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Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan han Xiao YOU Yue XU Shu-juan ZhanG Ye-hao CHEN Yuan-yuan XIN Gao-jie LIU Zi-xin REN Jun-guo CAO Ce LI Ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing Key Laboratory of Chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–160 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-18, IL-1β, monocyte chemotactic protein 1(MCP-1), tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1(Caspase-1), GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β, MCP-1, TNF-α and IL-6(P<0.01 or P<0.05). At the same time, by inhibiting NLRP3/Caspase-1/GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1, GSDMD and GSDMD-N proteins(P<0.01). Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： Chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

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星载电子器件温控的系统多尺度分析

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物理学报 2024年第18期73卷 185-194页

作者：李心泽唐桂华汪子涵冯建朝张晓峰西安交通大学能源与动力工程学院热流科学与工程教育部重点实验室西安710049 中国科学院微小卫星创新研究院上海201304

为提高星载电子器件热分析的模拟分辨率和精度以及被动热控装置的控温效果,本文建立系统多尺度模型获得不同尺度下卫星内部电子器件的温度场和热流信息.结果表明:系统多尺度模型在系统级尺度模拟精度与实际模型相对误差小于9%,并且可消... 详细信息

为提高星载电子器件热分析的模拟分辨率和精度以及被动热控装置的控温效果,本文建立系统多尺度模型获得不同尺度下卫星内部电子器件的温度场和热流信息.结果表明:系统多尺度模型在系统级尺度模拟精度与实际模型相对误差小于9%,并且可消耗较少的计算资源获得器件级尺度芯片微小结构的热信息.系统级模型可从宏观尺度评估星载被动热控材料的控温隔热性能,采用复合相变隔热材料可将载荷舱室温度波动幅值降至2.43 K,相比平台舱室温度波动幅值降低约69.43%,通过复合相变隔热材料隔热后的温度波动信号呈现向高频域部分转移的特征.基于多元回归分析选定需要进行重点隔热控温的舱室后,采用器件级简化模型得到不同热控装置布局下的温度场信息形成训练数据集,采用神经网络遗传算法在器件尺度预测被动热控装置的最佳安装位置,并得到减小器件最大温度波动的热控布局方案,最大温度波动降低2.74 K.

关键词：星载电子器件系统多尺度温度控制神经网络遗传算法

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Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao gui Quan Lu Yong Yin Jian-hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

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三治如何融合——制度成本的视角

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学习与探索 2024年第7期 26-35页

作者：贺雪峰桂华武汉大学社会学院

在国家资源下乡和快速城市化背景下,自治、法治、德治“三治融合”是新时代乡村治理现代化的必然要求。法治保障主要是指自上而下的国家资源与国家行政权力下乡,为村民自治提供资源条件和制度条件。以党建引领为基础、以组织农民为手段... 详细信息

在国家资源下乡和快速城市化背景下,自治、法治、德治“三治融合”是新时代乡村治理现代化的必然要求。法治保障主要是指自上而下的国家资源与国家行政权力下乡,为村民自治提供资源条件和制度条件。以党建引领为基础、以组织农民为手段的德治,是克服村民自治中少数人“搭便车”所带来的集体行动困境的必要手段。只有以法治为保障、以德治为动力,村民自治才能有效运转,基层治理才能符合实际需要,低成本高效率的基层治理也才可能实现。法治是保障,德治是动力,自治是基础。只有在这个认识基础上理解作为乡村治理现代化典型的“枫桥经验”和“桐乡实践”,“三治融合”的实现才能更加具有针对性和现实性。

关键词： “三治融合” 基层治理现代化党建引领资源下乡

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Effect of inorganic salt impurities on seeded precipitation of silica hydrate from sodium silicate solution

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 3016-3028页

作者： Xiao-bin LI Xiao-bing GAO Qiu-sheng ZHOU Yi-lin WANG Tian-gui QI Lei-ting SHEN gui-hua LIU Zhi-hong PENG School of Metallurgy and Environment Central South UniversityChangsha 410083China

To clarify the precipitation of silica hydrate from the real desilication solutions of aluminosilicate solid wastes by adding seeds and improve integrated waste utilization,the seeded precipitation was studied using synthesized sodium silicate solution containing different inorganic salt *** results show that sodium chloride,sodium sulfate,sodium carbonate,or calcium chloride can change the siloxy group *** number of high-polymeric siloxy groups decreases with increasing sodium chloride or sodium sulfate concentration,which is detrimental to seeded *** chloride favors the polymerization of silicate ions,and even the chain groups precipitate with the precipitation of high-polymeric sheet and cage-like siloxy *** introduced sodium cations in sodium carbonate render a more open network structure of high-polymeric siloxy groups,although the carbonate ions favor the polymerization of siloxy *** matter how the four impurities affect the siloxy group structure,the precipitates are always amorphous opal-A silica hydrate.

关键词： aluminosilicate sodium silicate solution siloxy group impurity silica hydrate

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Left inferior phrenic arterial malformation mimicking gastric varices: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3057-3064页

作者： han Wang Yi-Qing Tan Ping han An-Hui Xu han-Lin Mu Zhe Zhu Li Ma Mei Liu hua-Ping Xie Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Radiology Tongren Hospital of Wuhan University(Wuhan Third Hospital)Wuhan UniversityWuhan 430063Hubei ProvinceChina Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pathology and Cell Biology Columbia University Irving medical centerNew York-Presbyterian HospitalNew YorkNY 10065United States Department of Gastroenterology Jianli People's HospitalJianli 433300Hubei ProvinceChina

BACKGROUND Gastric submucosal arterial dilation resulting from splenic artery occlusion represents an exceedingly rare etiology of acute upper gastrointestinal bleeding(UGIB).Although endoscopy is a widely utilized diagnostic and therapeutic modality for gastrointestinal bleeding,it has limitations in detecting arterial *** SUMMARY This report presents a rare case of massive UGIB in a 57-year-old male with a tortuous left inferior phrenic artery accompanied by splenic artery occlusion.“Gastric varices”was identified during the patient's endoscopy one year before *** initial hemostasis by endoscopic clipping,the patient experienced massive rebleeding after one month,requiring intervention with transcatheter arterial embolization(TAE)to achieve *** This is the first case to report UGIB due to a tortuous left inferior phrenic *** case highlights the limitations of endoscopy in identifying arterial abnormalities and emphasizes the potential of TAE as a viable alternative for the management of arterial bleeding in the gastrointestinal tract.

关键词： Upper gastrointestinal bleeding Left inferior phrenic artery Splenic artery occlusion Gastrointestinal endoscopy Digital subtraction angiography Case report

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基于工况知识引导注意力时间卷积网络的烧结终点预测

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控制理论与应用 2024年第3期41卷 447-453页

作者：方怡静蒋朝辉桂卫华潘冬中南大学自动化学院湖南长沙410083 南洋理工大学化学化工与生物工程学院新加坡637459

烧结终点位置的实时准确预测对于优化烧结工艺具有重要的意义.针对烧结过程中强非线性和动态时变性造成烧结终点高精度预测难的问题,本文提出了一种基于工况知识引导注意力时间卷积网络(AM–TCN)模型.首先,构建堆叠的时间卷积模块用于... 详细信息

烧结终点位置的实时准确预测对于优化烧结工艺具有重要的意义.针对烧结过程中强非线性和动态时变性造成烧结终点高精度预测难的问题,本文提出了一种基于工况知识引导注意力时间卷积网络(AM–TCN)模型.首先,构建堆叠的时间卷积模块用于充分提取烧结过程数据中深层次的非线性特征;其次,将历史工况知识引入注意力机制,引导模型在保留过程数据时序特征的同时区分不同特征的重要性;最后,构建预测模型用于烧结终点位置在线预测.工业数据实验表明,所提AM–TCN模型具有较好的烧结终点预测精度,对提升烧结过程热状态稳定性具有重要意义.

关键词：注意力机制时间卷积网络工况知识烧结终点预测

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Whole breast ultrafractionation radiotherapy after breast-conserving surgery in early breast cancer: A single-center, prospective, observational study from China

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Malignancy Spectrum 2024年第2期1卷 113-122页

作者： Rui-Zhi Zhao Cheng huang Tian-Lan Tang gui-Qing Shi Si-Lin Chen Yu-Ping Lin Ying Wang Liu-Qing Jiang Jin-hua Chen Chun-Sen Xu Fang-Meng Fu Zhong-hua han Shun-Guo Lin Chuan Wang Yong Yang Department of Radiation Oncology Fujian Medical University Union HospitalFujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors(Fujian Medical University)Clinical Research Center for Radiology and Radiotherapy of Fujian Province(DigestiveHematological and Breast Malignancies)FuzhouFujianChina Department of Follow-Up Center Fujian Medical University Union HospitalFuzhouFujianChina Department of Breast Surgery Fujian Medical University Union HospitalFuzhouFujianChina

Objective:This single-center,prospective,observational study was designed to investigate the toxicities,patient-reported outcome(PRO),and dosimetric analysis of whole breast ultrafractionation radiotherapy(RT)after breast-conserving surgery(BCS)in early breast cancer(BC).Patients and methods:Patients diagnosed with BC stage I,II and treated with BCS were enrolled.A dose of 26 Gray(Gy)in five fractions was prescribed to the whole breast and tumor *** endpoints included toxicities,PRO,and dosimetric *** was measured by the European Organization for Research and Treatment of Cancer general quality of life questionnaire(EORTC QLQ-C30)and the BC-specific questionnaire(EORTC QLQ-BR23)***:Between January 2022 and June 2023,62 female patients were *** median age was 45 *** patients(83.9%)were diagnosed with pathological stage I *** median planning target volume(PTV)was 456.4 *** minimum,maximum,and mean doses,and D95(dose of PTV irradiated volume more than 95%)to PTV were 20.2,28.8,27.2,and 26.3 Gy,*** median mean lung dose and percentage lung volume receiving 8 Gy(V8)were 3.6 Gy and 13.4%,*** median mean heart dose,V1.5(percentage of organ volume irradiated with 1.5 Gy or higher),and V7(percentage of organ volume irradiated with 7 Gy or higher)were 0.6 Gy,6.8%,and 0.4%,*** effects before RT showed no obvious differences compared to that post *** toxicities of grade 3 or higher *** patients had asymptomatic radiation pneumonia(grade 1),and 12 patients had radiation dermatitis(grade 1).No factor was significantly related to radiation dermatitis or radiation *** the EORTC QLQ-C30 and QLQ-BR23 questionnaires,all function and symptom scores before RT had no significant differences compared with that after RT,1−2 months after RT,and 3−4 months after *** RT did not worsen *** 1-year crude local control was 100%.Conclusion:Whole br

关键词： ultrafractionation radiotherapy breast cancer breast-conserving surgery toxicities patient-reported outcome

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Landscape of human organoids:Ideal model in clinics and research

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The Innovation 2024年第3期5卷 146-164页

作者： Xinxin han Chunhui Cai Wei Deng Yanghua Shi Lanyang Li Chen Wang Jian Zhang Mingjie Rong Jiping Liu Bangjiang Fang hua He Xiling Liu Chuxia Deng Xiao He Xin Cao Organ Regeneration X Lab Lisheng East China Institute of BiotechnologyPeking UniversityJiangsu 226200China Shanghai Lisheng Biotech Shanghai 200092China Longhua Hospital Shanghai University of Traditional Chinese Medicine725 Wanping South RoadXuhui DistrictShanghai 200032China Department of Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Neurosurgery Third Affiliated HospitalNaval Medical UniversityShanghai 200438China Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic ScienceMinistry of JusticeShanghai 200063China Cancer Center Faculty of Health SciencesUniversity of MacaoTaipaMacao SARChina Ministry of Education Frontiers Science Center for Precision Oncology University of MacaoTaipaMacao SAR 999078China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical CollegeShanghai 200032China

In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical *** year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential ***,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously *** review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid *** meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical *** present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this *** narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug *** delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease *** comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid *** spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other *** ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical *** trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical *** offer a broad view of the

关键词： landscape intended advances

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Ultra-wide dual-band Rydberg atomic receiver based on space division multiplexing radio-frequency chip modules

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Chip 2024年第2期3卷 53-61页

作者： Li-hua Zhang Bang Liu Zong-Kai Liu Zheng-Yuan Zhang Shi-Yao Shao Qi-Feng Wang Yu Ma Tian-Yu han Guang-Can Guo Dong-Sheng Ding Bao-Sen Shi Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

Detecting microwave signals over a wide frequency range is endowed with numerous advantages as it enables simultaneous transmission of a large amount of information and access to more spectrum *** capability is crucial for applications such as microwave communication,remote sensing and ***,conventional microwave receiving systems are limited by amplifiers and band-pass filters that can only operate efficiently in a specific frequency ***,these systems can only process signals within a three-fold frequency range,which limits the data transfer bandwidth of the microwave communication *** novel atom-integrated microwave sensors,for example,radio-frequency(RF)chip–coupled Rydberg atomic receiver,provides opportunities for a large working bandwidth of microwave sensing at the atomic *** the current work,an ultrawide dual-band RF sensing scheme was demonstrated by spacedivision multiplexing two RF-chip-integrated atomic receiver *** system can simultaneously receive dual-band microwave signals that span a frequency range exceeding 6 octaves(300 MHz and 24 GHz).This work paves the way for multi-band microwave reception applications within an ultra-wide range by RF-chip-integrated Rydberg atomic sensor.

关键词： Dual-band Rydberg Radio-frequency chip Atomic receiver Space-division multiplexing

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