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Sulfuretin exerts diversified functions in the processing of amyloid precursor protein

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Genes & Diseases 2021年第6期8卷 867-881页

作者： Jian Chen Biao Luo Bi-Rou Zhong Kun-Yi Li Qi-Xin Wen Li Song Xiao-Jiao Xiang gui-feng zhou Li-Tian Hu Xiao-Juan Deng Yuan-Lin Ma Guo-Jun Chen Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Neurology1 Youyi RoadChongqing400016PR China Department of Neurology Nanchong Central HospitalThe Second Clinical College of North Sichuan Medical CollegeNanchongSichuan Province637000PR China

Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and *** this study,we investigated the role of sulfuretin in the processing of amyloid precursor protein(APP),in association with the two catalytic enzymes the a-secretase a disintegrin and metalloproteinase(ADAM10),and the beta-site APP cleaving enzyme 1(BACE1)that play important roles in the generation of β amyloid protein(Aβ)in Alzheimer’s disease(AD).We found that sulfuretin increased the levels of the immature but not the mature form of ADAM10 *** enhanced ADAM10 transcription by sulfuretin was mediated by the nucleotides444 to300 in the promoter region,and was attenuated by silencing or mutation of transcription factor retinoid X receptor(RXR)and by GW6471,a specific inhibitor of peroxisome proliferator-activated receptor α(PPAR-α).We further found that sulfuretin preferentially increased protein levels of the immature form of APP(im-APP)but significantly reduced those of BACE1,sAPPβ and β-CTF,whereas Ab1-42 levels were slightly ***,the effect of sulfuretin on BACE1 and im-APP was selectively attenuated by the translation inhibitor cycloheximide and by lysosomal inhibitor chloroquine,*** together,(1)RXR/PPAR-α signaling was involved in sulfuretin-mediated ADAM10 transcription.(2)Alteration of Aβ protein level by sulfuretin was not consistent with that of ADAM10 and BACE1 protein levels,but was consistent with the elevated level of im-APP protein,suggesting that im-APP,an isoform mainly localized to trans-Golgi network,plays an important role in Ab generation.

关键词： Ab ADAM10 BACE1 Immature APP RXR/PPAR-a Sulfuretin Trans-Golgi network

Correction to:Influence of inclusions on hydrogen-induced delayed cracking in hot stamping steels

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Journal of Iron and Steel Research International 2021年第4期28卷 505-505页

作者： Yong Chen Jing Liu feng Huang Ling Chen Yan-jing Su gui-feng zhou School of Materials and Metallurgy Wuhan University of Science and TechnologyWuhan 430080HubeiChina Wuhan Branch of Baosteel Central Research Institute(R&D Center)of Wuhan Iron&Steel Co. Ltd.Wuhan 430080HubeiChina Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

Correction to:*** Steel ***.(2019)26:1199-1208 https://d0i.0rg/l 0.1007/S42243-019-00312-z The original version of this article unfortunately contained a *** 6 was *** corrected table is given *** line 11 of page 1205 is revised as“The diffusion coefficient of hydrogen in CSPS is 2.76×10^(-7)cm^(2)/s,which is lower than that of CRS”.

关键词： cracking hydrogen diffusion

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong Chen Ruili zhou Hanyu Diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

上海地区居民死亡原因、时间、地点分析及其对策

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上海预防医学 2001年第8期13卷 355-356页

作者：宋桂香周峰上海市疾病预防控制中心上海200336

[目的 ]　分析上海市居民的死亡谱、死亡地点分布和死亡时间趋势等死亡特征。 [方法 ]　采用描述性统计方法 ,死亡时间趋势分析采用圆分布统计方法。 [结果 ]　上海市居民的死亡构成因年龄而不同 ,青少年的主要死亡原因为损伤中毒 ,中... 详细信息

[目的 ]　分析上海市居民的死亡谱、死亡地点分布和死亡时间趋势等死亡特征。 [方法 ]　采用描述性统计方法 ,死亡时间趋势分析采用圆分布统计方法。 [结果 ]　上海市居民的死亡构成因年龄而不同 ,青少年的主要死亡原因为损伤中毒 ,中年为肿瘤 ,老年为慢性非传染性疾病。成年组及老年组的死亡时间呈集中趋势 ,死亡时间均趋向集中于冬季。不同疾病的死亡地点特征不同。随年龄增大 ,在家死亡比重上升。 [结论 ]　各种疾病死亡率在冬季较高。

关键词：死亡原因死亡地点死亡时间上海地区季节年龄阶段

循环系疾病已经成为上海地区60岁以上老人首位死因

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上海预防医学 2001年第8期13卷 357-358页

作者：宋桂香周峰上海市疾病预防控制中心上海200336

[目的 ]　分析上海地区 6 0岁以上老年人循环系病死亡情况。 [方法 ]　利用上海市 2 0 0 0年死亡个案记录 ,按国际疾病分类 (ICD— 9)进行分类。用DIS居民死亡分析软件处理。 [结果 ]　 6 0岁以上老年人循环系病死亡占 6 0岁以上死亡总... 详细信息

[目的 ]　分析上海地区 6 0岁以上老年人循环系病死亡情况。 [方法 ]　利用上海市 2 0 0 0年死亡个案记录 ,按国际疾病分类 (ICD— 9)进行分类。用DIS居民死亡分析软件处理。 [结果 ]　 6 0岁以上老年人循环系病死亡占 6 0岁以上死亡总数的 36 .2 9% ,男性死亡率大于女性 ,各年龄组死亡率上升幅度呈几何级数增加 ,高血压、糖尿病、脑血管病的晚期(残留 )效应是主要的危险因素。 [结论 ]　循环系病是 6 0岁以上老人的首位死因。

关键词： 60岁以上老年人脑血管病心血管病危险因素上海地区

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三江源区生态移民整合问题研究

生态经济(学术版) 2007年第2期 403-406页

作者：王小梅刘峰贵周强张海峰黄芸玛青海师范大学生命与地理科学学院青海师范大学生命与地理科学学院西宁810008

三江源生态移民工程是源区有史以来从未有过的人口整体迁移过程。目前,源区迁移牧民正在通过政府规划,进行有秩序的空间转移。然而由于迁移主体是那些长久以来适应游牧散居生活的群体,加之迁入区环境承载能力有限,因此生态移民过程中存... 详细信息

三江源生态移民工程是源区有史以来从未有过的人口整体迁移过程。目前,源区迁移牧民正在通过政府规划,进行有秩序的空间转移。然而由于迁移主体是那些长久以来适应游牧散居生活的群体,加之迁入区环境承载能力有限,因此生态移民过程中存在自然、经济、社会等诸多整合问题:安置区自然负载增大,甚至可能出现草地进一步退化;在新的生存环境中移民的适应与发展,以及与原住居民之间经济利益协调;原生态文化的保护及发展教育等。

关键词：三江源区移民整合生产方式转变文化保护教育

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang zhou feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode