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Location of Sentinel Lymph Node in Gastric Cancer:A Modified,Painless And Noninvasive Approach

Chinese Journal of Cancer Research 2010年第1期22卷 55-61页

作者： Xin-hui Su Qiang chen Long Sun Hua Wu Wei-Ming Pan gui-bing chen Zuo-Ming Luo Wei Wang Department of Nuclear Medicine the First Hospital of Xiamen Fujian Medical University Xiamen 361003 China School of Life Sciences Xiamen University Xiamen China Department of Anatomy Histology and Embryology School of Basic Medical Sciences Fuiian Medical University Fuiian China

Objective： The presence of lymph node metastases is an important factor in the prognosis of gastric cancer patient. Therefore, the precise identification of sentinel lymph nodes （SLN） in these patients is critical. In this work, we investigated the feasibility and preciseness by injection of 99mTc-sulfur colloid （SC） 2 hours before operation after general anesthesia, instead of one day before surgery. Methods： Thirty-one patients of gastric cancer diagnosed as T1-T3 were enrolled in this study. During operation, a SLN was defined as those containing 10 times more radioactivity than surrounding tissue with a hand-held gamma probe and removed. All the patients underwent radical gastrectomy with extended lymphadenectomy. All resected nodes were examined postoperatively by routine H＆E stain and those negative SLNs were examined with further cytokeratin immunohistochemistical staining. Results： The incidence of metastasis was significantly higher in SLNs than in non-SLNs （x2=67.48, P〈0.001）. The overall sensitivity, specificity and accuracy of the SLN status in the diagnosis of the lymph node status of the patient were 86.36%, 100% and 96.77%, respectively. The positive predictive value and negative predictive value of SLN biopsy were 100%, and 75.0%, respectively. SLNs were used to diagnose the lymph node status with 100% accuracy in the T1 group. In the T2 and T3 groups, the sensitivity, specificity, and diagnostic accuracy were 92.3%, 100%, and 94.44%, 60.0%, 100%, and 66.66%, respectively. Most of the SLNs were located in the #1, #2, #3, #4, #5, and #6, except in 3 patients （9.68%）.With cytokeratin immunohistochemical staining, lymphatic pathologic staging in 1 patient was upstaged. Conclusion： SLN biopsy with the above approach is a feasible and accurate diagnostic procedure for detecting lymph node metastasis in patients with gastric cancer, which is painless, noninvasive, easily accepted by patients and suitable for extensive clinical applications.

关键词： Gastric cancer Sentinel lymph node location Radiocolloid Injection time

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Positron emission tomography/computer tomography in guidance of extrahepatic hepatocellular carcinoma metastasis management

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World Journal of Gastroenterology 2007年第40期13卷 5413-5415页

作者： Long Sun Yong-Song Guan Wei-Ming Pan gui-bing chen Zuo-Ming Luo Hua Wu The First Hospital of Xiamen Fujian Medical University Xiamen 316003 Fujian Province China West China Hospital of Sichuan University State Key Laboratory of Biotherapy West China Medical SchoolSichuan University Gaopeng Street Keyuan Road 4 Chengdu610041 Sichuan Province China

Hepatocellular carcinoma （HCC） is one of the most common primary cancers in the world. Surgery is the gold standard for treatment of patients with HCC. Recurrence and metastasis are the major obstacles to further improve the prognosis of HCC. Most recurrences are intrahepatic. However, 30% of the recurrences are extrahepatic. The role of resection in intrahepatic recurrences is widely accepted. The role of resection in extrahepatic HCC recurrence and metastasis is not well established. 18F fluorodeoxyglucose （18F-FDG） positron emission tomography/computer tomography （PET/CT） is useful in detecting distant metastasis from a variety of malignancies and shows superior accuracy to conventional imaging modalities in identification of intrahepatic and extrahepatic metastasis. We present one patient with one new isolated omental lymph node metastasis, who had a history of huge HCC resected six years ago. The metastatic focus was identified with 18 F-FDG PET/CT and resected. The follow-up revealed good prognosis with a long-term survival potential after resection of the omental lymphatic metastasis.

关键词： Fluorodeoxyglucose Positron emissiontomography/computer tomography Huge hepatocellular carcinoma Omental node metastasis Extrahepatic metastasis

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Highly metabolic thrombus of the portal vein:^(18)F fluorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical significance in hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第8期14卷 1212-1217页

作者： Long Sun Yong-Song Guan Wei-Ming Pan gui-bing chen Zuo-Ming Luo Ji-Hong Wei Hua Wu Minnan PET: Center The First Hospitalof Xiamen Fujian Medical University Xiamen 316003 FujianProvince China West China Hospital of Sichuan University Chengdu China 610041 State Key Laboratory of Biotherapy West China Medical School Sichuan University Gaopeng StreetKeyuan Road 4 Chengdu 610041 Sichuan Province China

AIM： To assess the ability of ^18F-fluorodeoxyglucose positron emission tomography/computer tomography （^18F-FDG PET/CT） to differentiate between benign and malignant portal vein thrombosis in hepatocellular carcinoma （HCC） patients.METHODS： Five consecutive patients who had HBV cirrhosis, biopsy-proven HCC, and thrombosis of the main portal vein and/or left/right portal vein on ultrasound （US）, computer tomography （CT） or magnetic resonance imaging （MRI） were studied with ^18F-FDG PET/CT. The presence or absence of a highly metabolic thrombus on ^18F-FDG PET/CT was considered diagnostic for malignant or benign portal vein thrombosis, respectively. All patients were followed-up monthly with US, CT or MRI. Shrinkage of the thrombus or recanalization of the vessels on US, CT or MRI during follow-up was considered to be definitive evidence of the benign nature of the thrombosis, whereas enlargement of the thrombus, disruption of the vessel wall, and parenchymal infiltration over follow-up were considered to be consistent with malignancy. ^18SF-FDG PET/CT, and US, CT or MRI results were compared.RESULTS： Follow-up （1 to 10 mo） showed signs of malignant thrombosis in 4 of the 5 patients. US, CT or MRI produced a true-positive result for malignancy in 4 of the patients, and a false-positive result in 1. ^18F-FDG PET/CT showed a highly metabolic thrombus in 4 of the 5 patients. ^18F-FDG PET/CT achieved a true-positive result in all 4 of these patients, and a true-negative result in the other patient. No false-positive result was observed using ^18F-FDG PET/CT.CONCLUSION： ^18F-FDG PET/CT may be helpful in discriminating between benign and malignant portal vein thrombi. Patients may benefit from ^18F-FDG PET/CT when portal vein thrombi can not be diagnosed exactly by US, CT or MRI.

关键词： ^ 18F-fluorodeoxyglucose Positron emission tomography/computer tomography Hepatocellular carcinoma Portal vein tumor thrombus Portal vein blood thrombus

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Comparison of hand-assisted laparoscopic radical gastrectomy and laparoscopic-assisted radical gastrectomy:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第6期8卷 471-480页

作者： Wei Gan Zhen-Yu chen Li-Ye Liu gui-bing chen Jun Zhou Ya-Ning Song Yong-Kuan Cao Department of Gastrointestinal Surgery The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of General Surgery The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

BACKGROUND Gastrectomy is the optimal treatment for gastric ***-assisted gastrectomy(LAG)has been extensively employed,while hand-assisted laparoscopic gastrectomy(HALG),which is similar to LAG,remains *** HALG is popular in China,some surgeons do not accept it as a minimal-access *** To assess the safety and practicability of HALG by comparing the short-term outcomes of HALG and *** The electronic databases of EMBASE,PubMed,China National Knowledge Infrastructure,and Cochrane Library were thoroughly searched,and randomized controlled trials(RCTs)comparing HALG and LAG were *** study results,including surgery time,blood loss,retrieved lymphatic nodes,incision length,time to first flatus,hospitalization duration,and all postsurgical complications,were compared between the two *** Five RCTs,which included 302 cases with HALG and 298 cases with LAG,were considered eligible for ***-analysis showed that HALG significantly reduced surgery time(P0.05).CONCLUSION Compared with LAG,HALG is a simpler and safer ***,HALG should be used as a minimal-access technique,especially in technologically undeveloped areas.

关键词： Gastric cancer Hand-assisted laparoscopy Gastrectomy Laparoscopicassisted gastrectomy Meta-analysis Systematic review

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Studies on Growing Edible Fungi on Improved Straw from a Dual Use Rice Cultivar

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Agricultural Sciences in China 2002年第8期1卷 871-877页

作者： ZHENG Jin-gui, chen Jun-chen, YANG Jing, ZHENG Kai-bin, YE Xin-fu, HUANG Qin-lou, XIE Bao-gui, chen bing-huan, TU Gai-lin and chen Wang-rui( Fujian Agriculture and Forestry University, Fuzhou 350002, P. R . China Fujian Academy of Agricultural Sciences,Fuzhou 350003, P.R. China) Fujian Agriculture and Forestry University Fuzhou 350002 P.R. China Fujian Academy of Agricultural Sciences Fuzhou 350003 P. R . China

Every year 500 million tons of rice (Oryza sativa L.) straw are generated worldwide, which was almost equal to the production of rice grain. Most straw is not recovered due to the poor quality, high cost or complicated treatment operations. Through genetic improvements, a rice cultivar '201' was developed with both high nutrient content in straw and high grain yield. The results of 15N tracer experiments showed thatls N of urea could be effectively transformed into straw protein of ' 201' and the recovery rate of 15N in the straw of '201' was 104% higher than that of the check 'TY 63'. The straw protein of '201' could be effectively transformed into mushroom protein and the recovery rate of 15N was 21.7% higher than that of 'TY 63'. Using the straw of ' 201' as material to cultivate straw-based edible fungi, improved the yield and protein content of mushrooms. A total of 7.5 mg·ha-1straw of '201' increased the yield and crude protein of the edible mushroom Volvariella volvacea 797 kg yield and 67.9 kg respectively, and increased the yield and crude protein of the edible mushroom Agaricus blazei Murrill 675 kg and 80 kg respectively. The straw powder of '201' could be used to substitute for the same weight of wheat bran to cultivate lignicolous edible fungi, with no significant difference in terms of mushroom yield or the crude protein content. Straw powder could substitute for 20% of total amount of material to grow Auricularia polytricha, Auricularia auricula, Hypsizygus tessulatus, Lentinula edodes and Hericium erinaceus, 8% of that to grow Agrocybe cylindracea and 7.5% of that to grow Flammulina velutipes respectively.

关键词： Rice Oryza sativa Straw quality Breeding Edible fungi

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing chen Huatian Shi Yue Wei gui chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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基于路径与网络质量相结合的动态迁移算法

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中北大学学报（自然科学版） 2017年第2期38卷 173-177,185页

作者：王子珍李晋军宋秋贵陈兵北方自动控制技术研究所山西太原030001

针对现有旅级指挥信息系统中存在服务器单点失效问题,设计并实现了基于路径与网络质量相结合的服务动态迁移机制.该机制基于分布式指挥系统,是服务器集群技术的应用.该算法有以下特点:可以针对不同请求分析网络质量,确定网络资源,制定... 详细信息

针对现有旅级指挥信息系统中存在服务器单点失效问题,设计并实现了基于路径与网络质量相结合的服务动态迁移机制.该机制基于分布式指挥系统,是服务器集群技术的应用.该算法有以下特点:可以针对不同请求分析网络质量,确定网络资源,制定动态阀值,形成节点候选方案;引入时间距离,并与负载组合,选择最佳迁移路径;取消前端服务器,实现系统容错,同时实现服务动态迁移.经实验证明,该算法与轮循算法相比,性能提高49.65%,一定程度上节约了时间成本.该算法已应用到旅级指挥信息系统中.

关键词：服务迁移网络质量路径面向服务的体系结构(SOA)

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韩国技术转移体系建设概述

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全球科技经济瞭望 2017年第7期32卷 11-14页

作者：富贵陈炳硕中国科学技术交流中心北京100045 淄博国家高新技术创业服务中心山东淄博255086

有效促进技术转移与产业化是技术创新体系的重要组成部分。韩国作为创新型国家,十分重视技术转移与产业化的体系建设,做了很多探索,体系建设日趋完善,其经验值得我国研究。本文介绍韩国近年来技术转移与产业化体系建设的主要政策措施、... 详细信息

有效促进技术转移与产业化是技术创新体系的重要组成部分。韩国作为创新型国家,十分重视技术转移与产业化的体系建设,做了很多探索,体系建设日趋完善,其经验值得我国研究。本文介绍韩国近年来技术转移与产业化体系建设的主要政策措施、模式及存在的问题,以期为完善我国技术转移体系提供参考。

关键词：韩国技术转移产业化扶持政策

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Surface-confined persistent luminescence with amplified FRET efficiency for cell-cell communication monitoring

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Science China Chemistry 2025年

作者： Ziyun Miao Wenjing Dai Yubin Jin bing Qi Jiayi chen Lingling Qiu Yurong Wei Jie Wang The Key Lab of Health Chemistry&Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering&Materials ScienceSoochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections,and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent ***, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr（ZGGO@ZGGO:Cr） persistent luminescence nanoparticles（PLNPs） with amplified FRET efficiency for the detection of azoreductase（AzoR） that participates in bacterial communication. ZGGO@ZGGO:Cr nanoparticles were functionalized with an azo black hole quencher（ZGGO@ZGGO:Cr-BHQ-3）. Due to the proximity of surface-confined persistent luminescence with the surface-bound BHQ-3,ZGGO@ZGGO:Cr-BHQ-3 exhibited a FRET efficiency up to 1.6 times that of traditional ZGGO:Cr-BHQ-3. Further, the specific catalytic reduction of azo bonds in BHQ-3 by bacterial extracellular AzoR recovers the persistent luminescence of ZGGO@ZGGO:Cr. ZGGO@ZGGO:Cr-BHQ-3 displayed superior sensitivity and speed in detecting extracellular AzoR over ZGGO:Cr-BHQ-3, attributed to its surface-confined persistent luminescence. We found that the peak secretion of AzoR occurs during the exponential growth period of bacteria including S. aureus and E. coli based on the persistent luminescence recovery rate of ZGGO@ZGGO:Cr-BHQ-3. Furthermore, ZGGO@ZGGO:Cr-BHQ-3 was used to probe the communication between different bacterial species. R. palustris is a kind of lycopene-production bacteria. We found that the cohabitation of R. palustris and S. putrefaciens boosted both AzoR secretion and lycopene production. Moreover, the secretion and activity of AzoR positively correlated with lycopene production, suggesting that AzoR may participate in the communication between R. palustris and S. putrefaciens to promote lycopene production. This study offers a robust method to enhance PLNP-based biosensing sensitivity and provides a promising strategy for microbial communication monitoring.

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