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Diagnostic delay in inflammatory bowel diseases in a German population

World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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Do supplemental perches influence electrocution risk for diurnal raptors?

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Avian Research 2020年第2期11卷 139-149页

作者： Roberto Sánchez Javier Sánchez Javier Oria Francisco guil Fundación CBD-Hábitat C/Gustavo Fernández Balbuena28002 MadridSpain Tragsa Group C/Conde de Peñalver8428006 MadridSpain Boscaje S.L. Plaza Conde de Cheste540001 SegoviaSpain Ministry for the Ecological Transition and the Demographic Challenge Plaza San Juan de la CruzS/N28071 MadridSpain

Background:Power lines are amongst the main causes of mortality for birds *** drives the population dynamics of several threatened species of raptors,at local and global *** the many solutions that have been tested to minimize this threat are supplemental perches;however,their efficiency has rarely been ***:We designed 43 transects in 4 districts in mainland Portugal to gather data from birds perching on pylons with or without supplemental *** 2015 to 2018,transects were surveyed by car at least *** analyzed the factors driving the use of these supplemental perches,and we analyzed if there were differences in the perceived risk(calculated from measurements and not from field surveys)depending on whether the perching was on pylons with or without supplemental ***:We recorded 548 perches of 14 *** conditions seemed to play a role in birds’choice of pylons with supplemental perches versus pylons without supplemental *** also indicated a strong influence of observational *** use of models showed us an important specific effect in the selection of supplemental perches where available:there are some species with a greater tendency to perch on supplemental perches,even when they use both pylons with and without supplemental *** most of the analyzed species and species groups,perceived risk was higher in pylons without supplemental perches compared to pylons with supplemental perches,but there were differences between ***:Supplemental perches may be a useful and efficient tool for mitigating raptor ***,there are many influential factors affecting their success,and their effectiveness with different species groups is not *** studies show higher electrocution rates for certain species and devices and thus,their efficacy must be *** propose a two-step validation process,first in controlled conditions and then in the

关键词： Aquila adalberti Circaetus gallicus Diurnal raptors Electrocution Power lines Pylons

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A New Method with High Confidence for Validation of Computer Simulation Models of Flight Systems

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Journal of Systems Engineering and Electronics 1993年第4期4卷 43-52页

作者： Zhou XianminShanghai Research & Development Centre, 412 guil in Road, Shanghai 200233, P.R.China Shanghai Research & Development Centre 412 Guil in Road Shanghai 200233 P.R. China

Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis for confidence in the model's results and is a necessary step if the model is to be used to draw inference about the behavior of the real missile. This paper is a review of methods useful for validation of computer simulation models of missile systems and provides a new method with high degree of confidence for validation of computer simulation models of missile systems. Some examples of the use of the new method in validating computer simulation models are given.

关键词： Model validation Model credibility Simulation modeling System simulation.

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CONVERGENCE OF A CONSERVATIVE DIFFERENCE SCHEME FOR THE ZAKHAROV EQUATIONS IN TWO DIMENSIONS

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Journal of Computational Mathematics 1997年第3期15卷 219-232页

作者： Guo, bl Chang, QS INST APPL PHYS & COMPUTAT MATH BEIJING 100088PEOPLES R CHINA CHINESE ACAD SCI INST APPL MATHBEIJINGPEOPLES R CHINA

A conservative difference scheme is presented for the initial-boundary-value problem of a generalized Zakharov equations. On the basis of a prior estimates in L-2 norm, the convergence of the difference solution is proved in order O(h(2) + r(2)). In the proof, a new skill is used to deal with the term of difference quotient (e(j,k)(n))t. This is necessary, since there is no estimate of E(x, y, t) in L-infinity norm.

关键词： Math CONVERGENCE OF A CONSERVATIVE DIFFERENCE SCHEME FOR THE ZAKHAROV EQUATIONS IN TWO DIMENSIONS

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THE GLOBAL DUFORT-FRANKEL DIFFERENCE APPROXIMATION FOR NONLINEAR REACTION-DIFFUSION EQUATIONS

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Journal of Computational Mathematics 1998年第3期16卷 275-288页

作者： Lu, BN Wan, GH Guo, bl Xiangtan Univ Inst Computat & Appl Math Xiangtan 411105 Peoples R China Inst Appl Phys & Computat Math Lab Computat Phys Beijing 100088 Peoples R China Shaanzi Normal Univ Dept Math Xian 710062 Peoples R China Inst Appl Phys & Computat Math Ctr Nonlinear Studies Beijing 100088 Peoples R China

In this paper, the initial value problem of nonlinear reaction-diffusion equation is considered. The Dufort-Frankel finite difference approximation for the long time scheme is given for the d-dimensional reaction-diffusion equation with the two different cases. The global solution and global attractor are discussed for the Dufort-Frankel scheme. Moreover properties of the solution are studied. The error estimate is presented in a finite time region and in the global time region for some special cases. Finally the numerical results for the equation are investigated for Allen-Cahn equation and some other equations and the homoclinic orbit is simulated numerically.

关键词： global Dufort-Frankel method reaction-diffusion equation global attractor error estimate numerical experiments

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STM image of tungstosilicic acid molecular layer on highly oriented pyrolytic graphite

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Chinese Journal of Chemistry 1995年第6期13卷 493-496页

作者： Zhang, bl Wang, EK CHINESE ACAD SCI CHANGCHUN INST APPL CHEMELECTROANALYT CHEM LABCHANGCHUN 130022JILINPEOPLES R CHINA

Molecular layer of tungstosilicic acid (H4SiW12O40) deposited on freshly-cleaved highly oriented pyrolytic graphite (HOPG) was observed by scanning tunneling microscopy (STM) in air at room temperature. The molecular dimension (11.5 Angstrom) of H4SiW12O40 measured by STM is consistent with known crystallographic parameter. We also imaged the boundary of H4SiW12O40 molecular layer on HOPG showing that molecular layer of H4SiW12O40 was formed. It has been proved that individual tungstosilicic acid species is imaged. The probable reason for the formation of the molecular layer is also discussed.

关键词： tungstosilicic acid HOPG STM

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TENSILE PROPERTIES OF COATED CARBON FIBER REINFORCED MAGNESIUM COMPOSITES

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中国有色金属学会会刊：英文版 1997年第3期7卷 87-90页

作者： Zhang, K Wang, YQ Zhou, bl CHINESE ACAD SCI INST MET RESSHENYANG 110015PEOPLES R CHINA ACAD SINICA INT CTR MAT PHYSSHENYANG 110015PEOPLES R CHINA

ＴＥＮＳＩＬＥＰＲＯＰＥＲＴＩＥＳＯＦＣＯＡＴＥＤＣＡＲＢＯＮＦＩＢＥＲＲＥＩＮＦＯＲＣＥＤＭＡＧＮＥＳＩＵＭＣＯＭＰＯＳＩＴＥＳ①ＺｈａｎｇＫｕｎ，ＷａｎｇＹｕｑｉｎｇ，ＺｈｏｕＢｅｎｌｉａｎＩｎｓｔｉｔｕｔｅｏｆ... 详细信息

ＴＥＮＳＩＬＥＰＲＯＰＥＲＴＩＥＳＯＦＣＯＡＴＥＤＣＡＲＢＯＮＦＩＢＥＲＲＥＩＮＦＯＲＣＥＤＭＡＧＮＥＳＩＵＭＣＯＭＰＯＳＩＴＥＳ①ＺｈａｎｇＫｕｎ，ＷａｎｇＹｕｑｉｎｇ，ＺｈｏｕＢｅｎｌｉａｎＩｎｓｔｉｔｕｔｅｏｆＭｅｔａｌＲｅｓｅａｒｃｈ，Ｃｈｉ...

关键词： C/Mg composites coating thickness tensile properties

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Persistent Currents in Toroidal Single-wall Carbon Nanotubes

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Journal of Materials Science & Technology 1999年第4期15卷 342-344页

作者： Liu, JJ Zhang, G Gu, bl Tsing Hua Univ Dept Phys Beijing 100084 Peoples R China

In this paper the persistent currents of ideal toroidal single-wall carbon nanotubes (TSWNTs) are calculated from the tight-binding model and the periodic boundary conditions. The electronic structure and persistent current of a TSWNT strongly depend on its helicity and longitudinal circumference, making the TSWNTs a geometry-sensitive kind of materials. The interatomic carbonic interactions other than pp pi-type are also studied and are found to introduce more steps to the persistent current. The diamagnetic-paramagnetic transitions occur more frequently, and the persistent current depends on the interaction energy values, while the periodicity of magnetic flux preserves.

关键词： Nanotubes

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Biomimetic Study on Helical Fiber Composites

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Journal of Materials Science & Technology 1998年第1期14卷 29-32页

作者： Zhang, K Wang, YQ Zhou, bl Chinese Acad Sci Inst Met Res Shenyang 110015 Peoples R China Acad Sinica Int Ctr Mat Phys Shenyang 110015 Peoples R China

The innovative approach imparting strength and toughness to carbon fiber reinforced polymer composites (CFRP) is put forward from the viewpoint of biomimetics. Helical fibers produced by twisting fiber bundle are arranged in the matrix to simulate the unique structure of natural fibers. The results on the CFRP with helical fiber bundles show that, under the same state of strong fiber/matrix interface, the impact fracture toughness can be improved substantially compared to conventional composites with plain fibers. The beneficial effect is attributed to the helical fiber bundles which act as single fibers of huge diameter effectively increasing the fiber elastic energy.

关键词： Carbon fiber reinforced plastics

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Electron–plasmon and electron–magnon scattering in ferromagnets from first principles by combining GW and GT self-energies

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npj Computational Materials 2021年第1期7卷 1619-1632页

作者： Dmitrii Nabok Stefan blügel Christoph Friedrich Peter Grünberg Institut and Institut for Advanced Simulation Forschungszentrum JülichJülich 52425Germany

This work combines two powerful self-energy techniques:the well-known GW method and a self-energy recently developed by us that describes renormalization effects caused by the scattering of electrons with magnons and Stoner *** GT selfenergy,which is fully k-dependent and contains infinitely many spin-flip ladder diagrams,was shown to have a profound impact on the electronic band structure of Fe,Co,and *** the present work,we refine the method by combining GT with the GW *** resulting GWT spectral functions exhibit strong lifetime effects and emergent dispersion *** are in an overall better agreement with experimental spectra than those obtained with GW or GT alone,even showing partial improvements over local-spin-density approximation dynamical mean-field *** performed analysis provides a basis for applying the GWT technique to a wider class of magnetic materials.

关键词： materials theory infinitely

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