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Characteristics of Radar Echo Parameters and Microphysical Structure Simulation of a Short-Time Heavy Precipitation Supercell

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Journal of Tropical Meteorology 2022年第4期28卷 388-404页

作者： zhao gui-xiang WANG Yi-jie LIAN Zhi-luan Shanxi Meteorological Observatory Taiyuan 030006 China Hebei Meteorological Observatory Shijiazhuang 050021 China

By using the conventional observations, radar data, NCEP/NCAR FNL 1°×1° reanalysis data and numerical simulation data and with the construction and calculation of radar echo parameters, this paper presents the structural characteristics and physical processes of a short-time heavy precipitation supercell that occurred in the squall line process in Shanxi Province on 24 June 2020. The results show that this squall line event occurred in front of a surface cold front,combined with infiltration of low-level cold air and continuous increase of near-surface humidity in the afternoon. The surface mesoscale convergence line and mesoscale dew point front contributed to the development and systemization of the squall line by a large degree. The short-time extremely heavy precipitation in Pingshun County was caused by the development of a supercell from thunderstorm cells on the front side of the squall line. The characteristics of sharp increase in vertical integral liquid water content, persistent increase in reflectivity factor and continuous rise in the echo top height appeared about 23 min earlier than the severe precipitation, which has qualitative indicating significance for the nowcasting of short-time heavy precipitation. A quantitative analysis of the radar echo parameters suggests that the“sudden drop”of FV40was a precursor signal of cells’ coalescence and rapid development to the mature stage. The areal change of the echo core at the 6 km height was highly subject to the merging and developing of cells, the rapid change of hydrometeor particles in clouds and the precipitation intensity. Changes in the cross-sectional area of convective cells at different heights can indirectly reflect the changes of liquid particles and ice particles in clouds, which is indicatively meaningful for predicting the coalescing and developing-to-maturing of cells and heavy precipitation 30-45 min earlier.A comprehensive echo parameter prediction model constructed by the random forest p

关键词： supercell short-time heavy rainfall radar echo parameters microphysical structure

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Expression and significance of factors related to angiogenesis in choroidal melanoma

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 49-54页

作者： Qiang Xu gui-Qiu zhao Jie zhao Hong Lin Ying-Ying Mou Qing Wang and Wei-Rong Sun Department of Ophthalmology Affiliated Hospital of Qingdao University Medical Collage Qingdao 266003 Shandong Province China

AIM: To investigate expression of factors related to angiogenesis: HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma and its clinical significance. METHODS: Fifty samples of choroidal melanoma and 15 samples of melanocytic nevi of the eyelid identified by pathology were collected. Immunohistochemistry SP method was used to examine the expression of HIF-1 alpha, iNOS, COX-2 and VEGF in these samples. The comparison among groups was done by SPSS 13.0 software. RESULTS: The positive expression rates of HIF-1 alpha, iNOS, COX-2 and VEGF in choroidal melanoma group were significantly higher than those in eyelid nevi group (chi(2)= 6.5542, 7.7224, 8.5828, 15.1749). The positive expression rate of VEGF was associated with the tumor size (chi(2)= 10.9194), but was not associated with pathological type (chi(2)=2.0712) and the situation of scleral invasion (chi(2)= 5.4289). The positive expression rate of HIF-1 alpha was associated with the tumor size (chi(2)=7.1216) and pathological type (chi(2)=9.0889), but was not associated with the situation of scleral invasion (chi(2)=3.3586). The positive expression rate of iNOS was associated with the tumor size (chi(2)=9.5503), but was not associated with pathological type (chi(2)=1.9450) and the situation of scleral invasion (chi(2)=2.3810). The positive expression rate of COX-2 was associated with the tumor size (chi(2)=7.2970), but was not associated with pathological type (chi(2)=1.8421) and the situation of sclera! invasion (chi(2)= 0.4018). The expression of HIF-1 alpha, iNOS and COX-2 were significantly associated with the expression of VEGF (r = 0.9429, 1, 0.9857). The expression of COX-2 was significantly associated with the expression of iNOS (r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of COX-2 ( r=0.9857). The expression of HIF-1 alpha was significantly associated with the expression of iNOS (r= 0. 9429). CONCLUSION: The expression of HIF-1 alpha, iNOS and COX-2 protein

关键词： choroidal melanoma immunohistoehemistry hypoxia inducible factor-1a inducible nitric oxide synthase cyclooxygenase-2

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Protein tyrosine phosphatase 1B regulates migration of ARPE-19 cells through EGFR/ERK signaling pathway

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 891-897页

作者： zhao-Dong Du Li-Ting Hu gui-Qiu zhao Qian Wang Qiang Xu Nan Jiang Jing Lin Department of Ophthalmology Affiliated Hospital of Qingdao University

AIMTo evaluate whether protein tyrosine phosphatase 1B (PTP1B) contributed to initiate human retinal pigment epithelium cells (A)-19 migration and investigate the signaling pathways involved in this ***-19 cells were cultured and treated with the siRNA-PTP1B. Expression of PTP1B was confirmed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). AG1478 [a selective inhibitor of epidermal growth factor receptor (EGFR)] and PD98059 (a specific inhibitor of the activation of mitogen-activated protein kinase) were used to help to determine the PTP1B signaling mechanism. Western blot analysis verified expression of EGFR and extracellular signal-regulated kinase (ERK) in ARPE-19 cells. The effect of siRNA-PTP1B on cell differentiation was confirmed by immunostaining for α-smooth muscle actin (α-SMA) and qRT-PCR. Cell migration ability was analyzed by transwell chamber *** mRNA levels of PTP1B were reduced by siRNA-PTP1B as determined by qRT-PCR assay. SiRNA-PTP1B activated EGFR and ERK phosphorylation. α-SMA staining and qRT-PCR assay demonstrated that siRNA-PTP1B induced retinal pigment epithelium (RPE) cells to differentiate toward better contractility and motility. Transwell chamber assay proved that PTP1B inhibition improved migration activity of RPE cells. Treatment with AG1478 and PD98059 abolished siRNA-PTP1B-induced activation of EGFR and ERK, α-SMA expression and cell ***1B inhibition promoted myofibroblast differentiation and migration of ARPE-19 cells, and EGFR/ERK signaling pathway played important role in migration process.

关键词： protein tyrosine phosphatase 1B retinal pigment epithelium cell migration epidermal growth factor receptor extracellular signal-regulated kinase

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A two-dimensional microporous metal–organic framework for highly selective adsorption of carbon dioxide and acetylene

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Chinese Chemical Letters 2017年第8期28卷 1653-1658页

作者： Osamah Alduhaish Bin Li Hadi Arman Rui-Biao Lin John Cong-gui zhao Banglin Chen Deportment of Chemistry University of Texas at San AntonioSon AntonioTX 78249-0698USA

Solvothermal reaction of 3-aminoisonicotinic acid（Haina） and Cu（NO_3）_2·2.5H_2O gave a novel twodimensional（2D） microporous metal–organic framework, [Cu（aina）_2（DMF）]·DMF（1, DMF = N,N-dimethylformamide）. Single-crystal X-ray crystallographic study of compound 1 revealed that Cu（II）ions are linked by ainaàligands forming square grid-like layers, which stack together via multiple hydrogen bonding interactions. The solvent-free framework of 1a displayed considerable porosity（void = 46.5%） with one-dimensional（1D） open channels（4.7 ？？ 4.8 ？） functionalized by amino *** sorption measurements of 1 revealed selective carbon dioxide（CO_2） and acetylene（C_2H_2） adsorption over methane（CH_4） and nitrogen（N_2） at ambient temperature.

关键词： Metal–organic frameworks Two-dimensional structure 3-Aminoisonicotinic acid Hydrogen bonding Gas separation Acetylene

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Epidemiological characteristics and risk factors of diabetic retinopathy in type 2 diabetes mellitus in Shandong Peninsula of China

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 202-206页

作者： zhao-Dong Du Li-Ting Hu gui-Qiu zhao Yan Ma Zhan-Yu Zhou and Tao Jiang Department of Ophthalmology Affiliated Hospital of Medical College of Qingdao University Qingdao 266003 Shandong Province China

AIM: To determine the epidemiological characteristics and estimate the risk factors of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Shandong Peninsula of China. METHODS: The cases of T2DM admitted to Affiliated Hospital of Medical College of Qingdao University, Shandong Province, China, from January 2006 to December 2010 were retrospectively reviewed. The epidemiological characteristics of DR were estimated. The cases were divided into two groups according to degrees of retinopathy: non-DR group and DR group. Logistic regression analysis was used to study the related risk factors of DR. RESULTS: The prevalence of DR in patients with T2DM was 25.08% (834/3326). There was significant difference between the average age for men (59.08 +/- 15.43 years) and for women (62.92 +/- 18.19 years, P=0.0021). The majority of DR occurred in women (female: male ratio=1.76:1, P<0.0001). The incidence rate of DR in urban (489/834) was higher than that in rural area (345/834, P<0.0001). In 834 DR patients, the mean duration of T2DM was 8.90 +/- 4.15 years (range: 0-16 years); 440 people (52.76%) had received varying degrees of health education about prevention and primary care of DM; and 473 people (56.71%) suffered from other DM complications confirmed at the same time. In addition, the incidence rate of monocular (551/3326) and binocular retinopathy (283/3326) were statistically different (P<0.0001). Factors associated (p<0.05) with the presence of DR included old age, lower health educational level, intraocular surgery history, longer duration of T2DM, accompanying with other DM complications, no standard treatment procedure, lower body mass index (BMI) and higher fasting plasma glucose (FPG), glycated hemoglobin A(1)C (HbA(1)C), urine albumin (UA), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C). The risk factors (P<0.05) independently associated with the presence of DR were: longer duration of T2DM, lower health educational lev

关键词： diabetic retinopathy type 2 diabetes mellitus risk factors

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Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism

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World Journal of Gastroenterology 2007年第26期13卷 3625-3630页

作者： Han Bai Lin Zhang Li Ma Xiao-Guang Dou Guo-He Feng gui-Zhen zhao Department of Infectious Diseases Shenging Hospital Affiliated to CMU Shenyang 110004 Liaoning Province China

AIM: To explore the mechanism of intra-uterine transmission,the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments. METHODS: A variety of methods,such as ELISA,RT- PCR,IHC staining and immunofluorescent staining were employed to test the HBV marker positive pregnant women's placenta and in vitro cultured placental trophoblastic cells. RESULTS: The HBV DNA levels in pregnant women's serum and fetal cord blood were correlated. For those cord blood samples positive for HBV DNA,their maternal blood levels of HBV DNA were at a high level. The HBsAg IHC staining positive cells could be seen in the placental tissues and the presence of HBV DNA detected. After co-incubating the trophoblastic cells and HBV DNA positive serum in vitro,the expressions of both HBsAg and HBV DNA could be detected. CONCLUSION: The mechanism of HBV intra-uterine infection may be due to that HBV breaches the placental barrier and infects the fetus.

关键词： Hepatitis B virus Infection Intra-uterinetransmission Mechanism

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Interference study on the free calcium in the human peripheral lymphocyte by acrylamide

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Chinese Chemical Letters 2008年第6期19卷 756-757页

作者： Hai Yan Wang Chun gui zhao Ye Hong Zhou Shao Min Shuang Chuan Dong School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China Medical College of Shanxi Datong University Datong 037000 China

The role of acrylamide on the human peripheral lymphocytes was studied by laser scanning confocal microscopy technique and fluo-3. The calibration value of the apparent dissociation constant （Kd） of the fluo-3-Ca^2＋ complex was obtained as 4.83 × 10^-7 moi/L. Acrylamide （〈54 μg/mL） evoked a rise in free intracellular calcium concentration [Ca^2＋]i, in a dosedependent manner. Acrylamide induced the increase of [Ca^2＋]i was discussed in detail.

关键词： Laser scanning confocal microscopy Acrylamide Lymphocytes Fluo-3 [Ca^2+]i

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施氮制度及间作对燕麦氮素吸收和土壤氮素的影响

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草原与草坪 2024年第2期44卷 164-172页

作者：张宁赵桂琴张丽睿杜文盼柴继宽甘肃农业大学草业学院草业生态系统教育部重点实验室甘肃省草业工程实验室中-美草地畜牧业可持续发展研究中心甘肃兰州730070

【目的】研究不同的施氮制度对燕麦/豌豆间作体系中燕麦的吸收情况以及对土壤氮素的影响。【方法】采用随机区组试验设计,设N0(不施氮)、N1(基肥20%+分蘖期追肥20%+开花期追肥60%)、N2(基肥20%+分蘖期追肥30%+开花期追肥50%)和N3(基肥2... 详细信息

【目的】研究不同的施氮制度对燕麦/豌豆间作体系中燕麦的吸收情况以及对土壤氮素的影响。【方法】采用随机区组试验设计,设N0(不施氮)、N1(基肥20%+分蘖期追肥20%+开花期追肥60%)、N2(基肥20%+分蘖期追肥30%+开花期追肥50%)和N3(基肥20%+分蘖期追肥40%+开花期追肥40%)4个施氮制度;3种种植模式(燕麦/豌豆间作、燕麦单作和豌豆单作),研究施氮制度对间作燕麦氮素吸收和土壤氮素的影响。【结果】施氮制度和间作对燕麦籽粒产量、氮素吸收和土壤氮素影响显著。间作燕麦籽粒产量在N2处理下最大,较N3增产22.48%。随着生育期的推进,在拔节期、抽穗期、灌浆期和成熟期间作燕麦的吸氮量较单作燕麦分别提高了26.5%、15.8%、7.3%和17.1%;间作燕麦在N2处理下吸氮量最大,为71.2 kg/hm^(2),较N0增加了49.9%。在0~20 cm土层间作燕麦的土壤全氮含量在N0、N1、N2和N3处理下分别较单作提高12.9%、11.2%、15.4%和6.9%;间作燕麦在拔节期、抽穗期、灌浆期和成熟期的土壤硝态氮含量和铵态氮均高于单作燕麦。【结论】在20~40 cm土层,间作燕麦较单作燕麦的土壤全氮和硝态氮含量增加;铵态氮含量降低,但增加和降低差异不显著。

关键词：燕麦/豌豆间作氮素吸收土壤氮素

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SIMULATION OF BOUNDARY LAYER EFFECTS ON A HEAVY RAINFALL EVENT CAUSED BY A MESOSCALE CONVECTIVE SYSTEM OVER THE YELLOW RIVER MIDSTREAM AREA

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Journal of Tropical Meteorology 2020年第1期26卷 111-124页

作者： zhao gui-xiang WANG Yi-jie WANG Xiao-li Shanxi Meteorological Observatory Taiyuan 030006 China

A heavy rainfall event caused by a mesoscale convective system(MCS),which occurred over the Yellow River midstream area during 7-9 July 2016,was analyzed using observational,high-resolution satellite,NCEP/NCAR reanalysis,and numerical simulation *** heavy rainfall event was caused by one mesoscale convective complex(MCC)and five MCSs *** MCC rainstorm occurred when southwesterly winds strengthened into a *** MCS rainstorms occurred when low-level wind fields weakened,but their easterly components in the lower and boundary layers increased *** analysis revealed that there were obvious differences between the MCC and MCS rainstorms,including their three-dimensional airflow structure,disturbances in wind fields and vapor distributions,and characteristics of energy conversion and *** of the MCC was related to southerly conveyed water vapor and energy to the north,with obvious water vapor exchange between the free atmosphere and the boundary *** regeneration and development of the MCSs mainly relied on maintenance of an upward extension of a positive water vapor *** MCC rainstorm was triggered by large range of convergent ascending motion caused by a southerly jet,and easterly disturbance within the boundary *** a southerly fluctuation and easterly disturbance in the boundary layer were important triggers of the MCS *** and development of the MCC and MCSs were linked to secondary circulation,resulting from convergence of Ekman non-equilibrium flow in the boundary *** intensity and motion of the convergence centers in MCC and MCS cases were ***,sub-synoptic scale systems in the middle troposphere played a leading role in determining precipitation distribution during this *** mesoscale systems triggered by the sub-synoptic scale system induced the heavy rainfall,small-scale disturbances within the boundary layer determined its inte

关键词： heavy rainfall MCS boundary layer disturbance Ekman adaptation energy wave packet propagation numerical simulation

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Effects of Danggui-Shaoyao-San on the Influence of Spatial Learning and Memory Induced by Experimental Tooth Movement

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Chinese Medical Journal 2015年第14期128卷 1948-1955页

作者： Hong-Shi Li Jie Ke gui-Zhi zhao Li-An Wu Jun-Ping Kou Hong-Chen Liu Department of Stomatology of the General Air Force Hospital Beijing 100142 China Department of Paediatric Dentistry School of Stomatology Fourth Military Medical University Xi'an Shaanxi 710032 China State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing Jiangsu 210038 China Institute of Stomatology Chinese PLA General Hospital Beijing 100853 China

Background： The pain caused by orthodontic treatment has been considered as tough problems in orthodontic practice. There is substantial literature on pain which has exactly effected on learning and memory; orthodontic tooth movement affected the emotional status has been showed positive outcomes. Danggui-Shaoyao-San （DSS） is a Traditional Chinese Medicine prescription that has been used for pain treatment and analgesic effect for orthodontic pain via inhibiting the activations of neuron and glia. We raised the hypothesis that DSS could restore the impaired abilities of spatial learning and memory via regulating neuron or glia expression in the hippocampus. Methods： A total of 36 rats were randornly divided into three groups：（ 1 ） Sham group （n = 12）, rats underwent all the operation procedure except for the placement of orthodontic forces and received saline treatment：（2） experimental tooth movement （ETM） group （n - 12）, rats received saline treatment and ETM：（3） DSS ＋ ETM （DETM） group （n = 12）, rats received DSS treatment and ETM. All DETM group animals were administered with DSS at a dose of 150 mg/kg. Monis water maze test was evaluated： immunofluorescent histochemistry was used to identity astrocytes activation, and immunofluorescent dendritic spine analysis was used to identify the dendritic spines morphological characteristics expression levels in hippocampus. Results： Maze training sessions during the 5 successive days revealed that ETM significantly deficits in progressive learning in rats, DSS that was given from day 5 prior to ETM enhanced progressive learning. The ETM group rats took longer to cross target quadrant during the probe trial and got less times to cross-platform than DETM group. The spine density in hippocampus in ETM group was significantly decreased cornpared to the sham group. In addition, thin and mature spine density were decreased too. However, the DSS administration could reverse the dendritic shrinkage and increase the spine de

关键词： Astrocytes Danggui-Shaoyao-San Dendritic Spines Experimental Tooth Movement Hippocampus Spatial Learning and Memory

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