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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing Yang Wen-Jing Zhang Yi-Ling Zhou gui-jun zhao Ya Huang Shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice

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World Journal of Gastroenterology 2012年第47期18卷 7087-7092页

作者： gui-jun zhao Li-Xia Xu Eagle SH Chu Ning Zhang Jia-Yun Shen Alatangaole Damirin Xiao-Xing Li College of Life Sciences Inner Mongolia University Department of Gastroenterology and Hepatology Inner Mongolia People's Hospital Institute of Digestive Disease Department of Medicine and TherapeuticsLi Ka Shing Institute of Health Sciencesthe Chinese University of Hong Kong Shenzhen Research Institute the Chinese University of Hong Kong Department of Gastroenterology First Affiliated HospitalSun Yat-sen University

AIM:To improve the outcome of orthotopic transplantation in a mouse model,we used an absorbable gelatin sponge(AGS) in nude mice to establish an orthotopic implantation tumor ***:MHCC-97L hepatocellular carcinoma(HCC)cells stably expressing the luciferase gene were injected into the subcutaneous region of nude *** week later,the ectopic tumors were harvested and transplanted into the left liver lobe of nude *** AGS was used to establish the nude mouse orthotopic implantation tumor *** tumor suppressor gene,paired box gene 5(PAX5),which is a tumor suppressor in HCC,was transfected into HCC cells to validate the *** growth was measured by bioluminescence imaging ***-quantitative reverse transcription polymerase chain reaction(RT-PCR) and histopathology were used to confirm the tumorigenicity of the implanted tumor from the MHCC-97L cell ***:We successfully developed an orthotopic transplantation tumor model in nude mice with the use of an *** success rate of tumor transplantation was improved from 60% in the control group to 100% in the experimental group using *** detection of fluorescent signals showed that tumors grew in all live nude *** mice were divided into 3 groups:AGS-,AGS+/PAX5-and AGS+/PAX5 +.Tumor size was significantly smaller in PAX5 transfected nude mice compared to control mice(P < 0.0001).These fluorescent signal results were consistent with observations made during *** examination further confirmed that the tissues from the ectopic tumor were *** from RT-PCR proved that the HCC originated from MHCC-97L ***:Using an AGS is a convenient and efficient way of establishing an indirect orthotopic liver transplantation tumor model with a high success rate.

关键词： Hepatocellular carcinoma Orthotopic transplantation tumor model Absorbable gelatin sponge Nude mice Bioluminescence imaging

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Safety and effectiveness of lurasidone in the treatment of Chinese schizophrenia patients:An interim analysis of post-marketing surveillance

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World Journal of Psychiatry 2023年第11期13卷 937-948页

作者： Yu-Mei Wei Xi-Jin Wang Xiao-Dong Yang Chuan-Sheng Wang Li-Li Wang Xiao-Ying Xu gui-jun zhao Bin Li Dao-Min Zhu Qi Wu Yi-Feng Shen Shanghai Clinical Research Center for Mental Health School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Department of Psychiatry The First Psychiatric Hospital of HarbinHarbin 150056Heilongjiang ProvinceChina Department of Psychiatry Shandong Provincial Mental Health CenterJinan 250014Shandong ProvinceChina Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453002Henan ProvinceChina Department of Psychiatry Tianjin Mental Health CenterTianjin Anding HospitalTianjin 300222China Department of Psychiatry The Fifth People’s Hospital of ZigongZigong 643020Sichuan ProvinceChina Department of Psychiatry Guangyuan Mental Health CenterGuangyuan 628001Guizhou ProvinceChina Department of Psychology Fujian Energy General HospitalFuzhou 350001Fujian ProvinceChina Department of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical UniversityHefei Fourth People’s HospitalAnhui Mental Health CenterHefei 230022Anhui ProvinceChina Sumitomo Pharma(China) Co.Ltd.Shanghai 200025China Shanghai Key Laboratory of Psychotic Disorders Shanghai Clinical Research Center for Mental HealthShanghai Jiao Tong UniversityShanghai 200030China

BACKGROUND Schizophrenia is a psychiatric disorder characterized by chronic or recurrent *** was licensed in China in 2019 for the treatment of adult schizophrenia in adults with a maximum dose of 80 mg/***,post-market surveillance(PMS)with an adequate sample size is required for further validation of the drug’s safety profile and *** To conduct PMS in real-world clinical settings and evaluate the safety and effectiveness of lurasidone in the Chinese *** A prospective,multicenter,open-label,12-wk surveillance was conducted in China's *** patients with schizophrenia from 10 sites who had begun medication with lurasidone between September 2019 and August 2022 were eligible for *** assessments included adverse events(AEs),adverse drug reactions(ADRs),extrapyramidal symptoms(EPS),akathisia,use of EPS drugs,weight gain,and laboratory values as metabolic parameters and the QTc *** effectiveness was assessed using the brief psychiatric rating scale(BPRS)from baseline to the end of *** A total of 965 patients were enrolled in the full analysis set and 894 in the safety set in this interim *** average daily dose was 61.7±19.08 mg(mean±SD)during the *** and ADRs were experienced by 101 patients(11.3%)and 78 patients(8.7%),respectively,which were mostly *** occurred in 25 individuals with a 2.8%incidence,including akathisia in 20 individuals(2.2%).Moreover,59 patients received drugs for treating EPS during the treatment,with an incidence of 6.6%which dropped to 5.4%at the end of the *** average weight change was 0.20±2.36 kg(P=0.01687)with 0.8%of patients showing a weight gain of≥7%at week 12 compared with that at the *** mean values of metabolic parameters and the QTc interval at baseline and week 12 were within normal *** mean changes in total BPRS scores were-8.9±9.76(n=959),-13.5±12.29(n=959),and-16.8±13.97(n=959)after 2/4,6/8,a

关键词： Lurasidone Safety Effectiveness Surveillance Schizophrenia Chinese

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Who can benefit more from its twelve-week treatment:A prospective cohort study of blonanserin for patients with schizophrenia

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World Journal of Psychiatry 2024年第11期14卷 1735-1745页

作者： Bao-Yan Xu Kun Jin Hai-Shan Wu Xue-jun Liu Xi-Jin Wang Hong Sang Ke-Qing Li Mei-Juan Sun Hua-Qing Meng Huai-Li Deng Zhi-Yuan Xun Xiao-Dong Yang Lin Zhang Guan-jun Li Rui-Ling Zhang Duan-Fang Cai Jia-Hong Liu gui-jun zhao Long-Fa Liu Gang Wang Chang-Lie zhao Bin Guo Sheng-Chun Jin Ling-Yun Huang Fu-De Yang Jian-Min Zheng gui-Lai Zhan Mao-Sheng Fang Xiang-jun Meng Guang-Ya Zhang Hai-Min Li Xiang-Lai Liu Ju-Hong Li Bin Wu Hai-Yun Li Jin-Dong Chen Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Hebei Provincial Mental Health CenterHebei Key Laboratory of Major Mental and Behavioral DisordersThe Sixth Clinical Medical College of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceChangsha 410000Hunan ProvinceChina Department of Psychiatry The First Psychiatric Hospital of HarbinHarbin 150000Heilongjiang ProvinceChina Mental Health Center Changchun Sixth HospitalChangchun 130000Jilin ProvinceChina Department of Pharmacy Daqing Third HospitalDaqing 163000Heilongjiang ProvinceChina Department of Physical and Psychological Rehabilitation Guangda Rehabilitation HospitalChongqing 400000China Department of Psychology Shanxi Provincial Mental Health CenterTaiyuan 030000Shanxi ProvinceChina Department of Psychiatry Tianjin Anding HospitalTianjin 300000China Department of Psychiatry Shandong Mental Health CenterJinan 250000Shandong ProvinceChina Department of Psychiatry Fuzhou Shenkang HospitalFuzhou 350000Fujian ProvinceChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200000China Department of Psychiatry The Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Psychiatry The Fifth People’s Hospital of ZigongZigong 643000Sichuan ProvinceChina Department of Psychiatry The Affiliated Kangning Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Psychiatry Guangyuan Mental Health CenterGuangyuan 628000Sichuan ProvinceChina Department of Psychiatry Jilin Sixth People’s HospitalJilin 132000Jilin ProvinceChina The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital

BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating *** To investigate which types of patients would obtain the most benefit from BNS *** A total of 3306 participants were evaluated in a 12-week,prospective,multicenter,open-label post-marketing surveillance study of *** psychiatric rating scale(BPRS)scores were calculated to evaluate the effectiveness of BNS,and its safety was assessed with the incidence of adverse drug *** regression was used to screen the influencing factors for the reduction of BPRS total score,and logistic regression was used to identify patients with a better response to *** The baseline BPRS total score(48.8±15.03)decreased to 27.7±10.08 at 12 weeks(P<0.001).Extrapyramidal symptoms(14.6%)were found to be the most frequent adverse drug *** acute phase,baseline BPRS total score,current episode duration,number of previous episodes,dose of concomitant antipsychotics,and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment ***,patients in the acute phase with baseline BPRS total score≥45,current episode duration<3 months,and≤3 previous episodes derived greater benefit from 12-week treatment with *** Patients in the acute phase with more severe symptoms,shorter current episode duration,fewer previous episodes,and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.

关键词： Schizophrenia Blonanserin Effectiveness Psychosocial functioning Prospective cohort study

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao Qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-jun Zhang Wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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基于信息系统的装备保障指挥流程分析

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兵器装备工程学报 2017年第3期38卷 104-107,159页

作者：许贵君王晖赵凯装甲兵工程学院装备指挥与管理系北京100072

针对基于信息系统的装备保障指挥特点,分析研究了信息化条件下装备保障指挥活动的组成与流程,构建了装备保障指挥总体流程模型及其活动间的信息交互矩阵,为深入准确把握基于信息系统的装备保障指挥能力形成途径提供了理论参考。

关键词：装备保障基于信息系统指挥流程

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多次兼并公告对目标公司股东收益影响的案例分析

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徐州建筑职业技术学院学报 2002年第2期2卷 59-61,64页

作者：杨旭桂昭君郑东雅浙江大学经济学院浙江杭州310027

以方正科技 (6 0 0 6 0 1 )为典型案例 ,采用事件研究的方法 ,分析了该股三次收购公告对于目标公司股东收益产生的影响 .实证分析的结果表明 ,尽管目前我国的股票市场还不成熟。

关键词：事件研究并购股东收益

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Reverse modulation of defect density of Ce-MOF-808 by solventassisted ligand exchange for dicyclopentadiene hydrogenation

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Science China Chemistry 2025年

作者： Danfeng zhao Fajie Hu Rushuo Li Xinmeng Xu zhaokun Wang Zuoshuai Xi jun Tong Xiubing Huang Ge Wang Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing

Defect engineering is a pivotal strategy for tailoring the electronic structure and physicochemical properties of catalysts, yet the straightforward manipulation of defect density in porous materials presents a current challenge. In this work, we achieved precise control over the coordination unsaturated site（CUS） content and pore architecture of Ce-MOF-808 by employing 2-fluorobenzoic acid（2-FBA） as a modifier. Leveraging the p Kadisparities among three ligands（1,3,5-tricarboxylic benzoic acid,formic acid, and 2-FBA）, we preserved the spn topology of Ce-MOF within an aqueous system, while realizing partial substitution of the auxiliary ligands and saturation of the CUS. The amount of 2-FBA was negatively correlated with the number of ligand defects, and the consequent decrease in Ce3+content and the increase in the number of ligand linkages also induced crystal structure transformation. The modulation of the defect structure was correlated with the catalytic performance of dicyclopentadiene（DCPD） hydrogenation reaction, in which Ce-MMF0.15, constructed by the modulation of 0.15 mol amount of 2-fluorobenzoic acid, exhibited an optimal ligand defect density and micro-mesoporous structure, enabling almost complete conversion of DCPD at 100 ℃ and 2 MPa. This article also elucidates the correlation between the regulation of defect density and the accessibility of frustrated Lewis pair（FLP） active sites, guiding the application of novel porous intrinsic FLP materials in hydrogenation catalysis.

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Liquid refractive index measurement method based on orthogonal polarization laser self-mixing interference

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Optoelectronics Letters 2025年

作者： zhao Yan WANG Haipeng DU Shengzhi TONG Jigang KANG jun School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In this paper， a novel method combining orthogonal polarization laser self-mixing interference is proposed. The method utilizes a rotating cuvette to measure the refractive index of liquids at different concentrations. The cuvette is filled with the liquid to be measured and rotated by a certain angle. The change in the number of interference fringes， caused by comparing an empty cuvette with a liquid-filled cuvette， is used to calculate the refractive index of the liquid. A four-fold logic subdivision algorithm is then used to improve measurement resolution. The experimental results show that for pure water and different NaCl and glucose solutions concentrations， the average relative errors are 0.47%， 0.59%， and 2.17%， respectively， with the maximum relative error within ±2.54%. The standard deviation of all solutions is less than 3.4%.

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