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Global Energy Interconnection 2024年第2期7卷 206-216页

作者： Lu Li Zeduan Zhang wang Cai Qikang Zhuang guihong Bi Jian Deng Shilong Chen Xiaorui Kan Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming 650500P.R.China Brunel University London London UB83PHUnited Kingdom Yunnan Power Grid Co. Ltd.Kunming 650041P.R.China

This paper proposes a longitudinal protection scheme utilizing empirical wavelet transform(EWT)for a through-type cophase traction direct power supply system,where both sides of a traction network line exhibit a distinctive boundary structure.This approach capitalizes on the boundary’s capacity to attenuate the high-frequency component of fault signals,resulting in a variation in the high-frequency transient energy ratio when faults occur inside or outside the line.During internal line faults,the high-frequency transient energy at the checkpoints located at both ends surpasses that of its neighboring lines.Conversely,for faults external to the line,the energy is lower compared to adjacent lines.EWT is employed to decompose the collected fault current signals,allowing access to the high-frequency transient energy.The longitudinal protection for the traction network line is established based on disparities between both ends of the traction network line and the high-frequency transient energy on either side of the boundary.Moreover,simulation verification through experimental results demonstrates the effectiveness of the proposed protection scheme across various initial fault angles,distances to faults,and fault transition resistances.

关键词： Through-type Cophase traction direct power supply system Traction network Empirical wavelet transform(EWT) Longitudinal protection

New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186

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Journal of Ocean University of China 2024年第1期23卷 216-220页

作者： YU guihong ZHOU Luning WU Guangwei LI Dehai Shandong Province Key Laboratory of Applied Mycology and Qingdao International Center on Microbes Utilizing BiogasSchool of Life SciencesQingdao Agricultural UniversityQingdao 266109China School of Medicine and Pharmacy and Sanya Oceanographic InstitutionOcean University of ChinaQingdao 266003China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China Laboratory for Marine Drugs and Bioproducts Laoshan LaboratoryQingdao 266237China

Two new dihydropyrones,rhytismatones C(1)and D(2),and a known compound,penicillenol A1(3),were isolated from the co-culture broth of the deep-sea-derived fungus Penicillium crustosum PRB-2 and Suaeda salsa-derived endophytic fungus Peni-cillium citrinum HDN11-186.Their structures were elucidated through comprehensive analysis of nuclear magnetic resonance(NMR)spectra and mass spectra.The absolute configurations of new compounds were determined by calculating the electronic circular di-chroism(ECD)spectrum.UPLC-MS data showed that compounds 1–3 could only be detected in the media of co-culture,suggesting new biosynthetic pathways were activated in the co-cultured fungi.Compound 1 showed obvious antibacterial activities against Pro-teus sp.MMBC-1002 and Bacillus subtilis MMBC-1004 with minimum inhibitory concentration(MIC)both at 25μmolL^(-1).

关键词： co-culture Penicillium crustosum Penicillium citrinum dihydropyrones antibacterial activity

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu guihong Liu Tieming Xie Xing Zhang Xiaoxuan wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiotherapy Dongguan Institute of Clinical Cancer Research Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors Affiliated Dongguan Hospital Southern Medical University The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen University Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen University Department of Oncology Maoming People's Hospital Department of Radiation Oncology Kecheng District People's Hospital Chinese Academy of Sciences Department of Radiation Oncology State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co. Ltd Department of Radiation Oncology The Second Affiliated Hospital of Soochow University Department of Radiation Oncology Yuebei People's Hospital Affiliated to the Medical College of Shantou University Chinese Academy of Sciences Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical University Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical University Chinese Academy of Sciences State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co. Ltd Department of Radiation Oncology The Affiliated Huai'an First People's Hospital of Nanjing Medical University Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang University

Objective: Glioblastomas are highly vascularized malignant tumors. We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor, anlotinib, for a newly diagnosed glioblastoma.Methods: This multicenter, single-arm trial（NCT04119674） enrolled 33 treatment-na?ve patients with histologically proven glioblastomas between March 2019 and November 2020. Patients underwent treatment with the standard STUPP regimen [fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w × 6 w（total = 54-60 Gy）] or radiotherapy plus continuous daily temozolomide（TMZ）(75 mg/m2of body surface area/d, 7 d/w from the first to the last day of radiotherapy), followed by 6 cycles of adjuvant TMZ（150±200 mg/m2× 5 d during each 28-d cycle） plus anlotinib(8 mg/d on d 1±14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy, 8 maximal cycles as adjuvant therapy, followed by maintenance at 8 mg/d. The primary endpoint was progression-free survival（PFS）. Secondary endpoints included overall survival（OS） and adverse events（AEs）.Results: Thirty-three patients received the planned treatment. The median PFS was 10.9 months（95% CI, 9.9±18.7 months） and the 12-month PFS rate was 48.5%. The median OS was 17.4 months（95% CI, 14.5±21.1 months） and the 12-month OS rate was 81.8%. The most common AEs included hypertriglyceridemia [58%（n = 19）], hypoalbuminemia [46%（n = 15）], and hypercholesterolemia [46%（n = 15）] during concurrent chemoradiotherapy and leukopenia [73%（n = 24）], hypertriglyceridemia [67%（n = 22）], and neutropenia [52%（n = 17）] during adjuvant therapy. Five patients discontinued treatment due to AEs. HEG1（HR, 5.6; 95% CI, 1.3±23.7; P = 0.021） and RP1L1 alterations（HR, 11.1; 95% CI, 2.2±57.2; P = 0.004） were associated with a significantly shorter PFS.Conclusions: Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable toxicity. HEG1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anlotinib anti-angiogenesis multi-kinase inhibitor progression-free survival temozolomide

Relationship between the unique microstructures and behaviors of high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi Wu Peter KLiaw Ruixuan Li Weiran Zhang guihong Geng Xuehui Yan Guiqun Liu Yong Zhang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the keen interest of nu-merous researchers.Entropy,in this context,can be perceived as representing disorder and randomness.By contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as structure.In accordance with Shannon entropy,structure is analogous to information.Generally,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its properties.In addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural designs.The profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous examples.These features include remarkably high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion resistance.In this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design

Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication

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Journal of Integrative Agriculture 2024年第3期23卷 988-1005页

作者： Qi Gao Yongzhi Feng Ting Gong Dongdong Wu Xiaoyu Zheng Yizhuo Luo Yunlong Yang Zebu Song Lang Gong guihong Zhang Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China Maoming Branch Guangdong Laboratory for Lingnan Modern AgricultureMaoming 525000China Key Laboratory of Animal Vaccine Development Ministry of Agriculture and Rural AffairsGuangzhou 510000China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Coronaviruses are widely transmissible between humans and animals, causing diseases of varying severity. Porcine enteric alphacoronavirus(PEAV) is a newly-discovered pathogenic porcine enteric coronavirus in recent years, which causes watery diarrhea in newborn piglets. The host inflammatory responses to PEAV and its metabolic regulation mechanisms remain unclear, and no antiviral studies have been reported. Therefore, we investigated the pathogenic mechanism and antiviral drugs of PEAV. The transcriptomic analysis of PEAV-infected host cells revealed that PEAV could upregulate lipid metabolism pathways. In lipid metabolism, steady-state energy processes, which can be mediated by lipid droplets(LDs), are the main functions of organelles. LDs are also important in viral infection and inflammation. In infected cells, PEAV increased LD accumulation, upregulated NF-κB signaling, promoted the production of the inflammatory cytokines IL-1β and IL-8, and induced cell death. Inhibiting LD accumulation with a DGAT-1 inhibitor significantly inhibited PEAV replication, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. The NF-κB signaling pathway inhibitor BAY11-7082 significantly inhibited LD accumulation and PEAV replication. Metformin hydrochloride also exerted anti-PEAV effects and significantly inhibited LD accumulation, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. LD accumulation in the lipid metabolism pathway therefore plays an important role in the replication and pathogenesis of PEAV, and metformin hydrochloride inhibits LD accumulation and the inflammatory response to exert anti-PEAV activity and reducing pathological injury. These findings contribute new targets for developing treatments for PEAV infections.

关键词： porcine enteric alphacoronavirus NF-κB inflammatory pathway lipid droplet metformin hydrochloride

Constructing efficient bacterial cell factories to enable one-carbon utilization based on quantitative biology:A review

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Quantitative Biology 2024年第1期12卷 1-14页

作者： Yazhen Song Chenxi Feng Difei Zhou Zengxin Ma Lian He Cong Zhang guihong Yu Yan Zhao Song Yang Xinhui Xing School of Life Sciences Shandong Province Key Laboratory of Applied Mycologyand Qingdao International Center on Microbes Utilizing BiogasQingdao AgriculturalUniversityQingdaoChina Department of Chemical Engineering University of WashingtonSeattleWashingtonUSA Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjinChina Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijingChina Center for Synthetic and Systems Biology Tsinghua UniversityBeijingChina Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate Schooland Insttute of Biomedical Health Technology and EngineeringShenzhen Bay LaboratoryShenzhenChina

Developing methylotrophic cell factories that can efficiently catalyze organic one-carbon(C1)feedstocks derived from electrocatalytic reduction of carbon dioxide into bio-based chemicals and biofuels is of strategic significance for building a carbon-neutral,sustainable economic and industrial system.With the rapid advancement of RNA sequencing technology and mass spectrometer analysis,researchers have used these quantitative microbiology methods extensively,especially isotope-based metabolic flux analysis,to study the metabolic processes initiating from C1 feedstocks in natural C1-utilizing bacteria and synthetic C1 bacteria.This paper reviews the use of advanced quantitative analysis in recent years to understand the metabolic network and basic principles in the metabolism of natural C1-utilizing bacteria grown on methane,methanol,or formate.The acquired knowledge serves as a guide to rewire the central methylotrophic metabolism of natural C1-utilizing bacteria to improve the carbon conversion efficiency,and to engineer non-C1-utilizing bacteria into synthetic strains that can use C1 feedstocks as the sole carbon and energy source.These progresses ultimately enhance the design and construction of highly efficient C1-based cell factories to synthesize diverse high value-added products.The integration of quantitative biology and synthetic biology will advance the iterative cycle of understand–design–build–testing–learning to enhance C1-based biomanufacturing in the future.

关键词： ^(13)C-metabolic flux analysis methylotrophic cell factories one-carbon feedstock quantitative biology

Numerical Study of the Biomechanical Behavior of a 3D Printed Polymer Esophageal Stent in the Esophagus by BP Neural Network Algorithm

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2709-2725页

作者： Guilin Wu Shenghua Huang Tingting Liu Zhuoni Yang Yuesong Wu guihong Wei Peng Yu Qilin Zhang Jun Feng Bo Zeng College of Civil Engineering and Architecture Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationGuangxi Key Laboratory of Disaster Prevention and Structural SafetyScientific Research Center of Engineering MechanicsGuangxi UniversityNanning530004China Anaesthesiology Department of the 923th The 923th Hospital of PLA Joint Logistic Support ForceNanning530021China Biomedical Materials Engineering Research Center Tsinghua Innovation Center in DongguanDongguan523808China Research Centre Guangxi Nanning Ruifeng Medical Devices Co.Ltd.Nanning530000China Department of Thoracic Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Esophageal disease is a common disorder of the digestive system that can severely affect the quality of life andprognosis of patients. Esophageal stenting is an effective treatment that has been widely used in clinical practice.However, esophageal stents of different types and parameters have varying adaptability and effectiveness forpatients, and they need to be individually selected according to the patient’s specific situation. The purposeof this study was to provide a reference for clinical doctors to choose suitable esophageal stents. We used 3Dprinting technology to fabricate esophageal stents with different ratios of thermoplastic polyurethane (TPU)/(Poly-ε-caprolactone) PCL polymer, and established an artificial neural network model that could predict the radial forceof esophageal stents based on the content of TPU, PCL and print parameter. We selected three optimal ratios formechanical performance tests and evaluated the biomechanical effects of different ratios of stents on esophagealimplantation, swallowing, and stent migration processes through finite element numerical simulation and in vitrosimulation tests. The results showed that different ratios of polymer stents had different mechanical properties,affecting the effectiveness of stent expansion treatment and the possibility of postoperative complications of stentimplantation.

关键词： Finite element method 3D printing polymer esophageal stent artificial neural network

基于T区中低频衰减特性构成方向元件的特高压三端混合直流输电线路单端方向保护研究

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电网技术 2024年第6期48卷 2622-2631,I0110-I0114页

作者：邢超黄泽毕贵红陈仕龙王龙牛元有云南电网有限责任公司电力科学研究院云南省昆明市650217 昆明理工大学电力工程学院云南省昆明市650500

将保护装置安装在T区两侧,基于T区中低频衰减特性构成方向元件,提出一种特高压三端混合直流输电线路单端方向保护方法。分析特高压三端混合直流输电系统整流侧、T区以及线路末端逆变侧三端边界频率特性,发现T区边界对故障电流暂态信号... 详细信息

将保护装置安装在T区两侧,基于T区中低频衰减特性构成方向元件,提出一种特高压三端混合直流输电线路单端方向保护方法。分析特高压三端混合直流输电系统整流侧、T区以及线路末端逆变侧三端边界频率特性,发现T区边界对故障电流暂态信号中低频分量有一定的衰减作用、整流侧边界和线路末端逆变侧边界对故障电流暂态信号高频分量有明显衰减作用。利用小波分解,根据T区两侧线路暂态电流中低频能量差判断故障方向,并提出故障方向判据。当T区左侧发生故障时,利用线路L1末端所检测到的高频暂态电流能量与低频暂态电流能量的比值来判别整流侧区内、外故障;当T区右侧发生故障时,利用线路L2首端所检测到的高频暂态电流能量与低频暂态电流能量的比值来判别线路末端逆变侧区内、外故障;T区发生故障时,判定为线路区外故障。给出基于T区中低频衰减特性构成方向元件的特高压三端混合直流输电线路单端方向保护方案,最后在PSCAD/EMTDC仿真平台搭建昆柳龙特高压三端混合直流输电系统模型并对所提保护方法进行验证,仿真表明该文所提保护方法能实现特高压三端混合直流输电线路全线速动保护。

关键词：特高压三端混合直流输电线路 T区暂态电流高低频能量差方向保护

人参多糖干预创伤性骨关节炎模型大鼠前列腺素E_(2)/6-酮-前列腺素F_(1α)的表达

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中国组织工程研究 2024年第8期28卷 1235-1240页

作者：李蕊张桂红王涛樊萍陕西能源职业技术学院陕西省咸阳市712000 陕西省人民医院陕西省西安市710007 西安交通大学医学院第一附属医院陕西省西安市710007

背景:目前已有研究发现植物人参提取物对骨关节炎有明显的改善作用,但是关于人参多糖提对骨关节炎的治疗作用尚未见报道。目的:探讨人参多糖干预创伤性骨关节炎模型大鼠前列腺素E_(2)/6-酮-前列腺素F_(1α)的表达变化。方法:选取60只雄... 详细信息

背景:目前已有研究发现植物人参提取物对骨关节炎有明显的改善作用,但是关于人参多糖提对骨关节炎的治疗作用尚未见报道。目的:探讨人参多糖干预创伤性骨关节炎模型大鼠前列腺素E_(2)/6-酮-前列腺素F_(1α)的表达变化。方法:选取60只雄性SD大鼠,随机分为健康组、模型组、人参多糖低、中、高剂量组、地塞米松组,除健康组外,其余大鼠均建立创伤性骨关节炎模型。造模成功后,健康组与模型组采用生理盐水0.2 mL腹腔注射,人参多糖低、中、高剂量组分别采用0.1,0.25,0.5μg/mL人参多糖0.2 mL腹腔注射,地塞米松组采用0.2 mg/kg地塞米松腹腔注射,均每3 d注射一次,连续干预4周。给药结束后采用ELISA法检测大鼠血清中前列腺素E_(2)、6-酮-前列腺素F_(1α)水平,Mankin’s评分法检测大鼠膝关节软骨功能,苏木精-伊红染色观察大鼠膝关节病理形态,免疫印迹与PCR分别检测关节软骨组织中肿瘤坏死因子α、白细胞介素1β、白细胞介素10的表达。结果与结论:①与模型组比较,人参多糖中剂量组、地塞米松组大鼠血清前列腺素E_(2)降低,6-酮-前列腺素F_(1α)升高(P0.05);②与模型组比较,人参多糖中剂量组、地塞米松组大鼠Mankin’s评分降低(P0.05);③模型组与人参多糖低剂量组大鼠软骨组织层明显变薄,深达骨质层的裂隙及软骨细胞大量丢失,潮线严重断裂、模糊,滑膜层胶原纤维增多、增粗,可见大量软骨细胞被破坏,排列不规则;人参多糖中剂量组、地塞米松组较模型组改善;人参多糖高剂量组较人参多糖中剂量组改善;④与模型组比较,人参多糖中剂量组、地塞米松组大鼠关节软骨组织中肿瘤坏死因子、白细胞介素1β表达降低,白细胞介素10表达升高(P0.05);⑤提示人参多糖可改善创伤性骨关节炎大鼠炎性水平及病理形态,降低Mankin’s评分,其中人参多糖高剂量组效果最好,其作用机制可能与调控前列腺素E_(2)/6-酮-前列腺素F_(1α)表达水平有关。

关键词：人参多糖创伤性骨关节炎前列腺素E_2 6-酮-前列腺素F_(1α) 动物模型

基于特征图像组合与改进ResNet-18的电能质量扰动识别方法

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中国电机工程学报 2024年第7期44卷 2531-2544,I0003页

作者：张逸欧杰宇金涛毕贵红福州大学电气工程与自动化学院福建省福州市350108 昆明理工大学电力工程学院云南省昆明市650500

针对传统电能质量扰动(power quality disturbance,PQD)识别体系中单一图像特征信息受限与算法识别能力不足等问题,依据特征融合的思想,提出一种基于特征图像组合与改进ResNet-18的PQD识别方法。首先,对PQD信号进行变分模态分解(variati... 详细信息

针对传统电能质量扰动(power quality disturbance,PQD)识别体系中单一图像特征信息受限与算法识别能力不足等问题,依据特征融合的思想,提出一种基于特征图像组合与改进ResNet-18的PQD识别方法。首先,对PQD信号进行变分模态分解(variational mode decomposition,VMD)得到一系列固有模态函数(intrinsic mode functions,IMFs)与残差分量;其次,将IMFs、残差分量、原始扰动信号与Subtract分量纵向拼接成分量矩阵,利用信号-图像转化方法生成特征分量彩色图;再次,对原始扰动信号进行连续小波变换(continuous wavelet transform,CWT)生成小波时-频图;最后,将特征分量彩色图与小波时-频图组合输入改进的六通道ResNet-18中训练学习并完成扰动识别。通过仿真对PQD识别方法进行分析并将其与目前常用识别体系进行比较。结果表明,所提方法具有较好的抗噪性能并且能够更好地提取PQD特征信息,达到更高的识别准确率。

关键词：电能质量扰动变分模态分解特征分量彩色图小波时-频图残差网络