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Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation

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World Journal of Gastroenterology 2006年第25期12卷 3999-4003页

作者： Javier Magaa-Gómez guillermo lópez-Cervantes Ana María Calderón de la Barca Departamento de Nutrición Centro de Investigación en Alimentación y Desarrollo A.C. HermosilloSonoraMéxicoDepartamento de Patología Hospital Infantil del Estado de SonoraHermosilloSonoraMéxicoDepartamento de Nutrición Centro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico

AIM： To study the histological and pancreatitis-associated protein mRNA accumulation changes of pancreas from acute phase of caerulin-induced pancreatitis to recuperation in rats. METHODS： Acute pancreatitis was induced by caerulein in male Wistar rats and followed up for 90 d by histological and mRNA analyses of pancreas. Pancreases were dissected at 0, 9, 24 h and 3, 5, 15, 30, 60, 90 d post-induction. Edema （E）, polymorphonuclear neutrophU （pIVlN） infiltration, cytoplasmic vacuolization （V）, zymogen granule depletion （ZD） and acinar disorganization （AD） were microscopically evaluated. Accumulation of pancreatitis- associated protein （PAP） and l13A mRNAs were quantified by real-time PCR. RESUlTS： The main histological changes appeared at 9 h post-induction for PMN infiltration and cytoplasmic V, while at 24 h and 3 d for E and ZD, respectively. All the parameters were recovered after 5 d, except for ZD which delayed more than 30 d. The main AD was observed after 15 d and values returned to normal after 30 d. Similarly to histological changes, accumulation of the PAP mRNA was increased at 9 h with the highest accumulation at 24 h and differences disappeared after 5 d. CONClUSION： From the acute phase to recuperation of pancreatitis, regeneration and re-differentiation of pan- creas occur and PAP expression is exclusively an acute response of pancreatitis.

关键词： Acute pancreatitis Histological changes PAP mRNA l13A mRNA

Properties of nuclear pastas

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Frontiers of physics 2021年第2期16卷 119-173页

作者： Jorge A.lopez Claudio O.Dorso guillermo Frank Department of Physics University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisica FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigacion y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuclear pastas as they are expected to be formed in neutron star *** start with a study of the pastas formed in nuclear matter(composed of protons and neutrons),we follow with the role of the electron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuclear matter embedded in an electron gas).Nuclear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton content ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the critical points,and the symmetry energy was calculated and compared to experimental data and other *** low temperatures(T≤1 MeV)NM produces crystal-like structures around satura-tion densities,and pasta-like structures at sub-saturation *** of the pasta structures were studied with cluster-recognition algorithms,caloric curve,the radial distribution function,the lindemann coefficient,Kolmogorov statistics,Minkowski functionals;the symmetry energy of the pasta showed a connection with its *** star matter(NSM)is nuclear matter embedded in an electron *** electron gas is included in the calculation by the inclusion of an screened Coulomb *** connect the NM pastas with those in neutron star matter(NSM),the role the strength and screening length of the Coulomb interaction have on the formation of the pastas in NM was *** was found to exist even without the presence of the electron gas,but the effect of the Coulomb interaction is to form more defined pasta structures,among other ***,it was determined that there is a minimal screening length for the developed structures to be independent of the cell *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,structure function and thermal *** in NM,pasta f

关键词： nuclear pasta neutron star matter nuclear symmetry energy molecular dynamics nuclear phase transitions

Arylhydrazones Derivatives Containing a Benzothiazole Moiety, Efficient ligands in the Palladium-Catalyzed Mizoroki-Heck and Suzuki-Miyaura Cross-coupling Reactions under IR Irradiation

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Chinese Journal of Chemistry 2017年第12期35卷 1881-1888页

作者： Fernando Ortega-Jiménez José guillermo Penieres-Carrillo José Guadalupe lópez-Cortés M. Carmen Ortega-Alfaro Selene lagunas-Rivera Departamento de Cieneias Qulmicas Facultad de Estudios Superiores Cuautitlān-UNAM Campo i Avenida lro. de Mayo s/n Cuautitlán Izcalli C.P. 54740 Estado de México México Instituto de Qulmiea UNAM Circuito Exterior Ciudad Universitaria Coyoacán C.P. 04360 Cuidad de México México Instituto de Ciencias Nucleares UNAM Circuito Exterior Ciudad Universitaria Coyoacán C.P. 04360 Ciudad de México México Catedrático CONA CyT-TecNM-Instituto Tecnológico de Tuxtla Gutiérrez Carretera Panamericana Km 1080 Col Juan Crispin Tuxtla Gutiérrez C.P. 29050 Chiapas México

A simple arylhydrazone containing the benzothiazole moiety which may be used as an efficient ligand in the palladium-catalyzed Mizoroki-Heck and Suzuki-Miyaura cross-coupling reactions, under infrared irradiation as an alternative source of energy, is presented. The reactions proceeded with extremely high efficiency under mild conditions and produced very good yields.

关键词： arylhydrazones palladium-catalyzed cross-coupling reaction IR-irradiation

Global pattern of conodont similarity and faunal constraints during the highstand of the Evae eustatic event(late Floian,lower Ordovician)

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Journal of Palaeogeography 2024年第4期13卷 883-905页

作者： Gisella M.Della Costa guillermo l.Albanesi CiGEA Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaAv.Vélez GEAFacuitadaeCienciasExactasFisicas Sarsfield 299X5000GCB CordobaArgentina

One of the largest Ordovician sea-level rises is the Evae transgression,which occurs in the lower part of the Oepikodus evae Biozone,indicative of a late Floian ***,the characteristics associated with the highstand of this event included:a higher proportion of specimens of the index species *** than other species,a diversity acme in the evae Biozone,and a reduction of biogeographic barriers that resulted in a high proportion of species with cosmopolitan *** the present contribution,the pattern of species similarity among laurentia,Argentine Precordillera,Baltica,Kazakhstania,South China,and Australia is evaluated with a multiple coefficient analysis including only the sections that recorded the highstand of the Evae ***,the effect of possible terrestrial,latitudinal,physicochemical barriers and palaeogeographic distance on the species distribution is statistically *** results show a global pattern of conodont species distribution that is highly constrained by the tested palaeoenvironmental *** suggests that contrary to what was expected for a prominent transgression,faunal barriers did not decrease significantly during the Evae drowning peak.

关键词： Evae transgression Oepikodus evae Biozone Statistical analyses Faunal similarities Palaeoenvironmental barriers

US children with special health care needs and ethnic discrimination: results from multivariate modeling

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World Journal of Pediatrics 2019年第2期15卷 182-189页

作者： guillermo Montes St.John Fisher College Alesi 106C3690 East Ave.RochesterNY 14618USA Children's Institute Inc. RochesterNYUSA

Background To determine the prevalence of parent-reported ethnic/racial discrimination,and to determine if children with special health care needs are more likely to experience ethnic discrimination than other children who have similar family income,age,sex,race,parental education and Hispanic *** Using the National Survey of Children's Health 2011-2012 (n =95,677),ethnic discrimination was measured by two questions that asked 'was child ever treated or judged unfairly because of his/her race or ethnic group?' and if so,how often it occurred in the last 12 months prior to the *** An estimated 3 million US children aged 0-17 years have experienced parent-reported ethnic discrimination (1.4% White,9.1% Black,9.9% other race,4.7% Hispanic).The likelihood to experience ethnic discrimination is much higher for Black and other race children,compared to White *** with special health care needs were two times more likely to experience ethnic discrimination frequently in the 12 months prior to the survey than comparable children in terms of age,sex,race,family income,parental education,and social *** family income did not prevent the exposure to ethnic discrimination but was associated with fewer *** Theoretical frameworks,such as social determinants of health,must account for the bidirectional nature of the relationship between health and ethnic *** care must assess if ethnic discrimination has occurred and whether trauma-informed approaches are needed.

关键词： Children with special health care needs Ethnic discrimination United States

Aquaporins:Their role in cholestatic liver disease

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World Journal of Gastroenterology 2008年第46期14卷 7059-7067页

作者： guillermo l lehmann Maria C larocca leandro R Soria Raúl A Marinelli Instituto de Fisiología Experimental Consejo Nacional de Investigaciones Científicas y TécnicasFacultad de Ciencias Bioquímicas y FarmacéuticasUniversidad Nacional de Rosario2000 RosarioSanta FeArgentina

This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and *** bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of *** question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of *** in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein *** combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water *** cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability.

关键词： Aquaporin Cholestasis Estrogen Hepatocyte Obstructive cholestasis, Sepsis Water transport

Empirical formulae to describe some physical properties of small groups of protogalaxies with multiplicity

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Research in Astronomy and Astrophysics 2021年第8期21卷 141-158页

作者： guillermo Arreaga-Garcia Departamento de Investigacion en Fisica Universidad de Sonora Apdo.Postal 14740C.P.83000HermosilloSonoraMexico

By means of identical cubic elements,we generate a partition of a volume in which a particle-based cosmological simulation is carried *** each cubic element,we determine the gas particles with a normalized density greater than an arbitrarily chosen density *** using a proximity parameter,we calculate the neighboring cubic elements and generate a list of *** imposing dynamic conditions on the gas particles,we identify gas clumps and their neighbors,so that we calculate and fit some properties of the groups so identified,including the mass,size and velocity dispersion,in terms of their multiplicity(here defined simply as the number of member galaxies).Finally,we report the value of the ratio of kinetic energy to gravitational energy of such dense gas clumps,which will be useful as initial conditions in simulations of gravitational collapse of gas clouds and clusters of gas clouds.

关键词： galaxies:kinematics and dynamics hydrodynamics methods:numerical

A thick-disk galaxy model and simulations of equal-mass galaxy pair collisions

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Research in Astronomy and Astrophysics 2020年第11期20卷 333-353页

作者： guillermo Arreaga-Garcıa Departamento de Investigacion en Fsica Universidad de Sonora.Apdo.Postal 14740C.P.83000HermosilloSonoraMexico

We implement a numerical model reported in the literature to simulate the evolution of a galaxy composed of four matter components,such as:a dark-matter halo;a rotating disk of stars;a spherical bulge of stars and a ring of molecular *** show that the evolution of this galaxy model is stable at least for 10 Gyr(Gyr=109 years).We characterize the resulting configuration of this galaxy model by figures of the circular velocity and angular momentum distribution;the tangential and radial components of the velocity;the peak density evolution and the radial density ***,we calculate several models of equal-mass galaxy binary collisions,such as:(i)frontal and(ii)oblique(with an impact parameter),(iii)two models with initial conditions taken from a 2-body orbit and(iv)a very close *** allow comparison with the galaxy model,we characterize the dynamics of the collision models in an analogous ***,we determine the de Vaucouleurs fitting curves of the radial density profile,on a radial scale of 0–100 kpc,for all the collision models irrespective of the pre-collision *** study the radial mass density and radial surface density profiles at a smaller radial scale,0–20 kpc,we use a four-parameter fitting curve.

关键词： galaxies kinematics and dynamics galaxies interaction methods numerical

Macrobioerosion and Microbioerosion in Marine Molluscan Shells from Holocene and Modern Beaches (39°-40°S, South of Buenos Aires Province, Argentina)

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1215-1230页

作者： Melisa P. CHARO Jose l. CAVAllOTTO guillermo ACENOlAZA Instituto Superior de Correlacion Geologica (INSUGEO/CONICET-UNT) Miguel lillo 205 4000 Tucuman Argentina Servicio de Hidrografia Naval Av. Montes de Oca 2124 C1270ABWBuenos Aires Argentina

The marine sediments of the area of Verde Peninsula - Jabali Island （39°28＇S/62°19%V-40°28＇ S/62°11＇W） Holocene in age （3-2 ky）, and modern beaches contain a significant amount of bioeroded mollusc shells. Fifteen sites were analyzed, in which 20.11% of the mollusc shells （2168 valves） presented bioerosion traces, in 54 species （30 bivalves and 24 gastropods）. Fourteen ichnogenera were reported： Entobia, Maeandropolydora, Iramena, Caulostrepsis, Pennatichnus, Pinaceocladichnus, Trypanites, and Gastrochaenolites （Domichnia）, Gnathichnus and Radulichnus （Pascichnia）, Finichnus and Centrichnus （Fixichnia）, Oichnus （Praedicnia）（macrobioerosion）, y Semidendrina （microbioerosion）, the latter is first reported in mollusc shells in Argentina. Eleven ichnospecies were identified Finichnus peristroma, Maeandropolydora sulcans, Gnathichnus pentax, Pinaceocladichnus onubensis, Caulostrepsis taeniola, Centrichnus eccentricus, Radulichnus inopinatus, Oichnus simplex, Oichnus paraboloides, Oichnus gradatus, and Gastrochaenolites torpedo （lithic remains）. The dominant ichnogenera in the Holocene deposits are Iramena, Entobia and Oichnus. The same ichnogenera are constant with different abundance in the modern beaches, and increasing representation of Pinaceocladichnus and Pennatichnus. The dominant ichnofacies in the Holocene deposits is Trypanites, revealing a benthonic marine community composed of cheilostome bryzoans, clionaid sponges, predator gastropods, regular echinoids, polychaete annelids, bivalves, thallophytas and fungi. Generally, the area was described as a sublittoral, low-energy, stable environment with high rate of oxygenation, and sandy bottoms, with rocky bottoms at Villalonga locality.

关键词： molluscan bioerosion Holocene south of Buenos Aires Province