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Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

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Petroleum Science 2024年第1期21卷 609-620页

作者： Fu-Cheng Deng Fu-Lin gui Bai-Tao Fan Lei Wen Sheng-Hong Chen ning Gong Yun-Chen Xiao Zhi-Hui Xu Yangtze university Jingzhou434023HubeiChina CnOOC Research Institute Ltd. Beijing100028China CnOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CnOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas ***,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the *** explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined *** to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was *** results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of *** the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control *** the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the *** the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage *** microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

Analysis and Key Parameter Optimization Design of Leningrader Seal Performance

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Wuhan university Journal of natural Sciences 2024年第2期29卷 177-192页

作者： YAnG Dongya WAnG Xuelin WAnG Feng ZHAnG Hailong GAO gui College of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050Gansu China Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of TechnologyWenzhou 325000ZhejiangChina State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000GansuChina

In order to improve the performance and service life of the Leningrader seal of the Stirling engine piston rod,interference,pre-load and friction coefficient were taken as influencing factors,and the curved surface response method was adopted to reduce the contact stress of sealing surface and von Mises stress of the sealing sleeve as the response index,with the optimization goal of reducing wear and extending *** above three key parameters are analyzed and optimized,the influence of each parameter on the sealing performance and service life is obtained,and the best combination scheme of the three is *** results show that the interaction between pre-tightening force and interference fit has the greatest impact on contact *** interaction between interference fit and friction coeffi-cient has the most significant effect on von Mises *** optimized parameters can reduce the maximum contact stress and maximum von Mises stress of the sealing sleeve by 26.3%and 20.6%,respectively,under a media pressure of 5-9 *** bench verification shows that the leakage of the optimized sealing device in 12 h is reduced by 0.44 cc·min^(-1)(1 cc=1 cm^(3)).The wear rate of the sealing sleeve is 1.08%before optimization and 0.45%after optimization,indicating that the optimized parameters in this paper are effective.

关键词： Leningrader seal Stirling engine performance analysis optimized design parameter configuration

The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing Yang Wen-Jing Zhang Yi-Ling Zhou gui-Jun Zhao Ya Huang Shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

A review of methane leakage from abandoned oil and gas wells:A case study in Lubbock,Texas,within the Permian Basin

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Energy Geoscience 2024年第3期5卷 1-12页

作者： Stanley u.Opara Chinedu J.Okere Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityTXUSA

In the pursuit of global net zero carbon emissions and climate change mitigation,ongoing research into sustainable energy sources and emission control is *** review examines methane leakage from abandoned oil and gas(AOG)wells,focusing particularly on Lubbock,a geographic area situated within the larger region known as the Permian Basin in West Texas,united *** objective is to assess the extent and environmental implications of methane leakage from these *** analysis integrates pertinent literature,governmental and industry data,and prior Lubbock *** affecting methane leakage,including well integrity,geological characteristics,and human activities,are *** research estimates 1781 drilled wells in Lubbock,forming a foundation for targeted assessments and monitoring due to historical drilling *** hierarchy of well statuses in Lubbock highlights the prevalence of“active oil wells,”trailed by“plugged and abandoned oil wells”and“inactive oil wells.”Methane leakage potential aligns with these well types,underscoring the importance of strategic monitoring and *** analysis notes a zenith in“drilled and completed”wells during *** our study's case analysis and literature review reiterate the critical significance of assessing and mitigating methane emissions from AOG wells,it's important to clarify that the research does not directly provide methane leakage ***,it contextualizes the issue's magnitude and emphasizes the well type and status analysis's role in targeted mitigation *** summary,our research deepens our understanding of methane leakage,aiding informed decision-making and policy formulation for environmental *** clarifying well type implications and historical drilling patterns,we aim to contribute to effective strategies in mitigating methane emissions from AOG wells.

关键词： net zero carbon emissions Climate change mitigation Methane emission control Abandoned oil and gas(AOG)well Permian Basin

Management and classification of the fracture of lateral process of talus:An overview and literature update

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World Journal of Clinical Cases 2024年第15期12卷 2487-2498页

作者： Chao-Qun Wang ulrich Stockle Sheng-nan Dong Xu-gui Li Ze-Xi Ling Department of Traumatic Orthopedics The Affiliated Hospital of Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Center of Musculoskeletal Surgery Berlin CharitéMedical University HospitalBerlin 13353Germany

Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or *** recent years,as researchers from all over the world have further deepened their research on FLPT,there has been a breakthrough in the classification,and the methods and principles of clinical management have changed accordingly;however,there is still no standardized guideline for the diagnosis and management of FLPT,and there have been few relevant literature review articles related to this kind of fracture in the past at least 5 *** this article,we review the clinical classification,classification-based therapeutic recommendations,and prognosis of FLPT,with the aim of providing a reference for the clinical diagnosis and management of this infrequent fracture.

关键词： Fracture of the lateral process of the talus Fracture of the talus Hindfoot injuries Intraarticular fracture Subtalar joint

Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study

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World Journal of Psychiatry 2024年第8期14卷 1244-1253页

作者： Yan-Mei Yu gui-Hong Jin Chong Zhong Hao Qian Lei Wang Feng Zhan Department of Pediatrics The First People's Hospital of ChuzhouChuzhou 239001Anhui ProvinceChina Department of Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000Zhejiang ProvinceChina

BACKGROunD The interplay between inflammation,immune dysregulation,and the onset of neurological disorders,including epilepsy,has become increasingly ***(IL)-6,a pro-inflammatory cytokine,is suspected to not only mediate traditional inflammatory pathways but also contribute to neuroinflammatory responses that could underpin neuropsychiatric symptoms and broader psychiatric disorders in epilepsy *** role of IL-6 receptor(IL6R)blockade presents an intriguing target for therapeutic intervention due to its potential to attenuate these *** conditions due to *** Mendelian randomization(MR)analysis employing single nucleotide poly-morphisms(SnPs)in the vicinity of the IL6R gene(total individuals=408225)was used to evaluate the putative causal relationship between IL6R blockade and epilepsy(total cases/controls=12891/312803),focal epilepsy(cases/controls=7526/399290),and generalized epilepsy(cases/controls=1413/399287).SnP weights were determined by their effect on C-reactive protein(CRP)levels and integrated using inverse variance-weighted meta-analysis as surrogates for IL6R *** address potential outlier and pleiotropic influences,sensitivity analyses were conducted employing a variety of MR methods under different modeling *** The genetic simulation targeting IL6R blockade revealed a modest but significant reduction in overall epilepsy risk[inverse variance weighting:Odds ratio(OR):0.827;95%confidence interval(CI):0.685-1.000;P=0.05].Subtype analysis showed variability,with no significant effect observed in generalized,focal,or specific childhood and juvenile epilepsy *** the primary inflammatory marker CRP,the findings also suggested potential non-inflammatory pathways mediated by IL-6 signaling contributing to the neurobiological landscape of epilepsy,hinting at possible links to neuroinflammation,psychiatric symptoms,and associated mental *** The i

关键词： Epilepsy Interleukin-6 receptor blockade Mendelian randomization neuroinflammation Psychiatric disorders

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多措并举标本兼治有力有效做好基督教工作

中国宗教 2024年第5期 33-34页

作者： 1.中共山东省委统战部 2.山东省民宗委中共山东省委统战部山东省民宗委

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责... 详细信息

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责任制,通过强化组织保障“小切口”,推动基层宗教事务管理“大文章”。一是压实主体责任。将宗教工作纳入各级党委重要议事日程,构建起各级党委齐抓共管的工作体制。

关键词：基督教中国化齐抓共管宗教事务管理主体责任工作责任制和谐稳定严格落实标本兼治

The impact of being in the COVID-19 pandemic on in-hospital mortality of non-infected patients aged 80 years and older with ST-elevation myocardial ınfarction

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Journal of Geriatric Cardiology 2024年第7期21卷 768-774页

作者： Mustafa Ebik Muhammet Gürdoğan uğurÖzkan Department of Cardiology Edirne SultanMurat State HospitalEdirneTurkey Department of Cardiology School of MedicineTrakya UniversityEdirneTurkey

The COVID-19 outbreak in late 2019 was declared a pandemic by the World Health Organization(WHO)on March 12,2020.[1]As of the latest WHO data,COVID-19 has caused over 770 million cases and nearly 7 million deaths worldwide.[2]Hospitalizations due to COVID-19 are correlated with advanced age.[3,4]According to re-ports,individuals over the age of 65 account for 80%of COVID-19-related deaths.[3,4]This is primar-ily due to the increased burden of comorbidity with age.

关键词： infected patients mortality

On some new travelling wave structures to the(3+1)-dimensional Boiti-Leon-Manna-Pempinelli model

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Journal of Ocean Engineering and Science 2024年第2期9卷 99-111页

作者： Kalim u.Tariq Ahmet Bekir Muhammad Zubair Department of Mathematics Mirpur University of Science and TechnologyMirpur 10250 AJKPakistan neighbourhood of Akcaglan Imarli StreetNumber:28/4Eskisehir26030 Turkey

In this article,the(1/G')-expansion method,the Bernoulli sub-ordinary differential equation method and the modified Kudryashov method are implemented to construct a variety of novel analytical solutions to the(3+1)-dimensional Boiti-Leon-Manna-Pempinelli model representing the wave propagation through incompressible *** linearization of the wave structure in shallow water necessitates more critical wave capacity conditions than it does in deep water,and the strong nonlinear properties are *** novel travelling wave solutions have been observed including solitons,kink,periodic and rational solutions with the aid of the latest computing tools such as Mathematica or *** physical and analytical properties of several families of closed-form solutions or exact solutions and rational form function solutions to the(3+1)-dimensional Boiti-Leon-Manna-Pempinelli model problem are examined using Mathematica.

关键词： The(3+1)-dimensional Boiti-Leon-Manna-Pempinelli model The(1/G')-expansion method The Bernoulli sub-ODE method The modified Kudryashov method