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Restoring p53 in cancer:the promises and the challenges

Journal of Molecular Cell Biology 2019年第7期11卷 615-619页

作者： guillermina lozano Department of Genetics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

A tribute to Dr Arnold *** This perspective was written in celebration of Dr Arnold ***'s 80th birthday.I chose to write this prospective about restoration of p53 activity in tumors for two reasons:Arnie (as we all know him) has become interested in restoring p53 activity in tumor cells and such a review did not *** was also my postdoctoral advisor and writing this perspective is just a small tribute for the huge impact he has had on my research career (and that of many others),from supporting me when I left his laboratory for a faculty position before I had even published a paper,to serving as a sounding board for numerous ideas.

关键词： tribute written ideas

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Mdm proteins： critical regulators of embryogenesis and hornoeostasis

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Journal of Molecular Cell Biology 2017年第1期9卷 16-25页

作者： Sydney M. Moyer Connie A. Larsson guillermina lozano Department of Genetics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA

Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancerrelated studies. A multitude of experiments across various developmental stages have been conducted to explore the tissuespecific roles of these proteins in the mouse. When Mdm2 or Mdm4 are deleted in the germiine or specific tissues, they display different phenotypic defects, some of which lead to embryonic lethaLity. Mdm2 loss is often more deleterious than toss of its homotogue Mdm4. ALL tissues experience activation of p53 target genes upon toss of Mdm2 or Mdm4; however, the degree to which the p53 pathway is perturbed is highly tissue-specific and does not correlate to the severity of the morphological pheno- types. Therefore, a need for further understanding of how these proteins regulate p53 activity is warranted, as therapeutic targeting of the p53 pathway is rapidly evoLving and gaining attention in the field of cancer research. In this review, we discuss the tissue-specificity of Mdm proteins in regulating p53 and expose the need for investigation at the celt-specific level.

关键词： Mdm2 Mdm4 MdmX development embryogenesis tissue-specific p53

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