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Identification and validation of cardiac nonconserved human-specific enhancers

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genes & Diseases 2023年第1期10卷 55-57页

作者： Yawen Zhang Yiting gui Xudong.chen Feng Wang Fang Wu Youhua Wang Xu Wang Yonghao gui qiang Li Translational Medical Center for Development and Disease Shanghai Key Laboratory of Birth DefectInstitute of PediatricsChildren's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Cardiovascular Center NHC Key Laboratory of Neonatal Diseases(Fudan University)Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Department of Cardiology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterShanghai200032China

Congenital heart disease(CHD)is one of the most common causes of neonatal *** worldwide morbidity of CHD is 9.410%o,while the proportion of CHD patients who are reported to carry mutations in coding regions is<50%.Enh... 详细信息

关键词： mortality conserved neonatal

A method for determining vegetation growth process using remote sensing data: A case study in the Three-River Headwaters Region, China

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Journal of Mountain Science 2019年第9期16卷 2001-2014页

作者： chen Tian-tian YI gui-hua ZHANg Ting-bin WANg qiang BIE Xiao-juan Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China University of Chinese Academy of Sciences Beijing 100049 China School of geography and Tourism Chongqing Normal University Chongqing 401331 China College of Management Science Chengdu University of Technology Chengdu 610059 China College of Earth Science Chengdu University of Technology Chengdu 610059 China Chongqing Institute of Surveying and Planning for Land Resources and Housing Chongqing 400020 China

Accurate measurements of the associated vegetation phenological dynamics are crucial for understanding the relationship between climate change and terrestrial ecosystems. However, at present, most vegetation phenological calculations are based on a single algorithm or method. Because of the spatial, temporal, and ecological complexity of the vegetation growth processes, a single algorithm or method for monitoring all these processes has been indicated to be elusive. Therefore, in this study, from the perspective of plant growth characteristics, we established a method to remotely determine the start of the growth season(SOg) and the end of the growth season(EOg), in which the maximum relative change rate of the normalized difference vegetation index(NDVI) corresponds to the SOg, and the next minimum absolute change rate of the NDVI corresponds to the EOg. Taking the Three-River Headwaters Region in 2000–2013 as an example, we ascertained the spatiotemporal and vertical characteristics of its vegetation phenological changes. Then, in contrast to the actual air temperature data, observed data and other related studies, we found that the SOg and EOg calculated by the proposed method is closer to the time corresponding to the air temperature, and the trends of the SOg and EOg calculated by the proposed method are in good agreement with other relevant studies. Meantime, the error of the SOg between the calculated and observed in this study is smaller than that in other studies.

关键词： Vegetation phenology Normalized difference vegetation index (NDVI) Start of the growth season (SOg) End of the growth season (EOg) Three-River Headwaters Region(TRHR)

Microbial transformation of glycyrrhetinic acid and potent neural anti-inflammatory activity of the metabolites

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Chinese Chemical Letters 2017年第6期28卷 1200-1204页

作者： Yuan Ma Ji-Mei Liu Ri-Dao chen Xi-qiang An Jun-gui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100050 China Xinjiang Institute of Materia Medica Urumqi 830004 China Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study Institute of Materia Medica Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100050 China

The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CgMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data *** involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at ***,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.

关键词： glycyrrhetinic acid Microbial transformation Anti-inflammatory activity Cunninghamella blakesleana Triterpenoid

基于无人机多光谱数据和氮素空间分异的玉米冠层氮浓度估算

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作物学报 2025年第1期51卷 189-206页

作者：郝琪陈天陆王富贵王振白岚方王永强王志刚内蒙古农业大学农学院内蒙古呼和浩特010010

作物冠层氮素营养的遥感诊断对指导作物精准施氮,提高作物氮效率和产量具有重要意义。本研究针对玉米冠层纵深大影响无人机估算氮浓度精度的问题,基于2022年和2023年不同氮肥运筹处理下田间无人机多光谱数据和氮浓度实测数据,分析玉米... 详细信息

作物冠层氮素营养的遥感诊断对指导作物精准施氮,提高作物氮效率和产量具有重要意义。本研究针对玉米冠层纵深大影响无人机估算氮浓度精度的问题,基于2022年和2023年不同氮肥运筹处理下田间无人机多光谱数据和氮浓度实测数据,分析玉米冠层氮浓度空间分布特征,并利用随机森林算法确定估算冠层氮浓度的有效叶层。进一步结合随机森林算法和多光谱植被指数构建有效叶层氮浓度估算模型,最终将有效叶层氮浓度转换到冠层尺度实现冠层氮浓度的估算。结果表明:(1)九叶展期和大喇叭口期玉米冠层氮浓度表现为上层叶片>中层叶片>下层叶片,吐丝期和乳熟期表现为中层叶片>上层叶片>下层叶片。(2)各时期估算冠层氮浓度的有效叶层分别为下层、中层、中层和中层。与支持向量回归模型相比,随机森林回归估算冠层氮浓度的精度较高。(3)结合随机森林算法,基于有效叶层氮浓度估算冠层氮浓度的平均RMSE、NRMSE和MAE分别为0.10%、4.41%和0.07%,而直接基于植被指数估算冠层氮浓度的平均RMSE、NRMSE和MAE分别为0.19%、9.00%和0.15%。综上,玉米冠层氮浓度存在空间分异特征,估算冠层氮浓度时考虑基于随机森林和植被指数估算的有效叶层氮浓度能明显提高冠层氮浓度的估算精度。本研究确定的考虑空间分异的冠层氮浓度估算框架可为玉米氮素营养实时诊断提供理论支撑。

关键词：玉米冠层氮浓度氮素空间分异多光谱数据机器学习

Potential Benefits of green Tea in Prostate Cancer Prevention and Treatment:A Comprehensive Review

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： LIU gui-hong YAO Ze-qin chen guo-qiang LI Ya-lang LIANg Bing Department of Urology Sanya Central Hospital(The Third People's Hospital of Hainan Province)Sanya CityHainan Province 572000China Department of Urology Yuzhou People's HospitalXuchang CityHenan Province 461670China

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment *** tea,a well-known beverage derived from the Camellia sinensis plant,contains bioactive compounds with potential health benefits,including catechins and *** comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing *** tea possesses antioxidant,anti-inflammatory,and anti-carcinogenic properties attributed to its catechins,particularly epigallocatechin *** studies have reported an inverse association between green tea consumption and prostate cancer risk,with potential protection against aggressive forms of the *** studies demonstrate that green tea components inhibit tumor growth,induce apoptosis,and modulate signaling pathways critical to prostate cancer development and *** trials and human studies further support the potential benefits of green *** tea consumption has been found to be associated with a reduction in prostate-specific antigen levels,tumor markers,and played a potential role in slowing disease ***,challenges remain,including optimal dosage determination,formulation standardization,and conducting large-scale,long-term clinical *** review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： green tea prostate cancer prevention treatment epigallocatechin gallate review

Multiple gastric angiolipomas: A case report

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World Journal of Clinical Cases 2019年第6期7卷 778-784页

作者： Xin-He Lou Wen-guo chen Long-gui Ning Hong-Tan chen guo-qiang Xu Department of gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang University

BACKgROUND Angiolipoma is a benign tumor and is generally found in subcutaneous *** are rare in the gastrointestinal tract,including the *** diagnosis of the tumor is difficult,although there are several radiological examinations such as computed tomography and endoscopic *** SUMMARY We report a 24-year-old Chinese man with multiple gastric angiolipomas,with a positive stool occult blood examination. Endoscopic biopsy only showed nonspecific inflammation. Histological examination of the specimen by endoscopic snare resection showed that the tumor consisted of adipose tissues and blood vessels. We also performed a literature review. After the use of proton pump inhibitor,the fecal occult blood test was negative. Due to the difficulty of resecting multiple lesions in the stomach completely and the benign characteristics of angiolipoma,we chose to have regular upper gastrointestinal endoscopy evaluation of the lesion. No evidence of significant change in lesion size was detected after 3-years *** gastric angiolipoma is rare,and benign neoplasm should be considered when lesions occur submucosally in the gastrointestinal tract.

关键词： Angiolipoma gastric angiolipoma Endoscopic snare resection Case report

32-site microelectrode modified with Pt black for neural recording fabricated with thin-film silicon membrane

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Science China(Information Sciences) 2014年第5期57卷 292-298页

作者： chen SanYuan PEI WeiHua ZHAO Hui gui qiang TANg RongYu chen YuanFang FANg XiaoLei HONg Bo gAO XiaoRong.chen HongDa State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of Sciences Institute of Neural Engineering Department of Biomedical Engineering Tsinghua University

Multi-electrode array is an important tool in the study of neural-network,cognition,remembrance,as well as brain-computer-interface,***-like 32-site microelectrodes are developed with *** use of integrated circuit technology,the length of the electrodes,the area of the recording sites,as well as the spaces between the sites are closely ***2/SiNx/SiO2composite dielectric membrane and Pt black are introduced to improve the characteristics of the *** whole thickness of the thin-film probe was 21μ*** combining the modifying process with the micro-fabrication method,this kind of silicon based microelectrode satisfies high-density recording and the performance characterization is evaluated by test in vitro and in vivo.

关键词： microelectrode brain-computer interface thin-film Si Pt black neural recording

Investigation of flexible electrodes modified by TiN,Pt black and IrO_x

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Science China(Technological Sciences) 2011年第9期54卷 2305-2309页

作者： LI XiaoQian PEI WeiHua TANg RongYu gui qiang gUO Kai WANg Yu chen HongDa State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences BeOing 100083 China School of Physical Science and Technology LanZhou University Lanzhou 730000 China

TiN, platinum （Pt） black and iridium oxide are introduced to the stimulating sites to improve the performance of the flexible electrode. Low temperature process is used to fabricate the modifying films. TiN is coated on the gold sites by magnetron sputtering while platinum black and iridium oxide are coated by electroplating and electrodeposifion, respectively. The impedance of the electrode decreases dramatically after modification. The combined analysis of surface morphology and cyclic voltammograms （CV） in phosphate buffer saline （PBS） solution indicates that the modified electrode sites have larger electrode-electrolyte capacitance and smaller faradic resistance than unmodified sites, thus they have smaller electrochemical impedances.

关键词： flexible electrodes modification impedance cyclic voltammograms (CV)

Fabrication and characterization of implantable silicon neural probe with microfluidic channels

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Science China(Technological Sciences) 2012年第1期55卷 1-5页

作者： gUO Kai PEI WeiHua LI XiaoQian gui qiang TANg RongYu LIU Jian chen HongDa State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China

In this paper, a silicon-based neural probe with microfluidic channels was developed and evaluated. The probe can deliver chemicals or drugs to the target neurons while simultaneously recording the electrical action of these neurons extracellularly. The probe was fabricated by double-sided deep reactive ion etching （DRIE） from a silicon-on-insulator （SO1） wafer. The flu- idic channels were formed with V-shape groove etching on the silicon probe and sealed with silicon nitride and parylene-C. The shank of the probe is 4 mm long and 120 ~tm wide. The thickness of the probe is 100 ~tm. The probe has two fluidic chan- nels and two recording sites. The microfluidic channels can withstand a pressure drop as much as 30 kPa and the flow resisti ity of the microfluidic channel is 0.13 μL min-1 kPa-1, The typical impedance of the neural electrode is 32.3 kΩ at 1 kHz at room temperature.

关键词： neural probe parylene-C microfluidic channel