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International Journal of Extreme Manufacturing 2021年第1期3卷 98-120页

作者： Henrik Dobbelstein Easo P George Evgeny L Gurevich Aleksander Kostka Andreas Ostendorf guillaume laplanche Applied Laser Technologies Ruhr-University BochumUniversitätsstr.15044801 BochumGermany Material Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831-6115United States of America Materials Science and Engineering Department University of TennesseeKnoxvilleTN 37996-2100United States of America Center for Interface-Dominated High Performance Materials Ruhr-University BochumUniversitätsstr.15044801 BochumGermany Institute for Materials Ruhr-University BochumUniversitätsstr.15044801 BochumGermany

Progress in materials development is often paced by the time required to produce and evaluate a large number of alloys with different chemical *** applies especially to refractory high-entropy alloys(RHEAs),which are difficult to synthesize and process by conventional *** evaluate a possible way to accelerate the process,high-throughput laser metal deposition was used in this work to prepare a quinary RHEA,TiZrNbHfTa,as well as its quaternary and ternary subsystems by in-situ alloying of elemental *** graded variants of the quinary RHEA were also *** results show that the influence of various parameters such as powder shape and purity,alloy composition,and especially the solidification range,on the processability,microstructure,porosity,and mechanical properties can be investigated *** strength of these alloys was mainly affected by the oxygen and nitrogen contents of the starting powders,while substitutional solid solution strengthening played a minor role.

关键词： high-entropy alloy HfNbTaTiZr refractory powder blend laser metal deposition additive manufacturing high-throughput synthesis

Perspectives in human brain plasticity sparked by glioma invasion:from intraoperative(re)mappings to neural reconfigurations

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Neural Regeneration Research 2024年第5期19卷 947-948页

作者： Sam Ng Hugues Duffau guillaume Herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of Functional Genomics University of MontpellierCNRSINSERMMontpellierFrance Praxiling Laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative *** term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences

Systematic review of risk factors,prognosis,and management of colorectal signet-ring cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2141-2158页

作者： Frederiek Nuytens Vincent Drubay Clarisse Eveno Florence Renaud guillaume Piessen Department of Digestive and Oncological Surgery University LilleClaude Huriez University HospitalLille 59000France Department of Digestive and Hepatobiliary/Pancreatic Surgery AZ GroeningeKortrijk 8500Belgium Cambrai Hospital Center and Sainte Marie Group of Hospitals of The Catholic Institute of LilleCambrai 59400France CNRS InsermUMR9020-U1277-CANTHER-CancerUniversity LilleCHU LilleLille 59000France

BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal *** multiple studies concerning this specific topic have been published in the past decades,the pathogenesis,associated risk factors,and potential implications on treatment are still poorly *** the low incidence,historically confusing histological criteria have resulted in confusing ***,the rising incidence of CSRCC along with relatively young age at presentation and associated dismal prognosis,highlight the actual interest to synthesize the known literature regarding *** To provide an updated overview of risk factors,prognosis,and management of *** A literature search in the MEDLINE/PubMed database was conducted with the following search terms used:‘Signet ring cell carcinoma’and‘colorectal’.Studies in English language,published after January 1980,were *** included in the qualitative synthesis were evaluated for content concerning epidemiology,risk factors,and clinical,diagnostic,histological,and molecular features,as well as metastatic pattern and therapeutic *** possible,presented data was extracted in order to present a more detailed overview of the *** In total,67 articles were included for qualitative analysis,of which 54 were eligible for detailed data *** has a reported incidence between 0.1%-2.4%and frequently presents with advanced disease stage at the time of *** is associated with an impaired overall survival(5-year OS:0%-46%)and a worse stagecorrected outcome compared to mucinous and not otherwise specified *** systematic use of exploratory laparoscopy to determine the presence of peritoneal metastases has been *** is the mainstay of treatment,although the rates of curative resection in CSRCC(21%-82%)are lower compared to those in other histological *** case of peritoneal

关键词： Colorectal cancer Signet-ring cell histology Poorly cohesive cells Systematic review Risk factors Prognosis Therapeutic management

Comparative Study on Microstructure and Mechanical Properties of Coarse-grained WC-based Cemented Carbides Sintered with Ultrafine WC or (W+C) as Additives

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 399-409页

作者：于淞百闵凡路 LI De NOUDEM guillaume Jacques ZHANG Hailong MA Jichang ZHAO Kui YAO Zhanhu 张建峰 College of Mechanics and Materials Hohai UniversityNanjing 210098China Key Laboratory of Geomechanics and Embankment Engineering Hohai UniversityMinistry of EducationNanjing 210098China CRISMAT-ENSICAEN(UMR-CNRS 6508) Universitéde Caen-Basse-NormandieF-14050 CaenFrance Shaanxi Aeronautic Carbide Tool Co.Ltd. Hanzhong 724200China CCCC Tunnel Engineering Co.Ltd. Beijing 100102China

The effects of ultrafine WC(WC_(UF),0.5μm) or W(1μm) and C(0.3μm)(W+C)_(UF) additives on the densification,microstructure and mechanical properties of coarse-grained cemented carbides were compared ***,the cemented carbides with WC_(UF)/(W+C)_(UF) additives are almost fully densification to be higher than 99%,and the average grain size is kept above 2.8μ*** WC_(UF) additive assists grains to(truncated)trigonal prism shape by two dimensional(2D) growth,whereas the(W+C)_(UF) additive assists grains to rounded shape by three dimensional(3D) growth,lowers WC contiguity and increases face-centered-cubic *** hardness and bending strength of(75WC_(C)-15WC_(UF))-10Co are 86.6 HRA and 2 272 MPa,respectively,both higher than those of(75WC_(C)-15(W+C)_(UF))-10Co,which could be ascribed to the enhanced densification and unblemished ***,the fracture toughness of the(75WC_(C)-15(W+C)_(UF))-10Co is 23.5 MPa·m^(1/2),higher than that of the(75WC_(C)-15WC_(UF))-10Co due to the uniform WC-Co structure and flexible binder phase.

关键词： coarse-grained WC-based cemented carbide ultrafine WC ultrafine(W+C) microstructure mechanical properties

Predator-prey encounters:deciphering the robbery relationship between highwayman flies and their ant victims

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Integrative Zoology 2024年第2期19卷 253-261页

作者： Ying ZHAO Yulong YU Zhi CHEN Ying LI Huidan TENG guillaume CHOMICKI Chuntian ZHANG Gao CHEN Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations KunmingChina CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingChina College of Life Science Shenyang Normal UniversityShenyangChina School of Ecology and Environmental Science Yunnan UniversityKunmingChina University of Chinese Academy of Sciences BeijingChina Ecology and Evolutionary Biology School of BiosciencesAlfred Denny BuildingUniversity of SheffieldWestern BankSheffieldUK

Examples of predator–prey interactions in which flies rob ants are *** date,this behavior has only been recorded in the genus Bengalia Robineau-Desvoidy(Bengaliinae,Diptera,Calliphoridae).These predatory flies ambush ants,and rob them of the food or offspring that they are ***,because of the rarity of this behavior,the reasons and consequences(evolutionary advantages)are unknown,and indeed,the behavior has been sometimes considered *** this study,we employed field investigations and behavioral analyses to investigate whether the sex of the fly Bengalia varicolor,or the weight and quality of the food carried by Pheidole nodus ants influenced fly–ant interactions in their natural *** show that food weight and quality influenced the behavior of *** independent of the fly’s *** behavior by the flies was more successful when the food robbed was of high-quality and light in ***,the weight of the food robbed modulated the escape distance the flies could carry *** then may affect the food quality and weight transported by the *** is a novel example of deciphering the relationship between highwayman flies and their ant *** the widespread distribution of Bengalia flies,we suggest that such interspecific predator–prey encounters may shape the robbery interactions and the carrying behavior of further ant species in nature.

关键词： Bengalia kleptoparasitism Pheidole predatory flies robbing

Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

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World Journal of Pediatrics 2024年第5期20卷 451-460页

作者： Tae Hyeon Kim Hyeri Lee Selin Woo Hayeon Lee Jaeyu Park guillaume Fond Laurent Boyer Jong Woo Hahn Jiseung Kang Dong Keon Yon Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea CEReSS-Health Service Research and Quality of Life Center Assistance Publique des Hôpitaux de MarseilleAix-Marseille UniversityMarseilleFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnamSouth Korea Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital14913th StreetRoom 4140CharlestownBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea

Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is *** investigated the risk and protective factors related to *** We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related ***/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,*** extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assessment Systematic Reviews 2 following PRISMA *** to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protective factors for SIDS across 21 countries/regions and five *** risk factors,including prenatal drug exposure[eOR=7.84(95%CI=4.81–12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95%CI=4.87–18.72),CE=suggestive],prenatal methadone exposure[9.52(95%CI=3.34–27.10),CE=weak],prenatal cocaine exposure[4.38(95%CI=1.95–9.86),CE=weak],prenatal maternal smoking[2.25(95%CI=1.95–2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95%CI=1.75–2.22),CE=weak],bed sharing[2.89(95%CI=1.81–4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95%CI=5.40–22.45),CE=suggestive],were *** the other hand,three protective factors,namely,breastfeeding[0.57(95%CI=0.39–0.83),CE=non-significant],supine sleeping position[0.48(95%CI=0.37–0.63),CE=suggestive],and pacifier use[0.44(95%CI=0.30–0.65),CE=weak],were also *** Based on the evidence,we propose several risk and protecti

关键词： Infant Protective factor Risk factor Sudden infant death syndrome Umbrella review

Grain Refinement of CrCoNi Multi-principal-element Alloy

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Grain Refinement of CrCoNi Multi-principal-element Alloy

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

第十三届全国铸造年会暨2016中国铸造活动周

作者： Liu Xinwang guillaume laplanche AleksANDer Kostka Suzana G.Fries Janine Pfetzing-Micklich Liu Gang Fan Zitian Easo P.George Department of Materials Design Ruhr-University Bochum State Key Laboratory of Materials Processing and Die & Mould Technology Huazhong University of Science and Technology Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University Bochum

The equiatomic multi-principal-element alloy, CrCoNi, as a single-phase FCC solid solution, displays excellent strength-toughness properties that exceed those of all high entropy alloys, which is considered as a promising engineering alloy at cryogenic temperatures. Cast, as a common-used method to form complex-shaped components, is a necessary technique for engineering alloys, whereas the cast multi-principal-element alloys have not be systematically investigated previously. Here we study the grain refinement of cast CrCoNi alloy and their corresponding mechanical properties. The alloys were produced by arc melting and drop casting, which are much simpler than the preparation procedures of deformed alloys by cold deformation and recrystallization in the previous studies. The cast CrCoNi alloy consists with anisotropic coarse columnar grains with the average width of more than 210 m. Their microstructures, however, become equiaxed grains after grain modification which exhibit uniform fine equiaxed grains with the size of 76 m nearly throughout the entire ingots. The tensile tests at an engineering strain rate of 10-3 s-1 reveals that yield strength, ultimate tensile strength and elongation to fracture are all improved by grain refinement both at 293 and 77 K. Meanwhile, the cast alloy shows the comparable mechanical properties with the alloys after cold working and recrystallization. The corresponding mechanism was also discussed related to the constitutional supercooling.

关键词： multi-principal-element alloy grain refinement microstructures tensile properties

来源： cnki会议评论

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg Alexander Becker Sebastian Keppler guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing Alexander Kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

Machine learning approach to assess the association between anthropometric,metabolic,and nutritional status and semen parameters

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Asian Journal of Andrology 2024年第4期26卷 349-355页

作者： guillaume Bachelot Antonin Lamaziere Sebastien Czernichow Celine Faure Chrystelle Racine Rachel Levy Charlotte Dupont Nutrition and Fertility(ALIFERT)Group Author Information Sorbonne University School of Medicine Saint-Antoine Research CenterINSERM UMR 93827 rue ChalignyParis 75012France Reproductive Biology Department-CECOS Tenon HospitalAP-HP.Sorbonne UniversityParis 75020France Clinical Metabolomics Department Saint-Antoine HospitalAP-HP27 rue ChalignyParis 75012France Nutrition Department Obesity Specialist CentreGeorges Pompidou European HospitalAP-HPParis 75015France 不详

Many lifestyle factors,such as nutritional imbalance leading to obesity,metabolic disorders,and nutritional deficiency,have been identified as potential risk factors for male *** aim of this study was to evaluate the relationship between semen parameters and anthropometric,metabolic and nutritional *** was first assessed individually,then after the application of a previously constructed and validated machine learning score that allows their ***,metabolic,antioxidant,micronutrient,and sperm parameters from 75 men suffering from idiopathic infertility from four infertility centers in France(Jean-Verdier ART Center Hospital,Bondy;North Hospital ART Center,Saint-Étienne;Navarre Polyclinic ART Center,Pau;and Cochin Hospital ART Center,Paris)between September 2009 and December 2013 were *** assessing standard correlation analysis,a previously built machine learning model,providing a score ranging from 0(the poorest)to 1(the most favorable),was calculated for each man in the study *** machine learning model,which separates infertile/fertile men with unexplained infertility on the basis of their bioclinical signature,provides a more holistic evaluation of the influence of the considered markers(anthropometric,metabolic,and oxidative status).We observed a significant correlation of some anthropometric,metabolic,and nutritional disorders with some sperm ***,an unfavorable machine learning score was associated with a high level of sperm DNA *** anthropometric,metabolic,and oxidative patterns,which may reflect an appropriate lifestyle,appear to positively impact overall health,in particular reproductive *** study,consistent with previous publications,suggests that beyond semen quality parameters,in an essential assessment of male fertility,other key factors should be taken into *** this regard,the application of emerging artificial intelligence t

关键词： lifestyle machine learning metabolism nutrition sperm DNA fragmentation

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria