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Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： Qiang-Qiang Fu Le Ma Xiao-Min Niu hua-Xin Zhao Xu-hua Ge hua Jin De-hua Yu Sen Yang Department of General Practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai General Practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

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跨境资本流动对中国商业银行流动性风险的影响——兼论经济政策不确定性的调节作用

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亚太经济 2024年第3期 51-62页

作者：何英华桂宏南京师范大学商学院南京210023 南京师范大学南京210023

基于2010—2021年中国42家上市商业银行的数据,使用双向固定效应模型探讨跨境资本流动对银行流动性风险的影响。结果表明:跨境资本流动会提升商业银行的流动性风险,且通过提高流动性错配进而推升银行流动性风险;股份制银行、城市商业银... 详细信息

基于2010—2021年中国42家上市商业银行的数据,使用双向固定效应模型探讨跨境资本流动对银行流动性风险的影响。结果表明:跨境资本流动会提升商业银行的流动性风险,且通过提高流动性错配进而推升银行流动性风险;股份制银行、城市商业银行和非全球系统重要性银行的流动性更容易受到跨境资本流动的威胁,传统金融市场和数字金融市场的发展会强化银行流动性风险对跨境资本流动的反应,而适宜水平的银行收入结构多元化、提高市场化程度和强化金融监管强度均有助于弱化跨境资本流动对银行流动性风险的影响;经济政策不确定性强化了跨境资本流动对银行流动性风险的提升效应,特别是对于非全球系统重要性银行而言。

关键词：跨境资本流动流动性风险流动性错配经济政策不确定性

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Efficacy of budesonide/formoterol inhalation powder in treating viral pneumonia in children

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World Journal of Clinical Cases 2024年第21期12卷 4469-4475页

作者： Zi-Liang Lin Xu Xu jiao-jiao Yang Li-Qiang Lu Heng huang Xiao-Zhen hua Li-Dang Lu Department of Pediatrics Cangnan Hospital Affiliated to Wenzhou Medical UniversityWenzhou 325800Zhejiang ProvinceChina

BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired *** strategies to limit antibiotic use in children with viral pneumonia are *** To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor *** A total of 60 children with viral pneumonia were recruited:30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic *** measures included peripheral blood levels of inflammatory cytokines,CD4^(+),CD8^(+),Th1,Th2,Th17 and Treg,clinical efficacy,and incidence of adverse *** Compared with the control group,the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after *** with the control group,the observation group showed a significant increase in CD4^(+)/CD8^(+)and Th1/Th2 levels,and a decrease in Th17/Treg levels after *** total effective rates in the observation group and the control group were 93.75%and 85.00%,respectively,which was a significant difference(P=0.003).CONCLUSION Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in *** mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.

关键词： Budesonide/Formoterol inhalation powder Viral pneumonia Immunity CD4^(+)/CD8^(+) Th1/Th2 Th17/Treg

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Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

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LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

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Science China(Life Sciences) 2024年第8期67卷 1601-1619页

作者： hua Yang Lina Xuan Shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

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Mesoscale and Microphysical Characteristics of a Double Rain Belt Event in South China on May 10–13,2022

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Journal of Tropical Meteorology 2024年第1期30卷 61-75页

作者：郭照华谌芸肖天贵曾智琳 School of Atmospheric Sciences Chengdu University of Information TechnologyChengdu 610225 China National Meteorological Center Beijing 100081 China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519082 China Guangdong Meteorological Observatory Guangzhou 510640 China

A second rain belt sometimes occurs ahead of a frontal rain belt in the warm sector over coastal South China,leading to heavy *** examined the differences in the mesoscale characteristics and microphysics of the frontal and warm sector rain belts that occurred in South China on May 10–13,*** southern rain belt occurred in an environment with favorable mesoscale conditions but weak large-scale *** contrast,the northern rain belt was related to low-level horizontal shear and the surface-level *** interaction between the enhanced southeasterly winds and the rainfall-induced cold pool promoted the persistent growth of convection along the southern rain *** convective cell propagated east over the coastal area,where there was a large temperature *** bow-shaped echo in this region may be closely related to the rear-inflow *** contrast,the initial convection of the northern rain belt was triggered along the front and the region of low-level horizontal shear,with mesoscale interactions between the enhanced warm-moist southeasterly airflow and the cold dome associated with the earlier *** terrain blocked the movement of the cold pool,resulting in the stagnation of the frontal convective cell at an early ***,a meso-γ-scale vortex formed during the rapid movement of the convective cell,corresponding to an enhancement of *** representative raindrop spectra for the southern rain belt were characterized by a greater number and higher density of raindrops than the northern rain belt,even though both resulted in comparable hourly *** results help us better understand the characteristics of double rain belts over South China.

关键词： double rain belts in South China mesoscale rainstorm cyclonic shear line cold pool bow-shaped echo microphysical characteristics

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PPP投资是否促进了企业创新?——来自上市公司的微观证据

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改革 2024年第6期 108-126页

作者：李荣华王娇娇河南师范大学商学院

基于公共服务发展视角,以政府和社会资本合作快速发展为契机,采用2009—2020年上市公司与地市级PPP项目库的匹配数据,考察了PPP投资对企业创新的影响。结果表明:PPP投资能够显著增加企业创新产出,且作用强度因PPP投资类型而异;具体地,... 详细信息

基于公共服务发展视角,以政府和社会资本合作快速发展为契机,采用2009—2020年上市公司与地市级PPP项目库的匹配数据,考察了PPP投资对企业创新的影响。结果表明:PPP投资能够显著增加企业创新产出,且作用强度因PPP投资类型而异;具体地,相较于民生性和补短型投资,生产性和升级型投资对企业创新的影响更显著,这主要源于市场规模效应、成本节约效应和技术吸收能力提升效应等作用机制;异质性分析表明,PPP投资对企业创新的促进作用在大中型城市以及非高新技术企业更显著;拓展研究表明,行业市场竞争对PPP投资与企业创新具有正向调节效应,且资源再配置对行业创新强度的贡献超过50%。上述研究从优化创新资源空间配置角度,提供了公共服务促进企业创新的经验证据,对于优化PPP投资的创新服务效能具有重要政策启示。

关键词： PPP投资公共服务发展企业创新市场竞争资源再配置

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Analysis of the Clinical Value of Psychological Intervention in Gastric Cancer Care

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Proceedings of Anticancer Research 2024年第3期8卷 121-126页

作者： Wenwen Li Yan Xu jiao Jin Fang Wang hua Zhang Xuelan Yan Shanshan Cui Affiliated Hospital of Hebei University BaodingHebei 071000China

Objective: To analyze the application value of psychological intervention in gastric cancer nursing. Methods: This study analyzes gastric cancer patients admitted to hospitals from May 2022 to May 2023. Based on research requirements and patient willingness, 80 patients were selected and divided into observation and control groups using a lottery method. The control group received conventional nursing care, while the observation group received psychological intervention in addition to conventional nursing care. Results: After the psychological intervention, patients in the observation group showed significant improvements in anxiety and depression, better sleep quality, remarkable enhancement in psychological resilience, higher levels of health literacy, and increased nursing satisfaction compared to the control group (P < 0.05). Conclusion: Incorporating psychological intervention into the nursing care of gastric cancer patients enhances their psychological adjustment ability and improves treatment adherence.

关键词： Psychological intervention Gastric cancer Nursing Application

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The crosstalk between enteric nervous system and immune system in intestinal development,homeostasis and diseases

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Science China(Life Sciences) 2024年第1期67卷 41-50页

作者： Xindi Wang Chenbo Ding hua-Bing Li Shanghai Institute of Immunology State Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai jiao Tong University School of Medicine-Yale Institute for Immune Metabolism Shanghai Jiao Tong University School of MedicineShanghai 200025China

The gut is the largest digestive and absorptive organ,which is essential for induction of mucosal and systemic immune responses,and maintenance of metabolic-immune *** intestinal components contain the epithelium,stromal cells,immune cells,and enteric nervous system(ENS),as well as the outers,such as gut microbiota,metabolites,and *** dyshomeostasis of intestinal microenvironment induces abnormal intestinal development and functions,even colon diseases including dysplasia,inflammation and *** recent studies have identified that ENS plays a crucial role in maintaining the immune homeostasis of gastrointestinal(GI)*** crosstalk between ENS and immune cells,mainly macrophages,T cells,and innate lymphoid cells(ILCs),has been found to exert important regulatory roles in intestinal tissue programming,homeostasis,function,and *** this review,we mainly summarize the critical roles of the interactions between ENS and immune cells in intestinal homeostasis during intestinal development and diseases progression,to provide theoretical bases and ideas for the exploration of immunotherapy for gastrointestinal diseases with the ENS as potential novel targets.

关键词： enteric nervous system macrophages T cells innate lymphoid cells neuro-immune interactions

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体系动员视角下的乡村治理现代化——基于基层“中心工作泛化”现象的讨论

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理论学刊 2024年第3期 105-112页

作者：桂华周晓蓉武汉大学社会学院湖北武汉430072

治理体系与治理能力互为表里,在责权不匹配的治理结构下,基层工作存在治理能力和治理资源的短缺问题。通过中心工作与常规工作的划分,基层在特定情况下动员全部资源去完成阶段性的重要工作,实现了基层治理体系的激活。随着国家治理下乡... 详细信息

治理体系与治理能力互为表里,在责权不匹配的治理结构下,基层工作存在治理能力和治理资源的短缺问题。通过中心工作与常规工作的划分,基层在特定情况下动员全部资源去完成阶段性的重要工作,实现了基层治理体系的激活。随着国家治理下乡,越来越多的工作任务下沉到基层,使得基层治理出现了“中心工作泛化”现象,诸多的条线任务变成了中心工作,造成基层治理负担加重。在上级压力持续加大的背景下,受困于人财物相对短缺的基层组织采取了超常规治理来应对工作任务,对基层资源进行高强度动员,打破了体系的常规运转机制,在完成阶段性工作的同时也造成了基层治理透支。超常规治理可完成短期性、阶段性工作,但是存在不可持续的问题,因此推进基层治理现代化要回归常规治理模式,切实做到为基层减负,实现治理能力与治理体系的合理匹配。

关键词：基层治理常规治理超常规动员基层减负

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