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Use of Ointment or Aqueous Extract of Neem(Azadirachta indica)for the Repair of Experimental Skin Lesions in Sheep

American Journal of Plant Sciences 2020年第5期11卷 693-706页

作者： Tiago Luis Eilers Treichel Tales Dias do Prado Anaiza Simao Zucatto do Amaral Yeury de Sousa Gomes Lucas da Rocha Pinto guilherme toledo martins Arthur toledo martins Didier Quevedo Cagnini Veterinary Surgery Service Faculty of Veterinary MedicineUniversity of Rio VerdeRio VerdeBrasil Clinical Laboratory Faculty of Veterinary MedicineUniversity of Rio VerdeRio VerdeBrasil Faculty of Veterinary Medicine University of Rio VerdeRio VerdeBrazil Department of Morphophysiology Institute of Biological SciencesUniversidade Federal de JataiJataiBrazil

The skin is considered the largest organ in the body and this protective barrier can be broken in some situations. The wound healing process is a complex mechanism. Based on the difficulties encountered for treatment, alternatives are sought and one of the options may be phytotherapy. Azadirachta indica, known as Nim, is perhaps one of the most widely known and used medicinal plants. This research aimed to evaluate the viability and effectiveness of therapy with Neem, in the form of ointment or aqueous leaf extract. Eighteen sheep were randomly divided into three groups and subjected to the creation of a 7 × 7 cm excision wound on the chest wall. After, treatment was started according to each group. Animals in G1 did not receive any treatment;in G2, the ointment of Neem was applied and animals in G3 were treated with the preparation of an aqueous solution of Neem leaves. Photographic images were recorded, in addition to blood collection for complete blood count and tissue biopsy. The wound area measurements showed no statistically significant difference between the groups (p > 0.05). Fibrinogen levels were not different, and there was no difference in platelet levels. In the histopathological evaluation, G2 registered a greater presence of ulceration, when compared to G3, on day 7. On day 14, G2 still had a greater amount of ulceration, differentiating from G1. G2 also registered a greater presence of crust and a higher score of granulation tissue, in the last evaluation period, compared to G3. Analyzing the results obtained in this research and taking into account the conditions in which the study was carried out, it is possible to conclude that the use of Neem was not effective in accelerating the rate of wound healing in sheep.

关键词： Phytotherapy Sheep Skin Wound

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís guilherme de Oliveira Silva Mariana Santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Homeopathy for COVID-19 in primary care:A randomized,double-blind,placebo-controlled trial(COVID-Simile study)

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Journal of Integrative Medicine 2022年第3期20卷 221-229页

作者： Ubiratan Cardinalli Adler Maristela Schiabel Adler Ana Elisa Madureira Padula Livia Mitchiguian Hotta Amarilysde toledo Cesar JoséNelson martins Diniz Helen de Freitas Santos Edson Zangiacomi Martinez Department of Medicine Federal University of São CarlosSão Carlos 13565-905Brazil Homeopathy Solidarity Outpatient Extension Program Mackenzie Presbyterian UniversitySão Paulo 01302-907Brazil Municipal Center for Integrative and Complementary Practices in Health Guarulhos 07023-051Brazil HN-Cristiano Institute São Paulo 02013-001Brazil School Health Unit Federal University of São CarlosSao Carlos 13565-905Brazil Federal Institute of Education Science and Technology of São PauloBirigui 16201-407Brazil Department of Social Medicine Ribeirão Preto Medical SchoolUniversity of Sao PauloRibeirao Preto 14049-900Brazil

Background:Different homeopathic approaches have been used as supportive care for coronavirus disease 2019(COVID-19)cases,but none has been tested in a clinical ***:To investigate the effectiveness and safety of the homeopathic medicine,Natrum muriaticum LM2,for mild cases of ***,setting,participants,and interventions:A randomized,double-blind,two-armed,parallel,singlecenter,placebo-controlled clinical trial was conducted from June 2020 to April 2021 in S?o-Carlos,*** aged>18 years,with influenza-like symptoms and positive result from a real-time polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2 were recruited and randomized(1:1)into two groups that received different treatments during a period of *** group received the homeopathic medicine Natrum muriaticum,prepared with the second degree of the fifty-millesimal dynamization(LM2;Natrum muriaticum LM2),while the other group received a *** measures:The primary endpoint was time until recovery from COVID-19 influenza-like *** measures included a survival analysis of the number and severity of COVID-19 symptoms(influenza-like symptoms plus anosmia and ageusia)from a symptom grading scale that was informed by the participant,hospital admissions,and adverse ***-Meier curves were used to estimate time-to-event(survival)***:Data from 86 participants were analyzed(homeopathy,n=42;placebo,n=44).There was no difference in time to recovery between two groups among participants who were reporting influenzalike symptoms at the beginning of monitoring(homeopathy,n=41;placebo,n=41;P=0.56),nor in a sub-group that had at least 5 moderate to severe influenza-like symptoms at the beginning of monitoring(homeopathy,n=15;placebo,n=17;P=0.06).Secondary outcomes indicated that a 50%reduction in symptom score was achieved significantly earlier in the homeopathy group(homeopathy,n=24;placebo,n=25;P=0.0

关键词： Homeopathy COVID-19 Primary care Natrum muriaticum Randomized controlled trial

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Evaluation of Weather Research and Forecasting Model Parameterizations under Sea-Breeze Conditions in a North Sea Coastal Environment

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Journal of Meteorological Research 2016年第6期30卷 998-1018页

作者： SALVADOR Nadir REIS Jr. Neyval Costa SANTOS Jane Meri ALBUQUERQUE Taciana toledo de Almeida LORIATO Ayres Geraldo DELBARRE Herve AUGUSTIN Patrick SOKOLOV Anton MOREIRA Davidson martins Federal University of Espirito Santo Vitoria Espirito Santo Brazil Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil Universite Lille Nord de France Lille France Integrated Center for Manufacturing and Technology Salvador Bahia Brazil

Three atmospheric boundary layer （ABL） schemes and two land surface models that are used in the Weather Research and Forecasting （WRF） model, version 3.4.1, were evaluated with numerical simulations by using data from the north coast of France （Dunkerque）. The ABL schemes YSU （Yonsei University）, ACM2 （Asymmetric Convective Model version 2）, and MYJ （Mellor-Yamada-Janjic） were combined with two land surface models, Noah and RUC （Rapid Update Cycle）, in order to determine the performances under sea-breeze conditions. Particular attention is given in the determination of the thermal internal boundary layer （TIBL）, which is very important in air pollution scenarios. The other physics parameterizations used in the model were consistent for all simulations. The predictions of the sea-breeze dynamics output from the WRF model were compared with observations taken from sonic detection and ranging, light detection and ranging systems and a meteorological surface station to verify that the model had reasonable accuracy in predicting the behavior of local circulations. The temporal comparisons of the vertical and horizontal wind speeds and wind directions predicted by the WRF model showed that all runs detected the passage of the sea-breeze front. However, except for the combination of MYJ and Noah, all runs had a time delay compared with the frontal passage measured by the instruments. The proposed study shows that the synoptic wind attenuated the intensity and penetration of the sea breeze. This provided changes in the vertical mixing in a short period of time and on soil temperature that could not be detected by the WRF model simulations with the computational grid used. Additionally, among the tested schemes, the combination of the local- closure MYJ scheme with the land surface Noah scheme was able to produce the most accurate ABL height compared with observations, and it was also able to capture the TIBL.

关键词： sea-breeze detection WRF model parameterizations

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Dehydrated Natural Feed for Cats: Influence on Apparent Digestibility Coefficient, Feces Scores, and Serum Immune, Antioxidant, and Metabolic Biomarkers

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Food and Nutrition Sciences 2024年第7期15卷 594-611页

作者： Bruno Giorgio de Oliveira Cécere guilherme Luiz Deolindo Bianca F. Bissacotti Priscila Marquezin Copetti Maria Rosa Chitolina Schetinger Bruna Klein Matheus Delamea Baldissera Thiago Pereira Ribeiro Walter Hugo Cuelho Suarez Daniel Pigatto Monteiro Aleksandro Schafer Da Silva Graduate Multicenter Program in Biochemistry and Molecular Biology University of the State of Santa Catarina Lages Brazil Department of Biochemistry and Molecular Biology Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil Department of Animal Science Universidade Federal de Santa Maria (UFSM) Chapec Brazil Department of Health Science Universidade Franciscana (UFN) Santa Maria Brazil Department of Animal Nutrition Tectron-Tecnologia e Inovao Toledo Brazil

The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DCF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DCF. Cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. Cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DCF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DCF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.

关键词： Alternative Feed Antioxidant Companion Animals Health

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Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago martins guilherme Pugliesi Mariana Sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-Rojas Frederich D.Rodriguez Roney S.Ramos Andrea C.Basso Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of Animal Sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMPBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(P > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph Protein

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Design Procedure for Reinforced Concrete Beams and Reinforcement Replacement by Bamboo

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Computational Water, Energy, and Environmental Engineering 2020年第3期9卷 37-47页

作者： Eduarda Noriko Tokuda Juliana de toledo Viana guilherme Augusto Nascimento Amorim Renan Dias Sherington Bigotto UNIFEV Votuporanga Brazil FEIS/UNESP Ilha Solteira Brazil

The use of non-renewable resources by the construction industry has several environmental consequences, contributing to excessive energy consumption and loss of materials. So, the construction sector is always in search of improvement and methods that innovate the existing techniques, aiming at the use of alternative and sustainable materials. Bamboo is a perennial plant with fast growth rate and low cost that has great physical and mechanical characteristics that assure its performance in the building environment. The use of beams with total or partial replacement of steel by bamboo has been well studied, due to the possibility of using the same design methods used in reinforced concrete beams, since the bamboo-reinforced beams meet the Bernoulli-Kirchoff bending theory. The objective of the work was to adapt a design procedure into an electronic spreadsheet for bamboo reinforced concrete beams subjected to four-point bending, with rectangular section, according to Brazilian Standard NBR 6118 (2014). The spreadsheet was tested based on other authors taking into consideration a steel double reinforcement. The resulting values were equivalents to those obtained by the authors, validating the efficiency of the worksheet. This methodology aims to optimize the design process of beams and enable the substitution of steel by bamboo, highlighting the validation, from the structural point of view, obtained by the authors.

关键词： Bamboo Concrete Beam Alternative Material

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J-A formulation: A finite element methodology for simulating superconducting devices

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Superconductivity 2023年第2期6卷 64-73页

作者： Gabriel dos Santos Bárbara Maria Oliveira Santos Felipe Sass Flávio Goulart dos Reis martins guilherme Gonçalves Sotelo Rubens de Andrade Junior Federal Fluminense University Brazil State University of Rio de Janeiro Brazil Federal University of Rio de Janeiro Brazil

High‐temperature superconductors are a powerful technological option to be applied in the current scenario of energy *** applications include fault current limiters,power electrical cables,and electrical machines,for *** to the non‐linearities of superconductors,it is computationally costly to run real models of superconducting ***,it is of paramount importance to have a reliable and fast formulation to model superconducting *** paper proposes a new hybrid J‐A formulation to simulate superconducting *** new formulation is validated with 5 case studies,some of which are *** J‐A formulation agrees in all cases and has a smaller computation time when compared with the T‐A ***,due to the simple implementation,the proposed formulation allows the possibility of running the J and A formulations in the same order and presents itself as a potential feature to speed up and help the design of the superconducting devices.

关键词： High‐temperature superconductors Finite element method J‐A formulation

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Magnetic bearings with double crossed loops modelled with T-A formulation and electric circuits

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Superconductivity 2023年第3期7卷 65-74页

作者： Bárbara Maria Oliveira Santos Gabriel dos Santos Flávio Goulart dos Reis martins Felipe Sass guilherme Gonçalves Sotelo Rubens de Andrade Junior Francesco Grilli Electrical Engineering Department Rio de Janeiro State UniversityRio de Janeiro20550-900Rio de JaneiroBrazil Electrical Engineering Department Universidade Federal FluminenseNiterói24210-240Rio de JaneiroBrazil Electrical Engineering Department Universidade Federal do Rio de JaneiroRio de Janeiro21941-909Rio de JaneiroBrazil Institute for Technical Physics Karlsruhe Institute of TechnologyKarlsruhe76131Germany

The application of High‐Temperature Superconductor(HTS)coils made of coated conductors has been investigated for many years.A possible configuration for such coils is the jointless loop,also known as the ring *** double crossed loop coil(DCLC)has been successfully applied in superconducting magnetic bearings(SMBs).The design of SMBs with DCLCs requires flexible modelling to allow all parts of the device to be *** work proposes the T‐A formulation with a thin‐film approximation for modelling SMB with DCLCs in the finite element analysis framework.A 2D representation of the system is coupled with an external electric circuit to model the continuity of the lines that represent the parts of each jointless *** couple the T‐A formulation and the circuit,an average of the total electric field,with both resistive and inductive components,is applied to the *** total current computed by the circuit is applied to the T‐A *** proposed methodology was validated by comparison with levitation force experimental *** types of tests were simulated:five levitation force tests and three guidance force *** is shown that there is a limit to the behaviour of the levitation force related to the high‐loss *** this limit,the stack of DCLCs behaves as an equivalent *** this limit,a high‐loss state appears as a linear growth of the levitation *** is also shown that this high‐loss state in vertical displacement influences the lateral force.

关键词： Coated conductors Jointless loops T‐A formulation

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Studies on the Molecular Mechanism Underlying Resistance to Potato Virus X Conferred by Plant Argonaute2

Studies on the Molecular Mechanism Underlying Resistance to ...

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中国植物病理学会2021年学术年会

作者： ZHAO Zhenxing martins guilherme Silva JIAO Zhiyuan BROSSEAU Chantal FAN Zaifeng MOFFETT Peter Department of Plant Pathology China Agricultural University Centre SèVE Département de BiologieUniversité de Sherbrooke Institute of Plant Inspection and Quarantine Chinese Academy of Inspection and Quarantine

RNA silencing is one of the important mechanisms of plant antiviral innate immunity（Calil and Fontes,2017;Li and Wang,2019）.Arabidopsis is usually not considered a host of PVX and is immune to its *** certain circumstances,PVX can break this non-host *** combined with another virus,PVX can infect Arabidopsis ecotype *** previous studies,it was shown that PVX can achieve systemic infection after inoculation in the dcl2/dcl3/dcl4 triple mutant,indicating that RNA silencing may be the cause of Arabidopsis immunity to PVX（Jaubert et al.,2011）.It has also been shown that the AtCol-0-AGO2 allele confers resistance to PVX,whereas the AG02 allele from the C24 ecotype（AtC24-AG02） does *** reason for this difference may be the longer RGR repeat motif and D33 sites located in the N-terminus of *** variants are not located in the known functional domain of AG02（Brosseau et al.,2019）.The molecular role of these two sites involved in antiviral resistance is still *** study aims to use the tobacco leaf transient overexpression system and transgenic overexpression Arabidopsis lines to explore the function of the Nterminal region of the AGO2 protein and its effect on the relationship between PVX and P25.

关键词： RNA silencing ARGONAUTE 2 viral suppressor of RNA silencing Potato virus X

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