检索结果-南通市图书馆

Hepatobiliary Surgery and Nutrition 2021年第6期10卷 890-892页

作者： guillermo Daniel Mazzolini Eda Kaya Ali Canbay Gene Therapy Laboratory Instituto de Investigaciones en Medicina Traslacional(IIMT)Universidad Austral-CONICETBuenos AiresArgentina Liver Unit Hospital Universitario AustralUniversidad AustralBuenos AiresArgentina Section of Gastroenterology and Hepatology University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany Department of Medicine University Hospital Knappschaftskrankenhaus BochumRuhr University BochumBochumGermany

Hepatocellular carcinoma(HCC)is the sixth most common cancer and the second leading cause of cancer-related death worldwide(1).Unfortunately,the incidence and mortality of HCC are increasing steadily in formerly low-risk countries(2).Although the contribution of patients infected with hepatitis B virus(HBV)and hepatitis C virus(HCV)has dramatically decreased due to the use of highly effective antiviral agents,increasing epidemiologic evidence indicates a link between non-alcoholic fatty liver disease(NAFLD)and the risk of HCC(1).It is important to highlight that the prevalence of NAFLD has increased in parallel with the obesity,metabolic syndrome,and type 2 diabetes mellitus *** patients with NAFLD,the incidence of HCC is around 0.44 per 1,000 person-years(3).

关键词： NAFLD hepatitis mortality

Autoimmune hepatitis:Towards a personalized treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第11期16卷 1225-1242页

作者： Alejandro Costaguta guillermo Costaguta FernandoÁlvarez Department of Hepatology and Liver Transplant Unit Sanatorio de Niños de RosarioRosario 2000Santa FeArgentina Department of Gastroenterology Hepatologyand NutritionCHU Sainte-JustineMontreal H3T 1C5QuebecCanada of Pediatrics CHU Sainte-JustineMontreal H3T 1C5QuebecCanada

Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the *** inflammation is accompanied by elevated IgG and autoantibody ***,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of *** significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years *** review summarized the various treatment options currently available as well as our experiences using *** steroids are the standard treatment for induction therapy,other medications may be *** A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for ***,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side *** and everolimus have interesting effects on regulatory T cell populations and may become viable options in the *** mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long *** promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell *** growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.

关键词： Novel therapies Immunosuppressors Treatment tailoring Personalization Special populations

Differences in standing balance between patients with diplegic and hemiplegic cerebral palsy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第26期8卷 2478-2483页

作者： Valeska Gatica Rojas guillermo Méndez Rebolledo Eduardo Guzman Muoz Natalia Ibarra Cortés Caterine Berrios Gaete Carlos Manterola delgado Laboratory of Human Motor Control Faculty of Health Sciences University of Talca Laboratory of Human Motor Control School of Kinesiology Faculty of Health Sciences University of Talca School of Kinesiology University Santo Tomas Student School of Kinesiology Faculty of Health Sciences University of Talca Program in Medical Sciences University of the Frontera

Maintaining standing postural balance is important for walking and handling abilities in patients with cerebral palsy. This study included 23 patients with cerebral palsy （seven with spastic diplegia and 16 with spastic hemiplegia）, aged from 7 to 16 years of age. Standing posture balance measurements were performed using an AMTI model OR6-7 force platform with the eyes open and closed. Patients with diplegic cerebral palsy exhibited greater center of pressure displacement areas with the eyes open and greater center of pressure sway in the medial-lateral direction with the eyes open and closed compared with hemiplegic patients, Thus, diplegic patients exhibited weaker postural balance control ability and less standing stability compared with hemiplegic cerebral palsy patients.

关键词： neural regeneration cerebral palsy postural balance postural control center of pressure children diplegia hemiplegia grants-supported paper neuroregeneration

Foreign exchange trading and management with the stochastic dual dynamic programming method

在线全文

学校读者我要写书评

暂无评论

Financial Innovation 2023年第1期9卷 583-620页

作者： Lorenzo Reus guillermo Alexander Sepulveda‑Hurtado Escuela de Negocios Universidad Adolfo IbanezDiagonal Las Torres2640 SantiagoChile

We present a novel tool for generating speculative and hedging foreign exchange(FX)trading *** solution provides a schedule that determines trades in each rebalancing period based on future currency prices,net foreign account positions,and incoming(outgoing)flows from business *** obtain such policies,we construct a multistage stochastic programming(MSP)model and solve it using the stochastic dual dynamic programming(SDDP)numerical method,which specializes in solving high-dimensional MSP *** construct our methodology within an open-source SDDP package,avoiding implementing the method from *** measure the performance of our policies,we model FX prices as a mean-reverting stochastic process with random events that incorporate stochastic *** calibrate this price model on seven currency pairs,demonstrating that our trading policies not only outperform the benchmarks for each currency,but may also be close to ex-post optimal *** also show how the tool can be used to generate more or less conservative strategies by adjusting the risk tolerance,and how it can be used in a vari-ety of contexts and time scales,ranging from intraday speculative trading to monthly hedging for business ***,we examine the impact of increasing trade policy uncertainty(TPU)levels on our *** findings show that the volatility of currencies from emerging economies rises in comparison to currencies from devel-oped *** discover that an increase in the TPU level has no effect on the aver-age profit obtained by our ***,the risk exposure of the policies increases(decreases)for the group of currencies from emerging(developed)markets.

关键词： FX trading FX risk SDDP Multistage stochastic programming Julia Trade policy uncertainty

Microstructure and mechanical behavior of similar butt-joints of ZK60 and ZK60-1.5RE magnesium alloys produced by linear friction stir welding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2021年第5期9卷 1802-1817页

作者： Erenilton Pereira da Silva Ricardo Henrique Buzolin Ulises Alfaro guillermo Requena Haroldo Calvalcanti Pinto Institute of Engineering Science and Technology(IECT)Federal University of Vales do Jequitinhonha e Mucuri(UFVJM)JanaúbaMGBrazil Department of Materials Engineering São Carlos School of Engineering(EESC)University of São Paulo(USP)São Carlos-SP CEP 13563-120Brazil Christian Doppler Laboratory for Design of High-Performance Alloys by Thermomechanical Processing Kopernikusgasse 24Graz 8010Austria Institute of Materials Science Joining and Forming at Graz University of Technology opernikusgasse 24/IGraz 8010Austria German Aerospace Center(DLR)Institute of Materials Research Linder HöheCologne 51147Germany RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany.

The microstructure and mechanical properties of butt-joints produced by linear friction stir welding of similar plates of as-cast ZK60 and modified ZK60 with 1.5 wt.%RE(ZK60-1.5 RE)are *** thermomechanical affected zone is investigated in both advancing and retrieving sides,and the microstructure is compared to the base metal and the stirred *** backscattered diffraction measurements provide the average microstructural features of the transformed *** mechanical properties are assessed using hardness,tensile testing,and surface residual stress measured using X-ray *** torque and heat input are obtained for the ZK60-1.5 RE compared to the *** thermomechanical affected zone is notably larger for the ZK60 compared to the ZK60-1.5 RE.A gradient microstructure is formed in thermomechanical affected zones where deformed grains are progressively more recrystallised towards the stirred *** is no visible interface between the thermomechanical affected zone and the stirred zone.A fine and partially recrystallised microstructure is formed in the stirred *** retrieving side of the ZK60-1.5 RE has a slightly more refined microstructure compared to the other investigated *** measured with increment in the maximum intensity of the(0001)increases towards to stirred *** formed microstructure is correlated with the role of twinning,recovery,static,and dynamic recrystallisation that can occur during friction stir *** and grains with large misorientation spread are more pronounced in the thermomechanical affected zone and regions towards the base *** low angle grain boundaries are observed towards the stirred *** refined recrystallised grains decorating the grain in the thermomechanical affected zone,a mosaic-like of low and high angle grain boundaries are observed in the stirred *** joints have comparable surface residual *** friction stir welding improved th

关键词： ZK60 Mischmetal FSW Recrystallization Microstructure Thermomechanical

The Global Role of Kidney Transplantation

在线全文

学校读者我要写书评

暂无评论

肾脏病与透析肾移植杂志 2012年第1期21卷 1-7页

作者： guillermo Garcia Garcia Paul Harden Jeremy Chapman Nephrology Service Hospital Civil de GuadalajaraUniversity of Guadalajara Health Sciences Center (CUCS)Hospital 278GuadalajaraJal.44280MEXICO Oxford Kidney Unit and Oxford Transplant Centre Churchill HospitalOxfordUnited Kingdom Centre for Transplant and Renal Research Westmead Millennium InstituteSydney UniversityWestmead HospitalSydneyNSW2145Australia

World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost *** that is both cheaper and better,but is not actually the dominant therapy,must have other drawbacks that prevent replacement of all dialysis treatment by *** barriers to universal transplantation as the therapy for end stage kidney disease include the economic limitations which,in some countries place transplantation,appropriately,at a lower priority than public health fundamentals such as clean water,sanitation and *** in high income countries the technical challenges of surgery and the consequences of immunosuppression restrict the number of suitable recipients,but the major finite restrictions on kidney transplantation rates are the shortage of donated organs and the limited medical,surgical and nursing workforces with the required *** problems have solutions which involve the full range of societal,professional,governmental and political *** Kidney Day is a call to deliver transplantation therapy to the one million people a year who have a right to benefit.

关键词：肾脏病肾移植症状临床研究

Optimal Coordinated Operation of Distributed Static Series Compensators for Wide-area Network Congestion Relief

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1374-1384页

作者： Camilo Andres Ordonez M Antonio Gomez-Exposito guillermo EVinasco M Jose Maria Maza-Ortega IEEE Smart Wires Union CityUSA Department of Electrical Engineering University of SevilleSevillaSpain Interconexion Electrica SA Intercolombia Sevilla Spain

Relieving network congestions is a critical goal for the safe and flexible operation of modern power systems, especially in the presence of intermittent renewables or distributed generation. This paper deals with the real-time coordinated operation of distributed static series compensators(DSSCs) to remove network congestions by suitable modifications of the branch reactance. Several objective functions are considered and discussed to minimize the number of the devices involved in the control actions, the total losses or the total reactive power exchanged, leading to a non-convex mixed-integer non-linear programming problem. Then, a heuristic methodology combining the solution of a regular NLP with k-means clustering algorithm is proposed to get rid of the binary variables, in an attempt to reduce the computational cost. The proposed coordinated operation strategy of the DSSCs is tested on several benchmark systems, providing feasible and sufficiently optimal solutions in a reasonable time frame for practical systems.

关键词： Distributed static series compensation(DSSC) flexible AC transmission system(FACTS) mixed-integer non-linear programming(MINLP) wide-area network control

Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2021年第3期10卷 290-295页

作者： Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie guillermo F.Lopez-sanchez Lukas Schwingshackl Nicola Veronese Lee Smith Department of Geriatric Medicine Bezmialem Vakif UniversityIstanbul 34093Turkey Institute of Neuroscience Newcastle UniversityNewcastle upon Tyne NE17RUUK Primary Care Department Azienda Usl Toscana Sud EstGrosseto 52100Italy Division of Psychology and Mental Health University of ManchesterManchester M139PLUK College of Health&Human Services University of North Carolina at CharlotteLong BeachCA 90815USA Department of Cancer Epidemiology and Prevention Research Alberta Health ServicesHoly Cross CentreAlbertaT5J 3E4Canada School of Health Sciences Institute of Mental Health SciencesUlster UniversityNewtownabbey BT151EDUK Research and Development Unit Sant Joan de Deu Health ParkCIBER of Mental Health(CIBERSAM)Barcelona 08003Spain ICREA Pg.Lluis Companys 23Barcelona 08010Spain The Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust King’s Lynn PE304ETUK Faculty of Sport Sciences University of MurciaMurcia 30100Spain Institute for Evidence in Medicine Medical CenterUniversity of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79085Germany Neuroscience Institute Aging BranchNational Research CouncilPadua 35122Italy The Cambridge Centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridge CB11PTUK

Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbrella review of systematic reviews with meta-analyses of observational studies was *** assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess *** graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 ***,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing *** associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as *** further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.

关键词： Handgrip strength Health outcomes Meta-analysis Umbrella review

Precision silviculture:use of UAVs and comparison of deep learning models for the identification and segmentation of tree crowns in pine crops

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2022年第1期15卷 2223-2238页

作者： Manuel Ignacio Perez Bruno Karelovic Roberto Molina Rodrigo Saavedra Pierluigi Cerulo guillermo Cabrera Department of Computer Sciences Universidad de Concepcion Biblioteca CentralConcepcionChile Celulosa Arauco y Constitucion SA I&DSantiagoChile

The monitoring of trees is crucial for the management of large areas of forest cultivations,but this process may be ***,remotely sensed data offers a solution to automate this *** this work,we used two neural network methods named You Only Look Once(YOLO)and Mask R-CNN to overcome the challenging tasks of counting,detecting,and segmenting high dimensional Red–Green–Blue(RGB)images taken from unmanned aerial vehicles(UAVs).We present a processing framework,which is suitable to generate accurate predictions for the aforementioned tasks using a reasonable amount of labeled *** compared our method using forest stands of different ages and *** counting,YOLO overestimates 8.5%of the detected trees on average,whereas Mask R-CNN overestimates a 4.7%of the *** the detection task,YOLO obtains a precision of 0.72 and a recall of 0.68 on average,while Mask R-CNN obtains a precision of 0.82 and a recall of *** segmentation,YOLO overestimates a 13.5%of the predicted area on average,whereas Mask R-CNN overestimates a 9.2%.The proposed methods present a cost-effective solution for forest monitoring using RGB images and have been successfully used to monitor∼146,500 acres of pine cultivations.

关键词： Artificial intelligence tree identification forestry remote sensing

Use of high-resolution X-ray computed tomography and 3D image analysis to quantify mineral dissemination and pore space in oxide copper ore particles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 965-973页

作者： Bao-hua Yang Ai-xiang Wu guillermo A.Narsilio Xiu-xiu Miao Shu-yue Wu Information Science and Engineering School Hunan International Economics UniversityChangsha 410205China Department of Infrastructure Engineering The University of MelbourneVictoria 3010Australia Key Laboratory of High-efficient Mining and Safety of Metal Mines(Ministry of Education) University of Science and Technology BeijingBeijing 100083China

Mineral dissemination and pore space distribution in ore particles are important features that influence heap leaching performance. To quantify the mineral dissemination and pore space distribution of an ore particle, a cylindrical copper oxide ore sample (I center dot 4.6 mm x 5.6 mm) was scanned using high-resolution X-ray computed tomography (HRXCT), a nondestructive imaging technology, at a spatial resolution of 4.85 mu m. Combined with three-dimensional (3D) image analysis techniques, the main mineral phases and pore space were segmented and the volume fraction of each phase was calculated. In addition, the mass fraction of each mineral phase was estimated and the result was validated with that obtained using traditional techniques. Furthermore, the pore phase features, including the pore size distribution, pore surface area, pore fractal dimension, pore centerline, and the pore connectivity, were investigated quantitatively. The pore space analysis results indicate that the pore size distribution closely fits a log-normal distribution and that the pore space morphology is complicated, with a large surface area and low connectivity. This study demonstrates that the combination of HRXCT and 3D image analysis is an effective tool for acquiring 3D mineralogical and pore structural data.

关键词： high-resolution X-ray computed tomography 3D image analysis ore particles mineral dissemination pore space