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Ferulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance

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Journal of Environmental Sciences 2025年第5期151卷 616-626页

作者： Hanyu Wang Shenye feng Enzhuang Pan Xiaomeng Ji Mengyuan Zhou Shuai Zhang Baoshi Xu Huimiao feng Jilei Yin Zibo Dong Jiangsu Key Laboratory of Marine Bioresources and Environment Co-Innovation Center of Jiangsu Marine Bio-industry TechnologyJiangsu Marine Pharmaceutical Resources Development Engineering Research CenterJiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningCollege of PharmacyJiangsu Ocean UniversityLianyungang 222005China Department of Traditional Chinese Medicine Jiangsu Union Technical Institute Lianyungang Branch institute of Traditional Chinese MedicineLianyungang 222006China

Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in *** acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective function on the immunological damage caused by AVM is still *** this study,carp were chronically exposed to(1/1096 hr LC_(50))AVM for 30 day(s),with a dietary supplement of FA(400 mg/kg)to assess its effects on carp *** experimental groups(n=10)included:control,AVM-exposed(2.404μg/L),FA+AVM co-treated,and FA ***-term AVM exposure altered spleen tissue,reducing serum complement C3(p<0.01)and immunoglobulin M levels(p<0.001),and increasing proinflammatory tnf-α(p<0.001),il-6(p<0.001),il-1β(p<0.001),and inos mRNA levels,whilst down-regulating the anti-inflammatory tgf-β(p<0.05).Additionally,it disrupted the balance of oxidative stress indicators such asMDA(p<0.001),T-AOC,GSH,and CAT,leading to spleen tissue apoptosis(42.4%).However,the addition of FA reversed these conditions,elevated the anti-inflammatory factor,and improved spleen immune function following chronic exposure to AVMin ***,the ability to restore oxidative homeostasis in carp by adjusting the Nrf2/NQO-1 axis protected the health of spleen *** discovery also supports the development of fish feed for aquaculture.

关键词： Avermectin Ferulic acid Oxidative stress Inflammation response

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多发创伤患者血清α-黑色素细胞刺激素的变化。

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中华急诊医学杂志 2012年第2期21卷 189-192页

作者：周强冯贵龙冯杰杨晓明杜晓东边艳峰山西医科大学太原030001 山西医科大学第一医院急诊科

目的通过监测多发创伤患者血清α-MSH和TNF-α的动态变化,探讨其与创伤患者病情的关系.方法山西医科大学第一医院急诊科收治的50例多发创伤患者根据ISS评分分两组,中重型（ISS 16～25分）30例,特重型（＞25分）20例,健康对照组15例.... 详细信息

目的通过监测多发创伤患者血清α-MSH和TNF-α的动态变化,探讨其与创伤患者病情的关系.方法山西医科大学第一医院急诊科收治的50例多发创伤患者根据ISS评分分两组,中重型（ISS 16～25分）30例,特重型（＞25分）20例,健康对照组15例.分别于伤后1、3、5、7d抽取静脉血,分离血清后采用酶联免疫吸附双抗体夹心（ELISA）方法测定血清α-MSH和TNF-α的含量.采用SPSS 13.0统计软件处理,多组均数间比较进行方差齐性检验和重复测量方差分析（Repetitive measure ANOVA）,以P＜0.05为差异有统计学意义.结果两组创伤患者伤后24h内、3d、5d、7d血清α-MSH含量均显著低于健康对照组（P＜0.01）,特重型组比中重组更加明显（P＜0.01）；两组患者伤后24 h内、3d、5d、7d血清TNF-α含量均显著高于健康对照组（P＜0.01）,特重型组比中重组更加明显（P＜0.01）；伤后24 h、5d、7d血清α-MSH和TNF-α呈负相关.结论创伤后血清α-MSH含量下降且创伤越重下降越明显,血清TNF-α含量上升且创伤越重上升越明显,二者总体呈负相关.

关键词：多发创伤 α-黑色素细胞刺激素肿瘤坏死因子α- 炎症

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Pattern-based rapid and robust profiling of gut microbiota and its metabolism with a single fluorescent probe

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Science China Chemistry 2025年第2期68卷 781-788页

作者： Hongli Tan Meizi Zeng Cong Fang Xiaohua Zhu feng Liu Ying long Ruijie Deng Peng Yin Meiling Liu Haitao Li Youyu Zhang Shouzhuo Yao Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha 410013China College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610064China

The gut microbiota and the associated metabolism play a pivotal role in maintaining human health,yet their assessment is challenging due to their inherent diversity,variety,and ***,we developed a multichannel sensor array based on a single fluorescent probe,allowing for rapid and robust profiling gut microbiota and their key metabolites including cysteine(Cys),glutathione(GSH),and homocysteine(Hcy).The assay leverages the single fluorescent probe that is with multiple binding sites and the cross-reactive sensing principle to specifically recognize different biological *** analyzing the pattern of biological thiols,the assay is capable of rapidly identifying six gut-derived bacteria including probiotics,neutral,and pathogenic strains based on fluorescent fingerprints within 5 min,and also discriminating bacteria and their mixtures with different *** the assay that enables the simultaneous measurement of multiple gut-derived bacteria and their metabolites,the designed array achieved an accuracy of 0.99 when discriminating colorectal cancer(CRC)patient feces samples from healthy ***,the as-prepared sensor array can also be used to identify various stages of *** simplicity,rapidness,and cost-effectiveness of our approach render it a robust platform for the analysis of gut microbiota.

关键词： gut microbiota biological thiols sensor array fluorescent probe

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创伤失血性休克对肾上腺皮质激素水平影响的研究进展

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中国急救医学 2020年第1期40卷 85-89页

作者：李振兴冯贵龙李星花山西医科大学山西太原030001 山西医科大学第一医院山西太原030001 太原市迎泽区中医医院检验科山西太原030013

创伤失血性休克是多发伤的严重合并症及主要死因之一.失血性休克患者常出现肾上腺皮质激素水平紊乱,致使病情加重,面临更高病死率.本文就创伤失血性休克对糖皮质激素、盐皮质激素水平影响的国内外研究进行综述.

关键词：创伤失血性休克(THS) 肾上腺皮质功能不全(AI) 盐皮质激素缺乏症(MD) 危重症相关性肾上腺皮质功能不全(CIRCI)

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Predictor−corrector inverse design scheme for property−composition prediction of amorphous alloys

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 169-183页

作者： Tao long Zhi-lin long Bo PANG School of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan 411105China School of Civil Engineering Xiangtan UniversityXiangtan 411105China

In order to develop a generic framework capable of designing novel amorphous alloys with selected target properties,a predictor−corrector inverse design scheme(PCIDS)consisting of a predictor module and a corrector module was presented.A high-precision forward prediction model based on deep neural networks was developed to implement these two *** utmost importance,domain knowledge-guided inverse design networks(DKIDNs)and regular inverse design networks(RIDNs)were also *** forward prediction model possesses a coefficient of determination(R^(2))of 0.990 for the shear modulus and 0.986 for the bulk modulus on the testing ***,the DKIDNs model exhibits superior performance compared to the RIDNs *** is finally demonstrated that PCIDS can efficiently predict amorphous alloy compositions with the required target properties.

关键词： amorphous alloys machine learning deep neural networks inverse design elastic modulus

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Mass organic matter accumulation induced by rapid redox variations in lakes:Evidence from the Miaoxi area,Bohai Bay Basin,China

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Journal of Palaeogeography 2025年第01期14卷 291-313页

作者： Peng Sun Hai-feng Yang Fei-long Wang Jun-Pei Yue Yan-Fei Gao You-Jun Tang School of Petroleum Engineering Yangtze University Key Laboratory of Exploration Technologies for Oil and Gas Resources Ministry of Education Yangtze University Tianjin Branch of China National Offshore Oil Corporation College of Resource and Environment Yangtze University

The Member 4 of the Paleogene Shahejie Formation(Es4) in the Bohai Bay Basin is interspersed with a set of high-quality source rocks typified as intercalation of red and black mudstones. A large amount of petroleum(crude oil) originates from these source rocks. The Paleocene-Eocene Thermal Maximum(PETM)event occurred during the deposition of Es4 in the Bohai Bay Basin, and the organic matter enrichment model under this event is worth further investigation due to its relationship with and influence on petroleum accumulations. Well LK25-A, as the first oil exploration well drilled into the Es4 in Miaoxi area, serves as a valuable case to study organic matter accumulation. In this study, we integrate total organic carbon(TOC),Rock-Eval pyrolysis, microscopic observation, vitrinite reflectance(VRo), elemental analysis, and gas chromatography-mass spectrometry(GC-MS) to evaluate the hydrocarbon generation potential, organic matter types, thermal maturity, and sedimentary environment of the Es4 in Miaoxi area. The analysis of maceral and rock pyrolysis data reveals that Type I and Type II organic matter make up the majority of Paleogene mudstones in this region. The TOC and rock pyrolysis data show that mudstones in this area have high organic matter abundance and oil-generation potential. The measured vitrinite reflectance distribution of mudstone samples, which ranges from 0.3% to 0.74%, demonstrates that the Paleogene strata are at the immature to mature stage, and the samples from this area contain a sizable amount of bituminite and mineralbituminous groundmass. The analysis of biomarkers in the mudstone samples indicates that most of the mudstones in this area are in lacustrine and brackish-hypersaline lacustrine environment under a reducing condition, and some of the red mudstones in the Es4 are formed under a suboxic condition. Based on the size and morphology of the pyrite framboid, the redox conditions of the water mass during deposition or diagenesis are further

关键词： Hydrocarbon generation potential Biomarkers Optical microscopy Pyrite framboid Elemental geochemistry Red–black beds

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Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression

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Journal of Animal Science and Biotechnology 2025年第1期16卷 59-75页

作者： Jianchao Hu Lu gui Zhongzi Wu Lusheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangPeople’s Republic of China

Background Mobile element variants(MEVs)have a significant and complex impact on genomic diversity and phe-notypic ***,the quantity,distribution,and relationship with gene expression and complex traits of MEVs in the pig genome remain poorly *** We constructed the most comprehensive porcine MEV library based on high-depth whole genome sequencing(WGS)data from 747 pigs across 59 breeds *** database identified a total of 147,993 poly-morphic MEVs,including 121,099 short interspersed nuclear elements(SINEs),26,053 long interspersed nuclear elements(LINEs),802 long terminal repeats(LTRs),and 39 other transposons,among which 54%are newly *** found that MEVs are unevenly distributed across the genome and are strongly influenced by negative selec-tion ***,we identified 514,530,and 584 candidate MEVs associated with population differentiation,domestication,and breed formation,*** example,a significantly differentiated MEV is located in the ATRX intron between Asian and European pigs,whereas ATRX is also differentially expressed between Asian and European pigs in muscle *** addition,we identified 4,169 expressed MEVs(eMEVs)significantly associated with gene expression and 6,914 splicing MEVs(sMEVs)associated with gene splicing based on RNA-seq data from 266 porcine liver *** eMEVs and sMEVs explain 6.24%and 9.47%,respectively,of the observed cis-heritability and high-light the important role of MEVs in the regulation of gene ***,we provide a high-quality SNP–MEV reference haplotype panel to impute MEV genotypes from genome-wide ***,we identified a candidate MEV significantly associated with total teat number,demonstrating the functionality of this reference *** The present investigation demonstrated the importance of MEVs in pigs in terms of population diversity,gene expression and phenotypic traits,which may provide useful resources and theoretic

关键词： Gene expression Genetic diversity Mobile element variants Pig SNP–MEV reference panel

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一种L-苯丙氨酸衍生物的合成及其凝胶化研究

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井冈山大学学报（自然科学版） 2010年第6期31卷 35-39页

作者：冯桂龙洪亮井冈山大学化学化工学院江西吉安343009 武汉软件工程职业学院环境与生化工程系湖北武汉430205

本研究设计合成了一种可自组装的L-苯丙氨酸衍生物凝胶因子—3-{[2-(十二酰胺基)-3-苯丙基]酰氨基}丁酸(1),并用1H-NMR、元素分析和FTIR等手段对其结构进行了表征。考察了其在27种常见溶剂中的凝胶行为,结果表明化合物1可使其中的11种... 详细信息

本研究设计合成了一种可自组装的L-苯丙氨酸衍生物凝胶因子—3-{[2-(十二酰胺基)-3-苯丙基]酰氨基}丁酸(1),并用1H-NMR、元素分析和FTIR等手段对其结构进行了表征。考察了其在27种常见溶剂中的凝胶行为,结果表明化合物1可使其中的11种溶剂凝胶化而形成热可逆的超分子凝胶。室温下1在苯中的最低凝胶浓度为0.2%,苯凝胶的凝胶-溶胶相转变温度(Tgel)随凝胶因子的浓度的增加而升高。

关键词：凝胶因子超分子凝胶 L-苯丙氨酸衍生物合成

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由凝胶因子形成的十四酸异丙酯超分子凝胶制备与表征

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化学研究与应用 2012年第1期24卷 26-30页

作者：冯桂龙陈海辉易绣光钟路平井冈山大学化学化工学院江西吉安343009

采用双十八烷基-L-苯丙氨酸(Bis18-L-Phe)为凝胶因子,制备了具有热可逆性的十四酸异丙酯(IPM)超分子凝胶。IPM凝胶相转变温度(Tgel)随Bis18-L-Phe浓度增大而增加。偏光显微镜(POM)显示在整个IPM凝胶中形成了相互缠绕的针状聚集体。FT-I... 详细信息

采用双十八烷基-L-苯丙氨酸(Bis18-L-Phe)为凝胶因子,制备了具有热可逆性的十四酸异丙酯(IPM)超分子凝胶。IPM凝胶相转变温度(Tgel)随Bis18-L-Phe浓度增大而增加。偏光显微镜(POM)显示在整个IPM凝胶中形成了相互缠绕的针状聚集体。FT-IR光谱分析表明Bis18-L-Phe分子间酰胺的氢键作用是IPM凝胶形成的一个重要驱动力。IPM凝胶动力学研究表明凝胶时间随Bis18-L-Phe浓度的增大而缩短,随着温度升高而延长,因此IPM凝胶时间可以通过温度和Bis18-L-Phe浓度调控。

关键词：十四酸异丙酯凝胶因子超分子凝胶

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng Zhao-Ying Ding Ying-Chao Li Yuan-feng Wu Yuan-Yang Xu Rui Chen Xiao-Lei Zhao Hai-Yong Wang Da-Lei Zhang Yu-long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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