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In situ Synthesis of Rosin Derived Chiral Derivatizing Agents for 31p NMR Assays of Amine and Alcohol Enantiomers

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Chemical Research in Chinese Universities 2013年第5期29卷 894-899页

作者： WU Qiang YAO gui-yang ZHANG Ye wang Heng-shan yang Lin ZHU Yong-tao PAN Ying-ming Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry & Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 P R. China

Chiral alcohols（3, 5） were synthesized in optically pure forms from easily available rosin acid in short-steps. A comprehensive protocol for the enantiomeric excess assays of mono- or di-functional-grouped chiral secondary amine or alcohol has been established with them used as chiral auxiliary for chiral phosphorus derivatizing agents（CPDAs） in 3Jp NMR tests. Chemical shift difference（△δp） values ranging from 4.5 to 0.15 between two dias- tereoisomers of the CPDAs and the aryl substrates were obtained. Positive △δR-S was observed for all the tested alco- hol P（III） and P（V） derivatives, while negative △δR-S was observed for all the amines.

关键词： Chiral phosphorus derivatizing agent Rosin Enantiodiscrimination 31p NMR

Feasibility and safety of single-incision laparoscopic cholecystectomy versus conventional laparoscopic cholecystectomy in an ambulatory setting

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 273-277页

作者： Jun-Wen Qu Cheng Xin gui-yang wang Zhi-Qing Yuan Ke-Wei Li Department of Biliary-Pancreatic Surgery Renji Hospital School of Medicine Shanghai Jiao Tong University

Background: Single-incision laparoscopic surgery has emerged as an alternative to conventional laparoscopic cholecystectomy(LC) in the clinical setting. Limited information is available on the possibility of performing single-incision laparoscopic surgery as an ambulatory procedure. This study aimed to determine the feasibility and safety of single-incision laparoscopic cholecystectomy(SILC) versus conventional LC in an ambulatory setting. Methods: Ninety-one patients were randomized to SILC( n = 49) or LC( n = 42). The success rate, operative duration, blood loss, hospital stay, gallbladder perforation, drainage, delayed discharge, readmission, total cost, complications, pain score, vomiting, and cosmetic satisfaction of the two groups were then compared. Results: There were significant differences in the operative time(46.89 ± 10.03 min in SILC vs. 37.24 ± 10.23 min in LC;P 0.05). Conclusions: Ambulatory SILC is safe and feasible for selected patients. The advantages of SILC as compared with LC are improved cosmetic satisfaction and lower total costs.

关键词： Ambulatory Single incision Laparoscopic cholecystectomy Feasibility Safety

Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients

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World Journal of Gastroenterology 2015年第34期21卷 9957-9965页

作者： Rui Huang Chen-Chen yang Yong Liu Juan Xia Ran Su Ya-Li Xiong gui-yang wang Zhen-Hua Sun Xiao-Min Yan Shan Lu Chao Wu Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical School Department of Infectious Diseases Qidong People’s Hospital Department of Laboratory Medicine Nanjing Drum Tower HospitalNanjing University Medical School Department of Medicine University of Massachusetts Medical School

AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) ***:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUS

关键词： Gamma-glutamyl transferase Hepatitis B e antigen H

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基于曲线滑裂面的挡墙主动土压力分析

岩土力学 2017年第8期38卷 2182-2188页

作者：杨贵王阳阳刘彦辰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 河海大学安全与防灾工程研究所江苏南京210098

土体滑裂面形状对挡土墙主动土压力有重要影响。以无黏性填土挡墙为研究对象,假设在考虑土拱效应时,极限状态下墙后土体的滑裂面为曲线,基于水平微分单元法推导出平动模式下挡土墙主动土压力的分布。首先将计算与模型试验结果及已有理... 详细信息

土体滑裂面形状对挡土墙主动土压力有重要影响。以无黏性填土挡墙为研究对象,假设在考虑土拱效应时,极限状态下墙后土体的滑裂面为曲线,基于水平微分单元法推导出平动模式下挡土墙主动土压力的分布。首先将计算与模型试验结果及已有理论研究成果进行对比分析,验证了方法的可靠性;其次,研究土体内摩擦角和墙-土摩擦角对主动土压力分布、合力大小和作用点高度的影响。结果表明:基于曲线滑裂面假设得到的滑动楔体范围略大于采用直线滑裂面的假设;对于不同高度的挡土墙,建议的计算结果与模型试验结果更为符合;对于不同的土体内摩擦角和墙-土摩擦角,土压力的分布形式和合力作用点与Paik解较为接近,但合力略大于Paik解。

关键词：曲线滑裂面挡土墙土拱效应主动土压力

Underground water biological field＇s variation and geoenvironmental safety in city

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Journal of Civil Engineering and Architecture 2009年第5期3卷 16-21页

作者： YI Nian-ping ZHANG Xin-gui wang yang HUANG Jun-peng College of Civil and Architectural Engineering Guangxi University Nanning 530004 China

In the process of city construction, as a comprised factor of city geological environment, underground water takes the most active part, and its dynamic change is fiercest. The city construction unceasingly disturbs underground water chemical, dynamical, physical and biological field. In return, the four fields＇ changes also can affect the geological environment that city lived by, in other words they affect safety and stability of geological environment. Interaction of underground water and the geoenvironment directly displays in the following two ways： The first is that the underground water and the geological body transfer the energy each other; the second is that the strength balance of geological body is broken. Underground water variation brought about by city construction is the factor which cannot be neglected. Underground water variation on the one hand changes soils or rocks＇ physical, biological, chemical and mechanical properties, then influences the deformation and strength of geological body. On the other hand it changes its own physical, chemical properties and biochemical component. At present, from mechanics aspect, interaction between chemical field and biological field variation of the underground water and the geological body lacks research. Although interaction between them is long-term, slow, but when it compared with water-soil or water-rock interaction in the entire process of formation of rocks or soils or geologic evolution history, the qualitative change of the biological and chemical action of rocks or soils brought about by city construction is remarkable, in this paper, aiming at underground water biological field factor which is easily neglected by people, it analyzes that underground water biological field affects possible mechanism and approach of properties variation of rocks or soils in city construction, brings forward further research method and development direction have been also proposed.

关键词： underground water biological field microscopic structure

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在城市快速发展背景下的建筑设计策略

合肥工业大学学报（自然科学版） 2009年第7期32卷 1091-1093,1100页

作者：桂汪洋合肥工业大学建筑与艺术学院安徽合肥230009

为了解决我国城市化进程的加快所带来的建筑设计层面上的问题,提出了建筑设计观念的革新,建议采用可持续的设计方法、弹性的设计过程、标准化的设计以及采用开放式的建筑结构设计,同时强调融入情感的建筑设计方法以及建筑师的责任感和... 详细信息

为了解决我国城市化进程的加快所带来的建筑设计层面上的问题,提出了建筑设计观念的革新,建议采用可持续的设计方法、弹性的设计过程、标准化的设计以及采用开放式的建筑结构设计,同时强调融入情感的建筑设计方法以及建筑师的责任感和使命感,从而提高了建筑设计在城市快速扩张时期的适应性,最终实现人、建筑、环境的和谐发展,达到城市的可持续发展。

关键词：城市化建筑设计设计问题设计策略可持续发展

地形对贺兰山步甲群落物种多样性分布格局的影响

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昆虫学报 2017年第9期60卷 1060-1073页

作者：杨益春杨贵军王杰宁夏大学生命科学学院银川750021

【目的】步甲是主要栖息于地表的种类最丰富的昆虫类群之一,它们对生境的变化更为敏感。分析地形因子对贺兰山步甲昆虫群落物种多样性分布格局的影响,以期揭示步甲昆虫物种多样性分布格局形成和稳定的机制。【方法】2015年7-8月选取贺... 详细信息

【目的】步甲是主要栖息于地表的种类最丰富的昆虫类群之一,它们对生境的变化更为敏感。分析地形因子对贺兰山步甲昆虫群落物种多样性分布格局的影响,以期揭示步甲昆虫物种多样性分布格局形成和稳定的机制。【方法】2015年7-8月选取贺兰山山地针叶林、山地疏林、山地灌丛、山地草原和浅山荒漠5种生境98个样地,用杯诱法对步甲群落物种组成和多样性进行调查,并采用典范对应分析(CCA)分析物种多样性指数和物种分布与地形因子之间的关系,运用广义可加模型(GAM)拟合不同生境步甲群落多样性指数对海拔梯度的响应曲线,探讨贺兰山步甲群落物种多样性的垂直分布格局。【结果】共采集步甲昆虫21属65种10 989头,其中,直角通缘步甲Pterostichus gebleri和径婪步甲Harpalus salinus为优势种,其个体数量分别占总捕获个体数的44.93%和11.33%。山地疏林生境步甲物种丰富度最高,山地针叶林的步甲Shannon-Wiener多样性指数最高,浅山荒漠的步甲均匀度最高。海拔、坡向、坡度、剖面曲率和地形湿度指数的综合作用对步甲物种多样性分布格局有显著影响。其中,海拔对5种生境的步甲分布影响均显著,且解释力度最高;坡向对山地针叶林和浅山荒漠步甲分布影响显著。步甲总体丰富度和个体数量与海拔呈不对称的单峰曲线关系,Shannon-Wiener多样性指数随海拔呈先递增后保持稳定的变化,均匀度指数与海拔呈"V"型变化趋势。【结论】贺兰山山地步甲物种多样性的分布格局受海拔为主的多种地形因子综合作用的影响。

关键词：步甲物种多样性分布格局地形山地贺兰山

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益生菌在抗肠道寄生虫病感染中的作用

中国人兽共患病学报 2017年第5期33卷 459-464页

作者：杨桂连王春凤吉林农业大学动物科学技术学院/吉林省动物微生态制剂工程研究中心长春130118

益生菌是一类对宿主有益的活性微生物,可以有效治疗胃肠道、呼吸道感染和过敏性疾病。虽然目前主要用于治疗细菌和病毒感染,但也有研究表明益生菌对寄生虫感染有抑制作用。因此,以益生菌制成的微生态制剂将为寄生虫防治提供一种新的途径。

关键词：益生菌肠道寄生虫抑制

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo wang Ruifeng Xu Xu Zhang Peiyu wang Bao yang Bingjun yang Juan yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries