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Asian Journal of Andrology 2012年第6期14卷 884-889页

作者： Zhi-Ping Xia Xin-Min Zheng Hang Zheng Xiao-Jun liu gui-yong liu Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Urology Qianjiang Central Hospital Qianjiang 433100 China

Cold-inducible RNA-binding protein （CIRP） is an RNA-binding protein that is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures. The purpose of this study was to investigate the functions of CIRP in the testes. We employed RNAi technique to knock down the expression of CIRP in the testes, and performed haematoxylin and eosin staining to evaluate morphological changes following knockdown. Germ cell apoptosis was examined by terminal deoxynucleotidal transferase-mediated dUTP nick end labelling （TUNEL） assay, and mitogen-activated protein kinase （MAPK） signalling pathways were investigated by Western blotting to determine the possible mechanism of apoptosis. We found that using siRNA is a feasible and reliable method for knocking down gene expression in the testes. Compared to controls, the mean seminiferous tubule diameter （MSTD） and the thickness of the germ cell layers decreased following siRNA treatment, whereas the percentage of apoptotic seminiferous tubules increased. The p44/p42, p38 and SAPK/JNK MAPK pathways were activated after downregulation of CIRP. In conclusion, we discovered that downregulation of CIRP resulted in increased germ cell apoptosis, possibly viathe activation of the p44/p42, p38 and SAPK/JNK MAPK pathways.

关键词： cold-inducible RNA-binding protein (CIRP) mitogen-activated protein kinase (MAPK) siRNA in vivo spermatogenesis heat stress male infertility

Study on Sorption of Monocrotophos and Parathion-methyl on Yellow River's Sediments

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Journal of Shanghai University(English Edition) 2001年第4期5卷 334-337页

作者： LI gui zhi, liu yong ming College of Chemistry, Yantai University, Yantai 264005, China College of Chemistry Yantai University Yantai China

A study on the sorption of monocrotophos and parathion methyl on Yellow River's sediments was performed. The influence of some factors, such as pH value and ionic strength, on the sorption was investigated and first order kinetics mode for the sorption of monocrophos was shown. Freundlich isotherm was suggested as the most appropriate type for monocrophos and parathion methyl. But the sorption isotherms of monocrotophos and parathion methyl are also in conformity with Langmuir equation. Both partition and adsorption occur to the sorption of monocrophos to Yellow River's sediments, but partition is the predominant for that of parathion methyl.

关键词： monocrotophos parathion methyl sorption sediments

Groundwater Flow Driven by Heat

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Journal of Groundwater Science and Engineering 2013年第3期1卷 22-27页

作者： Zong-jun Gao yong-gui liu Shandong University of Science and Technology The Second Hydro-Engineering Geology Brigade Shanxi Geologic Bureau

The temperature of groundwater will be increasing gradually while it is recharged and infiltrated down to the depth because of the geothermal gradient. So the density of water is smaller and smaller. The author puts forward the heat-driving mechanism that the movement of the groundwater is caused by the density differences from different temperatures. Based on this idea, the author proposes the short range recharge model of geothermal water in flat terrain hilly area. The model explains the coexistence mechanism of recharge and discharge(hot springs) zones can be at the same altitude. Considering that the temperature is an important driving force of groundwater movement, the paper puts forward and demonstrates that the hot springs can expose at higher lands while the recharge zone being situated lower lying areas.

关键词： Groundwater flow Heat Temperature difference Density difference Driving mechanism

Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai liu yong-Wei Yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCM and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer Multicomponent Multitarget Therapy

GXDF-5型热风炉炉衬损坏原因与控制措施

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盐科学与化工 2017年第9期46卷 53-54页

作者：刘永博高桂芳刘勇彬中盐吉兰泰盐化集团有限公司内蒙古阿拉善750336

文章分析了电石生产中GXDF-5型热风炉炉衬损坏的部位、主要因素,有针对提出相应措施,为降低热风炉耐火炉衬损坏提供了参考。

关键词：热风炉耐火炉衬热应力

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang liu Yang-Pu Jia Zhao-Xiong Zhang Xin liu Dao-Han Wang yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong liu Ran An You-Liang Yao Dong-Bei Guo yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun liu Kai Gao Jingli Sun yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

Bounding the Inefficiency of the C-Logit Stochastic User Equilibrium Assignment

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Journal of Systems Science & Complexity 2016年第6期29卷 1629-1649页

作者： yong gui HUANG Haijun liu Tianliang XU Yan School of Economics and Management Beihang UniversityBeijing 100191China School of Statistics and Mathematics Inner Mongolia University of Finance and EconomicsHuhhot 010070China School of Statistics and Mathematics Inner Mongolia University of Finance and EconomicsHuhhot 010070China.

Compared with standard logit-based stochastic user equilibrium assignment model,the C-logit model describes route choice behavior in a more realistic way by considering the overlapping effect between *** paper investigates the inefficiency upper bounds of this model against the deterministic system optimum and the C-logit stochastic system optimum in terms of the total network travel *** is found that the commonality factor of overlapping routes significantly affects the inefficiency bound,besides link congestion degree,total demand and the number of feasible *** the commonality factor is not considered,the efficiency loss resulting from selfishly stochastic travel behavior will be to large extent underestimated.

关键词： Inefficiency bounding logit-based stochastic user equilibrium route overlapping.

N-Widths and Average Widths of Besov Classes in Sobolev Spaces

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1667-1678页

作者： gui Qiao XU yong Sheng SUN yong Ping liu School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China School of Mathematical Sciences Tianjin Normal University Tianjin 300074 P. R. China

In this paper, we consider the n-widths and average widths of Besov classes in the usual Sobolev spaces. The weak asymptotic results concerning the Kolmogorov n-widths, the linear n-widths, the Gel＇fand n-widths, in the Sobolev spaces on T^d, and the infinite-dimensional widths and the average widths in the Sobolev spaces on Ra are obtained, respectively.

关键词： Besov class n-width Sobolev space Average width