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Who can benefit more from its twelve-week treatment:A prospective cohort study of blonanserin for patients with schizophrenia

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World Journal of Psychiatry 2024年第11期14卷 1735-1745页

作者： Bao-Yan Xu Kun Jin Hai-Shan Wu Xue-Jun Liu Xi-Jin Wang Hong Sang Ke-Qing Li Mei-Juan Sun Hua-Qing Meng Huai-Li Deng Zhi-Yuan Xun Xiao-Dong Yang Lin zhang Guan-Jun Li Rui-Ling zhang Duan-Fang Cai Jia-Hong Liu gui-Jun Zhao Long-Fa Liu Gang Wang Chang-Lie Zhao Bin Guo Sheng-Chun Jin Ling-Yun Huang Fu-De Yang Jian-Min Zheng gui-lai zhan Mao-Sheng Fang Xiang-Jun Meng Guang-Ya zhang Hai-Min Li Xiang-lai Liu Ju-Hong Li Bin Wu Hai-Yun Li Jin-Dong Chen Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Hebei Provincial Mental Health CenterHebei Key Laboratory of Major Mental and Behavioral DisordersThe Sixth Clinical Medical College of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceChangsha 410000Hunan ProvinceChina Department of Psychiatry The First Psychiatric Hospital of HarbinHarbin 150000Heilongjiang ProvinceChina Mental Health Center Changchun Sixth HospitalChangchun 130000Jilin ProvinceChina Department of Pharmacy Daqing Third HospitalDaqing 163000Heilongjiang ProvinceChina Department of Physical and Psychological Rehabilitation Guangda Rehabilitation HospitalChongqing 400000China Department of Psychology Shanxi Provincial Mental Health CenterTaiyuan 030000Shanxi ProvinceChina Department of Psychiatry Tianjin Anding HospitalTianjin 300000China Department of Psychiatry Shandong Mental Health CenterJinan 250000Shandong ProvinceChina Department of Psychiatry Fuzhou Shenkang HospitalFuzhou 350000Fujian ProvinceChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Psychiatry The Fifth People’s Hospital of ZigongZigong 643000Sichuan ProvinceChina Department of Psychiatry The Affiliated Kangning Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Psychiatry Guangyuan Mental Health CenterGuangyuan 628000Sichuan ProvinceChina Department of Psychiatry Jilin Sixth People’s HospitalJilin 132000Jilin ProvinceChina The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital

BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating *** To investigate which types of patients would obtain the most benefit from BNS *** A total of 3306 participants were evaluated in a 12-week,prospective,multicenter,open-label post-marketing surveillance study of *** psychiatric rating scale(BPRS)scores were calculated to evaluate the effectiveness of BNS,and its safety was assessed with the incidence of adverse drug *** regression was used to screen the influencing factors for the reduction of BPRS total score,and logistic regression was used to identify patients with a better response to *** The baseline BPRS total score(48.8±15.03)decreased to 27.7±10.08 at 12 weeks(P<0.001).Extrapyramidal symptoms(14.6%)were found to be the most frequent adverse drug *** acute phase,baseline BPRS total score,current episode duration,number of previous episodes,dose of concomitant antipsychotics,and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment ***,patients in the acute phase with baseline BPRS total score≥45,current episode duration<3 months,and≤3 previous episodes derived greater benefit from 12-week treatment with *** Patients in the acute phase with more severe symptoms,shorter current episode duration,fewer previous episodes,and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.

关键词： Schizophrenia Blonanserin Effectiveness Psychosocial functioning Prospective cohort study

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui zhang Zhi-lai zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen zhan RongSheng Wang QuanMing Lu San Lu XinMin Li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

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MDCFS: few-shot object detection with multilevel decoupled classifiers

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Optoelectronics Letters 2025年

作者： LI Chuanhui ZHOU Mian FENG Zhikun SUI Zezhou GAO zhan School of Computer Science and Engineering， Tianjin University of Technology

Few-shot object detection poses unique challenges as it requires effectively learning novel classes with limited labeled data. Current approaches often suffer from biases towards base classes during fine-tuning， leading to suboptimal performance on detecting novel classes. Additionally， in complex scenes， the confusion between foreground and background objects further affects the accuracy and robustness of the model. To address these issues， we propose the Multilevel Decoupling Classification Few-Shot Algorithm (MDCFS). we decouple the standard classifier into a parallel foreground classifier and a background classifier in the Few-Shot Object Detection (FSOD) setting. This decoupling enables the independent separation of positive samples from noisy negative samples， alleviating the foreground-background confusion problem commonly encountered in few-shot detectors. For Generalized Few-Shot Object Detection (G-FSOD)， where the few-shot dataset contains base classes， we further decouple the foreground classification head into a base class classification head and a novel class classification head. To ensure balance， we assign more weight to the novel class classification head， effectively addressing the bias towards base classes. Furthermore， we optimize the initial weights of the few-shot fine-tuning stage， significantly reducing training time and mitigating catastrophic forgetting in G-FSOD. Additionally， we incorporate metric learning into our model with minimal cost. Experimental results demonstrate the effectiveness of our approach. Compared to state-of-the-art few-shot object detection methods based on fine-tuning， MDCFS achieves performance improvements of up to 6.3% on the PASCAL VOC dataset and 1.5% on the COCO dataset.

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Diffractive Scattering Factorization from J/ψ and γ Associated Production in HERA ep Collisions

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Communications in Theoretical Physics 2002年第11期37卷 583-586页

作者： YAN zhan-Yuan DUAN Chun-gui Department of Physics North China Electric Power University Baoding 071003 China Department of Physics Hebei Teachers'' University Shijiazhuang 050016 China CCAST (World Laboratory) P.O. Box 8730 Beijing 100080 China

Using three sets of Pomeron structure functions, the cross sections of J/ψ and γ associated productionvia resolved photon and proton diffractive scatting in ep collision are investigated. It is found that the cross sectionscalculated with various gluon distribution functions of Pomeron are different. The discrepancy is about 1.8 times fordifferential cross sections and 1.7 times for total cross sections. The experimental studies of the process could give valuableinsight in the diffractive production mechanism and test the color-octet mechanism for heavy quarkonium production ina new environment.

关键词：高能物理强子-强子碰撞 J/ψ介子

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Construction of dual Z-scheme Bi2WO6/g-C_(3)N_(4)/black phosphorus quantum dots composites for effective bisphenol A degradation

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Journal of Environmental Sciences 2023年第2期124卷 617-629页

作者： Fuyou Du zhan lai Huiyang Tang Haiyan Wang Chenxi Zhao College of Biological and Environmental Engineering Changsha UniversityChangsha 410022China

In this work,a novel dual Z-scheme Bi_(2)WO_(6)/g-C_(3)N_(4)/black phosphorus quantum dots(Bi_(2)WO_(6)/g-C_(3)N_(4)/BPQDs)composites were fabricated and utilized towards photocatalytic degradation of bisphenol A(BPA)under visible-light *** the content of g-C_(3)N_(4) and BPQDs in Bi_(2)WO_(6)/g-C_(3)N_(4)/BPQDs composites to a suitable mass ratio can enhance the visible-light harvesting capacity and increase the charge separation efficiency and the transfer rate of excited-state electrons and holes,resulting in much higher photocatalytic activity for BPA degradation(95.6%,at 20 mg/L in 120 min)than that of Bi2WO6(63.7%),g-C_(3)N_(4)(25.0%),BPQDs(8.5%),and Bi_(2)WO_(6)/g-C_(3)N_(4)(79.6%),*** trapping experiments indicated that photogenerated holes(h+)and superoxide radicals(•O_(2)−)played crucial roles in photocatalytic BPA ***,the possible degradation pathway and photocatalytic mechanism was proposed by analyzing the BPA *** also demonstrated that the Bi2WO6/g-C_(3)N_(4)/BPQDs as effective photocatalystswas stable and have promising potential to remove environmental contaminants from real water samples.

关键词： Dual Z-scheme Bi_(2)WO_(6) Graphitic carbon nitride(g-C_(3)N_(4)) Black phosphorus quantum dots (BPQDs) Bisphenol A(BPA)

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中山大学科技期刊出版史略(1866—2024)

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 1-27页

作者：张冰詹拔群中山大学学报编辑部广东广州510275 中山大学期刊管理中心广东广州510275

本文力图较为完整地展现中山大学100多年的科技期刊出版历史全貌,在明晰中山大学办学源流的基础上将其前身各校的科技期刊出版情况纳入梳理,整理统计出中山大学及其前身各校在正式建校前(1866—1923年)出版科技期刊25种、建校后的民国时... 详细信息

本文力图较为完整地展现中山大学100多年的科技期刊出版历史全貌,在明晰中山大学办学源流的基础上将其前身各校的科技期刊出版情况纳入梳理,整理统计出中山大学及其前身各校在正式建校前(1866—1923年)出版科技期刊25种、建校后的民国时期(1924—1948年)出版科技期刊87种,共和国时期(1949—2024年)出版科技期刊60种,共计172种,并对代表性刊物进行简要介绍。中山大学的科技期刊出版以医学类期刊的贡献最为突出,其影响一直延续至今。这些科技期刊从科研学术角度记录了中山大学的学科发展历史,同时为中国近代科学技术的传播和发展作出了重要的贡献。

关键词：中山大学科技期刊出版史校史

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守正创新勇担时代使命——中山大学学报自然科学版创刊70周年(1955—2024)

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 28-39页

作者：詹拔群张冰中山大学期刊管理中心广东广州510275 中山大学学报编辑部广东广州510275

本文介绍《中山大学学报(自然科学版中英文)》的创刊与源流,分为创刊初期(1955—1966)、首批复刊(1973—1978)、改革开放后(1979—2012)和迈进新时代(2013—2023)四个时间段回顾该刊70年的办刊历程,着重介绍了在各个时期为该刊的发展壮... 详细信息

本文介绍《中山大学学报(自然科学版中英文)》的创刊与源流,分为创刊初期(1955—1966)、首批复刊(1973—1978)、改革开放后(1979—2012)和迈进新时代(2013—2023)四个时间段回顾该刊70年的办刊历程,着重介绍了在各个时期为该刊的发展壮大作出了重要贡献的中山大学学者及其发表的成果,展现中山大学与该刊在推动国家科学技术发展进步方面所作出的贡献。新时代以来,自然科学版致力于内涵式高质量发展取得了成效。该刊以建设世界一流科技期刊为目标,采取了策划组织大型专题专辑、变更期刊文种为中英文、实施稿件质量提升计划、不断完善数字化出版等重要办刊举措,大力推进国际化高水平科技期刊建设。

关键词：科技期刊中山大学学报自然科学版重要作者数字化出版

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Growth and Saturation of the Relativistic Harmonic Radiation

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Chinese Physics Letters 1996年第1期13卷 31-34页

作者： ZENG gui-hua YU Wei SHEN Bai-fei XU Zhi-zhan Institute of Optics and Fine Mechanics Academia SinicaShanghai 201800

A series of coupling equations for the relativistic coherent harmonic generation is derived taking account of the coupling effect among the harmonic contents and plasmas *** these equations,the growth and satuTaiion of amplitude of the third harmonic wave is *** show that the coupling effect induces the saturation of harmonics,which is identical with ones of the Lagrangian description.

关键词： wave. harmonic coupling

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Classical Communication and Entanglement Cost in Preparing a Class of Multi-qubit States

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Communications in Theoretical Physics 2008年第3期49卷 631-634页

作者： PAN gui-Xia LIU Yi-Min zhanG zhan-Jun Department of Mathematics and Physics Anhui University of Science and Technology Huainan 232001 China Department of Physics Shaoguan University Shaoguan 512005 China Key Laboratory of Optoelectronic Information Acquisition ＆ Manipulation of Ministry of Education of China School of Physics ＆ Material Science Anhui University Hefei 230039 China

Recently, several similar protocols [J. Opt. B 4 （2002） 380; Phys. Lett. A 316 （2003） 159; Phys. Lett. A 355 （2006） 285; Phys. Lett. A 336 （2005） 317] for remotely preparing a class of multi-qubit states （i.e, α[0...0〉＋β[1... 1〉） were proposed, respectively. In this paper, by applying the controlled-not （CNOT） gate, a new simple protocol is proposed for remotely preparing such class of states. Compared to the previous protocols, both classical communication cost and required quantum entanglement in our protocol are remarkably reduced. Moreover, the difficulty of identifying some quantum states in our protocol is also degraded. Hence our protocol is more economical and feasible.

关键词： remote state preparation quantum entanglement classical communication cost projective measurement local unitary operation

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