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Prediction model for hepatitis B e antigen seroconversion in chronic hepatitis B with peginterferon-alfa treated based on a responseguided therapy strategy

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World Journal of Hepatology 2024年第3期16卷 405-417页

作者： Pei-Xin Zhang Xiao-Wei Zheng Ya-Fei Zhang Jun Ye Wei Li Qian-Qian Tang Jie Zhu gui-zhou zou Zhen-Hua Zhang Department of Infectious Diseases The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Infectious Diseases Anhui Provincial HospitalHefei 230000Anhui ProvinceChina Department of Hepatology The Second People’s Hospital of Fuyang CityFuyang 236000Anhui ProvinceChina

BACKGROUND Models for predicting hepatitis B e antigen(HBeAg)seroconversion in patients with HBeAg-positive chronic hepatitis B(CHB)after nucleos(t)ide analog treatment are *** To establish a simple scoring model based on a response-guided therapy(RGT)strategy for predicting HBeAg seroconversion and hepatitis B surface antigen(HBsAg)*** In this study,75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa(PEG-IFNα)treatment and a 24-wk *** regression analysis was used to assess parameters at baseline,week 12,and week 24 to predict HBeAg seroconversion at 24 wk *** two best predictors at each time point were used to establish a prediction model for PEG-IFNαtherapy *** at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or *** The two most meaningful predictors were HBsAg≤1000 IU/mL and HBeAg≤3 S/CO at baseline,HBsAg≤600 IU/mL and HBeAg≤3 S/CO at week 12,and HBsAg≤300 IU/mL and HBeAg≤2 S/CO at week *** a total score of 0 vs 2 at baseline,week 12,and week 24,the response rates were 23.8%,15.2%,and 11.1%vs 81.8%,80.0%,and 82.4%,respectively,and the HBsAg clearance rates were 2.4%,3.0%,and 0.0%,vs 54.5%,40.0%,and 41.2%,*** We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNαtherapy.

关键词： Chronic hepatitis B Hepatitis B e antigen-positive Peginterferon-alfa Prediction model Response-guided therapy strategy

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Association between TLR7 copy number variations and hepatitis B virus infection outcome in Chinese

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World Journal of Gastroenterology 2017年第9期23卷 1602-1607页

作者： Fang Li Xu Li gui-zhou zou Yu-Feng Gao Jun Ye Department of Infectious Disease The Second Affiliated Hospital of Anhui Medical University Department of Infectious Disease The First Affiliated Hospital of Anhui Medical University

AIM To explore whether copy number variations (CNVs) of toll-like receptor 7 (TLR7) are associated with susceptibility to chronic hepatitis B virus (HBV) infection. METHODS This study included 623 patients (495 males and 128 females) with chronic hepatitis B virus infection (CHB) and 300 patients (135 females and 165 males) with acute hepatitis B virus infection (AHB) as controls. All CHB patients were further categorized according to disease progression after HBV infection (CHB, liver cirrhosis, or hepatocellular carcinoma). Copy numbers of the TLR7 gene were measured using the AccuCopy method chi(2) tests were used to evaluate the association between TLR7 CNVs and infection type. P values, odds ratios, and 95% confidence intervals (CIs) were used to estimate the effects of risk. RESULTS Among male patients, there were significant differences between the AHB group and CHB group in the distribution of TLR7 CNVs. Low copy numberof TLR7 was significantly associated with chronic HBV infection (OR = 0.329, 95% CI: 0.229-0.473, P > 0.001). Difference in TLR7 copy number was also found between AHB and CHB female patients, with low copy number again associated with an increased risk of chronic HBV infection (OR = 0.292, 95% CI: 0.173- 0.492, P < 0.001). However, there were no significant differences in TLR7 copy number among the three types of chronic HBV infection (CHB, liver cirrhosis, or hepatocellular carcinoma). In addition, there was no association between TLR7 copy number and titer of the HBV e antigen. CONCLUSION Low TLR7 copy number is a risk factor for chronic HBV infection but is not associated with later stages of disease progression.

关键词： Toll-like receptor 7 Hepatitis B virus Copy number variations Gene susceptibility

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Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2018年第12期24卷 1312-1320页

作者： Yin-Qiu Wang Wen-Jun Cao Yu-Feng Gao Jun Ye gui-zhou zou Department of Infectious Disease The Second Affiliated Hospital of Anhui Medical University

AIM To investigate whether serum interleukin(IL)-34 levels are correlated with hepatic inflammation and fibrosis in patients with chronic hepatitis B virus(HBV) infection. METHODS In this study, serum IL-34 levels were assessed by enzyme-linked immunosorbent assay in 19 healthy controls and 175 patients with chronic HBV infection undergoing biopsy. The frequently used serological markers of liver fibrosis were based on laboratory indexes measured at the Clinical Laboratory of the Second Affiliated Hospital of Anhui Medical University. Liver stiffness was detected by transient elastography with Fibro Touch. The relationships of non-invasive makers of liver fibrosis and IL-34 levels with inflammation and fibrosis were analyzed. The diagnostic value of IL-34 and other liver fibrosis makers wereevaluated using areas under the receiver operating characteristic curves, sensitivity and *** Serum IL-34 levels were associated with inflammatory activity in the liver, and IL-34 levels differed among phases of chronic HBV infection(P = 0.001). By comparing serum IL-34 levels among patients with various stages of liver fibrosis determined by liver biopsy, we found that IL-34 levels ≥ 15.83 pg/m L had a high sensitivity of 86.6% and a specificity of 78.7% for identifying severe fibrosis(S3-S4). Furthermore, we showed that IL-34 is superior to the fibrosis-4 score, one of the serum makers of liver fibrosis, in identifying severe liver fibrosis and early cirrhosis in patients with HBV-related liver fibrosis in *** Our results indicate that IL-34, a cytokine involved in the induction of activation of profibrogenic macrophages, can be an indicator of liver inflammation and fibrosis in patients with chronic HBV infection.

关键词： Interleukin 34 Hepatitis B virus Liver fibrosis Diagnosis

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Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme

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Nuclear Science and Techniques 2024年第4期35卷 15-28页

作者： Xue-Chao Zhao Rui Yan gui-Feng Zhu Ya-Fen Liu Jian Guo Xiang-zhou Cai Yang zou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A molten salt reactor(MSR)has outstanding features considering the application of thorium fuel,inherent safety,sustainability,and resistance to ***,fissile material^(233)U is significantly rare at the current stage,thus it is difficult for MSR to achieve a pure thorium-uranium fuel ***,using plutonium or enriched uranium as the initial fuel for MSR is more *** this study,we aim to verify the feasibility of a small modular MSR that utilizes plutonium as the starting fuel(SM-MSR-Pu),and highlight its advantages and ***,the structural design and fuel management scheme of the SM-MSR-Pu were ***,the neutronic characteristics,such as the graphite-irradiation lifetime,burn-up performance,and coefficient of temperature reactivity were calculated to analyze the physical characteristics of the *** results indicate that plutonium is a feasible and advantageous starting fuel for a SM-MSR;however,there are certain shortcomings that need to be *** a 250 MWth SM-MSR-Pu,approximately 288.64 kg^(233)U of plutonium with a purity of greater than 90% is produced while 978.00 kg is burned every ten *** temperature reactivity coefficient decreases from -4.0 to -6.5 pcm K^(-1) over the 50-year operating time,which ensures a long-term safe ***,the amount of plutonium and accumulation of minor actinides(MAs)would increase as the burn-up time increases,and the annual production and purity of^(233)U will *** achieve an optimal burn-up performance,setting the entire operation time to 30 years is ***,more than 3600 kg of plutonium eventually accumulate in the *** research is required to effectively utilize this accumulated plutonium.

关键词： Molten salt fuel Plutonium utilization ^(233)U TRUs mole fraction Temperature feedback coefficient

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Voidage correction method for DEM study of 3D pebble flows in a bed of cycloidal base

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PARTICUOLOGY 2024年第10期93卷 30-40页

作者： Xia, Zirui Shi, Minglei zou, Quan gui, Nan Yang, Xingtuan Tu, Jiyuan Jiang, Shengyao Tsinghua Univ Inst Nucl & New Energy Technol Collaborat Innovat Ctr Adv Nucl Energy Technol Key Lab Adv Reactor Engn & SafetyMinist Educ Beijing 100084 Peoples R China Tsinghua Univ Dept Engn Phys Beijing 100084 Peoples R China Tsinghua Univ Dept Automat Beijing 100084 Peoples R China RMIT Univ Sch Engn Melbourne Vic 3083 Australia

Voidage (porosity or void fraction) in packed particles (or pebbles) is of fundamental importance in calculating the pressure drop, obtaining the drag, predicting the bed permeability, estimating the neutron streaming, etc. For the case when particles are deformed, a method of voidage correction during the packing state is proposed using a Discrete Element Method (DEM) simulation of 3D pebble flow inside a bed of cycloidal base. A function to evaluate the remaining volume of a pebble intercepted by horizontal and vertical planes is proposed for voidage calculation. After that, the process of solving voidage distribution is provided in detail. Using this method, the voidage inside the cycloidal-base pebble bed is obtained to refer to reported similar data for validation. This method can be potentially used for dynamical voidage calculation in CFD-DEM simulation which can get suitable voidage distribution after the correction. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Voidage Pebble flow Packed bed Discrete element method Cycloidal base KD-Tree Volume correction RADIAL POROSITY GAS MODEL SIMULATION PACKINGS SPHERES

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The radiative decay of scalar glueball from lattice QCD

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 63-74页

作者： Jintao zou Long-Cheng gui Ying Chen Wen Qin Jian Liang Xiangyu Jiang Yibo Yang Department of Physics Hunan Normal University and Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of EducationChangsha 410081China Synergetic Innovation Center for Quantum Effects and Applications(SICQEA) Hunan Normal UniversityChangsha 410081China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China International Centre for Theoretical Physics Asia-Pacific Beijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

We perform the first lattice QCD study on the radiative decay of the scalar glueball to the vector mesonφin the quenched *** calculations are carried out on three gauge ensembles with different lattice spacings,which enable us to do the continuum *** first revisit the radiative J/ψdecay into the scalar glueball G and obtain the partial decay widthΓ(J/ψ→γG)=0.578(86)keV and the branching fraction Br(J/ψ→γG)=6.2(9)×10^(-3),which are in agreement with the previous lattice *** then extend the similar calculation to the process G→γφand get the partial decay widthΓ(G→γφ)=0.074(47)keV,which implies that the combined branching fraction of J/ψ→γG→γγφis as small as O(10^(-9))such that this process is hardly detected by the BESⅢexperiment even with the large J/ψsample of O(10^(10)).With the vector meson dominance model,the two-photon decay width of the scalar glueball is estimated to beΓ(G→γγ)=0.53(46)e V,which results in a large stickiness S(G)~O(10^(4))of the scalar glueball by assuming the stickiness of f_(2)(1270)to be one.

关键词： lattice QCD scalar glueball radiative decay

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SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding zou Zhi-long LIU gui-xian WU Yuan-ze zhou Cheng-xin LUO Xiang-tao HUANG Ming-ling XIE Shuang-nian XU Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

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Effects of vitamin family members on insulin resistance and diabetes complications

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World Journal of Diabetes 2024年第3期15卷 568-571页

作者： Hong-Jin Chen Min Wang Ding-Min zou gui-You Liang Si-Yuan Yang Division of Cardiac Surgery Guizhou Institute of Precision MedicineThe Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Translational Medicine Research Center Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina School of Basic Medical Sciences/School of Biology and Engineering Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina

The following letter to the editor highlights the article“Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance”in World J Diabetes 2023 Oct 15;14(10):*** is necessary to explore the role of vitamin family members in insulin resistance and diabetes complications.

关键词： Vitamin Insulin resistance Diabetes complications Letter

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-Qing Zhang Xiao-Yu Xu Fu-Sheng Liu Shu-Qiang Cao Yu-Xin gui Yi-Wen Su Xiao-Yu He Ji-Yuan Liang You-Quan zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai Kang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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论发展不平衡视野下的乡村建设行动——兼议乡村转型的两种类型

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西北师大学报（社会科学版） 2024年第1期61卷 118-126页

作者：桂华邹蓉武汉大学社会学院湖北武汉430072

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了... 详细信息

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了优势积累,形成了城市经济带动的乡村持续发展;与此同时,中西部地区人财物大量流出,乡村不断收缩。由此,我国乡村现代化变迁过程中出现了中西部地区“收缩型”与东部地区“扩张型”两种基本形态。这种现代化不均衡格局及其带来的乡村转型地区差异,要求政府主导的乡村建设行动必须在做到因地制宜的同时,将乡村建设放在城乡关系动态演变这一框架下规划,在行动策略上将不平衡现状当作机遇,利用好城乡二元条件,努力推动发展并实现更高水平的平衡,为进一步实现中国式现代化作准备。

关键词：乡村转型发展不平衡收缩型扩张型乡村建设

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