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The antiviral effect of jiadifenoic acids C against coxsackievirus B3

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Acta Pharmaceutica Sinica B 2014年第4期4卷 277-283页

作者： Miao Ge Huiqiang Wang guijie zhang Shishan Yu Yuhuan Li Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Coxsackievirus B type 3(CVB3)is one of the major causative pathogens associated with viral meningitis and myocarditis,which are widespread in the human population and especially prevalent in neonates and children.These infections can result in dilated cardiomyopathy(DCM)and other severe clinical complications.There are no vaccines or drugs approved for the prevention or therapy of CVB3-induced diseases.During screening for anti-CVB3 candidates in our previous studies,we found that jiadifenoic acids C exhibited strong antiviral activities against CVB3 as well as other strains of Coxsackie B viruses(CVBs).The present studies were carried out to evaluate the antiviral activities of jiadifenoic acids C.Results showed that jiadifenoic acids C could reduce CVB3 RNA and proteins synthesis in a dose-dependent manner.Jiadifenoic acids C also had a similar antiviral effect on the pleconaril-resistant variant of CVB3.We further examined the impact of jiadifenoic acids C on the synthesis of viral structural and non-structural proteins,finding that jiadifenoic acids C could reduce VP1 and 3D protein production.A time-course study with Vero cells showed that jiadifenoic acids C displayed significant antiviral activities at 0–6 h after CVB3 inoculation,indicating that jiadifenoic acids C functioned at an early step of CVB3 replication.However,jiadifenoic acids C had no prophylactic effect against CVB3.Taken together,we show that jiadifenoic acids C exhibit strong antiviral activities against all strains of CVB,including the pleconaril-resistant variant.Our study could provide a significant lead for anti-CVB3 drug development.

关键词： CVB3 Jiadifenoic acids C Antiviral activity

一种基于超智能表面协助的密集毫米波通信模型

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火力与指挥控制 2024年第5期49卷 196-201页

作者：陈素霞张嘉晨张桂杰河南轻工职业学院计算机与艺术设计系郑州450052 波特兰州立大学计算机科学系美国俄勒冈州波特兰97201 吉林师范大学计算机科学与技术学院吉林四平136000

作为一种新型的反射材料,超智能表面将在未来通信网络中扮演重要的角色。将超智能表面应用于多点协作的毫米波通信系统,可极大提升系统性能。为此,提出基于超智能表面的密集毫米波通信模型,并分析了基于最大合并比(maximal-ratio combin... 详细信息

作为一种新型的反射材料,超智能表面将在未来通信网络中扮演重要的角色。将超智能表面应用于多点协作的毫米波通信系统,可极大提升系统性能。为此,提出基于超智能表面的密集毫米波通信模型,并分析了基于最大合并比(maximal-ratio combining,MRC)接收和选择(selection combining,SC)接收两类协作传输策略下系统性能。具体而言,阐述在Nakagami-m衰落模型下基站所接收的信号,推导了系统中断概率和各态历经容量表达式,并通过仿真验证。同时,通过仿真分析了系统参数对通信系统性能的影响。仿真结果表明,基于SC策略的系统性能略优于MRC策略。传输功率以及LIS中的反射元数对系统性能有较大影响。

关键词：超智能表面密集毫米波多点协作中断概率各态历经容量

Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia

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Animal Nutrition 2021年第1期7卷 206-215页

作者： Yanfen Ma Ying Feng Liwen Song Muyang Li Hongyu Dai Hua Bao guijie zhang Lei Zhao Chunhua zhang Jing Yi Yusheng Liang School of Agriculture Ningxia UniversityYinchuan 750021China Institute of Animal Nutrition and Feed Inner Mongolia Academy of Agriculture and Animal Husbandry SciencesHohhot 010031China College of Food Engineering&Biotechnology Tianjin University of Science&TechnologyTianjin 300457China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163316China College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbana 61801USA

Peripartal cows often experience negative energy balance,and are therefore prone to suffering from metabolic diseases such as hyperketonemia,which causes financial losses in dairy farms.This study aimed to investigate the effect of green tea polyphenol(GTP)supplementation during the periparturient period on production performance,oxidative stress and immunometabolism in dairy cows with hyperketonemia.One hundred Holstein cows were assigned to GTP(0.2 g/kg DM;n=50)or control(without GTP;n=50)group based on body weight,previous milk yield,and parity on d 15 before expected parturition.Subsequently,10 cows with hyperketonemia were selected from each group,according to bloodβ-hydroxybutyric acid(BHBA)concentration between 1.2 and 2.9 mmol/L from 2 to 3 d postpartum.All cows were fed a close-up diet and a lactation diet with or without GTP supply from 15 d prepartum until 30 d postpartum.Milk and blood samples were obtained from 20 cows selected with hyperketonemia on 10,20,and 30 d postpartum.Compared with control cows,greater milk yield and lower somatic cell count were observed in GTP cows.The GTP group had lower concentrations of BHBA,free fatty acids,cholesterol,triglyceride,reactive oxygen species,malondialdehyde,and hydrogen peroxide,greater concentrations of glucose,lower activities of aspartate aminotransferase,alanine aminotransferase,and glutamyl transpeptidase,alongside greater ac-tivities of superoxide dismutase,glutathione peroxidase,and total antioxidant capacity.Additionally,GTP supplementation up-regulated concentrations of interleukin-6 and interleukin-10,but down-regulated concentrations of tumor necrosis factor-α,interleukin-1β,interleukin-2,interleukin-8,and interferon-γin plasma.Greater concentrations of plasma immunoglobulin G were also detected in the GTP group.Overall,the data suggested that GTP supplementation from 15 d prepartum to 30 d postpartum improved the milk yield and health status in cows with hvoerketonemia during early lactation.

关键词： Green tea polyphenol Hyperketonemia Peripartal period Dairy cow

青贮饲料营养价值、影响因素及其在家畜生产中的应用

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中国畜牧杂志 2024年第2期60卷 58-64页

作者：刘杰杨蜜金孟达李柏珍张桂杰伍树松湖南农业大学动物科学技术学院湖南长沙410128 宁夏大学动物科技学院宁夏银川750021 湖南省畜禽安全生产协同创新中心湖南长沙410128 湘中幼儿师范高等专科学校湖南邵阳422000

青贮饲料是由青绿饲料通过厌氧微生物发酵而成,可有效改善青绿饲料营养结构和延长贮存时间,解决动物冬春季青绿饲料资源缺乏的问题。发酵微生物、原料、发酵条件和添加剂等是影响青贮饲料品质的主要因素。基于此,本文综述了青贮饲料的... 详细信息

青贮饲料是由青绿饲料通过厌氧微生物发酵而成,可有效改善青绿饲料营养结构和延长贮存时间,解决动物冬春季青绿饲料资源缺乏的问题。发酵微生物、原料、发酵条件和添加剂等是影响青贮饲料品质的主要因素。基于此,本文综述了青贮饲料的营养价值、青贮品质影响因素以及青贮饲料在家畜生产中的应用,为青贮饲料的进一步开发、应用和推广提供理论参考。

关键词：青贮饲料微生物发酵营养成分影响因素家畜生产

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高效液相色谱法测定人血浆中甲氨蝶呤的浓度

今日药学 2024年第2期34卷 117-120,126页

作者：张桂杰李祖荣接红宇陈文瑛李强南方医科大学第三附属医院药学部广东广州510630 南方医科大学第三附属医院风湿免疫科广东广州510630

目的建立一种全自动、快速、准确地测定人血液中甲氨蝶呤浓度的方法。方法采用双三元液相色谱系统串联紫外检测器,使用Athena C_(18)-WP(4 mm×20 mm,5μm)色谱柱作为在线固相萃取柱,Athena C18-WP柱(4.6 mm×150 mm,5μm)作为分析柱;... 详细信息

目的建立一种全自动、快速、准确地测定人血液中甲氨蝶呤浓度的方法。方法采用双三元液相色谱系统串联紫外检测器,使用Athena C_(18)-WP(4 mm×20 mm,5μm)色谱柱作为在线固相萃取柱,Athena C18-WP柱(4.6 mm×150 mm,5μm)作为分析柱;流动相为10 mmol·L^(-1)的乙酸铵,固定相为乙腈,流速为1 mL·min^(-1);检测波长为306 nm;柱温为40℃;进样体积为100μL。血清样本经过沉淀试剂(5%三氯乙酸+10%硫酸锌)沉淀蛋白后进样。同时考察该方法的专属性、标准曲线与定量下限、精密度与准确度、回收率和稳定性。结果甲氨蝶呤在0.078~8.000μmol·L^(-1)范围内线性良好(R2=0.9994),提取回收率分为86.41%~87.09%,日内、日间RSD<7%。结论该方法准确、重现性好、简化了样本前处理步骤,提高了分析效率,适用于大剂量甲氨蝶呤治疗时的血药浓度检测。

关键词：甲氨蝶呤在线固相萃取高效液相色谱紫外检测血药浓度

盐胁迫对紫花苜蓿生长发育及营养品质影响的研究进展

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草原与草业 2024年第1期36卷 1-7页

作者：史金红卢强张桂杰王世丛侯美玲刘丽英撒多文宁夏大学林业与草业学院银川750021 宁夏大学科学技术研究院银川750021 白城师范学院生命科学学院白城137000 内蒙古自治区林业科学研究院呼和浩特010010 中国农业科学院草原研究所呼和浩特010010

我国耕地资源紧张和优质饲草料严重短缺,利用盐碱地发展饲草产业既符合国家草牧业发展战略又能改变优质饲草料缺乏的局面。盐胁迫是重要的非生物胁迫之一,严重影响了植物的健康生长发育。了解盐胁迫对紫花苜蓿生长发育、产量及营养物质... 详细信息

我国耕地资源紧张和优质饲草料严重短缺,利用盐碱地发展饲草产业既符合国家草牧业发展战略又能改变优质饲草料缺乏的局面。盐胁迫是重要的非生物胁迫之一,严重影响了植物的健康生长发育。了解盐胁迫对紫花苜蓿生长发育、产量及营养物质的影响有利于实现盐碱地资源的开发与利用,减轻日益增加的粮食压力。文中总结了盐胁迫对紫花苜蓿种子萌发、气孔导度及发芽状态等生理变化,探讨了盐胁迫对紫花苜蓿产量、碳水化合物、蛋白质含量的调控作用,并对今后的研究进行了展望。

关键词：盐胁迫紫花苜蓿生长发育产量营养品质

Studies on Reducing Nitrogen Excretion: Ⅰ. Net Energy Requirement of Finishing Pigs Maximizing Performance and Carcass Quality Fed Low Crude Protein Diets Supplemented with Crystalline Amino Acids

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Journal of Animal Science and Biotechnology 2011年第2期2卷 84-93页

作者： Hongyu Chen Xuewu Yi guijie zhang Ning Lu Licui Chu P. A. Thacker Shiyan Qiao Ministry of Agriculture Feed Industry Centre State Key Laboratory of Animal Nutrition China Agricultural University Beijing 100193 China Department of Animal and Poultry Science University of Saskatchewan Saskatoon Saskatchewan STNSA8 Canada

Two experiments were conducted to in- vestigate the effects of net energy （NE） level on the performance and carcass traits of finishing pigs fed low crude protein （CP） diets supplemented with crystalline amino acids （CAA）. A total of 216 （Exp. 1） and 360 （Exp. 2 ） barrows （ Yorkshire × Landrace× Duroc ） were allotted to one of six treatments （n =6）. The experimental diets were based on corn and soybean meal, and consisted of a high-CP diet that contained approximately 16% CP and 2.50 Mcal/kg of NE as well as five low-CP diets in which the CP level of the diet was reduced by approximately four percentage units but was supplemented with crystalline lysine, methionine, threonine, and tryptophan. The low CP diets provided 2.64, 2.58, 2.50, 2.42, or 2.36 Mcal/kg in Exp. 1 as well as 2.45, 2.40, 2.35, 2.30, or 2.25 Mcai/kg in Exp.2. In Exp. 1, a linear （P=0.03） increase in weight gain was observed with decreasing NE level while the ratio of gain to feed was unaffect- ed （P 〉 0.05） by NE level. There was a linear in-crease （P = 0.01 ） in the percentage of fat-free lean and a linear decrease （ P = 0.03 ） in the percentage of total fat with decreasing NE levels. In Exp. 2, a sig- nificant quadratic （ P = 0.03 ） effect of NE level was observed for weight gain. The ratio of gain to feed demonstrated a significant （P 〈0.01 ） quadratic effect with pigs fed 2.35 and 2.40 Mcal/kg of NE, Pigs fed the diet containing 2.40 Mcal/kg of NE had the lowest percentage of total fat （36. 95% ） and the highest percentage of fat-free lean （49.36%）. The overall results of these experiments indicate that feed- ing either a surplus or a deficiency of NE is detrimen- tal to both pig performance and carcass composition when low CP diets supplemented with CAA are fed. Our results indicate that when the CP content of the diet is reduced by four percentage units and the diet is properly supplemented with CAA, maximum per- formance and carcass quality will be obtained if the diet provides approximately 2.42 Mcal/kg of NE.

关键词： carcass quality finishing pigs low protein diets net energy performance

Effect of Process Parameters on Hydroforming of Stainless Steel Tubular Components with Rectangular Section

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Effect of Process Parameters on Hydroforming of Stainless St...

不同蜡样芽孢杆菌对玉米籽粒中黄曲霉毒素B1、玉米赤霉烯酮和呕吐毒素脱毒效果及营养成分评价

中国材料大会2012

作者： Yong Xu Shihong zhang Qingxun Zhu Ming Cheng Hongwu Song guijie zhang Institute of Metal Research Chinese Academy of Sciences Metallurgy and Energy College Hebei United University

ISBN: (纸本)9783037856093

The effects of key process parameters including initial lengths of tube blank,forming velocity and loading paths on hydroformability of stainless steel tubular components with rectangular section were systematically investigated.The results showed that sufficient axial feed must be given before the tube contacting the surface of die in order to prevent the excessive thickness thinning,especially for longer tube blank.The lower loading velocity led to enhanced formability.It is more important that pulsating loading path observably improved the formability of 304 stainless steel.

关键词： Tube hydroforming Formability Rectangular section Loading paths Stainless steel.

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饲料工业 2022年第23期43卷 38-43页

作者：石楠张桂杰宁夏大学农学院宁夏银川750021

试验旨在评估可有效降低玉米籽粒中黄曲霉毒素B1(Aflatoxin B1,AFB1)、玉米赤霉烯酮(Zearalenone,ZEN)和呕吐毒素(Deoxynivalenol,DON)含量的优良菌株。试验以霉菌毒素超标的玉米籽粒作为脱毒材料,设置4个处理组:CK(对照组);TD-1蜡样芽... 详细信息

试验旨在评估可有效降低玉米籽粒中黄曲霉毒素B1(Aflatoxin B1,AFB1)、玉米赤霉烯酮(Zearalenone,ZEN)和呕吐毒素(Deoxynivalenol,DON)含量的优良菌株。试验以霉菌毒素超标的玉米籽粒作为脱毒材料,设置4个处理组:CK(对照组);TD-1蜡样芽孢杆菌处理组(1%、5%、10%);TD-2蜡样芽孢杆菌处理组(1%、5%、10%);TD-3蜡样芽孢杆菌处理组(1%、5%、10%)。在玉米籽粒发酵后48 h进行取样,测定AFB1、DON和ZEN含量及营养成分。结果表明:TD-1蜡样芽孢杆菌对AFB1、DON和ZEN脱毒效果最优。添加5%的TD-1蜡样芽孢杆菌对玉米籽粒中AFB1和DON脱毒率分别为67.59%和73.03%;添加10%的TD-1蜡样芽孢杆菌菌液发酵48 h后,对ZEN脱毒率可达65.71%;添加蜡样芽孢杆菌菌液会降低玉米籽粒可溶性碳水化合物(Water soluble carbohydrate,WSC)含量,对其他营养成分无显著影响(P>0.05)。

关键词：蜡样芽孢杆菌玉米籽粒黄曲霉毒素B1 玉米赤霉烯酮呕吐毒素