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Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani guilherme Vassalo Morais Fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de Barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

Deposition of nanoparticles on school eyeglasses in urban and rural areas:A methodology for a more real assessment of the possible impacts

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Geoscience Frontiers 2022年第1期13卷 498-505页

作者： Kátia Martinello James C.Hower guilherme L.Dotto Claudete G.ramos Carlos E.Schnorr Diana Pinto Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Chemical Engineering Department Federal University of Santa Maria97105-900 Santa MariaBrazil Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia

Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye *** that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural *** important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.

关键词： Indoor air pollution Nanoparticles Eyes health Allergic reaction Schools

Artisanal ceramic factories using wood combustion:A nanoparticles and human health study

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Geoscience Frontiers 2022年第1期13卷 488-497页

作者： Kátia Martinello James C.Hower Diana Pinto Carlos E.Schnorr guilherme L.Dotto Marcos Leandro Silva Oliveira Claudete G.ramos Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Centro de Estudos em Estresse Oxidativo-Departamento de Bioquímica-Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul(UFRGS) Porto AlegreRSBrazil Chemical Engineering Department Federal University of Santa MariaUFSMRoraima Avenue1000Santa MariaRS97105-900Brazil Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Peru

The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide *** ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and *** improvements are indispensable to diminish contact with *** present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic *** matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman *** NPs configuration(10 nm)were produced around the studied artisanal ceramic *** study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.

关键词： Ceramic manufacturing Nanoparticles Advanced characterization Multiple impacts

Experiences of the Electricity System Operator Incentive Scheme in Great Britain

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Energy and Power Engineering 2012年第4期4卷 218-225页

作者： guilherme Luiz Susteras Dorel Soares ramos Roland Berger Strategy Consultants Sao PauloBrazil Escola Politécnica University of Sao PauloSao PauloBrazil

National Grid is the electricity system operator in Great Britain and has an unique feature in so far as it is one of the world’s few for-profit system operators. In addition, the commercially orientation of the British market rules means that nearly every action taken by National Grid to operate the system has a cost associated to it. Based on those factors and in order to encourage National Grid to seek continuous improvements and drive for efficient and economic system operation, the regulator (Ofgem) offers an incentive scheme, whereby a target is agreed annually and any savings in relation to this target are shared between consumers and National Grid in the form of a profit. It is in National Grid’s best interest to have mechanisms to mitigate the impacts of volatility in the costs it faces as system operator so that it can implement cost saving actions without the risk of windfall losses (or gains) arising from sudden changes in uncontrollable drivers. The purpose of this paper is to share the experiences of National Grid in the operation of Great Britain's electricity system, with a special interest on the mechanisms created to manage the associated costs in response to the incentive scheme. It does so by describing the market operation in Great Britain and the costs drivers impacting National Grid’s system operation and illustrating the steps recently taken by National Grid to propose volatility mitigation mechanisms. It concludes with the rationale and expected results from the latest proposals as consulted with the industry for introduction in the incentive scheme starting on 1st April 2011. It is worth noting that with this work, the authors wish to both share the experience with other system operators and regulators in the world, as well as give British market participants an insight on the inner workings of National Grid.

关键词： Power System System Operation Ancillary Services Wholesale Electricity Market

Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago Martins guilherme Pugliesi Mariana Sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-Rojas Frederich D.Rodriguez Roney S.ramos Andrea C.Basso Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of Animal Sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMPBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(P > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph Protein

Plant growth and nutrient use efficiency of two native Fabaceae species for mineland revegetation in the eastern Amazon

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Journal of Forestry Research 2020年第6期31卷 2287-2293页

作者： Silvio J.ramos Markus Gastauer Simone K.Mitre Cecı´lio F.Caldeira Joyce R.Silva Antonio E.Furtini Neto guilherme Oliveira Pedro W.M.Souza Filho Jose´O.Siqueira Instituto Tecnolo´gico Vale Rua Boaventura da Silva955Belem 66055-090Brazil Departamento de Ciencia do Solo Universidade Federal de LavrasLavras 37200-000Brazil

The primary challenge of mineland revegetation is the establishment of species able to cope with low availability of nutrients,especially in steep slopes such as of mine *** evaluated plant growth response and nutrient use efficiency(NUE)of two promising native Fabaceae species(Dioclea apurensis—liana from metalliferous savannas;Bauhinia longipedicellata—tree from Amazon rainforest)from the Caraja´s Mineral Province,eastern *** were grown separately in 2-kg pots filled with mining *** were fertilized with nitrogen,phosphorus,potassium(NPK),lime,and *** results showed increments on growth of both species when nutrients were applied to the mining *** showed increases in leaf area,plant height,stem diameter,and shoot dry mass production when NPK or NPK?micronutrients were applied,while *** was responsive to application of NPK?lime or NPK?lime?***,*** showed higher NUE than ***,especially at the lowest doses of N,P and *** findings may indicate a substantial advantage of *** for mineland revegetation,as this species may require lower nutrient inputs,being,therefore,a more sustainable way to revegetate degraded areas.

关键词： Fertilizer application Mining soil Tropical forest Nutrient use efficiency

Impact of hormonal modulation at proestrus on ovarian responses and uterine gene expression of suckled anestrous beef cows

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Journal of Animal Science and Biotechnology 2018年第1期9卷 77-90页

作者： Manoel Francisco de Sá Filho Angela Maria Gonella-Diaza Mariana Sponchiado Marcio Ferreira Mendanha guilherme Pugliesi Roney dos Santos ramos Sónia Cristina da Silva Andrade Gustavo Gasparin Luiz Lehmann Coutinho Marcelo Demarchi Goissis Fernando Silveira Mesquita Pietro Sampaio Baruselli Mario Binelli Departamento de Reproducao Animal FMVZ USP Sao Paulo SP Brazil Departamento de Genetica e Biologia Evolutiva IB-USP- Sao Paulo SP Brazil Laboratorio de Biotecnologia Animal ESALQ USP Av Padua Dias Piracicaba SP 11 Brazil Universidade Federal do Pampa Uruguaiana RS Brazil Universidade de Sao Paulo Faculdade de Medicina Veterinriae Zootecnia Departamento de Reprodcao Animal Avenida Duque de Caxias Norte 225 Pirassununga SP Zip Code 13635900 Brazil

Background： This study evaluated the impact of hormonal modulation at the onset of proestrus on ovarian response and uterine gene expression of beef ***： A total of 172 anestrous beef cows were assigned to one of four groups according to the treatment with estradiol cypionate（ECP） and/or equine chorionic gonadotropin（eCG） [CON（n = 43）, ECP（n = 43）, eCG（n = 44）and ECP ＋ eCG（n = 42）].Results： ECP-treated cows（ECP and ECP ＋ eCG groups） presented greater occurrence of estrus（44.6% vs. 65.4%; P = 0.01） and pregnancy per AI [47.1% vs. 33.3%; P = 0.07], but similar progesterone（P4） concentration at subsequent diestrus than cows not treated with ECP（CON and eCG groups）. Nonetheless, eCG-treated cows（eCG and ECP ＋ eCG groups） presented larger follicle at timed AI（12.6 ± 0.3 vs. 13.5 ± 0.3 mm; P = 0.03）, greater ovulation rate（96.5%vs. 82.6%; P = 0.008） and greater P4 concentration at d 6（3.9 ± 0.2 vs. 4.8 ± 0.2 ng/mL; P = 0.001） than cows not treated with eCG（CON and ECP groups）. Next, cows with a new corpus luteum 6 d after TAI were submitted to uterine biopsy procedure. Uterine fragments [CON（n = 6）, ECP（n = 6）] were analyzed by RNA-Seq and a total of 135 transcripts were differentially expressed between groups（73 genes up-regulated by ECP treatment）. Subsequently,uterine samples were analyzed by q PCR（genes associated with cell proliferation）. ECP treatment induced greater abundance of PTCH2（P = 0.07） and COL4 A1（P = 0.02）, whereas suppressed EGFR（P = 0.09） expression. Conversely, eCG treatment increased abundance of HB-EGF（P = 0.06）, ESR2（P = 0.09）, and ITGB3（P = 0.05）, whereas it reduced transcription of ESR1（P = 0.05）. Collectively, supplementation with ECP or eCG at the onset of proestrous of anestrous beef cows influenced ovarian responses, global and specific endometrial gene ***： Proestrus estradiol regulate the endometrial transcriptome, particularly stimulating proliferative activity in the endometrium.

关键词： Cattle eCG Endometrium Estradiol Transcriptome

Growth and Production of Hydroponic Pepper under Salt Stress and Plant Density

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American Journal of Plant Sciences 2017年第9期8卷 2255-2267页

作者： guilherme De Freitas Furtado Antonio ramos Cavalcante Lúcia Helena G. Chaves José Amilton Santos Júnior Hans Raj Gheyi Department of Agricultural Engineering Federal University of Campina Grande Campina Grande Brazil Department of Agricultural Engineering Federal Rural University of Pernambuco Recife Brazil Postgraduate Program in Agricultural Engineering Federal University of Rec&#244 ncavo da Bahia Cruz das Almas Brazil

The viability of the use of brackish water in the hydroponic cultivation of vegetables cannot dispense with auxiliary techniques such as water mixing and the use of plant densities. In this sense, the objective of the present work was to analyze the growth and production of sweet pepper, cv. All Big, under hydroponic conditions, under different levels of electrical conductivity of the nutrient solution (1.7, 3.7, 5.7, 7.7, 9.7 and 11.7 dS·m-1) in plants spaced every 0.2 m and 0.3 m. These treatments were distributed in a completely randomized experimental design, analyzed in a 6 × 2 factorial scheme, with five replications. The growth variables were evaluated at 60, 75 and 90 days after sowing and the production variables at the time of harvest;however, the results were submitted to analysis of variance, at a 0.05 probability level. The interaction between the electrical conductivity of the nutrient solution and the density of plants influenced the behavior of the growth and production variables of pepper (All Big). It was verified that the pepper plants had better performance of the biometric variables plant height, stem diameter and number of leaves when cultivated every 30 cm. At the time, in the analysis by plant, the production of pepper fruits was more expressive when spacing of 30 cm was adopted, however, in the tube of six meters, when 20 cm of spacing was used, the number of fruits was on average, 26.38% and 16.40% higher than lower density, in the electrical conductivities 1.7 and 11.7 dS·m-1.

关键词： Capsicum annuum L. Brackish Water Rainwater

Growth of Pepper under Different Concentration of the Solutions Used in the Hydroponic System

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Agricultural Sciences 2018年第8期9卷 925-935页

作者： Felipe Guedes de Souza guilherme de Freitas Furtado Antonio ramos Cavalcante Lucia Helena Garófalo Chaves Josely Dantas Fernandes José Amilton Santos Júnior Department of Agricultural Engineering Federal University of Campina Grande Campina Grande Brazil Department of Agricultural Engineering Federal Rural University of Pernambuco Recife Brazil

Water availability is a fundamental condition for sustainable agriculture. However, a satisfactory water condition is not always possible in terms of quantity and quality in certain regions, such as the Brazilian semi-arid region. Thus, the purpose of this extremely important research was to evaluate the growth of cv. All Big with six combinations of wastewater plus saline (WW + SW) and two nutrient solution percentages, in a low-cost hydroponic system. The experiment was carried out in a greenhouse at the Department of Agricultural Engineering at Federal University of Campina Grande. A completely randomized experimental design was used, with treatments arranged in a factorial scheme (6 × 2), with 5 replications, being the treatments composed by the combination of six proportions of wastewater with saline water (50%/50%;60%/40%;70%/30%;80%/20%;90%/10%;100% of wastewater) and two nutrient solution concentration (80% and 100%), totalizing 60 experimental units. The biometric variables were analyzed at 55 and 96 days after sowing, namely: plant height (PH), stem diameter (SD), leaf number (LN) and leaf area (LA). The interaction between the concentration of the nutrient solution and the ratio of the saline water with wastewater was influenced in the behavior of peppers (cv. All Big) biometric variables. The nutrient solution prepared at 80% of its normal concentration had better performance in the development of plants when mixed with the proportions of water containing more wastewater. The proportion 30% saline water and 70% wastewater (30/70) with concentration of 80% of the nutrient solution obtained better satisfactory results in the studied biometric variables.

关键词： Capsicum annuum L. Saline Water Wastewater Nutrient Solution