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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 917-928页

作者： gui-jie wang Yun-long CAI Min-jian ZHAO jie ZHONG Department of Information Science and Electronic Engineering Zhejiang University

In this study, a two-hop wireless sensor network with multiple relay nodes is considered where the amplify-and-forward(AF) scheme is employed. Two algorithms are presented to jointly consider interference suppression and power allocation(PA) based on the minimization of the symbol error rate(SER) criterion. A stochastic gradient(SG) algorithm is developed on the basis of the minimum-SER(MSER) criterion to jointly update the parameter vectors that allocate the power levels among the relay sensors subject to a total power constraint and the linear receiver. In addition, a conjugate gradient(CG) algorithm is developed on the basis of the SER criterion. A centralized algorithm is designed at the fusion center. Destination nodes transmit the quantized information of the PA vector to the relay nodes through a limited-feedback channel. The complexity and convergence analysis of the proposed algorithms are carried out. Simulation results show that the proposed two adaptive algorithms significantly outperform the other previously reported algorithms.

关键词： Cooperative communications Adaptive filtering Symbol error rate(SER) Interference suppression Power allocation

Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera

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Insect Science 2021年第5期28卷 1399-1413页

作者： gui-jie wang Wen-Wen wang Yu Liu Lian-Qin Chai Guo-Xiu wang Xu-Sheng Liu Yu-Feng wang Jia-Lin wang Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079China School of Life Sciences Henan UniversityKaifengHenan475004China

Mermithid nematodes,such as Ovomermis sinensis,are used as biological control agents against many insect pests,including cotton bollworm(Helicoverpa armigera).However,given the host's robust immune system,the infection rate of *** is low,thus restricting its widespread *** understand the host defense mechanisms against mermithid nematodes,we identified and characterized a protein involved in the recognition of ***,the potential ***-binding protein C-type lectin 1(HaCTLla and/or HaCTLIb),which was eluted from the surface of *** after incubation with *** *** is homologous to the previously reported HaCTLla *** was predominantly expressed in hemocytes and was induced by the steroid hormone 20-hydroxyecdysone through ecdysone receptor(HaEcR)or ultraspiracle(HaUSP),or *** assays confirmed the interactions of the HaCTLI proteins with *** but not with Romanomermis wuchangensis,a parasitic nematode of ***,the HaCTL1 proteins were secreted into the hemocoel and promoted hemocyte-mediated encapsulation and phagocytosis.A knockdown of HaEcR and/or HaUSP resulted in compromised encapsulation and ***,HaCTLI appears to modulate cellular immunity in the defense against parasitic nematodes,and the 20-hydroxyecdysone-HaEcR-HaUSP complex is involved in regulating the process.

关键词： C-type lectin encapsulation phagocytosis 20-hydroxyecdysone

Theory and mechanism analysis of Wuji Pill in Anti-lung Cancer:A study based on network pharmacology and molecular docking technology

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Medical Theory and Hypothesis 2022年第3期5卷 12-20页

作者： Yi Li gui-jie wang Lu Feng Bo Pang Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355China College of Acupuncture and Massage Shandong University of Traditional Chinese MedicineJinan 250355China

Background:To explore the effective components and mechanism of Classic ancient prescription Wuji pill on lung cancer(LC)with the help of network pharmacology and molecular docking ***:TCMSP database,Chinese Pharmacopoeia(2020 Edition)and related literature were searched to identify the main chemical composition and targets of constituent drugs in Wuji pill,including Houpo(Magnoliae Officinalis Cortex),Huangqin(Scutellariae Radix),Badou(Crotonis Fructus),Huanglian(Coptidis Rhizoma)and Renshen(Ginseng Radix et Rhizoma).Meanwhile,Genecards,OMIM,TTD,Drugbank and PharmGkb databases were used to obtain the main targets of ***"chemical compound-target"network was constructed by using Cytoscape 3.8.2 software with the disease drug intersection gene as the research *** PPI network was constructed by using the string database for protein interaction analysis,and the core target genes were sorted *** Gene ontology go function enrichment analysis and KEGG signal pathway enrichment analysis were carried out based on the ClusterProfiler of R ***,the Autodock Vina software was used to conduct molecular docking between the core target with high value and the key ***:A total of 60 active components,190 corresponding targets and 2516 GO and 163 KEGG pathways of Wuji pill were screened out,including 179 potential targets of *** core targets were ESR1,CDKN1A,TP53,NR3C1,MAPK1,AKT1,MAPK8,JUN,RELA,the core components were quercetin,kaempferol,β-sitosterol,stigmasterol,tetrahedron,protoopioid,etc,and the core pathways were PI3K-Akt,MAPK,IL-17,***:This study preliminarily revealed the mechanism of action of Wuji pill on multi component-multi target-multi pathway of LC,which provided reference for the further clinical development and research of Wuji pill.

关键词： Wuji pill lung cancer network pharmacology molecular docking target prediction

Exploring the mechanisms of lipid regulation in metabolic syndrome: Recent developments

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Medical Theory and Hypothesis 2023年第2期6卷 15-18页

作者： gui-jie wang Qian Shen Chuan-Long Zhang Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

Metabolic syndrome(MetS)is an individual accumulation of multiple abnormal metabolic indicators,with insulin resistance and central obesity at its *** tissue is the core component of MetS,and adipokines secreted by various adipocytes play a crucial role in its regulatory *** this paper,we searched the literature from 2020 to 2022 on Pubmed and Knowledgeweb using the keywords of“metabolic syndrome,”“adipose tissue”and“adipokines”.We mainly explored the mechanisms of leptin,lipocalin,resistin,brown adipose tissue and beige adipose tissue secreted by white adipose tissue in regulating insulin resistance,inhibiting inflammatory response and neurohormonal regulation of lipid and glucose *** this paper,under various studies on lipids for MetS,the metabolic mechanisms of various adipose tissues,adipocytes,and adipokines were investigated systematically and *** was found that the regulation of adipokines and,thus,treatment of MetS by drugs is less and needs further exploration.

关键词： metabolic syndrome adipose tissue adipokines

From the imbalance of tumor amino acid metabolism,the application of fuzheng detoxification method in interfering with the transformation of colitis cancer was discussed

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Microenvironment & Microecology Research 2022年第3期4卷 15-18页

Objective:From the perspective of tumor amino acid metabolism imbalance,the application of fuzheng detoxification method in intervening in the transformation of colitis cancer was ***:By consulting CNKI's concept of tumor microenvironment,energy metabolism,amino acid metabolism,and colitis cancer transformation,it provides theoretical and data support for research ***:The study found that the transformation of colitis cancer refers to the metabolic imbalance of the tumor microenvironment under the condition of repeated stimulation of chronic inflammatory responses of colon tissue,which is mainly related to energy metabolism,sugar metabolism,fat metabolism,and amino acid metabolism imbalance,which promotes the transformation of the inflammatory microenvironment to the tumor *** acids as an important source of nutrients for cells,its metabolic imbalance is an important cause of inflammation and cancer ***:Chinese medicine believes that the transformation of inflammation and cancer is mainly related to the incurable treatment of evil in the internal organs,the loss of Qi,and the poison damage to the blood *** cancer disease mechanism is always positive deficiency and stasis,the pathogenesis is based on the virtual standard,the virtual and real are mixed,and the clinical use of correct detoxification to adjust the balance of the body.

关键词： chronic colitis inflammatory carcinogenesis amino acid metabolism correct detoxification

Discussion on reprogramming of tumor energy metabolism and intervention of traditional Chinese medicine based on the theory of“collateral Q i stagnation”

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Medical Theory and Hypothesis 2023年第1期6卷 18-21页

作者： Yi Li gui-jie wang Chuan-Long Zhang Bo Pang Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Xiyuan Hospital Chinese Academy of Chinese Medical SciencesBeijing 100091China

The theory of stagnation of collateral Qi(Chinese medicine refers to the most fundamental and subtle substances thatconstitute the human body and maintain life activities,and also has the meaning of physiological functions)originates from the theory of collateral disease,which refers to the deficiency of Qi in the body’s collaterals,the loss of Qi and blood,and the failure of stagnation of collateral Qi,which leads to the loss of Qi,blood and body fluid,and the formation of pathological products such as deficiency,depression,phlegm,blood stasis in the local area,and ultimately damage the pathological process of *** on the in-depth study of the pathogenesis of collateral Qi stagnation and the previous study of meridian channels,we believe that the key pathogenesis of the formation,evolution and spread of malignant tumors is“collateral Qi deficiency stagnation,collateral Qi stagnation and collateral Qi decay”.As an important energy resonance channel of the body,meridians play a key role in the process of material transformation and energy *** is believed that the small focus caused by the pathogenesis of stagnation is the cause of malignant transformation of tumor,the reprogramming of energy metabolism induced by the lesion of collateral Qi is the basis of the progress of tumor pathogenesis,and the formation of tumor microenvironment regulated by the tumor toxin vena is the root of alienation of tumor *** by this theory,focusing on the correlation between collateral Qi and tumor energy metabolism,using Professor Hua Baojin's treatment method of“Regulating Qi and detoxifying”to prescribe drugs can adjust collateral Qi function,achieve the relative balance of internal environment,and then inhibit the progress of *** on the above understanding,this study tries to enlighten new diagnosis and treatment ideas under the guidance of“stagnation of collateral Qi”in traditional Chinese medicine,in order to provide some theoretical s

关键词： stagnation of collaterals tumour energy metabolism reprogramming tumor microenvironment integrated traditional Chinese and Western Medicine

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang wang Yasu Chen jie Li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China

We report a novel cyano migration-mediated radical-polar crossover process,whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently *** transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic *** studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution,leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

Offload Strategy for Edge Computing in Satellite Networks Based on Software Defined Network

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Computers, Materials & Continua 2025年第1期82卷 863-879页

作者： Zhiguo Liu Yuqing gui Lin wang Yingru Jiang Communication and Network Laboratory Dalian UniversityDalian116622China College of Environment and Chemical Engineering Dalian UniversityDalian116622China

Satellite edge computing has garnered significant attention from researchers;however,processing a large volume of tasks within multi-node satellite networks still poses considerable *** sharp increase in user demand for latency-sensitive tasks has inevitably led to offloading bottlenecks and insufficient computational capacity on individual satellite edge servers,making it necessary to implement effective task offloading scheduling to enhance user *** this paper,we propose a priority-based task scheduling strategy based on a Software-Defined Network(SDN)framework for satellite-terrestrial integrated networks,which clarifies the execution order of tasks based on their ***,we apply a Dueling-Double Deep Q-Network(DDQN)algorithm enhanced with prioritized experience replay to derive a computation offloading strategy,improving the experience replay mechanism within the Dueling-DDQN ***,we utilize the Deep Deterministic Policy Gradient(DDPG)algorithm to determine the optimal resource allocation strategy to reduce the processing latency of *** results demonstrate that the proposed d3-DDPG algorithm outperforms other approaches,effectively reducing task processing latency and thus improving user experience and system efficiency.

关键词： Satellite network edge computing task scheduling computing offloading

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes:accessingβ-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang Chenxin wang Xu wang Xiaoyu Zhou Wei Xiao jie Wu School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies Taizhou UniversityTaizhou 318000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

The generation of variousβ-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is *** method features a broad substrate scope and excellent *** studies reveal that the dispersion interaction between sulfinyl group and CH_(2)SO_(2)Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

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Chinese Journal of Integrative Medicine 2025年第2期31卷 170-182页

作者： wang Xiang wang Xiao-qing LUO Kai BAI He QU Jia-lin ZHANG gui-xin Department of General Surgery the Second Hospital of Dalian Medical UniversityDalianLiaoning Province(116027)China Clinical Laboratory of Integrative Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning Province(116021)China Hepatobiliary Surgery Department Shandong Provincial Third HospittalShandong UniversityJinan(250031)China Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning Province(116044)China

Cholangiocarcinoma(CCA)is a malignant tumor originating from ***,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple ***,CCA is mainly treated by surgery,chemotherapy,and *** them,surgery is the only potentially curative option for ***,the high malignancy and asymptomatic nature of CCA may lead to poor treatment *** has been demonstrated that Chinese medicine(CM)plays a significant role in various antitumor ***,CM exhibits fewer side effects and high ***,the in vitro application of CM monomers has been explored in many domestic and foreign *** article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent *** findings are expected to provide new insights into the treatment of CCA.

关键词： cholangiocarcinoma Chinese medicine monomers antitumor signaling pathways molecular mechanisms review