Ecology Museo Nacional de Ciencias Naturales(CSIC)Calle JoseGutierrez Abascal2Madrid 28006Spain Department of Physical Chemical and Natural SystemsUniversidad Pablo de OlavideCarretera de Utrerakm 1Sevilla 41013Spain

Certain traits of recipient environments,such as the availability of limiting resources,strongly determine the establishment success and spread of non-native *** limitations may be overcome through behavioral plasticity,allowing them to exploit alternative ***,we show how a secondary cavity nester bird,the rose-ringed parakeet Psittacula krameri,innovates its nesting behavior as a response to the shortage of tree cavities for nesting in its invasive range in Tenerife(Canary Islands).We observed that some breeding pairs excavated their own nest cavities in palms,thus becoming primary cavity nester,whereas others occupied nests built with wood sticks by another invasive species,the monk parakeet Myiopsitta *** use of these novel nesting strategies increased the number of breeding pairs by up to 52%over 6 years,contributing to a 128.8%increase of the whole *** nests were located at greater heights above ground and were more aggregated around conspecifics but did not result in greater breeding success than natural *** of monk parakeet colonies by rose-ringed parakeets also benefited the former species through a protective-nesting association against nest *** results show how an invasive species innovate nesting behaviors and increase nest-site availability in the recipient environment,thus facilitating its population growth and invasion *** behavioral innovations in other invasive rose-ringed parakeet populations may be overlooked,and should be considered for effective management plans.

关键词： antipredator response behavioral flexibility biological invasions cavity nesters nesting innovation reproductive success

Tunable nano-engineered anisotropic surface for enhanced mechanotransduction and soft-tissue integration

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Nano Research 2023年第5期16卷 7293-7303页

作者： Pingping Han Tianqi Guo Anjana Jayasree guillermo A.Gomez Karan Gulati Sašo Ivanovski The University of Queensland School of DentistryEpigenetics nanodiagnostic and therapeutic groupCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia The University of Queensland School of DentistryBrisbaneQueensland 4006Australia The University of Queensland School of DentistryGroup for Anodized Therapies for OsseointegrationRegeneration and StimulationCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia Centre for Cancer Biology South Australia Pathology and the University of South AustraliaAdelaideSouth Australia 5001Australia

Electrochemically engineered titania(TiO_(2))nanopores enable tailored cellular function;however,the cellular mechanosensing mechanisms dictating the cell response and soft tissue integration are yet to be ***,we report the fabrication of anisotropic TiO_(2)nanopores with diameters of 46 and 66 nm on microrough titanium(Ti)via electrochemical anodization,towards short-and long-term guidance of human primary gingival fibroblasts(hGFs).Cells on tissue culture plates and bare Ti substrates were used as ***,we show that nanopores with a diameter of 66 nm induced more mature focal adhesions of vinculin and paxillin at the membrane,encouraged the development of actin fibers at focal adhesion sites,led to elongated cell and nuclear *** topographical-driven changes were attributed to the Ras-related C3 botulinum toxin substrate 1(Rac 1)GTPase pathway and nuclear localisation of LAMIN A/C and yes-associated protein(YAP)and associated with increased ligament differentiation with elevated expression of the ligament marker Mohawk homeobox(MKX).Study findings reveal that minor tuning of nanopore diameter is a powerful tool to explore intracellular and nuclear mechanotransduction and gain insight into the relationships between nanomaterials and mechanoresponsive cellular elements.

关键词： titanium nanopores nanotopography fibroblast mechanosensing mechanotransduction ligament differentiation

Sensitivity,specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis

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Eye and Vision 2017年第1期4卷 100-105页

作者： Carl Sjoholm-Gomez de Liano Vidal F.Soberon-Ventura guillermo Salcedo-Villanueva Abril Santos-Palacios Jose Luis Guerrero-Naranjo Jans Fromow-Guerra Gerardo garcía-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Retina Department Asociación para Evitar la Ceguera en MexicoHospital“Dr.Luis Sanchez Bulnes”IAPMexico CityMexico Universidad Popular Autonoma del Estado de Puebla PueblaMexico Ophthalmology Department Macula Retina ConsultantsMexico CityMexico

Background:To assess the sensitivity,specificity,positive predictive value and negative predictive value of anterior chamber tap for the diagnosis of bacterial endophthalmitis on a population with high ***:Retrospective,single centre,case series *** reviewed all medical records with clinical diagnosis of bacterial endophthalmitis in our hospital from January 1st,2000 to December 31st *** each record,we documented general demographic data,best corrected visual acuity and vitreous and aqueous tap microbiological *** cases were further divided according to the endophthalmitis aetiology to perform individual calculations of sensitivity,specificity,positive predictive value,negative predictive value,accuracy and *** used the results of the vitreous tap as the gold standard for diagnosis of bacterial *** excluded those records in which the aqueous and vitreous samples were not taken simultaneously or had an incomplete microbiological *** were assessed with chi squared statistics,with an alpha value of 0.05 for statistical ***:A total of 190 cases fulfilled the inclusion/exclusion *** culture rate from vitreous samples was 64.74%.Positive culture rate from aqueous sample was 32.11%.Bacteria isolated from aqueous samples matched those isolated from vitreous samples 78.68%of the *** overall sensitivity was 38.21%,specificity:75.51%,positive predictive value:79.66%,negative predictive value:32.74%(p=0.08).Subgroup analysis showed that anterior chamber taps in cases of post-surgical endophthalmitis had a moderate to low sensitivity(37.73%),high specificity(93%)and high positive predictive value(95%)(p<0.04).Conclusion:The sensitivity and specificity of anterior chamber tap are low and should not be used for critical therapeutic decisions in patients with suspected bacterial *** cases of post-surgical endophthalmitis,the result of an anterior chamber tap

关键词： Aqueous humour Endophthalmitis Anterior chamber tap Diagnostic test Vitreous tap Aqueous sampling Sensibility Sensitivity