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Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice

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World Journal of Stem Cells 2024年第5期16卷 575-590页

作者： han Duan Ning Tao Lin Lv Kai-Xin Yan Yong-Gang You Zhuang Mao Chang-Yao Wang Xue Li Jia-Yan Jin Chu-Tse Wu hua Wang School of Life Sciences Hebei UniversityBaoding 071002Hebei ProvinceChina Beijing Institute of Radiation Medicine Beijing 100850China Department of Cardiology The Sixth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100037China Department of Orthopaedics The Fourth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100853China Third Cadet Regiment School of Basic Medical ScienceAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Atherosclerosis(AS),a chronic inflammatory disease of blood vessels,is a major contributor to cardiovascular *** pulp stem cells(DPSCs)are capable of exerting immunomodulatory and anti-inflammatory effects by secreting cytokines and exosomes and are widely used to treat autoimmune and inflam-mation-related *** growth factor(HGF)is a pleiotropic cytokine that plays a key role in many inflammatory and autoimmune *** To modify DPSCs with HGF(DPSC-HGF)and evaluate the therapeutic effect of DPSC-HGF on AS using an apolipoprotein E-knockout(ApoE-/-)mouse model and an in vitro cellular *** ApoE-/-mice were fed with a high-fat diet(HFD)for 12 wk and injected with DPSC-HGF or Ad-Null modified DPSCs(DPSC-Null)through tail vein at weeks 4,7,and 11,respectively,and the therapeutic efficacy and mechanisms were analyzed by histopathology,flow cytometry,lipid and glucose measurements,real-time reverse transcription polymerase chain reaction(RT-PCR),and enzyme-linked immunosorbent assay at the different time points of the *** in vitro inflammatory cell model was established by using RAW264.7 cells and human aortic endothelial cells(HAOECs),and indirect co-cultured with supernatant of DPSC-Null(DPSC-Null-CM)or DPSC-HGF-CM,and the effect and mechanisms were analyzed by flow cytometry,RT-PCR and western *** factor-κB(NF-κB)activators and inhibitors were also used to validate the related signaling *** DPSC-Null and DPSC-HGF treatments decreased the area of atherosclerotic plaques and reduced the expression of inflammatory factors,and the percentage of macrophages in the aorta,and DPSC-HGF treatment had more pronounced *** treatment had no effect on serum lipoprotein *** FACS results showed that DPSCs treatment reduced the percentages of monocytes,neutrophils,and M1 macrophages in the peripheral blood and ***-Null-CM and DPSC-HGF-CM reduced adhesion molecule expression in tu

关键词： Atherosclerosis Apolipoprotein E-knockout mice Cell therapy Dental pulp stem cells Hepatocyte growth factor

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The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy

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Tungsten 2024年第2期6卷 342-354页

作者： Song-Wei Ge Ping Hu Jie Deng Shi-Lei Li Hai-Rui Xing Jia-Yu han Xing-Jiang hua Li Wang Jun-Zhou Yang Bo Jin Wen Zhang Kuai-She Wang School of Metallurgy Engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China Western Xinxing Rare and Precious Metals Co. Ltd.Shangluo 726000China Northwest Institute for Non-Ferrous Metal Research Xi’an 710016China

As the range of applications for molybdenum and its alloys has expanded,the corrosive environment for molybdenum alloys has become more *** the past,the content of doping elements has been studied to investigate their infl uence on the corrosion performance of titanium–zirconium–molybdenum(TZM)*** this paper,it is considered that the second phase in the alloy is the main factor aff ecting the corrosion performance of TZM *** comparing the corrosion behavior of molybdenum metal and TZM alloy,the eff ect of the secondary phase on corrosion behaviors of TZM alloy has been *** results show that the second phase reduces the corrosion resistance of the TZM *** potential of the second phase is 73.7 mV higher than that of the Mo matrix,which contributes to the formation of microscopic electric *** the action of microscopic electric couples,pitting corrosion is preferentially formed at the interface between the second phase and the matrix,which accelerates the corrosion of the *** paper provides a theoretical basis for the application of TZM alloys in corrosive environments.

关键词： Secondary phase Electrochemical corrosion Titanium–zirconium–molybdenum(TZM) Galvanic corrosion Corrosion resistance

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4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI

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Chinese Chemical Letters 2024年第6期35卷 486-490页

作者： hualei Xu Manman han Haiqiang Liu Liang Qin Lulu Chen Hao Hu Ran Wu Chenyu Yang hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Xiaodong Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) State Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Centre for Imaging&Systems BiologyMinzu University of ChinaBeijing 100081China

Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological *** direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive understanding of their essential ***,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by *** results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background *** use of 4-NC led to the successful detection of 232,218,and193 LMW compounds from the three abovementioned tissue sections,***,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds.

关键词： MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging

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Robust free-space optical frequency transfer in time-varying link distances conditions

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Chinese Physics B 2024年第2期33卷 271-276页

作者：童周刘雷王家亮操前金志成应康韩申生韩正甫桂有珍 School of Physical Sciences University of Science and Technology of ChinaHefei 230000China Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Space Laser Communication and Detection Technology Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Future inter-satellite clock comparison on high orbit will require optical time and frequency transmission technology between moving ***,we demonstrate robust optical frequency transmission under the condition of variable link *** variable link is accomplished by the relative motion of a single telescope fixed on the experimental platform to a corner-cube reflector(CCR)installed on a sliding *** acousto–optic modulators with different frequencies are used to separate forward signal from backward *** active phase noise suppression,when the CCR moves back and forth at a constant velocity of 20 cm/s and an acceleration of 20 cm/s^(2),we achieve the best frequency stability of 1.9×10^(-16) at 1 s and 7.9×10^(-19) at 1000 s *** work paves the way for future studying optical frequency transfer between ultra-high-orbit satellites.

关键词： free-space optical frequency transfer variable link distance

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基于BP神经网络的第四系覆盖物厚度预测及三维地质建模

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地球科学 2024年第2期49卷 550-559页

作者：张瀚桂蕾王腾飞杨赛中国地质大学工程学院湖北武汉430074 中国地质大学地质调查研究院湖北武汉430074

地质灾害风险精细化调查和评估是目前地质灾害减灾防控的重要内容.斜坡三维地质建模技术的发展为滑坡灾害风险精细化调查评估提供了新的思路,可大幅提高区域范围内滑坡灾害调查的效率和评估精度.基于Skua-Gocad平台,针对第四系覆盖物和... 详细信息

地质灾害风险精细化调查和评估是目前地质灾害减灾防控的重要内容.斜坡三维地质建模技术的发展为滑坡灾害风险精细化调查评估提供了新的思路,可大幅提高区域范围内滑坡灾害调查的效率和评估精度.基于Skua-Gocad平台,针对第四系覆盖物和下伏基岩两大模块开展区域斜坡三维地质建模技术研究,以重庆市万州区大周镇为例,采用BP神经网络模型,通过构建研究区第四系覆盖物厚度与地质环境指标的多维非线性网络实现了第四系覆盖物厚度预测.结合现场调查数据进行方法验证,基于BP神经网络的第四系覆盖物厚度预测精度达91.49%,在此基础上构建了三维地质模型,具有良好的可视化效果,并确保了数据的可靠性.克服了传统基于克里金插值方法无法反应地质环境因素的缺点,解决了区域范围第四系覆盖物厚度预测的难题.

关键词：第四系覆盖物预测 BP神经网络三维地质建模工程地质

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体系动员视角下的乡村治理现代化——基于基层“中心工作泛化”现象的讨论

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理论学刊 2024年第3期 105-112页

作者：桂华周晓蓉武汉大学社会学院湖北武汉430072

治理体系与治理能力互为表里,在责权不匹配的治理结构下,基层工作存在治理能力和治理资源的短缺问题。通过中心工作与常规工作的划分,基层在特定情况下动员全部资源去完成阶段性的重要工作,实现了基层治理体系的激活。随着国家治理下乡... 详细信息

治理体系与治理能力互为表里,在责权不匹配的治理结构下,基层工作存在治理能力和治理资源的短缺问题。通过中心工作与常规工作的划分,基层在特定情况下动员全部资源去完成阶段性的重要工作,实现了基层治理体系的激活。随着国家治理下乡,越来越多的工作任务下沉到基层,使得基层治理出现了“中心工作泛化”现象,诸多的条线任务变成了中心工作,造成基层治理负担加重。在上级压力持续加大的背景下,受困于人财物相对短缺的基层组织采取了超常规治理来应对工作任务,对基层资源进行高强度动员,打破了体系的常规运转机制,在完成阶段性工作的同时也造成了基层治理透支。超常规治理可完成短期性、阶段性工作,但是存在不可持续的问题,因此推进基层治理现代化要回归常规治理模式,切实做到为基层减负,实现治理能力与治理体系的合理匹配。

关键词：基层治理常规治理超常规动员基层减负

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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang Meng-Xia Zhang Xiao-Xiang Meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

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Identification of NR3C2 as a functional diagnostic and prognostic biomarker and potential therapeutic target in non‐small cell lung cancer

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Cancer Innovation 2024年第4期3卷 67-86页

作者： Yuan‐yuan Sun Hai‐cheng Gao Peng Guo Na Sun Chan Peng Zhi‐hua Cheng Jing Gu Jin‐yi Liu Fei han Department of Clinical Pharmacy Jilin University School of Pharmaceutical SciencesChangchunChina Institute of Toxicology College of Preventive MedicineArmy Medical UniversityChongqingChina Department of Hepatobiliary Surgery Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina College of Pharmaceutical Sciences Southwest UniversityChongqingChina Vascular Surgery Department General Surgery CenterFirst Hospital of Jilin UniversityChangchunChina Department of Toxicology School of Public HealthChongqing Medical UniversityChongqingChina Laboratory of Reproductive Biology Chongqing Medical UniversityChongqingChina

Background:Non‐small cell lung cancer(NSCLC),including the lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUAD)subtypes,is a malignant tumor type with a poor 5‐year survival *** identification of new powerful diagnostic biomarkers,prognostic biomarkers,and potential therapeutic targets in NSCLC is urgently ***:The UCSC Xena,UALCAN,and GEO databases were used to screen and analyze differentially expressed genes,regulatory modes,and genetic/epigenetic alterations in *** UCSC Xena database,GEO database,tissue microarray,and immunohistochemistry staining analyses were used to evaluate the diagnostic and prognostic ***‐of‐function assays were performed to examine the *** ESTIMATE,TIMER,Linked Omics,STRING,and DAVID algorithms were used to analyze potential molecular ***:NR3C2 was identified as a potentially important molecule in ***3C2 is expressed at low levels in NSCLC,LUAD,and LUSC tissues,which is significantly related to the clinical indexes of these *** operating characteristic curve analysis suggests that the altered NR3C2 expression patterns have diagnostic value in NSCLC,LUAD,and especially LUSC *** NR3C2 expression levels can help predict poor prognosis in NSCLC and LUAD patients but not in LUSC *** results have been confirmed both with database analysis and real‐world clinical samples on a tissue *** number variation contributes to low NR3C2 expression levels in NSCLC and LUAD,while promoter DNA methylation is involved in its downregulation in *** NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application ***3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell ***3C2 co‐expressed genes are involved in many cancer‐related signaling pathways,further supporting a potentially si

关键词： diagnosis and prognosis expression regulation function immune cell infiltration non‐small cell lung cancer NR3C2 therapeutic target tumor microenvironment

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Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction

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Chinese Journal of Integrative Medicine 2024年第10期30卷 886-895页

作者： CUI Xin-yu LIU Tian-hua BAI Ya-li ZhanG Meng-di LI Guo-dong ZhanG Yu-ting YUAN Yue-ying ZhanG Ya-wen YU Li-shuang han Li-na WU Yan School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Key Laboratory of Traditional Chinese Medicine Syndrome and Formula Ministry of Education Beijing University of Chinese MedicineBeijing100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:To study the effect of Shexiang Tongxin Dropping Pill(STDP)on angiogenesis in diabetic cardiomyopathy mice with coronary microcirculation dysfunction(CMD).Methods:According to a random number table,6 of 36 SPF male C57BL/6 mice were randomly selected as the control group,and the remaining 30 mice were injected with streptozotocin intraperitoneally to replicate the type 1 diabetes *** successfully copied the diabetes model were randomly divided into the model group,STDP low-dose group[15 mg/(kg·d)],medium-dose group[30 mg/(kg·d)],high-dose group[60 mg/(kg·d)],and nicorandil group[15 mg/(kg·d)],6 in each *** drug was given by continuous gavage for 12 *** cardiac function of mice in each group was detected at the end of the experiment,and coronary flow reserve(CFR)was detected by chest Doppler *** changes of myocardium were observed by hematoxylin-eosin staining,collagen fiber deposition was detected by masson staining,the number of myocardial capillaries was detected by platelet endothelial cell adhesion molecule-1 staining,and the degree of myocardial hypertrophy was detected by wheat germ agglutinin *** expression of the vascular endothlial growth factor(VEGF)/endothelial nitric oxide synthase(eNOS)signaling pathway-related proteins in myocardial tissue was detected by Western ***:Compared with the model group,medium-and high-dose STDP significantly increased the left ventricular ejection fraction and left ventricular fraction shortening(P<0.01),obviously repaired the disordered cardiac muscle structure,reduced myocardial fibrosis,reduced myocardial cell area,increased capillary density,and increased CFR level(all P<0.01).Western blot showed that high-dose STDP could significantly increase the expression of VEGF and promote the phosphorylation of vascular endothelial growth factor receptor 2,phosphoinositide 3-kinase,protein kinase B,and eNOS(P<0.05 or P<0.01).Conclusion:STDP has a definite therapeuti

关键词： Shexiang Tongxin Dropping Pill type 1 diabetes diabetic cardiomyopathy coronary microcirculation dysfunction angiogenesis

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A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease

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World Journal of Pediatrics 2024年第2期20卷 189-200页

作者： Shu-Na Sun Yan Zhou Xing Fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang Liu Chen Chu Feng Wang Cheng-Long Liu Qing-Tong Zhou De-hua Yang Di Zhu Ming-Wei Wang Yong-Hao gui Children's Hospital of Fudan University National Children's Medical CenterShanghai 201102China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(Shanghai)Ltd. Shanghai 200233China School of Pharmacy Fudan UniversityShanghai 201203China School of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 100,000 children aged 0-4 years was 71.9-110.0 in China,170.9-194.9 in Korea,and 18.1-21.3 in the USA[1].The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated

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