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Formation strategies,mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes

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Asian Journal of Pharmaceutical Sciences 2013年第6期8卷 319-328页

作者： Xin Liu guihua Huang School of Pharmaceutical Science Shandong UniversityNo.44 Wenhua Xi RoadJi’nan 250012China

pH-sensitive liposomes are designed to specifically triggered release the loaded drugs in response to the change of pH in the surrounding *** pH-sensitive liposomes can effectively deliver drug or gene fragments into the cytoplasm via the endocytotic ***,pH-sensitive liposomes can be successfully used in clinical if they enable the encapsulated drugs to be targeted to pathological tissues(such as primary tumors,metastases,local ischemia,inflammation and infection)of the body in which pH is less than the normal physiological ***’s the reason why a growing amount of literatures described the development and applications of pH-sensitive liposomes to improve the therapeutic index of the encapsulated active *** this review,the commonly used pH-sensitive molecules for pH-sensitive liposome and the mechanisms of intracellular delivery of pH-sensitive liposomes were ***,the potential clinical applications were fully discussed in detail with an expectation to contribute to the clinical research of pH-sensitive liposomes.

关键词： pH-sensitive liposomes Triggered release Drug delivery Gene therapy Vaccine Magnetic resonance imaging(MRI)

Inclusion complex of tamibarotene with hydroxypropyl-β-cyclodextrin: Preparation,characterization, in-vitro and in-vivo evaluation

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 187-192页

作者： Ying Yang Jinhua Gao Xiaoyu Ma guihua Huang School of Pharmaceutical Sciences Shandong University

The goal of this study was to improve the solubility and oral bioavailability of tamibarotene by complexing it with hydroxypropyl-β-cyclodextrin(HP-β-CD).The inclusion complex of tamibarotene with hydroxypropyl-β-cyclodextrin(Am80-HP-β-CD)was prepared through a freeze-drying method at the mole ratio of 1:1(Am80:HP-β-CD).Fourier transform infrared spectroscopy(FT-IR)and differential scanning calorimetry(DSC)indicated the formation of Am80-HP-β-*** vitro dissolution studies showed that the solubility and dissolution percentage of Am80-HP-β-CD was improved substantially compared to *** improved dissolution with approximately 97%drug release in 3 min was observed,in comparison with Am80 with approximately 60% release in 45 *** vivo studies indicated that the AUC0-∞ has increased 2.79 times and the Cmax 4.37 times after the formation of inclusion *** decrease of tmaxindicated the Am80-HP-β-CD inclusion complex can be absorbed into blood *** short,the solubility and bio-availability of Am80 has notably increased with the complexation of HP-β-***,using the inclusion technique is a promising method to improve the solubility of insoluble drugs.

关键词： Tamibarotene Hydroxypropyl-β-cyclodextrin Solubility Bio-availability

A notary group-based cross-chain mechanism

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Digital Communications and Networks 2022年第6期8卷 1059-1067页

作者： Anping Xiong guihua Liu Qingyi Zhu Ankui Jing Seng W.Loke School of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing400065China School of Cyber Security and Information Law Chongqing University of Posts and TelecommunicationsChongqing400065China School of Information Technology Deakin UniversityVictoria3125Australia

As an emerging distributed technology, blockchain has begun to penetrate into many fields such as finance, healthcare, supply chain, intelligent transportation. However, the interoperability and value exchange between different independent blockchain systems is restricting the expansion of blockchain. In this paper, a notary group-based cross-chain interaction model is proposed to achieve the interoperability between different blockchains. Firstly, a notary election mechanism is proposed to choose one notary from the notary group to act as a bridge for cross-chain transactions. Secondly, a margin pool is introduced to limit the misconduct of the elected notary and ensure the value transfer between the involved blockchains. Moreover, a reputation based incentive mechanism is used to encourage members of the notary group to participate in cross-chain transactions. Ethereum-based experiments demonstrate that the proposed mechanism can provide an acceptable performance for cross-chain transactions and provide a higher security level than ordinary cross-chain mechanisms.

关键词： Blockchain Cross-chain Notary group Reputation ranking Incentive mechanisms

Integrated host configuration of flexibly fibrous skeleton towards efficient polysulfide conversion and dendrite-free behavior in stable lithium-sulfur pouch cells

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Journal of Energy Chemistry 2023年第8期83卷 43-52,I0003页

作者： Tongtao Wan Yusen He Zongke He Wenjia Han Yongguang Zhang guihua Liu Hebei Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin300130China Key Laboratory of Pulp and Paper Science&Technology of Ministry of Education Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

The commercialization of lithium-sulfur(Li-S) batteries is obstructed by the sluggish sulfur electrochemical reaction,severe polysulfide shuttling effect,and damaging dendritic lithium ***,a threedimensional(3D) conductive carbon nanofibers skeleton-based bifunctional electrode host material is fabricated,which consists of a two-dimensional(2D) ultra-thin NiSe_(2)-CoSe_(2)heterostructured nanosheet built on one-dimensional(1D) carbon nanofibers(NiSe_(2)-CoSe_(2)@CNF).When serving as cathodic host,the heterostructured NiSe_(2)-CoSe_(2)@CNF offers a synergistic function of polysulfide confinement and catalysis *** S/NiSe_(2)-CoSe_(2)@CNF cathode shows outstanding cycling stability of 0.03% capacity decay rate per cycle over 500 cycles at 1 *** anodic host,the NiSe_(2)-CoSe_(2)@CNF with high-flux Li+diffusion property and good lithiophilic capability realizes dendrite-free Li plating/stripping *** from these synergistically merits,the Li-S full cell with S/NiSe_(2)-CoSe_(2)@CNFILi/NiSe_(2)-CoSe_(2)@CNF electrodes exhibits excellent electrochemical performance including a high specific capacity of1021 mA h g^(-1)over 100 cycles at 0.2 C and reversible areal capacity of 3.05 mA h cm^(-2)under a high sulfur loading of 4.33 mg cm^(-2)at 0.1 *** pouch cell also delivers ultra-stable Li/S *** study demonstrates a rational and universal electrode construction strategy for developing practical and high-energy Li-S batteries.

关键词： Polysulfides shuttling Lithiumdendrites Catalyticconversion NiSe_(2)-CoSe_(2)heterostructure Pouchcell

Continuous amino-functionalized University of Oslo 66 membranes as efficacious polysulfide barriers for lithium−sulfur batteries

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Frontiers of Chemical Science and Engineering 2023年第2期17卷 194-205页

作者： Bowen Du Yuhong Luo Feichao Wu guihua Liu Jingde Li Wei Xue Hebei Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China

The shuttle effect of soluble polysulfides is a serious problem impeding the development of lithium−sulfur ***,continuous amino-functionalized University of Oslo 66 membranes supported on carbon nanotube films are proposed as ion-permselective interlayers that overcome these issues and show outstanding suppression of the polysulfide shuttle *** proposed membrane material has appropriately sized pores,and can act as ionic sieves and serve as barriers to polysulfides transport while allowing the passage of lithium ions during electrochemical cycles,thereby validly preventing the shuttling of ***,a fast catalytic conversion of polysulfides is also achieved with the asdeveloped ***,lithium−sulfur batteries with this interlayer show a desirable initial capacity of 999.21 mAh·g^(-1)at 1 C and a durable cyclic stability with a decay rate of only 0.04%per cycle over 300 ***,a high area capacity of 4.82 mAh·cm^(-2)is also obtained even under increased sulfur loading(5.12 mg·cm^(-2))and a lean-electrolyte condition(E/S=4.8μL·mg^(-1)).

关键词： lithium−sulfur batteries aminofunctionalized University of Oslo 66 membrane polysulfide interlayer

The suitability assessment on site selection for bottom seeding scallop culture based on analytic hierarchy process

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Journal of Oceanology and Limnology 2024年第2期42卷 647-663页

作者： Ziniu ZHANG Zhenyan WANG guihua LI Meihan ZHAO Wenjian LI School of Earth Sciences and Engineering Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Mineral Resources National Laboratory for Marine Science and TechnologyQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

Scallop culture is an important way of bottom-seeding marine ranching,which is of great significance to improve the current situation of fishery ***,there are some problems in site-selection evaluation of marine ranching,such as imperfect criteria system,complex structure,untargeted criteria quantification,*** addition,no site-selection evaluation method of bottom-seeding culture areas for scallops is ***,we established a hierarchy structure model according to the analytic hierarchy process(AHP)theory,in which social,physical,chemical,and biological environments are used as main criteria,and marine functional zonation,water depth,current,water temperature,salinity,substrate type,water quality,sediment quality,red tide,phytoplankton,and zooplankton are used as sub-criteria,on which a multi-parameter evaluation system is set ***,the dualism method,assignment method,and membership function method were used to quantify sub-criteria,and a quantitative evaluation for the entire criteria was added,including the evaluation and analysis of two types of unsuitable environmental *** overall consideration in scallop yield,quality,and marine ranching construction objectives,the weight of the main criteria could be *** grades in the suitability corresponding to the evaluation result were divided,and the Python language was used to create an evaluation system for efficient calculation and intuitive presentation of the evaluation *** marine cases were simulated based on existing survey data,and the results prove that the method is feasible for evaluating and analyzing the site selection of bottom-seeding culture areas for scallops under various environmental *** proposed evaluation method can be promoted for the site selection of bottom-seeding marine *** study provided theoretical and methodological references for the site selection evaluation of other types of marine ranching.

关键词： marine ranching bottom-seeding scallops site selection evaluation analytic hierarchy process evaluation system

Evaluation of indoor air quality based on qualitative,quantitative and olfactory analysis

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Chinese Science Bulletin 2013年第9期58卷 986-991页

作者： YI Qin LIU JieMin WANG guihua ZHANG YanNi Department of Chemistry School of Chemical and Biological EngineeringUniversity of Science & Technology Beijing

In studying indoor atmospheric pollution,the concentration of air pollutants is considered to be the primary factor in judging indoor pollution level,while sensory effects accessed by olfactory analysis has not been paid enough *** this paper,twenty living rooms in Beijing including newly decorated,3 months and 6 months after decoration were sampled once a day for 10 d,and qualitative analysis,quantitative analysis and olfactory analysis of volatile organic compounds were carried *** results showed the concentrations of the 6 main compounds surpassed the limitation values released by World Health Organization;the pollutants with highest chemical concentrations were not the most odor active *** analysis which measured the odor characters such as odor detection threshold(ODT),odor active value(OAV) and odor quality was a helpful tool to identify possible chemicals which cause indoor smelling issues,and it was necessary to access indoor air quality in combination with their chemical concentrations to give a comprehensive judgment on indoor air quality.

关键词：室内空气质量空气质量评价嗅觉挥发性有机化合物空气污染物基础世界卫生组织化学物质

Corrosion and tribocorrosion resistance of MAO-based composite coating on AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2022年第12期10卷 3406-3417页

作者： Siqin Liu guihua Li Yuming Qi Zhenjun Peng Yinping Ye Jun Liang State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Key Laboratory of Science and Technology on Wear and Protection of Materials Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049PR China

In this paper, a multi-functional composite coating with low friction coefficient, high wear resistance and excellent tribocorrosion resistance is fabricated on AZ31 Mg alloys by micro-arc oxidation and spray-coating methods. The microstructure, and composition of the coating are characterized by SEM, EDS, XRD, and FT-IR. Potentiodynamic polarization and EIS tests are conducted to evaluate the corrosion resistance of the composite coating. The tribocorrosion property is also studied using pin-on-disk tribometer in 3.5 wt.% Na Cl solution. It is found that the composite coating possesses better long-term corrosion resistance than the single MAO coating. The tribocorrosion tests prove that the composite coating exhibits much better wear and tribocorrosion resistance than the single MAO coating and can protect the substrate from corrosion under a sliding condition.

关键词： Magnesium alloy Micro-arc oxidation Composite coating Corrosion Tribocorrosion

Restoring environmental flows and improving riparian ecosystem of Tarim River

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Journal of Arid Land 2010年第1期2卷 43-50页

作者： Zhang, JieBin Wu, guihua Wang, QiMeng Li, XiaoYan Chinese Acad Sci Xinjiang Inst Ecol & Geog Urumqi 830011 Peoples R China

Rapid population growth and artificial oasis enlargement did pose great threat to the natural riparian ecosystems of Tarim River and caused seriously ecological deterioration and greater desertification of the Tarim River Basin in the second half of 20 century. Restoration of the endangered riparian ecosystem requires that environmental flow should be restored through restricted and uncontrolled flow diversion irrigation in tributary areas. Implementation of such restriction needs further the basin-wide reallocation of water resources through a set of engineering and non-engineering measures taken to ensure the water requirement in the tributary and maintain effective flows in Tarim River. As one of evolving HELP (Hydrology for Environment, Life and Policy) basins, the article first presents an overview of hydrology, socio-economic development and ecosystem evolution of the Tarim River Basin. Then, those measures for restoring and maintaining environmental flow are reviewed and analyzed along with its applicability and validity. The issues emerging in implementing those measures are also explored, and then the conclusions were summarized. Lessons learned could provide a good example for other basins under similar conditions.

关键词： environmental flow IWRM riparian ecosystem Tarim River HELP