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Top 100 cited articles in ophthalmic epidemiology between 2006 and 2016

International Journal of Ophthalmology(English edition) 2018年第12期11卷 1994-1998页

作者： Lei Liu Yan Li gui-sen zhang Jing-Yang Wu Shivani Majithia Yih-Chung Tham Han zhang Lei Chen Department of Ophthalmology First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Public Service First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Singapore Eye Research Institute Singapore National Eye Centre168751Singapore Department of English School of Fundamental Sciences China Medical UniversityShenyang 110122Liaoning ProvinceChina Department of Ophthalmology Hohhot Chao Ju Eye Hospital Hohhot 010052Inner Mongolia Autonomous RegionChina Liaoning Diabetic Eye Center Shenyang 110001Liaoning ProvinceChina

AIM: To identify the most-cited articles in ophthalmic epidemiology over the last ***: We performed a cited reference search on articles that were included in the ISI Web of Science database using the terms "Epidemi*" AND "ophthalm*" AND "population*" during year 2006 to 2016. TOP 100 most cited articles(T100) in ophthalmic epidemiology were short listed and analysed using ***: These top 100 articles in ophthalmic epidemiology were cited between 61 to 333 times. Of these T100 articles, 36% originated from United States, and 34% were published in the Ophthalmology journal. The three major topics identified were age-related macular degeneration(AMD, n=23), glaucoma(n=16) and visual impairment(n=12). The top-cited article was a study on outdoor activities and its association with the prevalence of myopia in school-aged children, published in 2008. CONCLUSION: This bibliometric analysis provides useful insights into the current development in ophthalmicepidemiology in the past decade and can help recognizing the quality of the researches, discoveries, and trends steering ophthalmic epidemiology.

关键词： epidemiology ophthalmology article citation bibliometric analysis

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Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： Jia-xin Yu Xiao-yu Wang Jun-wei Shen Jin-sen Hu Xiang-qing zhang Da-qing He Yu-ning zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden *** present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the ***,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are ***,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and ***,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

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Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

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Chinese Chemical Letters 2024年第7期35卷 89-99页

作者： Yating Zheng Yulan Huang Jing Luo Xuqi Peng Xiran gui Gang Liu Yang zhang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China Shen Zhen Research Institute of Xiamen University Shenzhen 518057China Division of Urology and Department of Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high ***,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their *** can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the ***,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental *** this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and *** particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also *** further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

关键词： Biomacromolecules Supercritical fluid technology Therapeutic proteins Gene therapy Nanomedicine

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The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Cancer Biology & Medicine 2024年第1期21卷 65-82页

作者： sen Wang Benling Xu Yangyang zhang Guangyu Chen Peng Zhao Quanli Gao Long Yuan Department of Gastrointestinal Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Immunotherapy Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR *** recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC *** and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in ***,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 *** addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

关键词： Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell

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Middle hepatic vein variation provides a safe path for anterior transection of hepatocellular carcinoma in caudate lobe

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 438-440页

作者： Bing-Yi Lin Qi-Jun zhang Zhe Yang Shu-sen Zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

To the Editor:Hepatocellular carcinoma(HCC)is one of the main causes of cancer related death worldwide,and new cases are expected to continue to increase in future[1].Surgical resection is still the best way to remove the tumor and improve patient’s ***,resection of caudate lobe often presents a technical challenge,even to accomplished hepatic *** lobe is located anterior to the inferior vena cava(IVC)and posterior to the bifurcation of the portal vein(PV),generally consists of three regions:the paracaval portion,the left Spiegel lobe and the process portion[2].The anatomy of the paracaval portion includes the liver parenchyma ventral to the hepatic IVC and the area between the Spiegel lobe and the right lobe adjacent to the middle hepatic vein(MHV)ventrally,which was classified by Couinaud as segment IX[3].Here,we presented a case of HCC with successful downstaging therapy,as well as variation of MHV,which provides a safe path for anterior transection of segment IX.

关键词： hepatic anatomy Middle

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Contact angle and stability of interfacial nanobubble supported by gas monolayer

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Fundamental Research 2024年第1期4卷 35-42页

作者： Haichang Yang Yaowen Xing Fanfan zhang Xiahui gui Yijun Cao Chinese National Engineering Research Center of Coal Preparation and Purification China University of Mining and TechnologyXuzhou 221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China Henan Province Industrial Technology Research Institution of Resources and Materials Zhengzhou UniversityZhengzhou 450001China

Since solid-liquid interfacial nanobubbles(INBs)were first imaged,their long-term stability and large contact angle have been perplexing *** study aimed to investigate the influence of internal gas density and external gas monolayers on the contact angle and stability of INB using molecular dynamics ***,the contact angle of a water droplet was simulated at different nitrogen *** results showed that the contact angle increased sharply with an increase in nitrogen density,which was mainly caused by the decrease in solid-gas interfacial ***,when the nitrogen density reached 2.57 nm^(-3),an intervening gas monolayer(GML)was formed between the solid and *** the formation of GML,the contact angle slightly increased with increasing gas *** contact angle increased to 180°when the nitrogen density reached 11.38 nm^(-3),indicating that INBs transformed into a gas layer when they were too *** substrates with different hydrophobicities,the contact angle after the formation of GML was always larger than 140°and it was weakly correlated with substrate *** increase in contact angle with gas density represents the evolution of contact angle from macro-to nano-bubble,while the formation of GML may correspond to stable *** potential of mean force curves demonstrated that the substrate with GML could attract gas molecules from a longer distance without the existence of a potential barrier compared with the bare substrate,indicating the potential of GML to act as a gas-collecting *** research indicated that GML can function as a channel to transport gas molecules to INBs,which favors stability of *** research may shed new light on the mechanisms underlying abnormal contact angle and long-term stability of INBs.

关键词： Interfacial tension Hydrophobicity Potential of mean force Gas density Molecular dynamics simulations

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Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： Jian-Hu Gong Zheng-Ming zhang Cheng-Liang zhang Peng-Qiang Hu Chao Zhou Dun-Hui Wang sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

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Characterization of the pheromone receptors in Mythimna loreyi reveals the differentiation of sex pheromone recognition in Mythimna species

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Insect Science 2024年第1期31卷 173-185页

作者： Chan Wang Lei Liu Tian-Yu Huang Yu zhang Yang Liu gui-Rong Wang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Guangdong Laboratory of Lingnan Modern Agriculture ShenzhenGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina School of Forestry Northeast Forestry UniversityHarbinChina Key Laboratory of Biohazard Monitoring Green Prevention and Control for Artificial GrasslandMinistry of Agriculture and Rural AffairsInstitute of Grassland Research of Chinese Academy of Agricultural SciencesInner Mongolia HohhotChina

Pheromone receptors(PRs)are key proteins in the molecular mechanism of pheromone recognition,and exploring the functional differentiation of PRs between closely related species helps to understand the evolution of moth mating *** components of the agricultural pest Mythimna loreyi have turned into(Z)-9-tetradecen-1-yl acetate(Z9-14:OAc),(Z)-7-dodecen-1-yl acetate(Z7-12:OAc),and(Z)-11-hexadecen-1-yl acetate,while the composition differs from that of *** in the genus *** understand the molecular mechanism of pheromone recognition,we sequenced and analyzed antennal transcriptomes to identify 62 odorant receptor(OR)*** expression levels of all putative ORs were analyzed using differentially expressed gene *** candidate PRs were quantified and functionally characterized in the Xenopus oocytes ***6 and MlorPR3 were determined to be the receptors of major and minor components Z9-14:OAc and Z7-12:***1 and female antennae(FA)-biased MlorPR5 both possessed the ability to detect pheromones of sympatric species,including(Z,E)-9,12-tetradecadien-1-ol,(Z)-9-tetradecen-1-ol,and(Z)-*** on the comparison of PR functions between *** and ***,we analyzed the differentiation of pheromone recognition mechanisms during the evolution of the mating systems of 2 Mythimna species.

关键词： antennal transcriptome Mythimna loreyi pheromone receptor sex pheromone Xenopus oocyte

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TET1 Participates in Complete Freund’s Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model

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Neuroscience Bulletin 2024年第6期40卷 707-718页

作者： Dengcheng Zhan Jingjing zhang Songxue Su Xiuhua Ren sen Zhao Weidong Zang Jing Cao Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China Neuroscience Research Institute Zhengzhou UniversityZhengzhou450001China

Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;however,the underlying mechanisms remain largely *** this study,we investigated the possible contribution of interaction between ten-eleven translocation methylcytosine dioxygenase 1(TET1)and the voltage-gated K^(+)channel Kv7.2(encoded by Kcnq2)to orofacial inflammatory pain in *** found that complete Freund’s adjuvant(CFA)injection reduced the expression of Kcnq2/Kv7.2 in the trigeminal ganglion(TG)and induced orofacial inflammatory *** involvement of Kv7.2 in CFA-induced orofacial pain was further confirmed by Kv7.2 knockdown or ***,TET1 knockdown in Tet1^(flox/flox)mice significantly reduced the expression of Kv7.2 and M currents in the TG and led to pain-like ***,TET1 overexpression by lentivirus rescued the CFA-induced decreases of Kcnq2 and M currents and alleviated mechanical *** data suggest that TET1 is implicated in CFA-induced trigeminal inflammatory pain by positively regulating Kv7.2 in TG neurons.

关键词： Facial pain KCNQ2 potassium channel TET1 protein

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Numerical investigations of the interactions between bubble induced shock waves and particle based on OpenFOAM

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Journal of Hydrodynamics 2024年第2期36卷 355-362页

作者： Jia-xin Yu Jin-sen Hu Yu-hang Liu Yi-fan Liu Dan Gao Yu-ning zhang Key Laboratory of Power Station Energy Transfer Conversion and System Ministry of EducationSchool of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The presence of particles and the shock waves generated by the cavitation bubbles can significantly affect the safety and the performance of hydrodynamic *** the present paper,the shock waves generated by cavitation bubble collapsing near the particle are numerically investigated based on the OpenFOAM together with the numerical schlieren for the shock wave *** numerical results reveal that the stand-off distance is one of the paramount factors affecting the interactions between the particle and the shock *** different kinds of shock waves(e.g.,bubble-inception,jet formation,particle reflected and jet-split shock waves)are observed during the bubble collapsing near the *** stand-off distance smaller than 0.5 or larger than 1.1,the maximum pressure at particle surface generated by the bubble growth can surpass those of the collapse stage.

关键词： Particle-bubble interaction shockwaves jetdynamics

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