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Contamination of Water for Domestic Use and Human Consumption by Heavy Metals Derived from Mining Activity in Parral, Chihuahua, Mexico

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Journal of Environmental Science and Engineering(A) 2012年第3期1卷 286-294页

作者： Luis Miguel Rodriguez Ever Torres Luis Saenz Maria del Carmen Avitia guillermo Rodriguez Eduardo Herrera Carmen Julia Navarro guillermo gonzalez Luis Lozoya Damaris Acosta Technological Institute of Parral Parral Chihuahua 33850 Mexico Research Center for Advanced Materials （CIMA V） Chihuahua 31109 Mexico

Research was done with the objective of evaluating the quality of water supplied to the potable water system in Hidalgo Del Parral, which comes from two main supply sources: wells from "Valle del Verano", which provide water to the east side of the city, and the Water Treatment Plant, which receives water from different mines and supplies the west side of the city. When this plant is overcome on its capacity of treatment, a part of the water from the mines is fed directly to the northwest part of the city. The metals lead (Pb), chromium (Cr), cadmium (Cd), zinc (Zn), and arsenic (As) were analyzed by atomic absorption (AA) technique, based on the United States Environmental Protection Agency (EPA) Method 7000B (Revision 2, February 2007). The digestion process was done according to the guidelines established in Method NMX-AA-051-SCFI-2001, Analysis of Water-Determination of Metals by Atomic Absorption, developed by the National Standardization Technical Committee for Environmental Protection (Mexico). The samples were collected from the following points: 13 wells and 2 re-pumping stations of "Valle del Verano", the inlet and outlet of the Water Treatment Plant, and domestic faucets. The east side of the city, supplied by the wells of "Valle del Verano", is metal-pollution free. The water that comes from the mines contains high concentrations of As, Zn, Cd and Pb, with levels that can get to 0.12, 32.6, 0.26 and 3.5 mg/L, respectively. This water pollution generated by mining can be concluded from the high levels found in the domestic samples in which, for several points, the concentrations exceed the parameters set by the current guideline. According to the results, it is vital to set a plan of remediation for the water that comes from the mines, because there is a great risk for health in the consumption of this water.

关键词：饮用水系统重金属墨西哥无污染国内采矿活动标准化技术委员会原子吸收光谱法

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阻断传染性法氏囊病传播的工具

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国外畜牧学（猪与禽） 2017年第7期37卷 7-11页

作者：万建美(译) 孙相俞(译) 邵建忠(审) 何闪(制图表) guillermo gonzalez carlos gonzalez miren arbe 中鲨动物保健品(厦门)有限公司山东质德农牧集团发展有限公司诗华兽医服务和诗华疫苗服务&设备法国诗华大药厂不详

家禽行业面临着巨大的技术变革,其中之一就是孵化场进一步引进胚蛋免疫技术并扩大其应用,以及开发更多的可以通过胚蛋途径接种的疫苗。

关键词：传染性法氏囊病接种技术工具传播注射系统注射免疫马立克氏病 1日龄雏鸡

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Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： guillermo Valenzuela Mauricio Burotto Katherine Marcelain Jaime gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine Liquid biopsy Cetuximab Panitumumab

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Natural regeneration dynamics of three dry deciduous forest species in Chacocente Wildlife Reserve, Nicaragua

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Journal of Forestry Research 2009年第1期20卷 1-6页

作者： guillermo Castro Marin Mulualem Tigabu Benigno gonzalez Rivas Per Christer Oden Facultad de Recursos Naturales y del Ambiente Universidad Nacional Agraria Apartado posta 453 Managua Nicaragua Swedish University of Agricultural Sciences Faculty of Forest Sciences Department of Forest Genetics and Plant Physiology Tropical Silviculture and Seed Laboratory SE-901 83 Umea Sweden

研究被进行检验三干燥森林种， Lysiloma divaricatum (Jacq ) ， Tabebuia ochracea (可汗) 和 Lonchocarpus minimiflorus 的自然新生(Donn。Sm ) 在尼加拉瓜在一个三年的时期上并且到在到在 Chacocente 野生动物的光的地志的斜坡和... 详细信息

研究被进行检验三干燥森林种， Lysiloma divaricatum (Jacq ) ， Tabebuia ochracea (可汗) 和 Lonchocarpus minimiflorus 的自然新生(Donn。Sm ) 在尼加拉瓜在一个三年的时期上并且到在到在 Chacocente 野生动物的光的地志的斜坡和发生的关系中的新生的分析异质保留。永久样品阴谋在 2001 被建立，并且有象 10 厘米和象 10 厘米一样大的直径一样低的高度的所有个人从 2001 ～ 2003 被记录三连续的年。结果证明自然地改革的个人的密度在种类之中显著地变化了，以及随着时间的过去。L。minimiflorus 和 T。ochracea 与 L 相比有更高的密度。divaricatum，和在种群密度的网变化为 T 是稍微积极的。ochracea 仅仅。新生更充满在到日光的王冠的部分暴露下面的轻轻、陡峭的斜坡，因此导致分发的聚集的模式，特别为 L。minimiflorus 和 T。ochracea。我们断定那个自然新生独自不是足够的维持这些的股票的需要的数字种类，和一项立即的恢复措施应该被拿帮助自然新生过程。

关键词：尼加拉瓜野生动物保护区森林种群密度

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A chronosequence analysis of forest recovery on abandoned agricultural fields in Nicaragua

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Journal of Forestry Research 2009年第A3期20卷 213-222页

作者： guillermo Castro Matin Mulualem Tigabu Benigno gonzalez-Rivas Per Christer Oden Facultad de Recursos Naturales y del Ambiente Universidad Nacional Agraria Apartado posta 453 Managua Nicaragua. Swedish University of Agricultural Sciences Faculty of Forest Sciences Southern Swedish Forest Research Centre Tropical Silviculture and SeedLaboratory PO Box 101 SE-230 53 Alnarp Sweden.

Species composition, diversity and population structure of woody species recovered on three abandoned agricultural fields after 4, 9 and 14 years were characterized. Seedlings, saplings/poles and mature trees were identified and counted in 70 plots of 100 m^2 in each abandoned site. A total of 13, 29 and 22 families represented by 17, 48 and 44 species were registered in 4-, 9- and 14-year-old stands, respectively. There was a shift in dominant species across successional stages. Lonchocarpus acuminatus had the highest importance value in the 4-year old stand, whereas, Myrospermun frutescens, Guazurna ulmifolia and Cordia alliodora had the highest importance value in the 9-year-old-stand and Caesaeria corymbosa, Muntingia calabura, Gliricidia sepium and Tabebuia rosea in the 14-year-old stand. The total stem density increased from 5011 to 9631 individuals per hectare as the age of abandonment increased from 4 to 14 years. The total basal area of individuals _〉 I cm d.b.h, also increased with the age of abandonment. Overall, small individuals （〈 10 cm dbh） contributed to more than half of the total basal area. Species diversity was the highest in the 9-year old stand followed by 14- and 4-year-old stands. We concluded that floristic composition of secondary forests recovers rapidly to the mature forest level compared to structural attributes, which is consistent with the general successional trajectories of tropical dry forest.

关键词： Central America dry forest Neotropics restoration secondary succession abandoned agricultural field forest recovery

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Clinical,radiological and molecular diagnosis correlation in serum samples from patients with osteoarticular tuberculosis

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 581-585页

作者： Guadalupe Garcia-Elorriaga Olga Martinez-Elizondo guillermo del Rey-Pineda Cesar gonzalez-Bonilla Unidad de Investigacion Medica en Inmunologia e Infectologia Hospital de InfectologiaCentro Medico Nacional La Raza(CMNR).Instituto Mexicano del Seguro Social(IMSS)Mexico City.Mexico(Medical Research Unit in Immunology and Infectious DiseaseHospital for Infectious Disease"La Raza"National Medical Center(CMNR).Mexican Social Security Institute(IMSS)Mexico CityMexico) Hospital de Ortopedia "Dr.Victorio de la Fuente Narvaez" Instituto Mexicano del Seguro Social(IMSS)Mexico CityMexico(Orthopedics Hospital " Dr.Victorio de la Fuente Narvaez"Mexican Social Security Institute(IMSS)Mexico CityMexico) Banco Central de Sangre CMNRIMSSand Departamento de InfectologiaHospital Infantil de Mexico Federico Gomez.Secretaria de Salud(SSA)Mexico CityMexico(Central Blood BankCMNR.IMSS and Department of Infectious Disease "Federico Comez" Children's Hospital.Health Ministry (SSA)Mexico CityMexico)

Objective:To assess the role of polymerase chain reaction(PCR)in serum sauples,in the diagnosis of osteoarticular tuberculosis(OTB)in a setting where only clinical and imaging diagnoses determine the ***:A total of 44 consecutive serum specimens were collected from clinically suspected OTB patients,based on clinical and radiological[X-ray or magnetic resonance imagng/computecl tomography]*** were scrcened by in-house nested *** addition,a few specimens were examined by Gram stain,acid-fast bacilli stain,histand routine bacterial culture.A total of 39 specimens were collected from patients suffering from other bone diseases of nontuberculous origin and included as negative ***:of the 44 clinically suspected OTB patients,in-house nested PCR was positive in 40(91%)cases;PCR was negative in 38(97%)negative *** and specificity of our in—house nested PCR was 90.3%and 97.4%,*** PCR report was available within 48 *** was possible to standardize serum PCR technique and in positive cases,a good n was observed in terms of an adequate treatment ***:Nested PCR in serum samples is a rapid,highly sensitive and specific modality for OTB detection,PCR should be performed in addition to clinical evaluation,imaging studies,acidfast bacilli staining,culture and histopathology diagnosis,if possible.

关键词： Osteoarticular tuberculosis Molecular diagnosis Nested polymerase chain reaction Sensitivity Specificity

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Smoking and the risk of acute coronary syndrome in young women treated in an emergency department

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World Journal of Cardiovascular Diseases 2013年第4期3卷 9-12页

作者： Alberto Dominguez-Rodriguez Eduardo Arroyo-Ucar Pedro Abreu-gonzalez guillermo Burillo-Putze Department of Cardiology Hospital Universitario de Canarias Tenerife Spain Department of Cardiology Hospital Universitario de Canarias Tenerife Spain Facultad de Ciencias de la Salud Universidad Europea de Canarias Tenerife Spain Instituto Universitario de Tecnologías Biomédicas Tenerife Spain Facultad de Ciencias de la Salud Universidad Europea de Canarias Tenerife Spain Department of Emergency Medicine Hospital Universitario de Canarias Tenerife Spain Instituto Universitario de Tecnologías Biomédicas Tenerife Spain Department of Physiology Universidad de La Laguna Tenerife Spain

The aim of this study is to compare the clinical characteristics of young women (.

关键词： Women Smoke Acute Coronary Syndrome Emergency Department Risk Factors

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Design and Implementation of a Rehabilitation Upper-limb Exoskeleton Robot Controlled by Cognitive and Physical Interfaces

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Journal of Bionic Engineering 2022年第5期19卷 1374-1391页

作者： Arturo gonzalez‑Mendoza Ivett Quinones‑Uriostegui Sergio Salazar‑Cruz Alberto‑Isaac Perez‑Sanpablo Ricardo Lopez‑Gutierrez Rogelio Lozano LAFMIA UMI Center for Research and AdvancedStudies of National Polytechnic InstituteAv.Instituto Politecnico Nacional No.250807360 Mexico CityMexico Motion Analysis Lab National Institute of Rehabilitation Luis Guillermo Ibarra IbarraCalz.Mexico Xochimilco No.28914389 Mexico CityMexico CONACYT-CINVESTAV Av.Instituto Politecnico Nacional 250807360 Mexico CityMexico UTC-CNRS UMR Sorbonne UniversitesUTC-CNRS UMR7253 HeudiasycCompiegneFrance

This paper presents an upper limb exoskeleton that allows cognitive(through electromyography signals)and physical user interaction(through load cells sensors)for passive and active exercises that can activate neuroplasticity in the rehabilitation process of people who suffer from a neurological *** the exoskeleton to be easily accepted by patients who suffer from a neurological injury,we used the ISO9241-210:2010 as a methodology design *** the first steps of the design process,design requirements were collected from previous usability tests and ***,as a second step,a technological solution is proposed,and as a third step,the system was evaluated through performance and user *** part of the technological solution and to allow patient participation during the rehabilitation process,we have proposed a hybrid admittance control whose input is load cell or electromyography *** hybrid admittance control is intended for active therapy exercises,is easily implemented,and does not need musculoskeletal modeling to ***,electromyography signals classification models and features were evaluated to identify the best settings for the cognitive human–robot interaction.

关键词： Human Robot interaction Hybrid admittance control Surface electromyography Upper-limb exoskeletal robot

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在有 HIV/AIDS 和怀疑或潜伏的肺结核感染的病人的干扰素

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 157-160页

作者： Guadalupe Garcia-Elorriaga Mayte Martinez-Velazquez Veronica Gaona-Flores guillermo del Rey-Pineda Cesar gonzalez-Bonilla Unidad de Investigacion en Inmunologia e Infectologia Centro Medico Nacional La Raza(CMNR)Instituto Mexicano del Seguro Social(IMSS) Mexico CityMexico Hospital de Infectologia CMNRIMSSMexico CityMexico Banco Central de Sangre CMNR.Hospital Infantil de MexicoFederico Gomez.Dpto.de Infectologia

Objective:To assess the usefulness of IGRA test(QuantiFERON? -Cell mediated immune) compared with the tuberculin skin ***:A cross-sectional study was carried out in Mexico,25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection （LTBI） who were>18 years of age and without treatment for tuberculosis（TB）,were enrolled in the ***:Median cluster of differentiation（CD4） count was 364 cells/μL and median HIV viral load was 50 copies/***,20 patients（80%） had at least one positive diagnostic test for LTBI:four（16%） had a positive tuberculin skin test and 19（76%）,a positive QuantiFERON ? -***:No agreement is found between the two diagnostic tests:k = -0.004,95%confidence interval（-0.2219,0.2210）.Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.

关键词： AIDS HIV IGRA Interferonγ Latent tuberculosis infection

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Estimation of Contraction Coefficient of Gorlin Equation for Assessment of Aortic Valve Area in Aortic Stenosis

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World Journal of Cardiovascular Diseases 2017年第4期7卷 119-130页

作者： Ricardo A. Migliore María E. Adaniya Miguel Barranco guillermo Miramont Silvia gonzalez Horacio Tamagusuku Laboratory of Echocardiography Department of Cardiology Hospital Eva Perón San Martín Argentina

Background: The Gorlin equation is the reference method for the assessment of aortic valve area in aortic stenosis and is calculated using a constant, called the coefficient of contraction, which is empirically assumed to be 1. This coefficient is the ratio of effective aortic area to anatomic aortic area, and a value of 1 indicates that both are the same. The purpose of this study was to estimate the actual coefficient of contraction in patients with aortic stenosis and to evaluate its impact on aortic area as calculated by the Gorlin equation. Methods: We studied 17 patients with moderate to severe aortic stenosis. Effective aortic area was calculated using the continuity equation. Anatomic aortic area was obtained by planimetry with transesophageal echocardiography. Aortic valve area by the Gorlin equation was calculated from echocardiography data. The coefficient of contraction was derived as above. Results: The coefficient of contraction was inversely related to the pressure recovery. Effective area was correlated with anatomic area (r = 0.86, P 2). Aortic area by the Gorlin equation was not correlated with anatomic area, but the correlation became significant when the Gorlin equation was corrected for coefficient of contraction and pressure recovery. Conclusions: Using a coefficient of contraction of 1 in the Gorlin equation gives a poor correlation with anatomic area. Using the calculated coefficient of contraction for each patient and the mean gradient for pressure recovery improves the correlation with anatomic area. These facts could be taken in account when Gorlin equation is considered as the reference method.

关键词： Aortic Stenosis Echocardiography Hemodynamics Assessment

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