检索结果-南通市图书馆

New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2023年第2期11卷 303-315页

作者： Emilie Hascoet Frédéric Blanchard Claudine Blin-Wakkach Jérôme Guicheux Philippe Lesclous Alexandra Cloitre Nantes Université OnirisUniv AngersCHU NantesINSERMRegenerative Medicine and SkeletonRMeSUMR1229F-44000 NantesFrance UniversitéCote d'Azur CNRSLP2M NiceFrance

Rheumatoid arthritis(RA)and periodontitis are chronic inflammatory diseases leading to increased bone *** this inflammatory bone resorption is a major health *** diseases share immunopathogenic similarities and a common inflammatory *** autoimmune response or periodontal infection stimulates certain immune actors,leading in both cases to chronic inflammation that perpetuates bone ***,RA and periodontitis have a strong epidemiological association that could be explained by periodontal microbial *** dysbiosis is believed to be involved in the initiation of RA via three mechanisms.(i)The dissemination of periodontal pathogens triggers systemic inflammation.(ii)Periodontal pathogens can induce the generation of citrullinated neoepitopes,leading to the generation of anti-citrullinated peptide autoantibodies.(iii)Intracellular danger-associated molecular patterns accelerate local and systemic ***,periodontal dysbiosis could promote or sustain bone resorption in distant inflamed ***,in inflammatory conditions,the existence of osteoclasts distinct from“classical osteoclasts”has recently been *** have proinflammatory origins and *** populations of osteoclast precursors have been described in RA,such as classical monocytes,a dendritic cell subtype,and arthritis-associated osteoclastogenic *** aim of this review is to synthesize knowledge on osteoclasts and their precursors in inflammatory conditions,especially in RA and *** attention will be given to recent data related to RA that could be of potential value in periodontitis due to the immunopathogenic similarities between the two *** our understanding of these pathogenic mechanisms should lead to the identification of new therapeutic targets involved in the pathological inflammatory bone resorption associated with these diseases.

关键词： inflammatory osteoclast period

维普期刊数据库

Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2023年第5期13卷 254-263页

作者： Maria Clara morais Maria Eduarda Soares Gabriela Costa Laura Guerra Nayana Vaz Liana Codes Paulo Lisboa Bittencourt School of medicine Bahiana School of Medicine and Public HealthSalvador 40290-000BahiaBrazil School of medicine Federal University of BahiaSalvador 40110-100BahiaBrazil Unit of Gastroenterology and Hepatology Portuguese HospitalSalvador 40130-030BahiaBrazil

Tacrolimus(Tac)is currently the most common calcineurin-inhibitor employed in solid organ *** intra-patient variability(IPV)of Tac(Tac IPV)has been associated with an increased risk of immune-mediated rejection and poor outcomes after kidney *** data are available concerning the impact of high Tac IPV in non-kidney ***,even in kidney transplantation,there is still a controversy whether high Tac IPV is indeed detrimental in respect to graft and/or patient *** may be due to different methods employed to evaluate IPV and distinct time frames adopted to assess graft and patient survival in those reports published up to now in the *** is also known about the influence of high Tac IPV in the development of other untoward adverse events,update of the current knowledge regarding the impact of Tac IPV in different outcomes following kidney,liver,heart,lung,and pancreas tran-splantation to better evaluate its use in clinical practice.

关键词： Tacrolimus Intra-patient variability Rejection Organ transplantation Graft survival Outcomes

Functional responses to deforestation in fish communities inhabiting neotropical streams and rivers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2023年第1期12卷 716-732页

作者： Isabel Cantera Céline Jézéquel Tony Dejean Jérôme Murienne Régis Vigouroux Alice Valentini Sébastien Brosse Department of Environmental Science and Policy Universitàdegli Studi di MilanoVia Celoria 2620133 MilanItaly Laboratoire Evolution et DiversitéBiologique UMR5174-UniversitéPaul SabatierCNRSIRD118 Route de Narbonne31062 ToulouseFrance SPYGEN Savoie Technolac-BP 27417 Rue du Lac Saint-André73375 Le Bourget-du-Lac CedexFrance HYDRECO Laboratoire Environnement de Petit SautB.P 82397388 Kourou CedexFrench GuianaFrance

Background Deforestation is a widespread disturbance for neotropical freshwater *** biodiversity declines have been associated with deforestation,its functional consequences for stream and river fish faunas remain poorly *** this study,we explored how deforestation affects the different facets of the functional structure of fish communities inventoried using environmental DNA metabarcoding in 64 river and 35 stream sites of French ***,we investigated how functional richness,divergence,evenness and identity of fish faunas are affected by *** We showed that anthropogenic disturbances in French Guiana are modifying the functional diversity of freshwater fish *** disturbances not only affected the amount of functional traits held by the communities but also the identity of the traits and the internal structure of the functional ***,different facets of the functional diversity supported by fish assemblages were *** streams,deforestation did not affect the overall diversity of traits but reduced functional redundancy,underlined by a shift in functional identity towards assemblages dominated by pelagic *** contrast,river fish faunas experienced a decline in functional richness,paired with shifts in functional identity and a loss of fish species with extreme *** The response to deforestation differed between streams and rivers,but it supports the hypothesis that deforestation is linked to functional changes in fish *** diminishing the range of the functions in rivers or by jeopardizing the redundancy of functions in streams,deforestation could severely hamper the functioning and stability of neotropical freshwater ecosystems.

关键词： eDNA Traits Functional space Richness Divergence Evenness Identity Gold mining

维普期刊数据库

基于社区随访模式管理的泸州市中青年HIV/AIDS患者社会支持分析

在线全文

学校读者我要写书评

暂无评论

现代预防医学 2024年第2期51卷 285-290页

作者：陈小雪叶雨婷吕馨月华涵郎杰那么范颂陈润李爱玲西南医科大学公共卫生学院

目的应用社会网络分析法(SNA)分析泸州市接受社区随访管理的中青年(18～50岁)HIV/AIDS患者社会支持主体网络特征，为开展社会支持、健康干预工作提供依据。方法采用定额抽样方法以泸州市接受社区随访管理的中青年HIV/AIDS患者作为调... 详细信息

目的应用社会网络分析法(SNA)分析泸州市接受社区随访管理的中青年(18～50岁)HIV/AIDS患者社会支持主体网络特征，为开展社会支持、健康干预工作提供依据。方法采用定额抽样方法以泸州市接受社区随访管理的中青年HIV/AIDS患者作为调查对象，设计社会支持网络矩阵问卷，使用Excel 2016编制关系矩阵，使用ucinet 6.0软件分析社会支持网络特征，NetDraw绘制2-mode社会网络图。结果泸州市接受社区随访管理的165名中青年HIV/AIDS患者的社会支持得分24.15±8.10分，各维度依次为医院(2.45),社区(2.36),家庭(2.16),新媒体(1.65),传统媒体(1.59),朋友(1.47),亲戚(1.30),社会组织(1.18),同事(0.95),邻居(0.83);社会支持网络整体密度矩阵为1.59,核心-边缘最终拟合优度0.61,拟合较好；其中医院、社区的中心度最高，位于主核心位置，家庭和新媒体位于次核心位置，其余位于边缘位置。结论泸州市接受社区随访管理的中青年HIV/AIDS患者社会支持水平较低，主要依赖于医院、社区卫生服务中心，家庭、新媒体和社会组织集合的支持作为补充。建立以医院-社区为核心，家属为桥梁的社会支持网络，结合社会组织拓宽社会支持网络，开展互联网形式健康干预，增加其支持种类数量和力度，提高其生活质量，也可为其他地区提供借鉴。

关键词：社会网络分析法艾滋病中青年患者社会支持主体

Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2020年第2期12卷 110-122页

作者： Gabriela S Kronemberger Renata Akemi morais Matsui guilherme de Almeida Santos de Castro e Miranda JoséMauro Granjeiro Leandra Santos Baptista Bioengineering Directory of Metrology Applied to Life SciencesNational Institute of MetrologyQuality and Technology(INMETRO)Duque de CaxiasRJ 25250-020Brazil Post-graduate Program in Translational Biomedicine(Biotrans) UnigranrioCampus IDuque de CaxiasRJ 25250-020Brazil Post-graduate Program in Biotechnology National Institute of MetrologyQuality and Technology(INMETRO)Duque de CaxiasRJ 25250-020Brazil Federal University of Rio de Janeiro(UFRJ) Campus Duque de CaxiasDuque de CaxiasRJ 25250-020Brazil Laboratory of Clinical Research in Odontology Fluminense Federal University(UFF)Niterói 25255-030 Brazil Multidisciplinary Center for Biological Research(Numpex-Bio) Federal University of Rio de Janeiro(UFRJ)Campus Duque de CaxiasDuque de CaxiasRJ 25245-390Brazil

Scaffold-free techniques in the developmental tissue engineering area are designed to mimic in vivo embryonic processes with the aim of biofabricating,in vitro,tissues with more authentic *** clusters called spheroids are the basis for scaffold-free tissue *** this review,we explore the use of spheroids from adult mesenchymal stem/stromal cells as a model in the developmental engineering area in order to mimic the developmental stages of cartilage and bone *** from adult mesenchymal stromal/stem cells lineages recapitulate crucial events in bone and cartilage formation during embryogenesis,and are capable of spontaneously fusing to other spheroids,making them ideal building blocks for bone and cartilage tissue ***,we discuss data from ours and other labs on the use of adipose stromal/stem cell spheroids in chondrogenesis and osteogenesis in ***,recent studies support the notion that spheroids are ideal"building blocks"for tissue engineering by“bottom-up”approaches,which are based on tissue assembly by advanced techniques such as three-dimensional *** studies on the cellular and molecular mechanisms that orchestrate spheroid fusion are now crucial to support continued development of bottom-up tissue engineering approaches such as three-dimensional bioprinting.

关键词： Adipose stromal/stem cells Spheroids Building-blocks Bottom-up Developmental tissue engineering Cartilage and bone

methane production and small intestinal bacterial overgrowth in children living in a slum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第41期18卷 5932-5939页

作者： Carolina Santos mello Soraia Tahan Lígia Cristina FL melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de mello Isabel Cristina Affonso Scaletsky Mauro Batista de morais Pediatric Gastroenterology Division Federal University of Sao Paulo04039-031 Sao PauloBrazil Center Foundation Institute of Education for Osasco 06020-190 Sao PauloBrazil Infectology Division Federal University of Sao Paulo04025-010 Sao PauloBrazil Microbiology Immunology and Parasitology DivisionFederal University of Sao Paulo 04023-062 Sao PauloBrazil

AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath ***:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,*** characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were *** data was obtained in children from both *** children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ***:Children from the slum group had worse living conditions and lower nutritional indices than children from the private *** was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the *** production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane *** is a substrate for methane production in the colon.

关键词： Bacterial overgrowth Breath test Children Colon Hydrogen methane Small intestine

Synthesis of P,N-2,2'-biphenyl derivatives with central chirality

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第9期53卷 1907-1913页

作者： JEAN Ludovic POULIQUEN Michael BLANCHET Jérme LASNE Marie-Claire ROUDEN Jacques Laboratoire de Chimie Moléculaire et Thioorganique UMR 6507 CNRS-ENSICAEN & Université de Caen-Basse Normandie6 Boulevard du Maréchal Juin14050 CaenInstitut Normand de Chimie MoléculaireMédicinale et Macromoléculaire(INC3M)

Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were *** the compound bearing an acyclic chiral chain,the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2'-position of the biphenyl *** efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand.

关键词： 3-aminopyrrolidines Suzuki coupling biphenyls chiral ligand arylamination

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

巴西与南南合作：来自中国角色模式的启示

巴西与南南合作：来自中国角色模式的启示

作者： Ribeiro de morais Thauana 浙江大学

学位级别：硕士

The goal of this thesis is to asses useful ideas for emergent economies,especially Brazil of how to improve its participation in the multilateral agenda,in order to contribute to the South-South ***,by delving deeply into the genesis of Brazil and how it was influenced by the new development outlines for emergent economies,in the beginning of the 21rst *** innovative plan programmed by the new government,with the leadership of Lula da Silva,built new paths for the South-South *** then,looking at the newly-found BRICS,and other institutions,as the result of an age of transition highlighted after 2008’s ***,this study about the South-South approach,takes two broad shapes:one is the analysis about Brazil’s peculiarities in International Relations,which sustains the innovative approach,supportive for the multilateral global governance,and the efforts for a more democratic world order,with bigger representation of developing *** the other hand,we present China’s views in development and its relations with other emergent economies,towards its South-South cooperation *** seems to drive its foreign policies with certainty,asking how much of a difference they can actually make in the agenda leading emergent *** of those broad fields,though,address the theme which can truly answer our main questions,because since the creation of the concept of cooperation between the Souths’,these countries have changed substantially as well as the dominant economies,their paradigms,and their influence in international economic ***,aiming to add a new perspective to this debate,this thesis will make an attempt at assessing peculiarities about the Brazilian priority in South-South cooperation,the post-crisis with the neoliberal thinking,and its influences for emergent economies like China and *** differences between administrations in Brazil,and the consequences for newly-found participation of Bra

关键词：对外经济巴西南南合作新兴经济体

National Antibiotic Resistance Strategy for Human Health in France

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

China CDC weekly 2022年第49期4卷 1097-1100页

作者： Céline Pulcini Anne Berger-Carbonne Bruno Coignard Jérôme Salomon The Ministerial Mission for the Prevention of Infections and Antibiotic Resistance Ministry of Health and PreventionParisFrance Infectious Diseases Division French National Public Health AgencySaint-MauriceFrance French Chief medical Officer General Director for HealthWHO EB MemberHERA Board MemberMinistry of Health and PreventionParisFrance

France is a country with 67 million inhabitants and is part of the European *** consumption in humans is higher in France as compared to the European average,especially in outpatient settings(1–2).The burden of antibiotic resistance is also high,as compared to the European average,with an estimated 5,500 deaths per year associated with multidrug-resistant bacterial infections(3).Encouraging results have,however,been observed over the last several years:antibiotic consumption in the community,in nursing homes and in hospitals showed a decreasing trend,as well as certain resistant bacteria,such as 3rd-generation cephalosporin-or fluoroquinolone-resistant Escherichia coli(1–2,4–5).The COVID-19 pandemic has had a dramatic impact on antibiotic consumption and its long-term impact on antibiotic resistance is being carefully monitored(1).

关键词： Antibiotic nursing Strategy