检索结果-南通市图书馆

Three-dimensional structures of virulence proteins of Legionella establish targets for new antibacterials

微生物与感染 2012年第1期7卷 2-12页

作者： guido hansen Rolf Hilgenfeld Institute of Biochemistry Center for Structural and Cell Biology in MedicineUniversity of LübeckLübeck 23538Germany German Centre for Infection Research(DZIF) University of LübeckLübeck 23538Germany Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Laboratory for Structural Biology of Infection and Inflammation c/o DESYHamburg 22603Germany

Legionella pneumophila,the causative agent of Legionnaires' disease,has been recognized as a major health problem responsible for an estimated number of 15 000-30 000 cases of severe pneumonia per year in Germany *** of the high clinical relevance,many aspects of the intracellular life cycle of Legionella,especially details on interactions with host cells,are not well *** information on virulence proteins helps unravel basal pathogenicity mechanisms and is a prerequisite for the rational development of effective drug *** we discuss structures of three important virulence proteins of Legionella that have been determined in our *** structure of the macrophage infectivity potentiator(Mip) protein of Legionella pneumophila is the first of a novel subgroup within the family of FK506-binding protein(FKBP) peptidyl-prolyl cis/trans *** the basis of the Mip structure,promising antibacterial agents are being ***,structures of two equally exciting Legionella proteins have been *** ferrous iron transport protein FeoB is a transmembrane protein responsible for Fe2+ aquisition after entry of the pathogen into the host *** structure of the cytoplasmic domain of FeoB provides insights into the family of prokaryotic G proteins and allows a detailed comparison with structures of related ***,the characterization of DegQ,a periplasmatic chaperone-protease involved in protein quality control represents an intriguing example of how enzymatic activity is regulated by oligomerization as well as by an intrinsic loop activation cascade,depending on subtle conformational rearrangements.

关键词：摘要编辑部编辑工作读者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：