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T-cell immunoglobulin mucin molecule-3, transformation growth factor β, and chemokine-12 and the prognostic status of diffuse large B-cell lymphoma

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World Journal of Clinical Cases 2022年第32期10卷 11804-11811页

作者： Hao Wu Hui-Cong Sun gui-fang ouyang Department of Hematology Ningbo First HospitalNingbo Clinical Research Center for Hematologic MalignanciesNingbo 315010Zhejiang ProvinceChina Department of Adult Internal Medicine Ningbo Women and Children's HospitalNingbo 315012Zhejiang ProvinceChina

BACKGROUND The effects of T-cell immunoglobulin mucin molecule-3(Tim-3),transforming growth factor β(TGF-β),and chemokine-12(CXCL12) expression on the prognosis of patients with diffuse large B-cell lymphoma(DLBCL) have not been *** To examine the correlation between Tim-3,TGF-β and CXCL12 expression and DLBCL *** Lymph node tissues of 97 patients with DLBCL and 93 normal-response hyperplastic lymph node tissues treated from January 2017 to May 2019 were selected as the DLBCL and control groups,*** expression of Tim-3,TGF-β,and CXCL12 was detected *** were followed up for 3 years,and progression-free survival was *** mult-ifactorial analysis was performed to analyze the risk factors for poor *** The positive expression rates of Tim-3,TGF-β,and CXCL12 were higher in DLBCL tissues than in non-cancerous(control) tissues(P < 0.05).One-year postsurgery,the positive expression rates of Tim-3,TGF-β,and CXCL12 were higher in patients with effective treatment than in those with ineffective treatment(P < 0.05).The 3-year progression-free survival of 97 patients with DLBCL was 67.01%(65/97).Univariate analysis revealed that clinical stage,bone marrow infiltration,International Prognostic Index(IPI) score,Tim-3 positivity,TGF-β positivity,and CXCL12 positivity were associated with poor prognosis(P < 0.05).Multivariate Cox regression analysis demonstrated that clinical stage Ⅲ–Ⅳ,bone marrow infiltration,mediate-to-high-risk IPI scores,Tim-3 positivity,TGF-β positivity,and CXCL12 positivity were independent risk factors affecting prognosis(P < 0.05).CONCLUSION DLBCL tissues exhibit high positive expression of Tim-3,TGF-β,and CXCL12,and a high expression of all three indicates a poor prognosis.

关键词： T-cell immunoglobulin mucin molecule-3 Transforming growth factorβ Chemokine-12 Diffuse large B-cell lymphoma

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Clinical features and prognostic factors in 49 patients with follicular lymphoma at a single center:A retrospective analysis

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World Journal of Clinical Cases 2023年第14期11卷 3176-3186页

作者： Hao Wu Hui-Cong Sun gui-fang ouyang Department of Hematology Ningbo First HospitalNingbo 315010Zhejiang ProvinceChina Adult Internal Medicine Ningbo Women and Children's HospitalNingbo 315012Zhejiang ProvinceChina

BACKGROUND Follicular lymphoma(FL)is a type of B-cell lymphoma that originates at the germinal center and has a low malignancy *** has become the most common inert lymphoma in Europe and America but has a relatively low incidence in *** To explore the clinical features,curative effects,and prognostic factors of *** Completed medical records of 49 patients with FL who were admitted to the Ningbo First Hospital from June 2010 to June 2021 were *** patients were definitively diagnosed by pathological biopsy or immunohistochemical *** diagnostic criteria were based on the 2008 World Health Organization classification of *** Arbor staging was performed according to the imaging and bone marrow examination *** stratification of all patients was performed based on the International Prognostic Index(IPI),age-adjusted IPI,Follicular Lymphoma International Prognosis Index(FLIPI),and FLIPI2 to compare the efficacy of different treatment regimens and analyze the related prognostic *** The age of onset in patients ranged from 24 to 76 years,with a median age of 51 *** patients developed the disease at 40–59 years of age,and the male:female ratio was 1.6:*** significant difference was noted in the curative effect between the non-chemotherapy,combined chemotherapy,and other chemotherapy regimens(P>0.05).Hemoglobin(Hb)level50%,bone marrow involvement,and clinical stagesⅢ–IV were associated with a poor prognosis of FL(P<0.05).However,the influence of other indicators was not statistically *** grouping was performed using the FLIPI,and the results showed that 24.5%,40.8%,and 34.7%of patients were in the low-,moderate-,and high-risk groups,*** to the survival analysis results,the survival rate of patients was lower in the high-risk group than in the other low-risk and moderate-risk groups(P<0.05).CONCLUSION FL mainly occurs in middle-aged and elderly men,prima

关键词： Follicular lymphoma Clinical feature Curative effect Prognosis Survival analysis Follicular Lymphoma International Prognosis Index

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Effect of T-regulatory cells and interleukin-35, interleukin-10, and transforming growth factor-beta on diffuse large B-cell lymphoma

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World Journal of Clinical Cases 2023年第29期11卷 7075-7081页

作者： Hao Wu Hui-Cong Sun gui-fang ouyang Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo 315010Zhejiang ProvinceChina Adult Internal Medicine Ningbo Women and Children's HospitalNingbo 315012Zhejiang ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is an aggressive non-Hodgkin lymphoma that affects B *** can develop in the lymph nodes and can be localized or *** DLBCL being considered potentially curable,little research has been conducted on the relationship between the body's immune response and *** To study the expression and significance of T-regulatory cells(Tregs)interleukin(IL)-35,IL-10,and transforming growth factor-beta(TGF-β)in *** Data from 82 patients with DLBCL who were initially admitted to The First Affiliated Hospital of Ningbo University(Zhejiang Province,China)between January 2017 and June 2022 and treated with standard first-line regimens were *** patients were lost to follow-up;thus,79 patients were included in the statistical analysis and then divided into three groups according to the evaluation of clinical efficacy:Incipient(new-onset and treatment-naïve),effectively treated,and *** healthy individuals were included in the control *** expression of peripheral blood T lymphocytes and their associated factors IL-35,IL-10,and TGF-βin the four groups were *** In contrast to the successfully treated and normal control groups,both the incipient and relapse-refractory groups exhibited greater proportions of CD4-positive(+)Tregs(P0.05).The correlation between IL-35 and IL-10 concentrations was significantly positive,with a correlation coefficient of 0.531(P<0.05).The correlation between IL-35 and TGF-βconcentration was significantly positive,with a correlation coefficient of 0.375(P<0.05).The correlation

关键词： Diffuse large B-cell lymphoma T-regulatory cells Interleukin-35 Interleukin-10 Transforming growth factorbeta Immune response

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Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

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Current Medical Science 2024年第3期44卷 611-622页

作者： Ying CHEN Bi-xia LI Ting-ting NIU Shu-jun YANG Li-chao WU Le-huai SHI Duo-bing ZOU Ning-ning WU Li-xia SHENG Xiao YAN gui-fang ouyang Qi-tian MU Laboratory of Stem Cell Transplantation The First Affiliated Hospital of Ningbo UniversityNingbo315300China Ningbo Clinical Research Center For Hematologic Malignancies Ningbo315300China Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo315300China School of Medicine Hangzhou City UniversityZhejiang UniversityHangzhou310000China Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo315300China

Objective Acute myeloid leukemia(AML)is an aggressive hematological malignancy characterized by abnormal myeloid blast *** studies have demonstrated that circular RNAs play a role in AML *** this study,we aimed to investigate the clinical significance of circ_0012152 in AML and elucidate its underlying molecular mechanism in the pathogenesis of this *** Circ_0012152 expression was detected by quantitative real-time polymerase chain reaction in samples obtained from 247 patients with AML and 40 healthy controls.A systematic analysis of clinical characteristics and prognostic factors was also *** growth was assessed using the Cell Counting Kit-8(CCK-8)assay,and apoptosis and cell cycle progression were evaluated by flow ***,RNA pull-down was performed to identify target microRNAs,and transcriptome RNA sequencing and bioinformatics analyses were utilized to identify downstream mRNA *** Circ_0012152 was significantly upregulated in samples from patients with AML and served as an independent adverse prognostic factor for overall survival(OS)(hazard ratio:2.357;95%confidence interval 1.258–4.415).The circ_0012152 knockdown reduced cell growth,increased apoptosis,and inhibited cell cycle progression in AML cell *** pull-down and sequencing identified miR-652-3p as a target microRNA of circ_*** growth inhibition by circ_0012152 knockdown was significantly relieved by miR-652-3p *** suggested that miR-652-3p targeted SOX4,as the decrease in SOX4 expression resulting from circ_0012152 knockdown was upregulated by miR-652-3p inhibitors in AML *** Circ_0012152 is an independent poor prognostic factor for OS in AML,and it promotes AML cell growth by upregulating SOX4 through miR-652-3p.

关键词： acute myeloid leukemia circ_0012152 miR-652-3p SOX4 cell growth

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Effect of thermo-mechanical processing parameters on the dynamic restoration mechanism in an Mg-4Y-2Nd-1Sm-0.5Zr alloy during hot compression

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Journal of Materials Science & Technology 2021年第31期90卷 205-224页

作者： Yunwei gui Lingxiao ouyang Yibei Xue Quanan Li School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal New Materials and Advanced Processing Technology Luoyang 471023China Department of Materials Processing Graduate School of EngineeringTohoku University6-6-11 AobaAramakiAoba-kuSendai980-8579Japan School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

Microstructure evolution and dynamic restoration mechanism of solution-treated Mg-4Y-2Nd-1Sm-0.5Zr alloy have been studied under three TMP parameters consisting of deformation temperatures(350-500℃),strain rates(0.01-5 s^(-1)),and strains(0.2,0.4,and 0.8).A strong dynamic softening is observed in all stress-strain curves,even at higher strain rates(1 and 5 s^(-1))due to an adiabatic heating *** stress-strain curves are applied to construct a processing map and develop an Arrhenius-type constitutive *** the prediction of the processing map,an optimal processing domain has been determined to be the temperature range 450-500℃and strain rate range 0.01-0.1 s^(-1)at a strain of *** volume fraction of DRX grains is the largest in the corresponding domain of high temperature and low strain *** the effect of TMP parameters on the dynamic restoration,the discontinuous dynamic recrystallization(DDRX)and continuous DRX(CDRX)synergistic effect occur throughout the whole process at high temperature and high strain *** terms of high temperature and low strain rate,DDRX characteristics at a low strain and then the DDRX+CDRX synergistic effect is observed at a higher *** the DRX process is weak at low temperature and low strain rate,deformation twins have occurred and provided nucleation sites for DRX grains.

关键词： Mg-RE alloy TMP parameters Processing map prediction Constitutive analysis Dynamic restoration mechanism

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Twin-twin geometric structure effect on the twinning behavior of an Mg-4Y-3Nd-2Sm-0.5Zr alloy traced by quasi-in-situ EBSD

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Journal of Magnesium and Alloys 2023年第4期11卷 1381-1392页

作者： Yunwei gui Quanan Li Yibei Xue Lingxiao ouyang School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal New Materials and Advanced Processing Technology Luoyang 471023China Department of Materials Processing Graduate School of EngineeringTohoku University6-6-11 AobaAramakiAoba-kuSendai 980-8579Japan School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

We studied the microstructure evolution of Mg-4Y-3Nd-2Sm-0.5Zr alloy by quasi-in-situ electron backscatter diffraction(EBSD)along with several strains under compression tests,which provided direct evidence for the influence of different twin-twin geometric structure on the twinning *** results showed that the mechanical properties of the alloy were higher than traditional magnesium alloys(the maximum compressive strength reaches 402.5 MPa)due to the strengthening effect of Sm and Nd elements addition on solution strengthening,precipitation strengthening,and grain *** with the quasi-in-situ EBSD technique,two different twin-twin geometric structures,‘parallel structure’and‘cross structure’,were observed directly in the *** the later stage of deformation,for‘parallel structure’,residual stress and a large number of dislocations mainly existed in the twin boundary and tip *** the‘cross structure’,there was a lot of dislocation density in the interior of twins after *** twin growth rate of‘parallel structure’was much faster than that of‘cross structure’because the stress of twins was mainly concentrated on the tip of *** the movement for the tip of twin was blocked,the growth rate of twin would be obviously ***,the‘cross structure’was easy to produce closed *** to the constraints of surrounding twins,the confined space was easy to stress concentration,thus inhibiting the growth of *** the same time,the‘cross structure’of twins needed a more external force to continue to deform,which also served as a strengthening structure.

关键词： Mg-RE alloy Mechanical testing Twinning Quasi-in-situ EBSD

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Fluid identification and effective fracture prediction based on frequency-dependent AVOAz inversion for fractured reservoirs

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Petroleum Science 2021年第4期18卷 1069-1085页

作者： Muhammad Ajaz fang ouyang gui-Hai Wang Shuang-Lian Liu Li-Xin Wang Jian-Guo Zhao State Key Laboratory of Petroleum Resources and Prospecting Key Laboratory of Geophysical Prospecting of CNPCChina University of Petroleum(Beijing)Beijing102249China China National Oil&Gas Exploration and Development Corporation Beijing100034China Sinopec Research Institute of Petroleum Engineering Beijing100101China Sinopec North China E&P Company Beijing100728China

Fluid and effective fracture identification in reservoirs is a crucial part of reservoir *** frequency-dependent AVO inversion algorithms have proven to be effective for identifying fluid through its dispersion ***,the conventional frequency-dependent AVO inversion algorithms based on Smith&Gidlow and Aki&Richards approximations do not consider the acquisition azimuth of seismic data and neglect the effect of seismic anisotropic dispersion in the actual *** aligned fractures in the subsurface medium induce *** seismic anisotropy should be considered while accounting for the seismic dispersion properties through fluid-saturated fractured *** in such reservoirs is frequency-related due to wave-induced fluid-flow(WIFF)between interconnected fractures and *** can be used to identify fluid and effective fractures(fluid-saturated)by using azimuthal seismic data via anisotropic dispersion *** this paper,based on Rüger’s equation,we derived an analytical expression in the frequency domain for the frequencydependent AVOAz inversion in terms of fracture orientation,dispersion gradient of isotropic background rock,anisotropic dispersion gradient,and the dispersion at a normal incident *** frequency-dependent AVOAz equation utilizes azimuthal seismic data and considers the effect of both isotropic and anisotropic *** Gabor Transform(RGT)is used to achieve highresolution frequency division *** then propose the frequency-dependent AVOAz inversion method to identify fluid and characterize effective fractures in fractured porous *** application to high-qualified seismic data of dolomite and carbonate reservoirs,the results show that the method is useful for identifying fluid and effective fractures in fluid-saturated fractured rocks.

关键词： Frequency-dependent AVOAz inversion P-wave anisotropy Seismic dispersion Effective fractures Fluid identification

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On t-Dimension over Strong Mori Domains

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Acta Mathematica Sinica,English Series 2006年第1期22卷 131-138页

作者： fang gui WANG Institute of Mathematics and Software Science Sichuan Normal University Chengdu 610068 P. R. China

In this note we prove that if R is a strong Mori domain with t-dim R = n and with countably many prime v-ideals, then there is a chain of rings between R and R^w R1=R belong to R2……belong to Rn lohtuin in R^w such ... 详细信息

关键词： Strong Mori domain t-dimension w-integral closure

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Half-metallicity induced by out-of-plane electric field on phosphorene nanoribbons

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Chinese Physics B 2022年第7期31卷 524-528页

作者： Xiao-fang ouyang Lu Wang School of Physics and Electrical Information Shangqiu Normal UniversityHenan 476000China

Exploring the half-metallic nanostructures with large band gap and high carrier mobility is a crucial solution for developing high-performance spintronic *** electric and magnetic properties of monolayer zigzag black-phosphorene nanoribbons(ZBPNRs)with various widths are analyzed by means of the first-principles *** results show that the magnetic ground state is dependent on the width of the *** ground state of narrow nanoribbons smaller than 8ZBPNRs prefers ferromagnetic order in the same edge but antiferromagnetic order between two opposite *** addition,we also calculate the electronic band dispersion,density of states and charge density difference of 8ZBPNRs under the action of out-of-plane electric *** interesting,the addition of out-of-plane field can modulate antiferromagnetic semiconductor to the half metal by splitting the antiferromagnetic *** results propose a new approach to realize half-metal in phosphorene,which overcomes the drawbacks of graphene/silicene with negligible band gap as well as the transitional metal sulfide(TMS)with low carrier mobility.

关键词： half-metal antiferromagnetic two-dimensional materials spin polarization

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Corner Flow Control in High Through-Flow Axial Commercial Fan/Booster Using Blade 3-D Optimization

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Journal of Thermal Science 2012年第1期21卷 32-41页

作者： fang Zhu Donghai Jin Xingmin gui Aeroengine Numerical Simulation Research Center Beihang University Beijing China

This study is aimed at using blade 3-D optimization to control corner flows in the high through-flow fan/booster of a high bypass ratio commercial turbofan engine. Two kinds of blade 3-D optimization, end-bending and bow, are focused on. On account of the respective operation mode and environment, the approach to 3-D aerodynamic modeling of rotor blades is different from stator vanes. Based on the understanding of the mechanism of the corner flow and the consideration of intensity problem for rotors, this paper uses a variety of blade 3-D optimization approaches, such as loading distribution optimization, perturbation of departure angles and stacking-axis manipulation, which are suitable for rotors and stators respectively. The obtained 3-D blades and vanes can improve the corner flow features by end-bending and bow effects. The results of this study show that flows in corners of the fan/booster, such as the fan hub region, the tip and hub of the vanes of the booster, are very complex and dominated by 3-D effects. The secondary flows there are found to have a strong detrimental effect on the compressor performance. The effects of both end-bending and bow can improve the flow separation in corners, but the specific ways they work and application scope are somewhat different. Redesigning the blades via blade 3-D optimization to control the corner flow has effectively reduced the loss generation and improved the stall margin by a large amount.

关键词： corner flow control fan/booster blade 3-D optimization end-bending bow

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