检索结果-南通市图书馆

Establishment of an Assessment System for the Prediction of Severe Post-operative Complications after Hepatectomy Based on Preoperative Parameters

引用

Current Medical Science 2022年第5期42卷 1088-1093页

作者： li-ning XU Ying-ying XU gui-ping li Bo YANG Department of General Surgery The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective At present,there is no appropriate system to evaluate the severe complications of liver surgery through the preoperative *** study aimed to design and verify a risk assessment system for the prediction of severe post-operative complications after a hepatectomy based on the preoperative *** A retrospective analysis was performed on 1732 patients who had undergone liver *** severity of the complications was graded by Accordion Severity Grading of post-operative *** variables were screened by multivariate analysis,and graded scores were assigned to the selected variables.A logistic regression equation was used to form the liver operation risk formula(LORF)for the prediction of severe post-operative *** LORF was verified by the receiver operating characteristic(ROC)*** The multivariate correlation analysis revealed the independent influencing factors of the severe post-operative complications of liver surgery were Child-Pugh grade(OR=4.127;Pliver segments to be removed(OR=2.209;P=0.006),organ invasion(OR=4.538;P=0.024),and pathological type(OR=4.023;P=0.002).The binomial logistic regression model was established to obtain the calculation formula(LORF)of the severe complication *** area under the ROC curve(AUC)of the LORF was *** cut-off value of the expected probability of severe complications was 0.3225(32.25%).Furthermore,in the validation data set,the corresponding AUC of the LORF was *** As a novel and simplified assessment system,the LORF could effectively predict the severe post-operative complications of liver surgery through the preoperative factors,and therefore it could be used to evaluate the risk of severe liver surgical complications before surgery.

关键词： liver surgery complication prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Postoperativeω-3 Fatty Acid Immunonutritional Therapy on NK Cell Gene Methylation in Elderly Patients with Gastric Cancer

引用

Current Medical Science 2022年第2期42卷 373-378页

作者： li-ning XU Ying-ying XU gui-ping li Bo YANG Department of General Surgery The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study aims to investigate the effect ofω-3 fatty acid immunonutritional therapy on natural killer(NK)cell gene methylation and function in elderly patients with gastric *** A total of 70 cases of elderly patients with gastric cancer were randomized into theω-3 fatty acid group and placebo group,according to the type of nutritional support *** methylation status of the tumor necrosis factor(TNF)-αgene promoter in peripheral NK cells was detected by methylation specific polymerase chain reaction,and the TNF-αlevel in peripheral NK cells was detected by enzyme-linked immunosorbent *** After 14 days of immunonutritional therapy withω-3 fatty acid or placebo,patients in theω-3 group had significantly higher average NK cell activity(0.27 vs.0.24,P=0.013)and lower percentages of TNF-αgene promoter methylation(25.7%vs.60%,Plication ofω-3 fatty acid may improve the activity of NK cells,which is correlated to the methylation status of the TNF-αgene promoter.

关键词： perioperative gastric carcinoma natural killer cell DNA methylation immune nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avidin-biotin system pretargeting radioimmunoimaging and radioimmunotherapy and its application in mouse model of human colon carcinoma

引用

World Journal of Gastroenterology 2005年第40期11卷 6288-6294页

作者： gui-ping li Hui Zhang Cheng-Mo Zhu, Jian Zhang Xu-Feng Jiang Departmnent of Nuclear Medicine NanfangHospital Southern Medical University Guangzhou 510515Guangdong Province China Department of Nuclear Medicine Ruijin Hospital Shanghai Second Medical University Shanghai 200025 China

AIM： To evaluate the multi-step pretargeting radioimmunoimaging （RII） and radioimmunotherapy （RTT） in nude mice bearing human colon carcinoma with avidin-biotin system labeled with 153^Sm. METHODS： Two- and three-step strategies for avidinbiotin system pretargeting techniques were established. In a three-step procedure, human colon carcinoma bearing nude mice were first injected with biotinylated monoclonal antibody （McAb-Bt） followed by cold avidin （Av） 48 h later and then 153^Sm-DB2 24 h thereafter; whereas the twostep procedure consisted of injection of 153^Sm-SA 48 h after pretargeting with biotinylated anti-CEA monoclonal antibody （CEA McAb-Bt）. SPECT imaging and biodistribution were performed at 4, 24, 48, or 72 h after injection of 153^Sm-labeled compounds. Five groups of nude mice subcutaneously grafted with human colon carcinoma were treated 3 d after grafting. One group received the injection with 100 μg CEA McAb-Bt followed by cold avidin （80 μg） after 2 d and 11.1 MBCl I53Sm-DB2 after 1 d. Four control groups were treated respectively with 11.1 MBq 153^Sm- CEA McAb, ii.i MBq 153^Sm-nmIgG, ii.i MBq 153^Sm-DB2, 100 μL normal saline. Toxicity was evaluated by changes of leukocyte count, and the efficacy by variation in tumor volume. Histological analyses of tumors were performed. RESULTS： The three-step procedure allowed faster blood clearance and yielded higher tumor blood ratios （5.76 at 4 h and 12.94 at 24 h） of the 153^Sm-DB2. The tumor was clearly visualized at 4 h in y-imaging after the injection of 153^Sm-DB2, while a significant accumulation of 153^Sm-SA in the tumor was observed only 24 h after the injection and tumor blood ratios at 4 and 24 h were 1.00 and 2.03, respectively, in the two-step procedure. Pretargeting RIT and 153^Sm-CEA McAb had a strong tumor-inhibiting *** tumor inhibitory rate was 80.67% and 78.44%, respectively, five weeks after therapy. Histopathological evidence also indicated radioactive damage in tumor tissues as necr

关键词： Radioimmunoimaging Radioimmunotherapy Avidin-biotin Colon carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Individualized risk estimation for postoperative pulmonary complications after hepatectomy based on perioperative variables

引用

World Journal of Gastrointestinal Surgery 2022年第7期14卷 685-695页

作者： li-Ning Xu Ying-Ying Xu gui-ping li Bo Yang Department of General Surgery The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou 450003Henan ProvinceChina Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan 430015Hubei ProvinceChina Department of Radiology Affiliated Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND At present,there is no perfect system to evaluate pulmonary complications of liver surgery using perioperative *** To design and verify a risk assessment system for predicting postoperative pulmonary complications(PPCs)after hepatectomy based on perioperative *** A retrospective analysis was performed on 1633 patients who underwent liver *** variables were screened using univariate and multivariate analyses,and graded scores were assigned to the selected *** regression was used to develop the liver operation pulmonary complication scoring system(LOPCSS)for the prediction of *** LOPCSS was verified using the receiver operating characteristic *** According to the multivariate correlation analysis,the independent factors which influenced PPCs of liver surgery were age[≥65 years old/liver segments to be removed(≥3/≤2,OR=1.683,P=0.002),operation duration(≥180 min/lications was *** incidence of complications in the group with≤4 points was significantly lower than that in the group with≥6 points(2.95%vs 33.40%,Plidation dataset,the corresponding AUC of LOPCSS was *** As a novel and simplified assessment system,the LOPCSS can effectively predict PPCs of liver surgery through perioperative variables.

关键词： liver surgery Complication Pulmonary Prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological role of surface Toxoplasma gondii antigen in development of vaccine

引用

World Journal of Gastroenterology 2006年第15期12卷 2363-2368页

作者： Ke-Yi liu Dian-Bo Zhang Qing-Kuan Wei Jin li gui-ping li Jin-Zhi Yu Shandong Institute of Parasitic Diseases Jining 272633 Shandong Province China Department of Population Medicine and Diagnostic Sciences Veterinary Medical College Comell University IthacaNY 14853 United States

AIM： To analyze the biological role of the surface antigen of Toxoplasma gondii（Tgondii） in development of vaccine. METHODS： The surface antigen of Tgondii （SAG1） was expressed in vitro. The immune response of the host to the antigen was investigated by detection of specific antibody reaction to SAG1 and production of cytokines. Mice were immunized with recombinant SAG1 and challenged with lethal strain of Tgondii RH. The monoclonal antibody to r-SAG1 was prepared and used to study the effects of SAG1 on Tgondii tachyzoites under electromicroscope. RESULTS： The mice immunized with recombinant SAG1 delayed death for 60 h compared to the control group. The recombinant SAG1 induced specific high titer of IgG and IgM antibodies as well as IFN-y, IL-2 and IL-4 cytokines in mice. In contrast, IL-12, IL-6 and TNF-α were undetectable. When T gondii tachyzoites were treated with the monoclonal antibody to r-SAG1, the parasites were gathered together, destroyed, deformed, swollen, and holes and gaps formed on the surface. CONCLUSION： SAG1 may be an excellent vaccine candidate against T gondii. The immune protection induced by SAG1 against Tgondii may be regulated by both hormone- and cell-mediated immune response.

关键词： Toxoplasma gondii Recombinant SAG1 Monoclonal antibody Cytokines Morphology change

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune response pattern varies with the natural history of chronic hepatitis B

引用

World Journal of Gastroenterology 2019年第16期25卷 1950-1963页

作者： Wen-Tao Wang Xue-Qi Zhao gui-ping li Yi-Zhi Chen lin Wang Mei-Fang Han Wei-Na li Tao Chen Guang Chen Dong Xu Qin Ning Xi-ping Zhao Department of Infectious Diseases Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Huazhong University of Science and Technology Department of Heart Function Examination Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Pathophysiology Hubei University of Medicine

BACKGROUND Chronic hepatitis B is a highly heterogeneous disease that can be divided into four phases: Immune tolerant(IT), immune active(IA), inactive carrier(IC) and hepatitis B envelope antigen(HBeAg)-negative hepatitis(ENEG).AIM To investigate the immune status of natural killer(NK) and T cells in different phases of chronic hepatitis *** The frequency, phenotype and function of circulating NK cells, as well as nonantigen-specific and hepatitis B virus(HBV)-specific T cell responses were detected by flow cytometry in healthy and HBV-infected *** The ability of NK cells to produce IFN-γ was markedly attenuated in HBVinfected patients overall but was less compromised in IC patients. Patients in the IT and IA phases also displayed significantly lower TNF-α production compared to healthy subjects. NK cells were phenotypically activated in the IA and ENEGphases, as evidenced by the upregulation of NKp44 in CD56^(bright) NK cells and CD69 in CD56^(dim) NK cells. Furthermore, global T-cells from the ENEG phase displayed a proinflammatory cytokine profile with upregulated IFN-γ and TNF-αexpression, while this profile was suppressed in IT and IA patients. Finally, core and S antigen-specific T cell responses were significantly stronger after in vitro expansion in the IC phase compared to other *** Our findings demonstrate the changes in immune response pattern during the natural history of HBV infection. Both NK and T cells are functionally impaired in the IT and IA phases. With the spontaneous clearance of HBeAg and hepatitis B surface antigen decline, NK cell cytokine production and HBV-specific T responses are partially restored in IC phase, and the ENEG phase is dominated by nonantigen-specific T cell responses.

关键词： Chronic hepatitis Hepatitis B virus Natural killer cells Global-T cells Virusspecific T cells Natural history Heterogeneity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Prognostic Value of Red Cell Distribution Width in Critically Ill Cerebral Infarction Patients:A Retrospective Cohort Study

引用

Journal of Clinical and Nursing Research 2024年第2期8卷 1-12页

作者： lingyan Zhao linna Wu gui-ping li Wuxi Hospital of Traditional Chinese Medicine Wuxi 214071Jiangsu ProvinceChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China

Objective:Red blood cell distribution width(RDW)has been utilized as a prognostic indicator for mortality risk assessment in cardiovascular and cerebrovascular ***,the prognostic significance of RDW in critically ill patients with cerebral infarction is yet to be *** objective of this study is to examine the association between RDW and the risk of all-cause mortality in cerebral infarction patients admitted to the intensive care unit(ICU).Method:A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care IV 2.2(MIMIC-IV)intensive care dataset for data *** main results were the all-cause mortality rates at 3 and 12 months of *** curves were plotted using the Kaplan-Meier method,and Cox proportional hazards analysis was used to examine the relationship between RDW and mortality rates in critically ill cerebral infarction ***:The findings indicate that RDW serves as a significant prognostic factor for mortality risk in critically ill stroke patients,specifically at the 3 and 12-month follow-up *** observed correlation between increasing RDW levels and higher mortality rates among cerebral infarction patients further supports the potential utility of RDW as a predictive ***:RDW emerges as an independent predictor of mortality risk during the 3 and 12-month follow-up periods for critically ill patients with cerebral infarction.

关键词： Red blood cell distribution width Cerebral infarction Intensive care unit All-cause mortality rate MIMIC-IV database

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neonatal Staphylococcal Scalded Skin Syndrome:A Case Report

引用

TMR Integrative Nursing 2021年第3期5卷 115-119页

作者： Yuan-Xia Zou Jia-Yu Zhang Xiao-Xiu Ye Hui Zhou Run li gui-ping li Department of Newborn Medicine Hospital Affiliated to Southwest Medical UniversityLuzhouSichuanChina School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunmingYunnanChina

Objective:To summarize the clinical features,diagnosis,and treatment of neonatal staphylococcal scalded skin syndrome(SSSS).Methods:The clinical data with SSSS was analyzed,and the related literature was ***:The acute onset of the disease was characterized by generalized erythema,epidermis exfoliation,skin non-touch,radial chapping around the mouth,and positive Nissl *** culture of binocular secretions and neck exudates showed Staphylococcus aureus and was diagnosed as *** to the results of drug sensitivity of secretions and exudates,vancomycin was selected for anti-infective treatment,and skincare and symptomatic support were given *** child was cured and discharged after ten days of ***:SSSS belongs to neonatal acute and critical *** etiological examination and timely targeted anti-infective treatment is the key to correct diagnosis and recovery.

关键词： Newborn Staphylococcal scalded skin syndrome Staphylococcus aureus Mastitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the mechanism of Xingnao Kaiqiao acupuncture method for ischemicstroke based on EEG dynamic changes: a study protocol of an exploratory,prospective,interventional trial

引用

TMR Integrative Medicine 2022年第33期6卷 1-9页

作者： gui-ping li lin-Na Wu Kai li Fan Xu Jia-Rong Wu li-li Zhao Hao-Long Guo Ting-Wei Zhu First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China

Background: The Xingnao Kaiqiao acupuncture method, founded by Academician ShiXuemin, has outstanding efficacy in the treatment of ischemic stroke and has been widelyused at home and abroad. However, after half a century of animal experiments and clinicalstudies, clearly and intuitively revealing its therapeutic mechanism is still a great challengefor researchers. Therefore, this experiment is based on the combination of medicine andengineering to study the immediate effects of the acupuncture method in treating patientsby recording the electroencephalography (EEG) activities of subjects during the acupunctureprocess and to further reveal the therapeutic mechanism at the brain level. Methods: Thistrial is an exploratory, prospective, single-arm interventional study involving a total ofpatients with ischemic stroke. Physicians will record EEG data from patients duringacupuncture as the primary outcome indicator. After pre-processing the EEG data,researchers will use various methods to analyze the immediate effects of acupuncture toobtain brain effectiveness. Deep learning will then be used to identify acupoint stimuli andreceive correspondence between the acupuncture effect and the brain’s internal *** Institutes of Health Stroke Scale score before and after the acupuncture process willbe used as the secondary outcome indicator. Conclusion: This is the first study protocol toapply dynamic changes in EEG to explore a range of mechanisms of action of acupuncture inthe treatment of ischemic stroke. We propose a method to analyze EEG signals ofacupuncture patients. The deep learning model will be applied for supervised training toobtain the compelling relationship between the acupuncture method and internal brainstates, providing a new prospect for the digitization of traditional Chinese medicine.

关键词： Xingnao Kaiqiao acupuncture method ischemic stroke electroencephalography study protocol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

足尺变刚度控制系统性能试验与计算模型

引用

地震工程与工程振动 2000年第4期20卷 96-100页

作者：李敏霞欧进萍王刚桂丽萍华南建设学院西院哈尔滨工业大学土木工程学院黑龙江哈尔滨150090

本文充分考虑了实际工程应用中的诸多因素，成功地研制了４０吨足尺变刚度控制系统并对其进行了性能试验，实现了模型试验到实用样机的转化。性能试验结果表明，该足尺系统的性能满足各项设计技术要求；系统滞回曲线说明该系统充分发挥... 详细信息

本文充分考虑了实际工程应用中的诸多因素，成功地研制了４０吨足尺变刚度控制系统并对其进行了性能试验，实现了模型试验到实用样机的转化。性能试验结果表明，该足尺系统的性能满足各项设计技术要求；系统滞回曲线说明该系统充分发挥了可变刚度的吸能、释能减振控制作用；在此基础上，文中研究了足尺系统的设计与控制算法、试验工况与试验结果以及计算模型。

关键词：变刚度足尺系统性能试验控制算法计算模型抗震设计滞回曲线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：